Dynein regulatory complex protein 10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEM5_LEIMA

TriTrypDb:

LmjF.16.1410 , LMJLV39_160020700 , LMJSD75_160020300

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0005856	cytoskeleton	5	9
GO:0005929	cilium	4	9
GO:0031514	motile cilium	5	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

Q4QEM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.539
CLV_NRD_NRD_1	366	368	PF00675	0.560
CLV_NRD_NRD_1	377	379	PF00675	0.431
CLV_NRD_NRD_1	386	388	PF00675	0.571
CLV_NRD_NRD_1	511	513	PF00675	0.654
CLV_NRD_NRD_1	64	66	PF00675	0.603
CLV_PCSK_FUR_1	406	410	PF00082	0.561
CLV_PCSK_KEX2_1	366	368	PF00082	0.552
CLV_PCSK_KEX2_1	386	388	PF00082	0.590
CLV_PCSK_KEX2_1	408	410	PF00082	0.562
CLV_PCSK_KEX2_1	513	515	PF00082	0.673
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.562
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.673
CLV_PCSK_SKI1_1	140	144	PF00082	0.544
CLV_PCSK_SKI1_1	177	181	PF00082	0.481
DEG_Nend_UBRbox_2	1	3	PF02207	0.591
DEG_SCF_FBW7_2	130	135	PF00400	0.613
DEG_SPOP_SBC_1	122	126	PF00917	0.708
DOC_PP2B_LxvP_1	224	227	PF13499	0.477
DOC_USP7_MATH_1	122	126	PF00917	0.700
DOC_USP7_MATH_1	238	242	PF00917	0.749
DOC_USP7_MATH_1	244	248	PF00917	0.678
DOC_USP7_MATH_1	354	358	PF00917	0.528
DOC_USP7_MATH_1	411	415	PF00917	0.454
DOC_USP7_MATH_1	90	94	PF00917	0.770
DOC_USP7_MATH_2	32	38	PF00917	0.571
DOC_USP7_UBL2_3	218	222	PF12436	0.578
DOC_USP7_UBL2_3	509	513	PF12436	0.614
DOC_USP7_UBL2_3	517	521	PF12436	0.706
DOC_WW_Pin1_4	128	133	PF00397	0.652
DOC_WW_Pin1_4	77	82	PF00397	0.714
LIG_14-3-3_CanoR_1	252	259	PF00244	0.607
LIG_14-3-3_CanoR_1	280	286	PF00244	0.494
LIG_14-3-3_CanoR_1	366	371	PF00244	0.558
LIG_14-3-3_CanoR_1	500	507	PF00244	0.653
LIG_14-3-3_CanoR_1	99	107	PF00244	0.624
LIG_CaM_IQ_9	487	502	PF13499	0.453
LIG_FHA_1	184	190	PF00498	0.586
LIG_FHA_1	199	205	PF00498	0.534
LIG_FHA_1	304	310	PF00498	0.552
LIG_FHA_1	345	351	PF00498	0.428
LIG_FHA_1	440	446	PF00498	0.469
LIG_FHA_1	78	84	PF00498	0.748
LIG_FHA_2	156	162	PF00498	0.528
LIG_FHA_2	205	211	PF00498	0.451
LIG_FHA_2	282	288	PF00498	0.476
LIG_FHA_2	359	365	PF00498	0.564
LIG_FHA_2	392	398	PF00498	0.582
LIG_FHA_2	405	411	PF00498	0.482
LIG_FHA_2	414	420	PF00498	0.414
LIG_FHA_2	46	52	PF00498	0.655
LIG_FHA_2	5	11	PF00498	0.607
LIG_FHA_2	501	507	PF00498	0.633
LIG_LIR_Gen_1	170	180	PF02991	0.438
LIG_LIR_Gen_1	353	362	PF02991	0.493
LIG_LIR_Gen_1	461	469	PF02991	0.508
LIG_LIR_Nem_3	170	175	PF02991	0.378
LIG_LIR_Nem_3	210	216	PF02991	0.549
LIG_PTB_Apo_2	310	317	PF02174	0.547
LIG_PTB_Phospho_1	310	316	PF10480	0.549
LIG_SH2_CRK	292	296	PF00017	0.453
LIG_SH2_SRC	59	62	PF00017	0.655
LIG_SH2_STAP1	59	63	PF00017	0.620
LIG_SH2_STAT3	420	423	PF00017	0.434
LIG_SH2_STAT5	316	319	PF00017	0.534
LIG_SH2_STAT5	343	346	PF00017	0.425
