Paraflagellar rod protein 2C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Paraflagellar rod protein 2-3

Species:

Leishmania major

UniProt:

Q4QEM2_LEIMA

TriTrypDb:

LmjF.16.1425 , LMJLV39_160021000 , LMJSD75_160020600

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 46
NetGPI	no	yes: 0, no: 46

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005929	cilium	4	47
GO:0031514	motile cilium	5	47
GO:0031974	membrane-enclosed lumen	2	4
GO:0031981	nuclear lumen	5	4
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	4
GO:0042995	cell projection	2	47
GO:0043226	organelle	2	47
GO:0043227	membrane-bounded organelle	3	47
GO:0043233	organelle lumen	3	4
GO:0070013	intracellular organelle lumen	4	4
GO:0097014	ciliary plasm	5	4
GO:0099568	cytoplasmic region	3	4
GO:0110165	cellular anatomical entity	1	47
GO:0120025	plasma membrane bounded cell projection	3	47
GO:0005930	axoneme	2	1

Expansion

Sequence features

Q4QEM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEM2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	47
GO:0005515	protein binding	2	47
GO:0005516	calmodulin binding	3	47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.528
CLV_NRD_NRD_1	287	289	PF00675	0.430
CLV_NRD_NRD_1	30	32	PF00675	0.635
CLV_NRD_NRD_1	340	342	PF00675	0.423
CLV_NRD_NRD_1	363	365	PF00675	0.439
CLV_NRD_NRD_1	374	376	PF00675	0.425
CLV_NRD_NRD_1	447	449	PF00675	0.420
CLV_NRD_NRD_1	552	554	PF00675	0.434
CLV_PCSK_KEX2_1	273	275	PF00082	0.584
CLV_PCSK_KEX2_1	286	288	PF00082	0.394
CLV_PCSK_KEX2_1	316	318	PF00082	0.421
CLV_PCSK_KEX2_1	362	364	PF00082	0.431
CLV_PCSK_KEX2_1	373	375	PF00082	0.451
CLV_PCSK_KEX2_1	447	449	PF00082	0.409
CLV_PCSK_KEX2_1	462	464	PF00082	0.412
CLV_PCSK_KEX2_1	552	554	PF00082	0.434
CLV_PCSK_KEX2_1	579	581	PF00082	0.605
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.598
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.399
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.423
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.423
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.421
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.605
CLV_PCSK_PC7_1	370	376	PF00082	0.461
CLV_PCSK_PC7_1	575	581	PF00082	0.603
CLV_PCSK_SKI1_1	273	277	PF00082	0.574
CLV_PCSK_SKI1_1	287	291	PF00082	0.413
CLV_PCSK_SKI1_1	317	321	PF00082	0.533
CLV_PCSK_SKI1_1	389	393	PF00082	0.428
CLV_PCSK_SKI1_1	595	599	PF00082	0.573
CLV_PCSK_SKI1_1	86	90	PF00082	0.792
DOC_CYCLIN_RxL_1	386	395	PF00134	0.430
DOC_MAPK_gen_1	31	40	PF00069	0.631
DOC_MAPK_gen_1	389	396	PF00069	0.425
DOC_MAPK_gen_1	469	478	PF00069	0.420
DOC_MAPK_MEF2A_6	389	396	PF00069	0.425
DOC_MAPK_MEF2A_6	472	480	PF00069	0.430
DOC_MAPK_NFAT4_5	389	397	PF00069	0.430
DOC_PP4_FxxP_1	538	541	PF00568	0.430
DOC_USP7_MATH_1	17	21	PF00917	0.806
DOC_USP7_MATH_1	80	84	PF00917	0.758
DOC_USP7_UBL2_3	113	117	PF12436	0.592
DOC_USP7_UBL2_3	286	290	PF12436	0.396
DOC_USP7_UBL2_3	497	501	PF12436	0.401
LIG_14-3-3_CanoR_1	141	146	PF00244	0.558
LIG_14-3-3_CanoR_1	448	454	PF00244	0.411
LIG_14-3-3_CanoR_1	469	478	PF00244	0.394
LIG_14-3-3_CanoR_1	590	595	PF00244	0.712
LIG_14-3-3_CterR_2	595	599	PF00244	0.573
LIG_Actin_WH2_2	149	166	PF00022	0.534
LIG_Actin_WH2_2	389	406	PF00022	0.550
LIG_APCC_ABBA_1	436	441	PF00400	0.430
LIG_APCC_ABBAyCdc20_2	435	441	PF00400	0.430
LIG_BIR_II_1	1	5	PF00653	0.718
LIG_CtBP_PxDLS_1	103	109	PF00389	0.577
LIG_EH1_1	92	100	PF00400	0.554
LIG_eIF4E_1	235	241	PF01652	0.491
LIG_eIF4E_1	93	99	PF01652	0.561
LIG_FHA_1	138	144	PF00498	0.582
LIG_FHA_1	277	283	PF00498	0.451
LIG_FHA_1	40	46	PF00498	0.633
