Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 41

Species:

Leishmania major

UniProt:

Q4QEN7_LEIMA

TriTrypDb:

LmjF.16.1300 , LMJLV39_160019300 , LMJSD75_160018900

Length:

997

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QEN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	741	745	PF00656	0.422
CLV_C14_Caspase3-7	824	828	PF00656	0.669
CLV_NRD_NRD_1	289	291	PF00675	0.735
CLV_NRD_NRD_1	402	404	PF00675	0.459
CLV_NRD_NRD_1	456	458	PF00675	0.614
CLV_NRD_NRD_1	682	684	PF00675	0.499
CLV_NRD_NRD_1	69	71	PF00675	0.684
CLV_NRD_NRD_1	712	714	PF00675	0.435
CLV_NRD_NRD_1	796	798	PF00675	0.566
CLV_NRD_NRD_1	908	910	PF00675	0.811
CLV_PCSK_FUR_1	794	798	PF00082	0.671
CLV_PCSK_KEX2_1	289	291	PF00082	0.735
CLV_PCSK_KEX2_1	402	404	PF00082	0.531
CLV_PCSK_KEX2_1	456	458	PF00082	0.577
CLV_PCSK_KEX2_1	69	71	PF00082	0.564
CLV_PCSK_KEX2_1	712	714	PF00082	0.435
CLV_PCSK_KEX2_1	796	798	PF00082	0.566
CLV_PCSK_KEX2_1	907	909	PF00082	0.821
CLV_PCSK_SKI1_1	33	37	PF00082	0.647
CLV_PCSK_SKI1_1	43	47	PF00082	0.580
CLV_PCSK_SKI1_1	637	641	PF00082	0.565
CLV_PCSK_SKI1_1	670	674	PF00082	0.399
CLV_PCSK_SKI1_1	761	765	PF00082	0.440
CLV_PCSK_SKI1_1	909	913	PF00082	0.648
DEG_APCC_DBOX_1	490	498	PF00400	0.623
DEG_APCC_DBOX_1	731	739	PF00400	0.436
DEG_APCC_DBOX_1	74	82	PF00400	0.511
DEG_APCC_DBOX_1	837	845	PF00400	0.570
DEG_COP1_1	314	323	PF00400	0.546
DEG_SCF_FBW7_1	410	417	PF00400	0.516
DEG_SCF_FBW7_1	81	87	PF00400	0.749
DEG_SCF_FBW7_1	913	920	PF00400	0.697
DEG_SPOP_SBC_1	191	195	PF00917	0.673
DEG_SPOP_SBC_1	224	228	PF00917	0.713
DEG_SPOP_SBC_1	660	664	PF00917	0.453
DEG_SPOP_SBC_1	717	721	PF00917	0.442
DOC_CKS1_1	117	122	PF01111	0.609
DOC_CKS1_1	320	325	PF01111	0.718
DOC_CKS1_1	81	86	PF01111	0.754
DOC_CKS1_1	919	924	PF01111	0.695
DOC_CYCLIN_yClb3_PxF_3	753	761	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	525	531	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	782	788	PF00134	0.475
DOC_MAPK_gen_1	402	410	PF00069	0.438
DOC_MAPK_gen_1	668	676	PF00069	0.443
DOC_MAPK_gen_1	681	690	PF00069	0.451
DOC_MAPK_gen_1	730	738	PF00069	0.418
DOC_MAPK_gen_1	984	992	PF00069	0.481
DOC_MAPK_MEF2A_6	403	412	PF00069	0.444
DOC_MAPK_MEF2A_6	670	678	PF00069	0.534
DOC_MAPK_MEF2A_6	986	994	PF00069	0.489
DOC_PP1_RVXF_1	19	26	PF00149	0.412
DOC_PP2B_LxvP_1	230	233	PF13499	0.693
DOC_PP2B_LxvP_1	525	528	PF13499	0.667
DOC_USP7_MATH_1	130	134	PF00917	0.562
DOC_USP7_MATH_1	224	228	PF00917	0.715
DOC_USP7_MATH_1	333	337	PF00917	0.796
DOC_USP7_MATH_1	340	344	PF00917	0.633
DOC_USP7_MATH_1	414	418	PF00917	0.543
