Amidase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amidase, putative

Species:

Leishmania major

UniProt:

Q4QEN1_LEIMA

TriTrypDb:

LmjF.16.1360 , LMJLV39_160019900 , LMJSD75_160019500

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QEN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEN1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.512
CLV_NRD_NRD_1	166	168	PF00675	0.257
CLV_NRD_NRD_1	536	538	PF00675	0.327
CLV_PCSK_KEX2_1	134	136	PF00082	0.357
CLV_PCSK_KEX2_1	165	167	PF00082	0.254
CLV_PCSK_KEX2_1	536	538	PF00082	0.327
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.357
CLV_PCSK_SKI1_1	322	326	PF00082	0.357
CLV_PCSK_SKI1_1	433	437	PF00082	0.296
CLV_PCSK_SKI1_1	460	464	PF00082	0.290
CLV_PCSK_SKI1_1	5	9	PF00082	0.301
CLV_PCSK_SKI1_1	580	584	PF00082	0.380
DEG_SCF_FBW7_1	375	381	PF00400	0.557
DOC_CKS1_1	375	380	PF01111	0.557
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	518	524	PF00134	0.476
DOC_MAPK_DCC_7	438	448	PF00069	0.463
DOC_MAPK_gen_1	178	188	PF00069	0.476
DOC_MAPK_gen_1	536	542	PF00069	0.519
DOC_MAPK_MEF2A_6	181	190	PF00069	0.463
DOC_MAPK_MEF2A_6	395	403	PF00069	0.501
DOC_MAPK_MEF2A_6	5	12	PF00069	0.517
DOC_MAPK_NFAT4_5	5	13	PF00069	0.538
DOC_PP2B_LxvP_1	141	144	PF13499	0.463
DOC_PP2B_LxvP_1	456	459	PF13499	0.557
DOC_PP2B_LxvP_1	518	521	PF13499	0.463
DOC_PP2B_PxIxI_1	342	348	PF00149	0.529
DOC_PP4_FxxP_1	554	557	PF00568	0.538
DOC_USP7_MATH_1	157	161	PF00917	0.446
DOC_USP7_MATH_1	276	280	PF00917	0.492
DOC_USP7_MATH_1	378	382	PF00917	0.518
DOC_USP7_MATH_1	51	55	PF00917	0.595
DOC_USP7_MATH_2	387	393	PF00917	0.501
DOC_WW_Pin1_4	171	176	PF00397	0.463
DOC_WW_Pin1_4	260	265	PF00397	0.463
DOC_WW_Pin1_4	316	321	PF00397	0.534
DOC_WW_Pin1_4	374	379	PF00397	0.557
LIG_14-3-3_CanoR_1	166	176	PF00244	0.526
LIG_14-3-3_CanoR_1	438	444	PF00244	0.452
LIG_APCC_ABBA_1	540	545	PF00400	0.529
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_BIR_III_4	581	585	PF00653	0.573
LIG_BRCT_BRCA1_1	18	22	PF00533	0.397
LIG_Clathr_ClatBox_1	480	484	PF01394	0.557
LIG_deltaCOP1_diTrp_1	121	127	PF00928	0.463
LIG_EH_1	504	508	PF12763	0.529
LIG_eIF4E_1	20	26	PF01652	0.423
LIG_eIF4E_1	214	220	PF01652	0.463
LIG_FHA_1	191	197	PF00498	0.476
LIG_FHA_1	214	220	PF00498	0.463
LIG_FHA_1	235	241	PF00498	0.463
LIG_FHA_1	28	34	PF00498	0.324
LIG_FHA_1	284	290	PF00498	0.452
LIG_FHA_1	451	457	PF00498	0.514
LIG_FHA_2	144	150	PF00498	0.463
LIG_FHA_2	355	361	PF00498	0.538
LIG_FHA_2	564	570	PF00498	0.538
LIG_FHA_2	88	94	PF00498	0.486
LIG_GBD_Chelix_1	575	583	PF00786	0.301
LIG_IBAR_NPY_1	212	214	PF08397	0.452
LIG_IBAR_NPY_1	99	101	PF08397	0.463