LIG_FHA_1	471	477	PF00498	0.378
LIG_FHA_1	579	585	PF00498	0.774
LIG_FHA_2	127	133	PF00498	0.569
LIG_FHA_2	207	213	PF00498	0.597
LIG_FHA_2	256	262	PF00498	0.540
LIG_FHA_2	318	324	PF00498	0.438
LIG_FHA_2	425	431	PF00498	0.402
LIG_LIR_Apic_2	537	541	PF02991	0.417
LIG_LIR_Gen_1	264	269	PF02991	0.678
LIG_LIR_Gen_1	355	365	PF02991	0.429
LIG_LIR_Gen_1	377	384	PF02991	0.378
LIG_LIR_Nem_3	250	255	PF02991	0.493
LIG_LIR_Nem_3	264	268	PF02991	0.562
LIG_LIR_Nem_3	337	343	PF02991	0.424
LIG_LIR_Nem_3	355	361	PF02991	0.431
LIG_LIR_Nem_3	377	381	PF02991	0.378
LIG_LIR_Nem_3	444	449	PF02991	0.416
LIG_PTB_Apo_2	44	51	PF02174	0.612
LIG_SH2_CRK	450	454	PF00017	0.437
LIG_SH2_SRC	442	445	PF00017	0.456
LIG_SH2_STAT3	318	321	PF00017	0.526
LIG_SH2_STAT3	93	96	PF00017	0.635
LIG_SH2_STAT5	235	238	PF00017	0.464
LIG_SH2_STAT5	442	445	PF00017	0.415
LIG_SH3_3	173	179	PF00018	0.623
LIG_SH3_4	113	120	PF00018	0.575
LIG_SUMO_SIM_par_1	140	146	PF11976	0.685
LIG_SUMO_SIM_par_1	390	395	PF11976	0.430
LIG_TRAF2_1	159	162	PF00917	0.622
LIG_TRAF2_1	275	278	PF00917	0.555
LIG_TRAF2_1	427	430	PF00917	0.443
LIG_TRAF2_1	46	49	PF00917	0.627
LIG_TRAF2_1	541	544	PF00917	0.446
LIG_TRAF2_1	564	567	PF00917	0.583
LIG_WRC_WIRS_1	482	487	PF05994	0.411
MOD_CK1_1	20	26	PF00069	0.698
MOD_CK1_1	57	63	PF00069	0.670
MOD_CK2_1	104	110	PF00069	0.574
MOD_CK2_1	126	132	PF00069	0.535
MOD_CK2_1	206	212	PF00069	0.603
MOD_CK2_1	255	261	PF00069	0.500
MOD_CK2_1	317	323	PF00069	0.450
MOD_CK2_1	424	430	PF00069	0.404
MOD_CK2_1	43	49	PF00069	0.631
MOD_Cter_Amidation	284	287	PF01082	0.536
MOD_GlcNHglycan	417	420	PF01048	0.404
MOD_GlcNHglycan	82	85	PF01048	0.711
MOD_GSK3_1	137	144	PF00069	0.575
MOD_GSK3_1	39	46	PF00069	0.603
MOD_N-GLC_1	137	142	PF02516	0.581
MOD_N-GLC_1	188	193	PF02516	0.523
MOD_N-GLC_1	261	266	PF02516	0.628
MOD_NEK2_1	104	109	PF00069	0.565
MOD_NEK2_1	126	131	PF00069	0.537
MOD_NEK2_1	163	168	PF00069	0.545
MOD_NEK2_1	188	193	PF00069	0.508
MOD_NEK2_1	276	281	PF00069	0.450
MOD_NEK2_1	392	397	PF00069	0.419
MOD_NEK2_1	449	454	PF00069	0.406
MOD_NEK2_1	578	583	PF00069	0.635
MOD_PIKK_1	163	169	PF00454	0.558
MOD_PIKK_1	268	274	PF00454	0.631
MOD_PIKK_1	317	323	PF00454	0.440
MOD_PIKK_1	583	589	PF00454	0.641
MOD_PIKK_1	59	65	PF00454	0.682
MOD_PKA_1	490	496	PF00069	0.437
MOD_PKA_2	163	169	PF00069	0.553
MOD_PKA_2	471	477	PF00069	0.409
MOD_PKA_2	551	557	PF00069	0.414
MOD_Plk_1	104	110	PF00069	0.612
MOD_Plk_1	188	194	PF00069	0.555
MOD_Plk_1	23	29	PF00069	0.650
MOD_Plk_1	261	267	PF00069	0.650
MOD_Plk_1	392	398	PF00069	0.441
MOD_Plk_2-3	261	267	PF00069	0.462
MOD_Plk_2-3	296	302	PF00069	0.507
MOD_Plk_4	188	194	PF00069	0.562
MOD_Plk_4	392	398	PF00069	0.427
MOD_SUMO_for_1	154	157	PF00179	0.563
MOD_SUMO_for_1	495	498	PF00179	0.434
MOD_SUMO_for_1	564	567	PF00179	0.582
MOD_SUMO_rev_2	110	118	PF00179	0.562
MOD_SUMO_rev_2	259	265	PF00179	0.524
MOD_SUMO_rev_2	567	572	PF00179	0.564
MOD_SUMO_rev_2	574	581	PF00179	0.609
TRG_DiLeu_BaEn_2	376	382	PF01217	0.430
TRG_DiLeu_BaEn_3	507	513	PF01217	0.431
TRG_DiLeu_BaEn_4	429	435	PF01217	0.475
TRG_DiLeu_BaEn_4	508	514	PF01217	0.430
TRG_ENDOCYTIC_2	378	381	PF00928	0.368
TRG_ENDOCYTIC_2	450	453	PF00928	0.420
TRG_ER_diArg_1	287	289	PF00400	0.418
TRG_ER_diArg_1	363	365	PF00400	0.428
TRG_ER_diArg_1	373	375	PF00400	0.433
TRG_ER_diArg_1	446	448	PF00400	0.449
TRG_NES_CRM1_1	242	257	PF08389	0.504
TRG_NES_CRM1_1	96	110	PF08389	0.638
TRG_NLS_Bipartite_1	273	290	PF00514	0.437
TRG_NLS_MonoExtC_3	285	290	PF00514	0.430
TRG_NLS_MonoExtN_4	283	290	PF00514	0.430
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	595	599	PF00026	0.790