DOC_USP7_MATH_1	498	502	PF00917	0.791
DOC_USP7_MATH_1	579	583	PF00917	0.669
DOC_USP7_MATH_1	597	601	PF00917	0.611
DOC_USP7_MATH_1	659	663	PF00917	0.603
DOC_USP7_MATH_1	717	721	PF00917	0.442
DOC_USP7_MATH_1	820	824	PF00917	0.637
DOC_USP7_MATH_1	862	866	PF00917	0.645
DOC_USP7_MATH_1	875	879	PF00917	0.638
DOC_USP7_MATH_1	884	888	PF00917	0.596
DOC_USP7_MATH_1	899	903	PF00917	0.593
DOC_WW_Pin1_4	112	117	PF00397	0.625
DOC_WW_Pin1_4	13	18	PF00397	0.513
DOC_WW_Pin1_4	160	165	PF00397	0.695
DOC_WW_Pin1_4	210	215	PF00397	0.713
DOC_WW_Pin1_4	225	230	PF00397	0.818
DOC_WW_Pin1_4	309	314	PF00397	0.754
DOC_WW_Pin1_4	319	324	PF00397	0.687
DOC_WW_Pin1_4	363	368	PF00397	0.791
DOC_WW_Pin1_4	410	415	PF00397	0.518
DOC_WW_Pin1_4	567	572	PF00397	0.726
DOC_WW_Pin1_4	575	580	PF00397	0.688
DOC_WW_Pin1_4	587	592	PF00397	0.589
DOC_WW_Pin1_4	661	666	PF00397	0.510
DOC_WW_Pin1_4	80	85	PF00397	0.718
DOC_WW_Pin1_4	893	898	PF00397	0.713
DOC_WW_Pin1_4	913	918	PF00397	0.651
DOC_WW_Pin1_4	922	927	PF00397	0.689
LIG_14-3-3_CanoR_1	184	188	PF00244	0.563
LIG_14-3-3_CanoR_1	223	229	PF00244	0.741
LIG_14-3-3_CanoR_1	289	293	PF00244	0.791
LIG_14-3-3_CanoR_1	324	331	PF00244	0.638
LIG_14-3-3_CanoR_1	335	340	PF00244	0.629
LIG_14-3-3_CanoR_1	430	440	PF00244	0.516
LIG_14-3-3_CanoR_1	456	464	PF00244	0.637
LIG_14-3-3_CanoR_1	661	665	PF00244	0.477
LIG_14-3-3_CanoR_1	761	771	PF00244	0.450
LIG_Actin_WH2_2	8	23	PF00022	0.432
LIG_Actin_WH2_2	931	949	PF00022	0.693
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BIR_III_2	147	151	PF00653	0.646
LIG_BRCT_BRCA1_1	718	722	PF00533	0.384
LIG_CaM_NSCaTE_8	301	308	PF13499	0.573
LIG_deltaCOP1_diTrp_1	630	634	PF00928	0.617
LIG_deltaCOP1_diTrp_1	644	648	PF00928	0.443
LIG_deltaCOP1_diTrp_1	987	991	PF00928	0.453
LIG_FHA_1	192	198	PF00498	0.593
LIG_FHA_1	200	206	PF00498	0.632
LIG_FHA_1	289	295	PF00498	0.581
LIG_FHA_1	315	321	PF00498	0.663
LIG_FHA_1	326	332	PF00498	0.648
LIG_FHA_1	403	409	PF00498	0.561
LIG_FHA_1	520	526	PF00498	0.673
LIG_FHA_1	768	774	PF00498	0.422
LIG_FHA_1	869	875	PF00498	0.559
LIG_FHA_1	914	920	PF00498	0.648
LIG_FHA_1	925	931	PF00498	0.767
LIG_FHA_2	161	167	PF00498	0.717
LIG_FHA_2	309	315	PF00498	0.552
LIG_FHA_2	44	50	PF00498	0.553
LIG_FHA_2	458	464	PF00498	0.584
LIG_FHA_2	596	602	PF00498	0.621
LIG_FHA_2	640	646	PF00498	0.494
LIG_FHA_2	739	745	PF00498	0.445
LIG_IRF3_LxIS_1	962	969	PF10401	0.493
LIG_IRF3_LxIS_1	990	995	PF10401	0.458
LIG_LIR_Apic_2	115	120	PF02991	0.607
LIG_LIR_Apic_2	663	669	PF02991	0.624
LIG_LIR_Gen_1	44	52	PF02991	0.567