LIG_IRF3_LxIS_1	459	465	PF10401	0.488
LIG_LIR_Apic_2	338	343	PF02991	0.506
LIG_LIR_Apic_2	553	557	PF02991	0.465
LIG_LIR_Gen_1	19	29	PF02991	0.379
LIG_LIR_Gen_1	389	398	PF02991	0.513
LIG_LIR_Gen_1	410	417	PF02991	0.441
LIG_LIR_Gen_1	512	522	PF02991	0.463
LIG_LIR_Gen_1	590	599	PF02991	0.610
LIG_LIR_Nem_3	19	25	PF02991	0.386
LIG_LIR_Nem_3	389	393	PF02991	0.478
LIG_LIR_Nem_3	410	416	PF02991	0.441
LIG_LIR_Nem_3	512	518	PF02991	0.453
LIG_LIR_Nem_3	590	594	PF02991	0.552
LIG_MAD2	323	331	PF02301	0.538
LIG_NRBOX	476	482	PF00104	0.463
LIG_Pex14_1	42	46	PF04695	0.657
LIG_PTB_Apo_2	252	259	PF02174	0.452
LIG_PTB_Phospho_1	252	258	PF10480	0.492
LIG_Rb_LxCxE_1	79	93	PF01857	0.512
LIG_SH2_CRK	340	344	PF00017	0.508
LIG_SH2_CRK	586	590	PF00017	0.481
LIG_SH2_GRB2like	101	104	PF00017	0.463
LIG_SH2_GRB2like	372	375	PF00017	0.463
LIG_SH2_NCK_1	511	515	PF00017	0.452
LIG_SH2_PTP2	372	375	PF00017	0.476
LIG_SH2_SRC	101	104	PF00017	0.468
LIG_SH2_SRC	372	375	PF00017	0.538
LIG_SH2_STAP1	511	515	PF00017	0.452
LIG_SH2_STAT3	64	67	PF00017	0.474
LIG_SH2_STAT5	101	104	PF00017	0.475
LIG_SH2_STAT5	24	27	PF00017	0.307
LIG_SH2_STAT5	266	269	PF00017	0.463
LIG_SH2_STAT5	372	375	PF00017	0.465
LIG_SH2_STAT5	511	514	PF00017	0.452
LIG_SH2_STAT5	64	67	PF00017	0.489
LIG_SH3_2	317	322	PF14604	0.515
LIG_SH3_3	169	175	PF00018	0.557
LIG_SH3_3	310	316	PF00018	0.461
LIG_SH3_3	372	378	PF00018	0.532
LIG_SH3_3	487	493	PF00018	0.452
LIG_SH3_3	523	529	PF00018	0.516
LIG_SH3_CIN85_PxpxPR_1	493	498	PF14604	0.492
LIG_SUMO_SIM_anti_2	83	90	PF11976	0.538
LIG_SUMO_SIM_par_1	478	484	PF11976	0.501
LIG_TRFH_1	308	312	PF08558	0.538
LIG_TYR_ITIM	370	375	PF00017	0.476
LIG_WRC_WIRS_1	235	240	PF05994	0.463
LIG_WRC_WIRS_1	390	395	PF05994	0.501
LIG_WRC_WIRS_1	88	93	PF05994	0.557
MOD_CDC14_SPxK_1	319	322	PF00782	0.529
MOD_CDK_SPxK_1	316	322	PF00069	0.529
MOD_CDK_SPxK_1	374	380	PF00069	0.557
MOD_CDK_SPxxK_3	171	178	PF00069	0.476
MOD_CDK_SPxxK_3	316	323	PF00069	0.534
MOD_CK1_1	236	242	PF00069	0.463
MOD_CK1_1	379	385	PF00069	0.472
MOD_CK1_1	402	408	PF00069	0.480
MOD_CK1_1	439	445	PF00069	0.452
MOD_CK2_1	143	149	PF00069	0.463
MOD_CK2_1	221	227	PF00069	0.452
MOD_CK2_1	347	353	PF00069	0.492
MOD_CK2_1	354	360	PF00069	0.492
MOD_CK2_1	462	468	PF00069	0.524
MOD_CK2_1	538	544	PF00069	0.492
MOD_CK2_1	66	72	PF00069	0.559
MOD_CK2_1	80	86	PF00069	0.521
MOD_CK2_1	87	93	PF00069	0.488
MOD_CMANNOS	124	127	PF00535	0.263
MOD_GlcNHglycan	1	4	PF01048	0.460
MOD_GlcNHglycan	159	162	PF01048	0.246
MOD_GlcNHglycan	223	226	PF01048	0.252
MOD_GlcNHglycan	278	281	PF01048	0.303
MOD_GlcNHglycan	43	46	PF01048	0.387
MOD_GlcNHglycan	493	496	PF01048	0.357
