Diacylglycerol kinase (ATP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

diacylglycerol kinase, putative

Species:

Leishmania major

UniProt:

Q4QEN8_LEIMA

TriTrypDb:

LmjF.16.1290 , LMJLV39_160019200 , LMJSD75_160018800

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEN8

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0007165	signal transduction	2	10
GO:0007186	G protein-coupled receptor signaling pathway	3	10
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0044237	cellular metabolic process	2	10
GO:0050789	regulation of biological process	2	10
GO:0050794	regulation of cellular process	3	10
GO:0065007	biological regulation	1	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004143	diacylglycerol kinase activity	5	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	256	258	PF00675	0.296
CLV_NRD_NRD_1	473	475	PF00675	0.257
CLV_NRD_NRD_1	83	85	PF00675	0.623
CLV_PCSK_KEX2_1	195	197	PF00082	0.435
CLV_PCSK_KEX2_1	216	218	PF00082	0.398
CLV_PCSK_KEX2_1	256	258	PF00082	0.296
CLV_PCSK_KEX2_1	473	475	PF00082	0.265
CLV_PCSK_KEX2_1	567	569	PF00082	0.263
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.435
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.313
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.263
CLV_PCSK_PC7_1	212	218	PF00082	0.473
CLV_PCSK_SKI1_1	196	200	PF00082	0.310
CLV_PCSK_SKI1_1	574	578	PF00082	0.296
CLV_PCSK_SKI1_1	84	88	PF00082	0.576
DEG_COP1_1	102	110	PF00400	0.586
DEG_Nend_UBRbox_3	1	3	PF02207	0.635
DEG_SCF_FBW7_1	583	588	PF00400	0.263
DEG_SCF_TRCP1_1	157	163	PF00400	0.356
DEG_SPOP_SBC_1	320	324	PF00917	0.349
DEG_SPOP_SBC_1	36	40	PF00917	0.705
DOC_CKS1_1	111	116	PF01111	0.457
DOC_CKS1_1	222	227	PF01111	0.351
DOC_CKS1_1	599	604	PF01111	0.318
DOC_CKS1_1	649	654	PF01111	0.477
DOC_CYCLIN_RxL_1	544	552	PF00134	0.296
DOC_MAPK_DCC_7	361	371	PF00069	0.419
DOC_MAPK_DCC_7	503	513	PF00069	0.321
DOC_MAPK_gen_1	502	513	PF00069	0.263
DOC_MAPK_gen_1	95	103	PF00069	0.606
DOC_MAPK_MEF2A_6	506	513	PF00069	0.291
DOC_MAPK_MEF2A_6	535	542	PF00069	0.371
DOC_MAPK_MEF2A_6	685	692	PF00069	0.439
DOC_PP2B_LxvP_1	540	543	PF13499	0.371
DOC_PP4_FxxP_1	205	208	PF00568	0.337
DOC_PP4_FxxP_1	295	298	PF00568	0.312
DOC_USP7_MATH_1	106	110	PF00917	0.526
DOC_USP7_MATH_1	118	122	PF00917	0.463
DOC_USP7_MATH_1	135	139	PF00917	0.629
DOC_USP7_MATH_1	15	19	PF00917	0.749
DOC_USP7_MATH_1	320	324	PF00917	0.498
DOC_USP7_MATH_1	355	359	PF00917	0.448