LIG_LIR_Gen_1	449	454	PF02991	0.401
LIG_LIR_Gen_1	861	870	PF02991	0.640
LIG_LIR_Gen_1	987	994	PF02991	0.444
LIG_LIR_Nem_3	107	111	PF02991	0.663
LIG_LIR_Nem_3	24	28	PF02991	0.431
LIG_LIR_Nem_3	259	264	PF02991	0.475
LIG_LIR_Nem_3	44	48	PF02991	0.476
LIG_LIR_Nem_3	719	725	PF02991	0.399
LIG_LIR_Nem_3	781	786	PF02991	0.519
LIG_LIR_Nem_3	848	852	PF02991	0.558
LIG_LIR_Nem_3	861	866	PF02991	0.559
LIG_LIR_Nem_3	987	991	PF02991	0.462
LIG_PCNA_yPIPBox_3	372	383	PF02747	0.621
LIG_Pex14_1	631	635	PF04695	0.505
LIG_SH2_CRK	273	277	PF00017	0.648
LIG_SH2_CRK	390	394	PF00017	0.526
LIG_SH2_CRK	682	686	PF00017	0.510
LIG_SH2_CRK	783	787	PF00017	0.440
LIG_SH2_SRC	446	449	PF00017	0.410
LIG_SH2_STAP1	3	7	PF00017	0.591
LIG_SH2_STAP1	948	952	PF00017	0.609
LIG_SH2_STAT3	62	65	PF00017	0.631
LIG_SH2_STAT3	633	636	PF00017	0.504
LIG_SH2_STAT5	118	121	PF00017	0.587
LIG_SH2_STAT5	427	430	PF00017	0.502
LIG_SH2_STAT5	446	449	PF00017	0.436
LIG_SH2_STAT5	851	854	PF00017	0.546
LIG_SH3_1	750	756	PF00018	0.556
LIG_SH3_2	285	290	PF14604	0.657
LIG_SH3_2	571	576	PF14604	0.669
LIG_SH3_3	161	167	PF00018	0.733
LIG_SH3_3	194	200	PF00018	0.639
LIG_SH3_3	282	288	PF00018	0.653
LIG_SH3_3	317	323	PF00018	0.763
LIG_SH3_3	32	38	PF00018	0.620
LIG_SH3_3	362	368	PF00018	0.753
LIG_SH3_3	525	531	PF00018	0.649
LIG_SH3_3	568	574	PF00018	0.701
LIG_SH3_3	608	614	PF00018	0.769
LIG_SH3_3	750	756	PF00018	0.480
LIG_SH3_3	90	96	PF00018	0.704
LIG_SH3_3	923	929	PF00018	0.680
LIG_SH3_3	934	940	PF00018	0.546
LIG_SUMO_SIM_anti_2	213	220	PF11976	0.570
LIG_SUMO_SIM_par_1	213	220	PF11976	0.570
LIG_SUMO_SIM_par_1	963	969	PF11976	0.486
LIG_TRAF2_1	460	463	PF00917	0.683
LIG_TRAF2_1	63	66	PF00917	0.567
LIG_TRFH_1	13	17	PF08558	0.516
LIG_TYR_ITSM	779	786	PF00017	0.479
LIG_UBA3_1	990	997	PF00899	0.458
LIG_WRC_WIRS_1	447	452	PF05994	0.377
LIG_WW_3	286	290	PF00397	0.656
MOD_CDK_SPK_2	319	324	PF00069	0.687
MOD_CDK_SPxxK_3	569	576	PF00069	0.669
MOD_CDK_SPxxK_3	661	668	PF00069	0.502
MOD_CK1_1	112	118	PF00069	0.670
MOD_CK1_1	16	22	PF00069	0.420
MOD_CK1_1	190	196	PF00069	0.797
MOD_CK1_1	2	8	PF00069	0.510
MOD_CK1_1	325	331	PF00069	0.661
MOD_CK1_1	466	472	PF00069	0.696
MOD_CK1_1	53	59	PF00069	0.603
MOD_CK1_1	537	543	PF00069	0.724
MOD_CK1_1	564	570	PF00069	0.726
MOD_CK1_1	590	596	PF00069	0.684
MOD_CK1_1	74	80	PF00069	0.615
MOD_CK1_1	823	829	PF00069	0.654
MOD_CK1_1	854	860	PF00069	0.556
MOD_CK1_1	861	867	PF00069	0.551
MOD_CK1_1	876	882	PF00069	0.642
MOD_CK1_1	979	985	PF00069	0.571
MOD_CK2_1	160	166	PF00069	0.726
MOD_CK2_1	186	192	PF00069	0.654
MOD_CK2_1	333	339	PF00069	0.630