LIG_SH2_STAT5	55	58	PF00017	0.618
LIG_SUMO_SIM_par_1	439	450	PF11976	0.468
LIG_TRAF2_1	336	339	PF00917	0.556
LIG_TRAF2_1	357	360	PF00917	0.599
LIG_TRAF2_1	361	364	PF00917	0.538
LIG_TRAF2_1	447	450	PF00917	0.557
LIG_TRAF2_1	7	10	PF00917	0.605
LIG_WRC_WIRS_1	27	32	PF05994	0.421
MOD_CK1_1	124	130	PF00069	0.726
MOD_CK1_1	404	410	PF00069	0.562
MOD_CK1_1	89	95	PF00069	0.748
MOD_CK1_1	97	103	PF00069	0.771
MOD_CK2_1	185	191	PF00069	0.486
MOD_CK2_1	281	287	PF00069	0.511
MOD_CK2_1	354	360	PF00069	0.583
MOD_CK2_1	4	10	PF00069	0.609
MOD_CK2_1	404	410	PF00069	0.562
MOD_CK2_1	413	419	PF00069	0.556
MOD_CK2_1	500	506	PF00069	0.625
MOD_GlcNHglycan	413	416	PF01048	0.447
MOD_GlcNHglycan	423	426	PF01048	0.435
MOD_GlcNHglycan	88	91	PF01048	0.759
MOD_GlcNHglycan	96	99	PF01048	0.680
MOD_GSK3_1	103	110	PF00069	0.662
MOD_GSK3_1	121	128	PF00069	0.615
MOD_GSK3_1	228	235	PF00069	0.639
MOD_GSK3_1	238	245	PF00069	0.669
MOD_GSK3_1	248	255	PF00069	0.702
MOD_GSK3_1	354	361	PF00069	0.528
MOD_GSK3_1	411	418	PF00069	0.496
MOD_GSK3_1	45	52	PF00069	0.634
MOD_GSK3_1	86	93	PF00069	0.731
MOD_GSK3_1	94	101	PF00069	0.695
MOD_N-GLC_1	280	285	PF02516	0.496
MOD_N-GLC_1	404	409	PF02516	0.579
MOD_NEK2_1	204	209	PF00069	0.524
MOD_NEK2_1	229	234	PF00069	0.696
MOD_NEK2_1	269	274	PF00069	0.565
MOD_NEK2_1	358	363	PF00069	0.524
MOD_NEK2_1	49	54	PF00069	0.646
MOD_NEK2_1	86	91	PF00069	0.734
MOD_PIKK_1	232	238	PF00454	0.729
MOD_PIKK_1	500	506	PF00454	0.606
MOD_PK_1	40	46	PF00069	0.633
MOD_PKA_1	366	372	PF00069	0.554
MOD_PKA_2	366	372	PF00069	0.551
MOD_PKA_2	49	55	PF00069	0.672
MOD_PKA_2	64	70	PF00069	0.470
MOD_PKA_2	86	92	PF00069	0.716
MOD_PKA_2	93	99	PF00069	0.613
MOD_PKB_1	278	286	PF00069	0.605
MOD_Plk_1	280	286	PF00069	0.496
MOD_Plk_1	33	39	PF00069	0.577
MOD_Plk_1	40	46	PF00069	0.596
MOD_Plk_4	26	32	PF00069	0.435
MOD_Plk_4	34	40	PF00069	0.527
MOD_ProDKin_1	128	134	PF00069	0.644
MOD_ProDKin_1	77	83	PF00069	0.716
MOD_SUMO_for_1	12	15	PF00179	0.540
TRG_DiLeu_BaEn_4	23	29	PF01217	0.553
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.572
TRG_ENDOCYTIC_2	154	157	PF00928	0.583
TRG_ENDOCYTIC_2	172	175	PF00928	0.305
TRG_ENDOCYTIC_2	213	216	PF00928	0.455
TRG_ENDOCYTIC_2	292	295	PF00928	0.454
TRG_ENDOCYTIC_2	316	319	PF00928	0.483
TRG_ENDOCYTIC_2	494	497	PF00928	0.567
TRG_ER_diArg_1	277	280	PF00400	0.609
TRG_ER_diArg_1	386	388	PF00400	0.590
TRG_NLS_MonoCore_2	511	516	PF00514	0.634
TRG_NLS_MonoExtC_3	511	516	PF00514	0.603
TRG_NLS_MonoExtN_4	509	516	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I290	Leptomonas seymouri	56%	94%
A0A3Q8IJ71	Leishmania donovani	94%	100%
A0A3R7M3F0	Trypanosoma rangeli	38%	100%
A4HX37	Leishmania infantum	94%	100%
C9ZVV2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AQV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DJ53	Trypanosoma cruzi	36%	100%