DOC_USP7_MATH_1	36	40	PF00917	0.650
DOC_USP7_MATH_1	375	379	PF00917	0.403
DOC_USP7_MATH_1	407	411	PF00917	0.533
DOC_USP7_MATH_1	527	531	PF00917	0.302
DOC_USP7_MATH_1	64	68	PF00917	0.628
DOC_USP7_MATH_1	90	94	PF00917	0.721
DOC_USP7_UBL2_3	502	506	PF12436	0.349
DOC_WW_Pin1_4	10	15	PF00397	0.666
DOC_WW_Pin1_4	110	115	PF00397	0.506
DOC_WW_Pin1_4	137	142	PF00397	0.576
DOC_WW_Pin1_4	221	226	PF00397	0.551
DOC_WW_Pin1_4	32	37	PF00397	0.724
DOC_WW_Pin1_4	389	394	PF00397	0.547
DOC_WW_Pin1_4	415	420	PF00397	0.634
DOC_WW_Pin1_4	581	586	PF00397	0.364
DOC_WW_Pin1_4	598	603	PF00397	0.211
DOC_WW_Pin1_4	648	653	PF00397	0.420
LIG_14-3-3_CanoR_1	196	201	PF00244	0.358
LIG_14-3-3_CanoR_1	329	334	PF00244	0.545
LIG_14-3-3_CanoR_1	446	452	PF00244	0.284
LIG_14-3-3_CanoR_1	496	500	PF00244	0.268
LIG_14-3-3_CanoR_1	574	579	PF00244	0.263
LIG_14-3-3_CanoR_1	661	668	PF00244	0.472
LIG_14-3-3_CanoR_1	685	689	PF00244	0.499
LIG_14-3-3_CanoR_1	719	726	PF00244	0.355
LIG_APCC_ABBA_1	272	277	PF00400	0.246
LIG_BRCT_BRCA1_1	38	42	PF00533	0.670
LIG_FHA_1	192	198	PF00498	0.371
LIG_FHA_1	233	239	PF00498	0.234
LIG_FHA_1	281	287	PF00498	0.389
LIG_FHA_1	390	396	PF00498	0.568
LIG_FHA_1	448	454	PF00498	0.453
LIG_FHA_1	582	588	PF00498	0.493
LIG_FHA_1	634	640	PF00498	0.301
LIG_FHA_1	712	718	PF00498	0.523
LIG_FHA_2	248	254	PF00498	0.482
LIG_FHA_2	305	311	PF00498	0.256
LIG_FHA_2	649	655	PF00498	0.477
LIG_LIR_Apic_2	203	208	PF02991	0.403
LIG_LIR_Gen_1	161	171	PF02991	0.334
LIG_LIR_Gen_1	438	444	PF02991	0.354
LIG_LIR_Gen_1	534	543	PF02991	0.380
LIG_LIR_Gen_1	642	652	PF02991	0.339
LIG_LIR_Gen_1	663	670	PF02991	0.475
LIG_LIR_Nem_3	161	167	PF02991	0.334
LIG_LIR_Nem_3	260	266	PF02991	0.328
LIG_LIR_Nem_3	438	442	PF02991	0.350
LIG_LIR_Nem_3	450	454	PF02991	0.316
LIG_LIR_Nem_3	534	540	PF02991	0.380
LIG_LIR_Nem_3	642	648	PF02991	0.282
LIG_LIR_Nem_3	663	668	PF02991	0.540
LIG_MYND_1	298	302	PF01753	0.371
LIG_PCNA_yPIPBox_3	481	493	PF02747	0.378
LIG_Pex14_2	317	321	PF04695	0.469
LIG_SH2_CRK	164	168	PF00017	0.392
LIG_SH2_CRK	451	455	PF00017	0.287
LIG_SH2_CRK	573	577	PF00017	0.371
LIG_SH2_CRK	625	629	PF00017	0.371
LIG_SH2_CRK	665	669	PF00017	0.560
LIG_SH2_GRB2like	311	314	PF00017	0.278
LIG_SH2_STAP1	152	156	PF00017	0.442
LIG_SH2_STAP1	311	315	PF00017	0.278
LIG_SH2_STAP1	674	678	PF00017	0.554
LIG_SH2_STAT5	166	169	PF00017	0.237
LIG_SH2_STAT5	294	297	PF00017	0.371
LIG_SH2_STAT5	456	459	PF00017	0.256
LIG_SH2_STAT5	464	467	PF00017	0.256
LIG_SH2_STAT5	625	628	PF00017	0.296
