Putative cyclophilin 13

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 13, putative

Species:

Leishmania major

UniProt:

Q4QEP7_LEIMA

TriTrypDb:

LmjF.16.1200 , LMJLV39_160018300 , LMJSD75_160017900

Length:

366

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QEP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEP7

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	14
GO:0006457	protein folding	2	4
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	4
GO:0018193	peptidyl-amino acid modification	5	14
GO:0018208	peptidyl-proline modification	6	14
GO:0019538	protein metabolic process	3	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	14
GO:0003824	catalytic activity	1	14
GO:0005488	binding	1	2
GO:0016018	cyclosporin A binding	4	2
GO:0016853	isomerase activity	2	14
GO:0016859	cis-trans isomerase activity	3	14
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2
GO:0140096	catalytic activity, acting on a protein	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.218
CLV_NRD_NRD_1	7	9	PF00675	0.533
CLV_NRD_NRD_1	97	99	PF00675	0.301
CLV_PCSK_KEX2_1	166	168	PF00082	0.220
CLV_PCSK_KEX2_1	7	9	PF00082	0.533
CLV_PCSK_KEX2_1	97	99	PF00082	0.365
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.213
CLV_PCSK_SKI1_1	360	364	PF00082	0.667
DEG_Nend_UBRbox_3	1	3	PF02207	0.528
DOC_ANK_TNKS_1	307	314	PF00023	0.470
DOC_CDC14_PxL_1	46	54	PF14671	0.399
DOC_MAPK_gen_1	165	174	PF00069	0.218
DOC_MAPK_gen_1	30	40	PF00069	0.395
DOC_MAPK_MEF2A_6	33	42	PF00069	0.257
DOC_PP2B_LxvP_1	221	224	PF13499	0.347
DOC_USP7_MATH_1	277	281	PF00917	0.650
DOC_USP7_MATH_1	339	343	PF00917	0.759
DOC_USP7_UBL2_3	341	345	PF12436	0.643
DOC_USP7_UBL2_3	356	360	PF12436	0.624
DOC_WW_Pin1_4	11	16	PF00397	0.545
DOC_WW_Pin1_4	115	120	PF00397	0.279
DOC_WW_Pin1_4	252	257	PF00397	0.639
DOC_WW_Pin1_4	272	277	PF00397	0.700
DOC_WW_Pin1_4	318	323	PF00397	0.671
DOC_WW_Pin1_4	332	337	PF00397	0.583
DOC_WW_Pin1_4	69	74	PF00397	0.476
LIG_14-3-3_CanoR_1	281	286	PF00244	0.763
LIG_14-3-3_CanoR_1	30	36	PF00244	0.344
LIG_APCC_ABBA_1	82	87	PF00400	0.286
LIG_BRCT_BRCA1_1	186	190	PF00533	0.267
LIG_CSL_BTD_1	158	161	PF09270	0.205
LIG_FHA_1	139	145	PF00498	0.250
LIG_FHA_1	20	26	PF00498	0.401
LIG_FHA_1	346	352	PF00498	0.507
LIG_FHA_1	4	10	PF00498	0.509
LIG_FHA_2	70	76	PF00498	0.495
LIG_Integrin_isoDGR_2	202	204	PF01839	0.233
LIG_LIR_Gen_1	124	133	PF02991	0.255
LIG_LIR_Gen_1	216	225	PF02991	0.347
LIG_LIR_Gen_1	233	239	PF02991	0.218
LIG_LIR_Gen_1	34	43	PF02991	0.252
LIG_LIR_Gen_1	77	85	PF02991	0.268
LIG_LIR_Nem_3	124	129	PF02991	0.337
LIG_LIR_Nem_3	216	221	PF02991	0.347
LIG_LIR_Nem_3	233	238	PF02991	0.233
LIG_LIR_Nem_3	34	40	PF02991	0.253
LIG_LIR_Nem_3	44	49	PF02991	0.363
LIG_LIR_Nem_3	77	82	PF02991	0.335
LIG_MLH1_MIPbox_1	186	190	PF16413	0.256
LIG_PDZ_Class_2	361	366	PF00595	0.508
LIG_SH2_CRK	235	239	PF00017	0.242
LIG_SH2_NCK_1	152	156	PF00017	0.347
LIG_SH2_STAP1	235	239	PF00017	0.242
LIG_SH2_STAT3	112	115	PF00017	0.218
LIG_SH2_STAT3	133	136	PF00017	0.347
