Coatomer subunit delta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

coatomer delta subunit-like protein

Species:

Leishmania major

UniProt:

Q4QEP9_LEIMA

TriTrypDb:

LmjF.16.1180 , LMJLV39_160018100 , LMJSD75_160017700

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	12
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	12
GO:0030117	membrane coat	3	12
GO:0030120	vesicle coat	4	12
GO:0030126	COPI vesicle coat	5	12
GO:0031090	organelle membrane	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	12
GO:0098796	membrane protein complex	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QEP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEP9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	2
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	2
GO:0048193	Golgi vesicle transport	5	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	12
GO:0051645	Golgi localization	3	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	371	375	PF00656	0.357
CLV_C14_Caspase3-7	462	466	PF00656	0.479
CLV_C14_Caspase3-7	49	53	PF00656	0.439
CLV_NRD_NRD_1	166	168	PF00675	0.510
CLV_NRD_NRD_1	251	253	PF00675	0.679
CLV_PCSK_KEX2_1	124	126	PF00082	0.440
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.456
CLV_PCSK_SKI1_1	14	18	PF00082	0.447
CLV_PCSK_SKI1_1	145	149	PF00082	0.589
CLV_PCSK_SKI1_1	159	163	PF00082	0.571
CLV_PCSK_SKI1_1	19	23	PF00082	0.466
CLV_PCSK_SKI1_1	341	345	PF00082	0.335
CLV_PCSK_SKI1_1	361	365	PF00082	0.335
CLV_PCSK_SKI1_1	46	50	PF00082	0.504
CLV_PCSK_SKI1_1	494	498	PF00082	0.489
DEG_SPOP_SBC_1	406	410	PF00917	0.443
DOC_CYCLIN_RxL_1	356	367	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	489	495	PF00134	0.505
DOC_MAPK_DCC_7	315	324	PF00069	0.404
DOC_MAPK_MEF2A_6	286	295	PF00069	0.555
DOC_MAPK_MEF2A_6	325	332	PF00069	0.351
DOC_MAPK_MEF2A_6	423	432	PF00069	0.404
DOC_PP2B_LxvP_1	430	433	PF13499	0.455
DOC_USP7_MATH_1	222	226	PF00917	0.711
DOC_USP7_MATH_1	406	410	PF00917	0.455
DOC_USP7_MATH_1	496	500	PF00917	0.468
DOC_WW_Pin1_4	317	322	PF00397	0.464
LIG_14-3-3_CanoR_1	19	27	PF00244	0.500
LIG_14-3-3_CanoR_1	252	260	PF00244	0.722
LIG_14-3-3_CanoR_1	390	400	PF00244	0.422
LIG_14-3-3_CanoR_1	494	503	PF00244	0.466
LIG_14-3-3_CanoR_1	527	536	PF00244	0.446
LIG_APCC_ABBA_1	133	138	PF00400	0.520
LIG_BH_BH3_1	518	534	PF00452	0.481
LIG_BIR_III_4	273	277	PF00653	0.720
LIG_BRCT_BRCA1_1	347	351	PF00533	0.351
LIG_EH1_1	85	93	PF00400	0.387
LIG_FHA_1	209	215	PF00498	0.513
LIG_FHA_1	255	261	PF00498	0.503
LIG_FHA_1	327	333	PF00498	0.417
LIG_FHA_1	395	401	PF00498	0.466
LIG_FHA_1	420	426	PF00498	0.363
LIG_FHA_1	458	464	PF00498	0.380
LIG_FHA_1	82	88	PF00498	0.389
LIG_FHA_2	302	308	PF00498	0.455
LIG_FHA_2	318	324	PF00498	0.152