MOD_CK2_1	350	356	PF00069	0.699
MOD_CK2_1	457	463	PF00069	0.576
MOD_CK2_1	478	484	PF00069	0.723
MOD_CK2_1	639	645	PF00069	0.495
MOD_CMANNOS	631	634	PF00535	0.587
MOD_Cter_Amidation	454	457	PF01082	0.541
MOD_DYRK1A_RPxSP_1	661	665	PF00069	0.585
MOD_GlcNHglycan	102	105	PF01048	0.698
MOD_GlcNHglycan	111	114	PF01048	0.621
MOD_GlcNHglycan	123	126	PF01048	0.588
MOD_GlcNHglycan	131	135	PF01048	0.505
MOD_GlcNHglycan	189	192	PF01048	0.766
MOD_GlcNHglycan	194	197	PF01048	0.626
MOD_GlcNHglycan	208	211	PF01048	0.752
MOD_GlcNHglycan	219	222	PF01048	0.811
MOD_GlcNHglycan	317	320	PF01048	0.696
MOD_GlcNHglycan	342	345	PF01048	0.632
MOD_GlcNHglycan	352	355	PF01048	0.542
MOD_GlcNHglycan	416	419	PF01048	0.523
MOD_GlcNHglycan	465	468	PF01048	0.685
MOD_GlcNHglycan	480	483	PF01048	0.635
MOD_GlcNHglycan	56	59	PF01048	0.521
MOD_GlcNHglycan	582	585	PF01048	0.773
MOD_GlcNHglycan	604	607	PF01048	0.807
MOD_GlcNHglycan	694	697	PF01048	0.395
MOD_GlcNHglycan	704	707	PF01048	0.376
MOD_GlcNHglycan	764	767	PF01048	0.454
MOD_GlcNHglycan	811	814	PF01048	0.635
MOD_GlcNHglycan	860	863	PF01048	0.574
MOD_GlcNHglycan	878	881	PF01048	0.593
MOD_GlcNHglycan	891	894	PF01048	0.708
MOD_GlcNHglycan	913	916	PF01048	0.697
MOD_GlcNHglycan	97	100	PF01048	0.683
MOD_GSK3_1	112	119	PF00069	0.595
MOD_GSK3_1	156	163	PF00069	0.710
MOD_GSK3_1	170	177	PF00069	0.626
MOD_GSK3_1	183	190	PF00069	0.628
MOD_GSK3_1	206	213	PF00069	0.733
MOD_GSK3_1	305	312	PF00069	0.663
MOD_GSK3_1	315	322	PF00069	0.691
MOD_GSK3_1	363	370	PF00069	0.683
MOD_GSK3_1	410	417	PF00069	0.500
MOD_GSK3_1	463	470	PF00069	0.618
MOD_GSK3_1	474	481	PF00069	0.643
MOD_GSK3_1	50	57	PF00069	0.632
MOD_GSK3_1	500	507	PF00069	0.611
MOD_GSK3_1	519	526	PF00069	0.605
MOD_GSK3_1	543	550	PF00069	0.700
MOD_GSK3_1	559	566	PF00069	0.667
MOD_GSK3_1	575	582	PF00069	0.613
MOD_GSK3_1	593	600	PF00069	0.805
MOD_GSK3_1	712	719	PF00069	0.418
MOD_GSK3_1	734	741	PF00069	0.464
MOD_GSK3_1	762	769	PF00069	0.434
MOD_GSK3_1	788	795	PF00069	0.503
MOD_GSK3_1	80	87	PF00069	0.716
MOD_GSK3_1	851	858	PF00069	0.582
MOD_GSK3_1	875	882	PF00069	0.592
MOD_GSK3_1	889	896	PF00069	0.710
MOD_GSK3_1	911	918	PF00069	0.791
MOD_GSK3_1	971	978	PF00069	0.460
MOD_N-GLC_1	174	179	PF02516	0.640
MOD_N-GLC_1	206	211	PF02516	0.699
MOD_N-GLC_1	333	338	PF02516	0.617
MOD_N-GLC_1	53	58	PF02516	0.669
MOD_N-GLC_1	567	572	PF02516	0.679
MOD_N-GLC_1	766	771	PF02516	0.436
MOD_N-GLC_1	971	976	PF02516	0.445
MOD_NEK2_1	183	188	PF00069	0.708
MOD_NEK2_1	305	310	PF00069	0.542
MOD_NEK2_1	702	707	PF00069	0.476