LIG_SH2_STAT5	665	668	PF00017	0.567
LIG_SH3_1	222	228	PF00018	0.360
LIG_SH3_2	563	568	PF14604	0.263
LIG_SH3_3	105	111	PF00018	0.630
LIG_SH3_3	11	17	PF00018	0.627
LIG_SH3_3	222	228	PF00018	0.557
LIG_SH3_3	287	293	PF00018	0.239
LIG_SH3_3	349	355	PF00018	0.316
LIG_SH3_3	508	514	PF00018	0.323
LIG_SH3_3	560	566	PF00018	0.392
LIG_SH3_3	65	71	PF00018	0.577
LIG_SH3_CIN85_PxpxPR_1	600	605	PF14604	0.338
LIG_SUMO_SIM_anti_2	250	256	PF11976	0.280
LIG_SUMO_SIM_par_1	605	611	PF11976	0.371
LIG_SUMO_SIM_par_1	99	104	PF11976	0.722
LIG_TRAF2_2	145	150	PF00917	0.382
LIG_TYR_ITIM	454	459	PF00017	0.256
LIG_TYR_ITIM	571	576	PF00017	0.371
LIG_TYR_ITIM	623	628	PF00017	0.371
MOD_CDK_SPK_2	600	605	PF00069	0.246
MOD_CDK_SPxK_1	221	227	PF00069	0.372
MOD_CDK_SPxxK_3	598	605	PF00069	0.213
MOD_CK1_1	155	161	PF00069	0.526
MOD_CK1_1	175	181	PF00069	0.328
MOD_CK1_1	323	329	PF00069	0.566
MOD_CK1_1	35	41	PF00069	0.579
MOD_CK1_1	378	384	PF00069	0.589
MOD_CK1_1	530	536	PF00069	0.275
MOD_CK1_1	558	564	PF00069	0.359
MOD_CK1_1	59	65	PF00069	0.513
MOD_CK1_1	633	639	PF00069	0.296
MOD_CK1_1	663	669	PF00069	0.484
MOD_CK1_1	680	686	PF00069	0.649
MOD_CK2_1	155	161	PF00069	0.498
MOD_CK2_1	5	11	PF00069	0.577
MOD_CK2_1	673	679	PF00069	0.572
MOD_CK2_1	90	96	PF00069	0.688
MOD_GlcNHglycan	126	129	PF01048	0.669
MOD_GlcNHglycan	137	140	PF01048	0.609
MOD_GlcNHglycan	157	160	PF01048	0.534
MOD_GlcNHglycan	174	177	PF01048	0.405
MOD_GlcNHglycan	277	281	PF01048	0.336
MOD_GlcNHglycan	323	326	PF01048	0.456
MOD_GlcNHglycan	409	412	PF01048	0.649
MOD_GlcNHglycan	518	521	PF01048	0.456
MOD_GlcNHglycan	557	560	PF01048	0.389
MOD_GlcNHglycan	56	59	PF01048	0.647
MOD_GlcNHglycan	591	594	PF01048	0.296
MOD_GlcNHglycan	62	65	PF01048	0.666
MOD_GlcNHglycan	658	661	PF01048	0.594
MOD_GlcNHglycan	662	665	PF01048	0.539
MOD_GlcNHglycan	721	724	PF01048	0.377
MOD_GlcNHglycan	92	95	PF01048	0.631
MOD_GSK3_1	106	113	PF00069	0.526
MOD_GSK3_1	137	144	PF00069	0.520
MOD_GSK3_1	15	22	PF00069	0.591
MOD_GSK3_1	243	250	PF00069	0.310
MOD_GSK3_1	276	283	PF00069	0.384
MOD_GSK3_1	319	326	PF00069	0.449
MOD_GSK3_1	32	39	PF00069	0.577
MOD_GSK3_1	475	482	PF00069	0.319
MOD_GSK3_1	5	12	PF00069	0.625
MOD_GSK3_1	527	534	PF00069	0.277
MOD_GSK3_1	56	63	PF00069	0.698
MOD_GSK3_1	581	588	PF00069	0.298
MOD_GSK3_1	656	663	PF00069	0.502
MOD_GSK3_1	673	680	PF00069	0.582
MOD_LATS_1	572	578	PF00433	0.263
MOD_N-GLC_1	29	34	PF02516	0.825
MOD_N-GLC_1	623	628	PF02516	0.213