LIG_FHA_2	369	375	PF00498	0.390
LIG_FHA_2	47	53	PF00498	0.451
LIG_LIR_Apic_2	218	224	PF02991	0.754
LIG_LIR_Gen_1	109	116	PF02991	0.505
LIG_LIR_Gen_1	446	457	PF02991	0.448
LIG_LIR_Gen_1	64	71	PF02991	0.397
LIG_LIR_Nem_3	109	113	PF02991	0.479
LIG_LIR_Nem_3	191	197	PF02991	0.644
LIG_LIR_Nem_3	34	39	PF02991	0.406
LIG_LIR_Nem_3	446	452	PF02991	0.448
LIG_LIR_Nem_3	487	493	PF02991	0.402
LIG_LIR_Nem_3	64	70	PF02991	0.400
LIG_Pex14_2	110	114	PF04695	0.392
LIG_SH2_CRK	184	188	PF00017	0.617
LIG_SH2_NCK_1	415	419	PF00017	0.455
LIG_SH2_SRC	50	53	PF00017	0.415
LIG_SH2_SRC	60	63	PF00017	0.387
LIG_SH2_STAP1	142	146	PF00017	0.595
LIG_SH2_STAT3	58	61	PF00017	0.366
LIG_SH2_STAT5	136	139	PF00017	0.463
LIG_SH2_STAT5	210	213	PF00017	0.689
LIG_SH2_STAT5	50	53	PF00017	0.401
LIG_SH2_STAT5	58	61	PF00017	0.353
LIG_SH2_STAT5	95	98	PF00017	0.466
LIG_SH3_2	424	429	PF14604	0.455
LIG_SH3_3	286	292	PF00018	0.601
LIG_SH3_3	329	335	PF00018	0.351
LIG_SH3_3	377	383	PF00018	0.420
LIG_SH3_3	393	399	PF00018	0.375
LIG_SH3_3	414	420	PF00018	0.448
LIG_SH3_3	421	427	PF00018	0.442
LIG_SH3_3	56	62	PF00018	0.373
LIG_SUMO_SIM_anti_2	327	332	PF11976	0.352
LIG_SUMO_SIM_anti_2	460	465	PF11976	0.430
LIG_SUMO_SIM_par_1	327	334	PF11976	0.455
LIG_SUMO_SIM_par_1	459	465	PF11976	0.432
LIG_SUMO_SIM_par_1	507	514	PF11976	0.323
LIG_SUMO_SIM_par_1	67	74	PF11976	0.370
LIG_TRAF2_1	141	144	PF00917	0.474
LIG_TRAF2_1	147	150	PF00917	0.470
LIG_TRAF2_1	304	307	PF00917	0.455
LIG_TRAF2_1	485	488	PF00917	0.249
LIG_TRAF2_1	62	65	PF00917	0.477
LIG_UBA3_1	66	75	PF00899	0.394
MOD_CK1_1	208	214	PF00069	0.702
MOD_CK1_1	229	235	PF00069	0.679
MOD_CK1_1	392	398	PF00069	0.482
MOD_CK1_1	409	415	PF00069	0.376
MOD_CK1_1	42	48	PF00069	0.569
MOD_CK1_1	445	451	PF00069	0.337
MOD_CK1_1	499	505	PF00069	0.438
MOD_CK2_1	125	131	PF00069	0.445
MOD_CK2_1	138	144	PF00069	0.464
MOD_CK2_1	301	307	PF00069	0.455
MOD_CK2_1	482	488	PF00069	0.383
MOD_Cter_Amidation	122	125	PF01082	0.430
MOD_GlcNHglycan	200	203	PF01048	0.636
MOD_GlcNHglycan	224	227	PF01048	0.708
MOD_GlcNHglycan	232	235	PF01048	0.595
MOD_GlcNHglycan	243	246	PF01048	0.746
MOD_GlcNHglycan	309	312	PF01048	0.348
MOD_GlcNHglycan	33	36	PF01048	0.378
MOD_GlcNHglycan	4	7	PF01048	0.423
MOD_GlcNHglycan	470	473	PF01048	0.346
MOD_GlcNHglycan	484	487	PF01048	0.212
MOD_GSK3_1	222	229	PF00069	0.655
MOD_GSK3_1	251	258	PF00069	0.656
MOD_GSK3_1	345	352	PF00069	0.372
MOD_GSK3_1	359	366	PF00069	0.342
MOD_GSK3_1	405	412	PF00069	0.374
MOD_GSK3_1	42	49	PF00069	0.605
MOD_GSK3_1	495	502	PF00069	0.396
MOD_GSK3_1	69	76	PF00069	0.383
MOD_N-GLC_1	126	131	PF02516	0.459
MOD_N-GLC_1	205	210	PF02516	0.655
MOD_N-GLC_1	301	306	PF02516	0.455
MOD_N-GLC_1	359	364	PF02516	0.468
MOD_N-GLC_1	392	397	PF02516	0.446