MOD_GlcNHglycan	563	566	PF01048	0.338
MOD_GlcNHglycan	68	71	PF01048	0.311
MOD_GSK3_1	167	174	PF00069	0.524
MOD_GSK3_1	374	381	PF00069	0.538
MOD_GSK3_1	402	409	PF00069	0.520
MOD_GSK3_1	411	418	PF00069	0.529
MOD_N-GLC_1	157	162	PF02516	0.246
MOD_N-GLC_1	191	196	PF02516	0.276
MOD_NEK2_1	188	193	PF00069	0.468
MOD_NEK2_1	399	404	PF00069	0.500
MOD_NEK2_1	415	420	PF00069	0.538
MOD_NEK2_1	436	441	PF00069	0.500
MOD_NEK2_1	509	514	PF00069	0.455
MOD_NEK2_1	571	576	PF00069	0.511
MOD_NEK2_1	71	76	PF00069	0.586
MOD_NEK2_2	411	416	PF00069	0.473
MOD_PIKK_1	347	353	PF00454	0.464
MOD_PIKK_1	415	421	PF00454	0.557
MOD_PK_1	536	542	PF00069	0.541
MOD_PKA_1	536	542	PF00069	0.538
MOD_PKA_2	379	385	PF00069	0.476
MOD_PKA_2	51	57	PF00069	0.622
MOD_PKA_2	536	542	PF00069	0.512
MOD_PKB_1	165	173	PF00069	0.473
MOD_Plk_1	544	550	PF00069	0.501
MOD_Plk_4	135	141	PF00069	0.463
MOD_Plk_4	399	405	PF00069	0.516
MOD_Plk_4	476	482	PF00069	0.538
MOD_Plk_4	528	534	PF00069	0.548
MOD_Plk_4	87	93	PF00069	0.538
MOD_ProDKin_1	171	177	PF00069	0.463
MOD_ProDKin_1	260	266	PF00069	0.463
MOD_ProDKin_1	316	322	PF00069	0.534
MOD_ProDKin_1	374	380	PF00069	0.557
MOD_SUMO_rev_2	129	136	PF00179	0.518
MOD_SUMO_rev_2	407	414	PF00179	0.495
TRG_DiLeu_BaEn_1	452	457	PF01217	0.501
TRG_ENDOCYTIC_2	372	375	PF00928	0.463
TRG_ER_diArg_1	165	167	PF00400	0.473
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.273
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3K3	Leptomonas seymouri	79%	100%
A0A0S4JR69	Bodo saltans	45%	100%
A0A1X0NYV8	Trypanosomatidae	62%	99%
A0A3R7KJH6	Trypanosoma rangeli	61%	99%
A0A3S7WU46	Leishmania donovani	97%	100%
A4H8R4	Leishmania braziliensis	85%	100%
A4HX32	Leishmania infantum	98%	100%
A9M003	Neisseria meningitidis serogroup C (strain 053442)	27%	100%
B4RM85	Neisseria gonorrhoeae (strain NCCP11945)	26%	100%
B8GL95	Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)	26%	100%
C9ZVW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AQU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O00519	Homo sapiens	27%	100%
Q05AM4	Danio rerio	37%	100%
Q0ACB5	Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)	24%	100%
Q2YC91	Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)	26%	100%
Q5F8U8	Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)	27%	100%
Q60CK8	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	25%	100%
Q6DH69	Danio rerio	38%	100%
Q6GMR7	Homo sapiens	36%	100%
Q8FPZ0	Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)	25%	100%
Q8R679	Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)	26%	100%
V5BS79	Trypanosoma cruzi	61%	100%