MOD_NEK2_1	725	730	PF00069	0.475
MOD_NEK2_1	738	743	PF00069	0.469
MOD_NEK2_1	762	767	PF00069	0.517
MOD_NEK2_1	852	857	PF00069	0.567
MOD_NEK2_1	966	971	PF00069	0.463
MOD_NEK2_2	862	867	PF00069	0.639
MOD_NEK2_2	942	947	PF00069	0.562
MOD_PIKK_1	238	244	PF00454	0.595
MOD_PIKK_1	378	384	PF00454	0.637
MOD_PKA_1	402	408	PF00069	0.437
MOD_PKA_1	712	718	PF00069	0.399
MOD_PKA_2	183	189	PF00069	0.563
MOD_PKA_2	224	230	PF00069	0.722
MOD_PKA_2	288	294	PF00069	0.727
MOD_PKA_2	334	340	PF00069	0.678
MOD_PKA_2	402	408	PF00069	0.513
MOD_PKA_2	455	461	PF00069	0.642
MOD_PKA_2	534	540	PF00069	0.656
MOD_PKA_2	543	549	PF00069	0.616
MOD_PKA_2	660	666	PF00069	0.446
MOD_PKA_2	712	718	PF00069	0.489
MOD_PKA_2	74	80	PF00069	0.632
MOD_PKA_2	788	794	PF00069	0.528
MOD_PKB_1	984	992	PF00069	0.504
MOD_Plk_1	43	49	PF00069	0.629
MOD_Plk_1	434	440	PF00069	0.450
MOD_Plk_1	725	731	PF00069	0.377
MOD_Plk_1	820	826	PF00069	0.690
MOD_Plk_1	971	977	PF00069	0.448
MOD_Plk_1	986	992	PF00069	0.461
MOD_Plk_2-3	821	827	PF00069	0.549
MOD_Plk_4	434	440	PF00069	0.432
MOD_Plk_4	446	452	PF00069	0.434
MOD_Plk_4	778	784	PF00069	0.474
MOD_ProDKin_1	112	118	PF00069	0.626
MOD_ProDKin_1	13	19	PF00069	0.509
MOD_ProDKin_1	160	166	PF00069	0.693
MOD_ProDKin_1	210	216	PF00069	0.715
MOD_ProDKin_1	225	231	PF00069	0.818
MOD_ProDKin_1	309	315	PF00069	0.756
MOD_ProDKin_1	319	325	PF00069	0.688
MOD_ProDKin_1	363	369	PF00069	0.791
MOD_ProDKin_1	410	416	PF00069	0.527
MOD_ProDKin_1	567	573	PF00069	0.725
MOD_ProDKin_1	575	581	PF00069	0.690
MOD_ProDKin_1	587	593	PF00069	0.618
MOD_ProDKin_1	661	667	PF00069	0.508
MOD_ProDKin_1	80	86	PF00069	0.720
MOD_ProDKin_1	893	899	PF00069	0.714
MOD_ProDKin_1	913	919	PF00069	0.653
MOD_ProDKin_1	922	928	PF00069	0.689
MOD_SUMO_for_1	294	297	PF00179	0.711
TRG_DiLeu_BaEn_2	986	992	PF01217	0.489
TRG_ENDOCYTIC_2	273	276	PF00928	0.643
TRG_ENDOCYTIC_2	390	393	PF00928	0.536
TRG_ENDOCYTIC_2	783	786	PF00928	0.444
TRG_ER_diArg_1	288	290	PF00400	0.737
TRG_ER_diArg_1	402	404	PF00400	0.531
TRG_ER_diArg_1	456	459	PF00400	0.659
TRG_ER_diArg_1	69	71	PF00400	0.678
TRG_ER_diArg_1	711	713	PF00400	0.453
TRG_ER_diArg_1	729	732	PF00400	0.252
TRG_ER_diArg_1	793	796	PF00400	0.528
TRG_ER_diArg_1	906	909	PF00400	0.817
TRG_NLS_MonoCore_2	682	687	PF00514	0.501
TRG_NLS_MonoExtN_4	681	687	PF00514	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G9	Leptomonas seymouri	42%	99%
A0A3Q8IAI0	Leishmania donovani	92%	100%
A4H8Q8	Leishmania braziliensis	70%	98%
A4HX27	Leishmania infantum	92%	100%
E9AQU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%