MOD_N-GLC_1	400	405	PF02516	0.443
MOD_N-GLC_1	468	473	PF02516	0.367
MOD_NEK2_1	197	202	PF00069	0.669
MOD_NEK2_1	217	222	PF00069	0.673
MOD_NEK2_1	264	269	PF00069	0.743
MOD_NEK2_1	309	314	PF00069	0.451
MOD_NEK2_1	39	44	PF00069	0.461
MOD_NEK2_1	391	396	PF00069	0.443
MOD_NEK2_1	70	75	PF00069	0.389
MOD_NEK2_2	205	210	PF00069	0.681
MOD_PIKK_1	266	272	PF00454	0.784
MOD_PIKK_1	496	502	PF00454	0.530
MOD_PIKK_1	511	517	PF00454	0.490
MOD_PIKK_1	520	526	PF00454	0.348
MOD_PKA_1	159	165	PF00069	0.611
MOD_PKA_2	251	257	PF00069	0.671
MOD_PKA_2	389	395	PF00069	0.455
MOD_Plk_1	101	107	PF00069	0.436
MOD_Plk_1	125	131	PF00069	0.475
MOD_Plk_1	205	211	PF00069	0.645
MOD_Plk_1	217	223	PF00069	0.661
MOD_Plk_1	22	28	PF00069	0.419
MOD_Plk_1	301	307	PF00069	0.433
MOD_Plk_1	326	332	PF00069	0.341
MOD_Plk_1	359	365	PF00069	0.437
MOD_Plk_1	392	398	PF00069	0.404
MOD_Plk_1	40	46	PF00069	0.511
MOD_Plk_1	400	406	PF00069	0.453
MOD_Plk_2-3	106	112	PF00069	0.530
MOD_Plk_2-3	126	132	PF00069	0.262
MOD_Plk_2-3	138	144	PF00069	0.494
MOD_Plk_4	205	211	PF00069	0.684
MOD_Plk_4	326	332	PF00069	0.352
MOD_Plk_4	359	365	PF00069	0.482
MOD_Plk_4	382	388	PF00069	0.351
MOD_Plk_4	46	52	PF00069	0.466
MOD_ProDKin_1	317	323	PF00069	0.464
MOD_SUMO_for_1	324	327	PF00179	0.455
TRG_DiLeu_BaEn_1	327	332	PF01217	0.370
TRG_DiLeu_BaEn_1	64	69	PF01217	0.406
TRG_DiLeu_BaEn_4	143	149	PF01217	0.593
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.438
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.402
TRG_ENDOCYTIC_2	136	139	PF00928	0.465
TRG_ENDOCYTIC_2	184	187	PF00928	0.618
TRG_ENDOCYTIC_2	194	197	PF00928	0.613
TRG_ENDOCYTIC_2	449	452	PF00928	0.457
TRG_ENDOCYTIC_2	60	63	PF00928	0.387
TRG_ER_diArg_1	26	29	PF00400	0.417
TRG_NES_CRM1_1	255	270	PF08389	0.724
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I039	Leptomonas seymouri	74%	100%
A0A0S4KK09	Bodo saltans	44%	100%
A0A1X0NYY5	Trypanosomatidae	52%	97%
A0A3Q8IAE4	Leishmania donovani	97%	100%
A0A422N6V7	Trypanosoma rangeli	51%	100%
A4H8P5	Leishmania braziliensis	86%	100%
A4HX15	Leishmania infantum	97%	100%
C9ZVY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AQS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P43621	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	98%
P48444	Homo sapiens	32%	100%
P49661	Oryza sativa subsp. japonica	32%	100%
P53619	Bos taurus	32%	100%
Q09236	Caenorhabditis elegans	31%	100%
Q0DJ99	Oryza sativa subsp. japonica	32%	100%
Q0DJA0	Oryza sativa subsp. japonica	33%	100%
Q55EZ6	Dictyostelium discoideum	30%	99%
Q5RA77	Pongo abelii	32%	100%
Q5XJY5	Mus musculus	32%	100%
Q5ZL57	Gallus gallus	31%	100%
Q66H80	Rattus norvegicus	32%	100%
Q93Y22	Arabidopsis thaliana	31%	100%
V5BI39	Trypanosoma cruzi	51%	99%