Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEM4_LEIMA

TriTrypDb:

LmjF.16.1420 , LMJLV39_160020800 , LMJSD75_160020400

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.512
CLV_NRD_NRD_1	12	14	PF00675	0.675
CLV_NRD_NRD_1	312	314	PF00675	0.517
CLV_NRD_NRD_1	51	53	PF00675	0.461
CLV_NRD_NRD_1	95	97	PF00675	0.615
CLV_PCSK_KEX2_1	102	104	PF00082	0.518
CLV_PCSK_KEX2_1	12	14	PF00082	0.675
CLV_PCSK_KEX2_1	120	122	PF00082	0.571
CLV_PCSK_KEX2_1	50	52	PF00082	0.470
CLV_PCSK_KEX2_1	95	97	PF00082	0.494
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.495
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.571
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.471
CLV_PCSK_SKI1_1	26	30	PF00082	0.727
CLV_PCSK_SKI1_1	299	303	PF00082	0.504
CLV_PCSK_SKI1_1	313	317	PF00082	0.438
CLV_PCSK_SKI1_1	43	47	PF00082	0.386
DOC_MAPK_gen_1	146	155	PF00069	0.659
DOC_MAPK_gen_1	50	58	PF00069	0.564
DOC_MAPK_MEF2A_6	236	244	PF00069	0.562
DOC_PP1_RVXF_1	297	304	PF00149	0.537
DOC_USP7_MATH_1	36	40	PF00917	0.657
DOC_USP7_UBL2_3	120	124	PF12436	0.660
DOC_USP7_UBL2_3	146	150	PF12436	0.612
DOC_USP7_UBL2_3	187	191	PF12436	0.519
DOC_WW_Pin1_4	245	250	PF00397	0.446
DOC_WW_Pin1_4	317	322	PF00397	0.605
LIG_14-3-3_CanoR_1	13	19	PF00244	0.649
LIG_14-3-3_CanoR_1	26	34	PF00244	0.644
LIG_14-3-3_CanoR_1	3	7	PF00244	0.709
LIG_BRCT_BRCA1_1	19	23	PF00533	0.689
LIG_EH1_1	223	231	PF00400	0.426
LIG_FHA_1	320	326	PF00498	0.473
LIG_FHA_1	61	67	PF00498	0.513
LIG_FHA_2	139	145	PF00498	0.692
LIG_FHA_2	246	252	PF00498	0.568
LIG_Integrin_RGD_1	194	196	PF01839	0.392
LIG_LIR_Gen_1	334	343	PF02991	0.441
LIG_LIR_Gen_1	85	92	PF02991	0.505
LIG_LIR_Nem_3	33	37	PF02991	0.567
LIG_LIR_Nem_3	85	90	PF02991	0.567
LIG_SH2_CRK	298	302	PF00017	0.541
LIG_SH2_STAP1	78	82	PF00017	0.540
LIG_SH2_STAT5	283	286	PF00017	0.625
LIG_SH2_STAT5	34	37	PF00017	0.551
LIG_SH2_STAT5	44	47	PF00017	0.441
LIG_SH3_3	285	291	PF00018	0.554
LIG_SH3_3	298	304	PF00018	0.380
LIG_SUMO_SIM_anti_2	328	334	PF11976	0.487
LIG_SUMO_SIM_par_1	238	243	PF11976	0.614
LIG_SUMO_SIM_par_1	253	259	PF11976	0.463
LIG_SUMO_SIM_par_1	328	334	PF11976	0.481
LIG_TRFH_1	58	62	PF08558	0.587
LIG_UBA3_1	178	187	PF00899	0.492
MOD_CDK_SPxxK_3	245	252	PF00069	0.436
MOD_CK1_1	17	23	PF00069	0.703
MOD_CK1_1	243	249	PF00069	0.566
MOD_CK1_1	39	45	PF00069	0.510
MOD_CK2_1	138	144	PF00069	0.622
MOD_GlcNHglycan	162	165	PF01048	0.518
MOD_GlcNHglycan	226	229	PF01048	0.556
MOD_GlcNHglycan	271	274	PF01048	0.621
MOD_GlcNHglycan	7	10	PF01048	0.660
MOD_GSK3_1	220	227	PF00069	0.509
MOD_GSK3_1	32	39	PF00069	0.614
MOD_GSK3_1	333	340	PF00069	0.506
MOD_GSK3_1	7	14	PF00069	0.673
MOD_N-GLC_1	199	204	PF02516	0.628
MOD_N-GLC_1	224	229	PF02516	0.547
MOD_NEK2_1	224	229	PF00069	0.558
MOD_NEK2_1	341	346	PF00069	0.632
MOD_NEK2_1	7	12	PF00069	0.655
MOD_PKA_2	11	17	PF00069	0.629
MOD_PKA_2	2	8	PF00069	0.673
MOD_PKA_2	235	241	PF00069	0.445
MOD_Plk_1	224	230	PF00069	0.567
MOD_Plk_1	240	246	PF00069	0.429
MOD_Plk_1	32	38	PF00069	0.590
MOD_Plk_2-3	337	343	PF00069	0.368
MOD_Plk_4	148	154	PF00069	0.636
MOD_Plk_4	2	8	PF00069	0.692
MOD_Plk_4	235	241	PF00069	0.522
MOD_ProDKin_1	245	251	PF00069	0.437
MOD_ProDKin_1	317	323	PF00069	0.603
MOD_SUMO_for_1	286	289	PF00179	0.644
TRG_DiLeu_BaEn_2	84	90	PF01217	0.574
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.458
TRG_ENDOCYTIC_2	298	301	PF00928	0.539
TRG_ENDOCYTIC_2	335	338	PF00928	0.549
TRG_ENDOCYTIC_2	78	81	PF00928	0.500
TRG_ER_diArg_1	11	13	PF00400	0.661
TRG_ER_diArg_1	49	52	PF00400	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL8	Leptomonas seymouri	62%	69%
A0A1X0NYW3	Trypanosomatidae	40%	100%
A0A3R7JY16	Trypanosoma rangeli	36%	94%
A0A3S7WU51	Leishmania donovani	95%	100%
A4H8S0	Leishmania braziliensis	79%	99%
A4HX38	Leishmania infantum	95%	100%
E9AQV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BMN4	Trypanosoma cruzi	38%	96%