Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QEQ1_LEIMA

TriTrypDb:

LmjF.16.1160 , LMJLV39_160018000 , LMJSD75_160017600

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEQ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.650
CLV_NRD_NRD_1	169	171	PF00675	0.581
CLV_NRD_NRD_1	297	299	PF00675	0.612
CLV_NRD_NRD_1	371	373	PF00675	0.635
CLV_NRD_NRD_1	480	482	PF00675	0.571
CLV_PCSK_KEX2_1	158	160	PF00082	0.650
CLV_PCSK_KEX2_1	169	171	PF00082	0.581
CLV_PCSK_KEX2_1	297	299	PF00082	0.612
CLV_PCSK_KEX2_1	320	322	PF00082	0.623
CLV_PCSK_KEX2_1	371	373	PF00082	0.635
CLV_PCSK_KEX2_1	435	437	PF00082	0.629
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.623
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.649
CLV_PCSK_PC7_1	154	160	PF00082	0.654
CLV_PCSK_SKI1_1	235	239	PF00082	0.587
CLV_PCSK_SKI1_1	247	251	PF00082	0.427
CLV_PCSK_SKI1_1	400	404	PF00082	0.486
CLV_PCSK_SKI1_1	432	436	PF00082	0.629
CLV_Separin_Metazoa	21	25	PF03568	0.540
DEG_APCC_DBOX_1	234	242	PF00400	0.550
DEG_APCC_DBOX_1	246	254	PF00400	0.416
DEG_APCC_DBOX_1	296	304	PF00400	0.592
DEG_APCC_DBOX_1	399	407	PF00400	0.475
DOC_CKS1_1	203	208	PF01111	0.676
DOC_CKS1_1	212	217	PF01111	0.488
DOC_CKS1_1	303	308	PF01111	0.577
DOC_CYCLIN_RxL_1	232	242	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	212	218	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.490
DOC_MAPK_gen_1	24	32	PF00069	0.527
DOC_MAPK_MEF2A_6	396	403	PF00069	0.530
DOC_MAPK_NFAT4_5	396	404	PF00069	0.532
DOC_PP2B_LxvP_1	210	213	PF13499	0.606
DOC_PP2B_LxvP_1	7	10	PF13499	0.498
DOC_PP4_FxxP_1	3	6	PF00568	0.590
DOC_PP4_FxxP_1	95	98	PF00568	0.608
DOC_USP7_MATH_1	389	393	PF00917	0.486
DOC_USP7_MATH_1	98	102	PF00917	0.514
DOC_WW_Pin1_4	1	6	PF00397	0.608
DOC_WW_Pin1_4	202	207	PF00397	0.688
DOC_WW_Pin1_4	211	216	PF00397	0.482
DOC_WW_Pin1_4	302	307	PF00397	0.599
DOC_WW_Pin1_4	361	366	PF00397	0.538
DOC_WW_Pin1_4	76	81	PF00397	0.655
LIG_14-3-3_CanoR_1	162	167	PF00244	0.549
LIG_14-3-3_CanoR_1	170	180	PF00244	0.531
LIG_14-3-3_CanoR_1	331	338	PF00244	0.502
LIG_14-3-3_CanoR_1	351	356	PF00244	0.378
LIG_14-3-3_CanoR_1	371	377	PF00244	0.493
LIG_14-3-3_CanoR_1	78	86	PF00244	0.538
LIG_APCC_ABBA_1	23	28	PF00400	0.558
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_eIF4E_1	113	119	PF01652	0.447
LIG_EVH1_2	180	184	PF00568	0.641
LIG_FHA_1	231	237	PF00498	0.565
LIG_FHA_1	303	309	PF00498	0.620
LIG_FHA_1	373	379	PF00498	0.628
LIG_FHA_2	365	371	PF00498	0.583
LIG_FHA_2	410	416	PF00498	0.528
LIG_LIR_Apic_2	2	6	PF02991	0.595
LIG_LIR_Apic_2	92	98	PF02991	0.622
LIG_LIR_Gen_1	339	350	PF02991	0.552
LIG_LIR_Nem_3	244	249	PF02991	0.470
LIG_LIR_Nem_3	339	345	PF02991	0.493
LIG_MYND_1	5	9	PF01753	0.496
LIG_NRBOX	114	120	PF00104	0.452
LIG_PCNA_yPIPBox_3	19	27	PF02747	0.547
LIG_SH2_CRK	419	423	PF00017	0.563
LIG_SH2_STAT5	355	358	PF00017	0.543
LIG_SH2_STAT5	419	422	PF00017	0.563
LIG_SH3_3	187	193	PF00018	0.606
LIG_SH3_3	2	8	PF00018	0.607
LIG_SH3_3	200	206	PF00018	0.586
LIG_SH3_3	300	306	PF00018	0.584
LIG_SH3_3	374	380	PF00018	0.682