LIG_SH2_STAT3	296	299	PF00017	0.500
LIG_SH2_STAT5	112	115	PF00017	0.281
LIG_SH2_STAT5	121	124	PF00017	0.295
LIG_SH2_STAT5	125	128	PF00017	0.285
LIG_SH2_STAT5	133	136	PF00017	0.228
LIG_SH2_STAT5	24	27	PF00017	0.540
LIG_SH2_STAT5	296	299	PF00017	0.468
LIG_SH3_2	336	341	PF14604	0.498
LIG_SH3_3	333	339	PF00018	0.639
LIG_SH3_3	44	50	PF00018	0.387
LIG_SUMO_SIM_par_1	330	335	PF11976	0.456
LIG_TRAF2_1	284	287	PF00917	0.656
LIG_TRAF2_1	72	75	PF00917	0.514
MOD_CK1_1	151	157	PF00069	0.358
MOD_CK1_1	17	23	PF00069	0.486
MOD_CK1_1	184	190	PF00069	0.218
MOD_CK1_1	251	257	PF00069	0.675
MOD_CK1_1	26	32	PF00069	0.459
MOD_CK2_1	281	287	PF00069	0.618
MOD_CK2_1	340	346	PF00069	0.644
MOD_CK2_1	69	75	PF00069	0.498
MOD_GlcNHglycan	153	156	PF01048	0.374
MOD_GlcNHglycan	16	19	PF01048	0.486
MOD_GlcNHglycan	193	196	PF01048	0.276
MOD_GlcNHglycan	250	253	PF01048	0.504
MOD_GSK3_1	117	124	PF00069	0.287
MOD_GSK3_1	146	153	PF00069	0.330
MOD_GSK3_1	19	26	PF00069	0.473
MOD_GSK3_1	248	255	PF00069	0.501
MOD_GSK3_1	260	267	PF00069	0.569
MOD_GSK3_1	268	275	PF00069	0.684
MOD_GSK3_1	277	284	PF00069	0.608
MOD_GSK3_1	345	352	PF00069	0.649
MOD_GSK3_1	48	55	PF00069	0.415
MOD_LATS_1	358	364	PF00433	0.485
MOD_N-GLC_1	184	189	PF02516	0.285
MOD_NEK2_1	189	194	PF00069	0.286
MOD_NEK2_1	19	24	PF00069	0.630
MOD_NEK2_1	250	255	PF00069	0.524
MOD_NEK2_1	260	265	PF00069	0.589
MOD_NEK2_1	340	345	PF00069	0.691
MOD_NEK2_1	52	57	PF00069	0.426
MOD_NEK2_1	63	68	PF00069	0.436
MOD_NEK2_1	9	14	PF00069	0.507
MOD_NEK2_2	138	143	PF00069	0.226
MOD_PIKK_1	184	190	PF00454	0.256
MOD_PIKK_1	41	47	PF00454	0.482
MOD_PIKK_1	52	58	PF00454	0.482
MOD_PK_1	281	287	PF00069	0.475
MOD_Plk_1	138	144	PF00069	0.220
MOD_Plk_1	74	80	PF00069	0.496
MOD_Plk_4	121	127	PF00069	0.254
MOD_Plk_4	245	251	PF00069	0.485
MOD_Plk_4	74	80	PF00069	0.444
MOD_ProDKin_1	11	17	PF00069	0.541
MOD_ProDKin_1	115	121	PF00069	0.279
MOD_ProDKin_1	252	258	PF00069	0.639
MOD_ProDKin_1	272	278	PF00069	0.701
MOD_ProDKin_1	318	324	PF00069	0.671
MOD_ProDKin_1	332	338	PF00069	0.585
MOD_ProDKin_1	69	75	PF00069	0.474
TRG_DiLeu_BaEn_1	245	250	PF01217	0.379
TRG_DiLeu_BaEn_3	74	80	PF01217	0.444
TRG_ENDOCYTIC_2	235	238	PF00928	0.312
TRG_ER_diArg_1	7	9	PF00400	0.527
TRG_ER_diArg_1	96	98	PF00400	0.365
TRG_NLS_MonoCore_2	164	169	PF00514	0.210
TRG_NLS_MonoExtC_3	165	171	PF00514	0.337
TRG_NLS_MonoExtN_4	165	170	PF00514	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJB8	Leptomonas seymouri	78%	100%
A0A1X0P0F8	Trypanosomatidae	58%	100%
A0A3Q8IDR1	Leishmania donovani	95%	100%
A0A3R7MER6	Trypanosoma rangeli	60%	100%
A0A3S7WXF4	Leishmania donovani	34%	100%
A4H8P7	Leishmania braziliensis	77%	100%
A4HHU7	Leishmania braziliensis	30%	100%
A4HX17	Leishmania infantum	94%	100%
A4I042	Leishmania infantum	34%	100%
C9ZVY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AQT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
G5EEW6	Caenorhabditis elegans	25%	86%
P0C1J2	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	28%	70%
V5DJ29	Trypanosoma cruzi	62%	100%