Trafficking protein particle complex subunit

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

trafficking protein particle complex subunit- like protein

Species:

Leishmania major

UniProt:

Q4QEM6_LEIMA

TriTrypDb:

LmjF.16.1400 , LMJLV39_160020600 , LMJSD75_160020200

Length:

196

Annotations

LeishMANIAdb annotations

A conserved eukarytotic protein involved in ER-Golgi transport with no TM segment. Associated to the membrane from the cytoplasmic side.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005783	endoplasmic reticulum	5	10
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	5
GO:0030008	TRAPP complex	3	11
GO:0031090	organelle membrane	3	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	11
GO:0033106	cis-Golgi network membrane	5	2
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0097014	ciliary plasm	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0099023	vesicle tethering complex	2	11
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	10
GO:0140535	intracellular protein-containing complex	2	11
GO:0005794	Golgi apparatus	5	8

Expansion

Sequence features

Q4QEM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEM6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	2
GO:0006891	intra-Golgi vesicle-mediated transport	6	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	11
GO:0046907	intracellular transport	3	2
GO:0048193	Golgi vesicle transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.484
CLV_C14_Caspase3-7	131	135	PF00656	0.475
CLV_PCSK_SKI1_1	98	102	PF00082	0.275
DEG_SPOP_SBC_1	5	9	PF00917	0.678
DOC_MAPK_MEF2A_6	176	183	PF00069	0.367
DOC_MAPK_NFAT4_5	176	184	PF00069	0.371
DOC_USP7_MATH_1	5	9	PF00917	0.645
LIG_14-3-3_CanoR_1	83	92	PF00244	0.529
LIG_APCC_ABBA_1	126	131	PF00400	0.449
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_BRCT_BRCA1_1	25	29	PF00533	0.515
LIG_CaM_IQ_9	157	172	PF13499	0.447
LIG_FHA_1	114	120	PF00498	0.457
LIG_FHA_1	150	156	PF00498	0.447
LIG_FHA_1	188	194	PF00498	0.432
LIG_FHA_2	44	50	PF00498	0.502
LIG_Integrin_RGD_1	172	174	PF01839	0.449
LIG_LIR_Gen_1	26	37	PF02991	0.546
LIG_LIR_Nem_3	139	143	PF02991	0.515
LIG_LIR_Nem_3	26	32	PF02991	0.509
LIG_LIR_Nem_3	33	37	PF02991	0.460
LIG_Pex14_2	117	121	PF04695	0.463
LIG_SH2_CRK	143	147	PF00017	0.449
LIG_SH2_CRK	34	38	PF00017	0.449
LIG_SH2_GRB2like	143	146	PF00017	0.449
LIG_SH2_STAP1	143	147	PF00017	0.449
LIG_SH2_STAT5	140	143	PF00017	0.469
LIG_SH3_2	133	138	PF14604	0.501
LIG_SH3_3	127	133	PF00018	0.449
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.480
LIG_TYR_ITIM	141	146	PF00017	0.449
LIG_TYR_ITIM	32	37	PF00017	0.449
MOD_CK1_1	4	10	PF00069	0.694
MOD_CK1_1	74	80	PF00069	0.480
MOD_CK2_1	172	178	PF00069	0.329
MOD_GlcNHglycan	103	106	PF01048	0.307
MOD_GlcNHglycan	25	28	PF01048	0.244
MOD_GlcNHglycan	3	6	PF01048	0.476
MOD_GlcNHglycan	76	79	PF01048	0.254
MOD_GlcNHglycan	9	12	PF01048	0.345
MOD_GSK3_1	1	8	PF00069	0.673
MOD_GSK3_1	113	120	PF00069	0.486
MOD_GSK3_1	149	156	PF00069	0.443
MOD_NEK2_1	1	6	PF00069	0.725
MOD_NEK2_1	117	122	PF00069	0.473
MOD_NEK2_1	141	146	PF00069	0.447
MOD_NEK2_1	30	35	PF00069	0.449
MOD_PIKK_1	43	49	PF00454	0.475
MOD_PIKK_1	83	89	PF00454	0.529
MOD_PKA_2	164	170	PF00069	0.309
MOD_PKA_2	187	193	PF00069	0.449
MOD_PKB_1	170	178	PF00069	0.186
MOD_Plk_1	71	77	PF00069	0.501
MOD_Plk_4	153	159	PF00069	0.352
TRG_DiLeu_BaEn_1	90	95	PF01217	0.501
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.495
TRG_ENDOCYTIC_2	143	146	PF00928	0.449
TRG_ENDOCYTIC_2	34	37	PF00928	0.449
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P6	Leptomonas seymouri	85%	100%
A0A0S4IZC2	Bodo saltans	50%	83%
A0A1X0NYV5	Trypanosomatidae	63%	100%
A0A3R7N8V3	Trypanosoma rangeli	64%	100%
A0A3S5H6Y9	Leishmania donovani	99%	100%
A4H8R9	Leishmania braziliensis	92%	100%
C9ZVV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AGP3	Leishmania infantum	99%	100%
E9AQV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O43617	Homo sapiens	44%	100%
O55013	Mus musculus	44%	100%
P34605	Caenorhabditis elegans	33%	100%
P36149	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
Q4KL14	Mus musculus	40%	100%
Q5T215	Homo sapiens	39%	100%
Q5U1Z2	Rattus norvegicus	44%	100%
Q5ZI57	Gallus gallus	41%	100%
Q61IU9	Caenorhabditis briggsae	33%	100%
Q86K94	Dictyostelium discoideum	44%	100%
Q9P6P5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%