MOD_N-GLC_2	610	612	PF02516	0.246
MOD_NEK2_1	247	252	PF00069	0.329
MOD_NEK2_1	267	272	PF00069	0.245
MOD_NEK2_1	281	286	PF00069	0.296
MOD_NEK2_1	321	326	PF00069	0.421
MOD_NEK2_1	469	474	PF00069	0.289
MOD_NEK2_1	518	523	PF00069	0.471
MOD_NEK2_1	549	554	PF00069	0.256
MOD_NEK2_1	623	628	PF00069	0.371
MOD_NEK2_1	632	637	PF00069	0.339
MOD_PIKK_1	247	253	PF00454	0.361
MOD_PIKK_1	267	273	PF00454	0.172
MOD_PIKK_1	378	384	PF00454	0.496
MOD_PIKK_1	663	669	PF00454	0.531
MOD_PK_1	721	727	PF00069	0.484
MOD_PKA_2	232	238	PF00069	0.256
MOD_PKA_2	425	431	PF00069	0.395
MOD_PKA_2	495	501	PF00069	0.308
MOD_PKA_2	660	666	PF00069	0.382
MOD_PKA_2	684	690	PF00069	0.494
MOD_PKA_2	78	84	PF00069	0.613
MOD_PKB_1	719	727	PF00069	0.470
MOD_Plk_1	160	166	PF00069	0.447
MOD_Plk_1	276	282	PF00069	0.296
MOD_Plk_1	362	368	PF00069	0.405
MOD_Plk_1	623	629	PF00069	0.197
MOD_Plk_1	680	686	PF00069	0.561
MOD_Plk_1	701	707	PF00069	0.405
MOD_Plk_4	232	238	PF00069	0.256
MOD_Plk_4	243	249	PF00069	0.256
MOD_Plk_4	362	368	PF00069	0.405
MOD_Plk_4	64	70	PF00069	0.640
MOD_Plk_4	701	707	PF00069	0.414
MOD_Plk_4	721	727	PF00069	0.273
MOD_ProDKin_1	10	16	PF00069	0.666
MOD_ProDKin_1	110	116	PF00069	0.504
MOD_ProDKin_1	137	143	PF00069	0.565
MOD_ProDKin_1	221	227	PF00069	0.563
MOD_ProDKin_1	32	38	PF00069	0.722
MOD_ProDKin_1	389	395	PF00069	0.549
MOD_ProDKin_1	415	421	PF00069	0.620
MOD_ProDKin_1	581	587	PF00069	0.364
MOD_ProDKin_1	598	604	PF00069	0.211
MOD_ProDKin_1	648	654	PF00069	0.425
TRG_DiLeu_BaEn_1	277	282	PF01217	0.197
TRG_DiLeu_BaEn_2	261	267	PF01217	0.361
TRG_DiLeu_BaEn_2	642	648	PF01217	0.278
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.432
TRG_ENDOCYTIC_2	164	167	PF00928	0.358
TRG_ENDOCYTIC_2	294	297	PF00928	0.371
TRG_ENDOCYTIC_2	451	454	PF00928	0.305
TRG_ENDOCYTIC_2	456	459	PF00928	0.261
TRG_ENDOCYTIC_2	490	493	PF00928	0.349
TRG_ENDOCYTIC_2	573	576	PF00928	0.371
TRG_ENDOCYTIC_2	625	628	PF00928	0.371
TRG_ENDOCYTIC_2	665	668	PF00928	0.557
TRG_ER_diArg_1	255	257	PF00400	0.296
TRG_ER_diArg_1	718	721	PF00400	0.343
TRG_NLS_MonoExtN_4	566	571	PF00514	0.263
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRI7	Leptomonas seymouri	51%	97%
A0A3Q8IAN3	Leishmania donovani	91%	99%
A0A3R7MJ80	Trypanosoma rangeli	33%	100%
A4H8Q7	Leishmania braziliensis	70%	100%
A4HX26	Leishmania infantum	91%	99%
C9ZVX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AQU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5DJ39	Trypanosoma cruzi	34%	100%