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I5	Leptomonas seymouri	66%	100%
A0A0N0P5J5	Leptomonas seymouri	27%	75%
A0A0N1IFZ5	Leptomonas seymouri	94%	100%
A0A0S4IZY8	Bodo saltans	84%	100%
A0A0S4J193	Bodo saltans	28%	97%
A0A0S4J561	Bodo saltans	30%	85%
A0A0S4JS20	Bodo saltans	69%	100%
A0A1X0NR57	Trypanosomatidae	26%	76%
A0A1X0NYU4	Trypanosomatidae	84%	100%
A0A1X0P0B7	Trypanosomatidae	68%	100%
A0A381MH18	Leishmania infantum	99%	100%
A0A381MN58	Leishmania infantum	66%	100%
A0A3Q8IAP5	Leishmania donovani	99%	100%
A0A3Q8IEH2	Leishmania donovani	66%	100%
A0A3R7KDB9	Trypanosoma rangeli	84%	100%
A0A3S5IRI8	Trypanosoma rangeli	68%	100%
A0A3S7WQV4	Leishmania donovani	23%	99%
A0A3S7X0V5	Leishmania donovani	24%	77%
A0A3S7X2K1	Leishmania donovani	66%	100%
A0A422NJR9	Trypanosoma rangeli	25%	81%
A4H5W0	Leishmania braziliensis	24%	99%
A4H8S1	Leishmania braziliensis	94%	100%
A4HFV9	Leishmania braziliensis	25%	77%
A4HIY0	Leishmania braziliensis	66%	100%
A4HU55	Leishmania infantum	22%	99%
A4HX40	Leishmania infantum	99%	100%
A4I2Z1	Leishmania infantum	24%	77%
C9ZJD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	79%
C9ZLC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
C9ZLC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
C9ZU76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	87%
C9ZVV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
E9ADG3	Leishmania major	25%	77%
E9AE36	Leishmania major	66%	100%
E9AE37	Leishmania major	66%	100%
E9AHJ2	Leishmania infantum	66%	100%
E9ALP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
E9ALP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
E9AMY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	99%
E9AQV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	90%
E9AZ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	77%
P22225	Trypanosoma brucei brucei	83%	100%
Q26789	Trypanosoma brucei brucei	66%	100%
Q4QHP3	Leishmania major	22%	99%
V5ARJ3	Trypanosoma cruzi	28%	86%
V5BDW8	Trypanosoma cruzi	68%	100%
V5BIN9	Trypanosoma cruzi	27%	81%