LIG_SH3_3	443	449	PF00018	0.590
LIG_TYR_ITIM	219	224	PF00017	0.572
LIG_UBA3_1	249	258	PF00899	0.521
LIG_WW_2	5	8	PF00397	0.499
MOD_CDK_SPK_2	361	366	PF00069	0.570
MOD_CK1_1	123	129	PF00069	0.487
MOD_CK1_1	183	189	PF00069	0.583
MOD_CK1_1	289	295	PF00069	0.617
MOD_CK1_1	333	339	PF00069	0.557
MOD_CK1_1	364	370	PF00069	0.608
MOD_CK1_1	381	387	PF00069	0.494
MOD_CK1_1	388	394	PF00069	0.588
MOD_CK1_1	79	85	PF00069	0.656
MOD_CK1_1	99	105	PF00069	0.389
MOD_CK2_1	111	117	PF00069	0.429
MOD_CK2_1	141	147	PF00069	0.658
MOD_CK2_1	154	160	PF00069	0.563
MOD_CK2_1	364	370	PF00069	0.591
MOD_CK2_1	409	415	PF00069	0.522
MOD_GlcNHglycan	107	110	PF01048	0.411
MOD_GlcNHglycan	122	125	PF01048	0.489
MOD_GlcNHglycan	279	282	PF01048	0.624
MOD_GlcNHglycan	289	292	PF01048	0.659
MOD_GlcNHglycan	387	390	PF01048	0.617
MOD_GlcNHglycan	391	394	PF01048	0.518
MOD_GlcNHglycan	440	443	PF01048	0.598
MOD_GlcNHglycan	70	73	PF01048	0.547
MOD_GlcNHglycan	98	101	PF01048	0.494
MOD_GSK3_1	122	129	PF00069	0.622
MOD_GSK3_1	132	139	PF00069	0.592
MOD_GSK3_1	141	148	PF00069	0.524
MOD_GSK3_1	180	187	PF00069	0.697
MOD_GSK3_1	285	292	PF00069	0.689
MOD_GSK3_1	326	333	PF00069	0.625
MOD_GSK3_1	381	388	PF00069	0.520
MOD_GSK3_1	85	92	PF00069	0.632
MOD_N-GLC_1	141	146	PF02516	0.602
MOD_N-GLC_1	171	176	PF02516	0.555
MOD_NEK2_1	345	350	PF00069	0.424
MOD_NEK2_1	461	466	PF00069	0.659
MOD_PIKK_1	147	153	PF00454	0.591
MOD_PKA_1	371	377	PF00069	0.623
MOD_PKA_2	161	167	PF00069	0.548
MOD_PKA_2	254	260	PF00069	0.504
MOD_PKA_2	286	292	PF00069	0.712
MOD_PKA_2	330	336	PF00069	0.699
MOD_PKA_2	371	377	PF00069	0.623
MOD_PKA_2	409	415	PF00069	0.590
MOD_PKB_1	436	444	PF00069	0.614
MOD_Plk_1	82	88	PF00069	0.536
MOD_Plk_1	93	99	PF00069	0.468
MOD_Plk_2-3	136	142	PF00069	0.651
MOD_Plk_4	333	339	PF00069	0.677
MOD_Plk_4	345	351	PF00069	0.404
MOD_Plk_4	378	384	PF00069	0.557
MOD_Plk_4	409	415	PF00069	0.522
MOD_Plk_4	99	105	PF00069	0.559
MOD_ProDKin_1	1	7	PF00069	0.607
MOD_ProDKin_1	202	208	PF00069	0.689
MOD_ProDKin_1	211	217	PF00069	0.481
MOD_ProDKin_1	302	308	PF00069	0.600
MOD_ProDKin_1	361	367	PF00069	0.545
MOD_ProDKin_1	76	82	PF00069	0.655
TRG_DiLeu_BaEn_1	38	43	PF01217	0.474
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.613
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.420
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.585
TRG_DiLeu_LyEn_5	38	43	PF01217	0.490
TRG_ENDOCYTIC_2	221	224	PF00928	0.570
TRG_ENDOCYTIC_2	419	422	PF00928	0.522
TRG_ER_diArg_1	168	170	PF00400	0.620
TRG_ER_diArg_1	297	299	PF00400	0.612
TRG_ER_diArg_1	321	324	PF00400	0.611
TRG_NLS_MonoCore_2	319	324	PF00514	0.596
TRG_NLS_MonoCore_2	434	439	PF00514	0.646
TRG_NLS_MonoExtC_3	319	324	PF00514	0.616
TRG_NLS_MonoExtC_3	434	440	PF00514	0.650
TRG_NLS_MonoExtN_4	432	439	PF00514	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Q0	Leptomonas seymouri	30%	100%
A0A3Q8IAM2	Leishmania donovani	90%	100%
A4H8P3	Leishmania braziliensis	73%	100%
A4HX13	Leishmania infantum	90%	100%
E9AQS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%