Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QEM0_LEIMA

TriTrypDb:

LmjF.16.1450 , LMJLV39_160021300 , LMJSD75_160021000

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.608
CLV_NRD_NRD_1	102	104	PF00675	0.605
CLV_NRD_NRD_1	106	108	PF00675	0.599
CLV_NRD_NRD_1	142	144	PF00675	0.706
CLV_NRD_NRD_1	157	159	PF00675	0.716
CLV_NRD_NRD_1	57	59	PF00675	0.458
CLV_PCSK_KEX2_1	102	104	PF00082	0.605
CLV_PCSK_KEX2_1	106	108	PF00082	0.599
CLV_PCSK_KEX2_1	142	144	PF00082	0.706
CLV_PCSK_KEX2_1	157	159	PF00082	0.710
CLV_PCSK_KEX2_1	57	59	PF00082	0.458
CLV_PCSK_PC7_1	102	108	PF00082	0.588
CLV_PCSK_SKI1_1	157	161	PF00082	0.739
CLV_PCSK_SKI1_1	64	68	PF00082	0.440
DEG_APCC_DBOX_1	63	71	PF00400	0.439
DEG_Nend_UBRbox_3	1	3	PF02207	0.775
DOC_MAPK_gen_1	238	247	PF00069	0.652
DOC_MAPK_MEF2A_6	240	249	PF00069	0.679
DOC_USP7_MATH_1	52	56	PF00917	0.521
DOC_USP7_MATH_1	66	70	PF00917	0.442
DOC_USP7_UBL2_3	294	298	PF12436	0.539
DOC_WW_Pin1_4	11	16	PF00397	0.645
DOC_WW_Pin1_4	131	136	PF00397	0.733
DOC_WW_Pin1_4	191	196	PF00397	0.599
DOC_WW_Pin1_4	215	220	PF00397	0.755
LIG_14-3-3_CanoR_1	106	110	PF00244	0.587
LIG_14-3-3_CanoR_1	164	173	PF00244	0.813
LIG_14-3-3_CanoR_1	270	274	PF00244	0.650
LIG_14-3-3_CanoR_1	57	61	PF00244	0.527
LIG_FHA_1	145	151	PF00498	0.709
LIG_FHA_1	221	227	PF00498	0.702
LIG_FHA_1	277	283	PF00498	0.638
LIG_FHA_1	72	78	PF00498	0.442
LIG_FHA_2	163	169	PF00498	0.802
LIG_FHA_2	174	180	PF00498	0.619
LIG_FHA_2	232	238	PF00498	0.587
LIG_FHA_2	254	260	PF00498	0.676
LIG_FHA_2	57	63	PF00498	0.528
LIG_FHA_2	77	83	PF00498	0.330
LIG_LIR_Gen_1	14	24	PF02991	0.735
LIG_LIR_Gen_1	272	282	PF02991	0.643
LIG_LIR_Nem_3	108	112	PF02991	0.470
LIG_LIR_Nem_3	14	20	PF02991	0.731
LIG_PTAP_UEV_1	134	139	PF05743	0.542
LIG_SH2_CRK	112	116	PF00017	0.485
LIG_SH2_NCK_1	112	116	PF00017	0.465
LIG_SH2_STAP1	112	116	PF00017	0.485
LIG_SH3_3	132	138	PF00018	0.702
LIG_TRAF2_1	59	62	PF00917	0.643
MOD_CDK_SPxK_1	191	197	PF00069	0.602
MOD_CDK_SPxxK_3	191	198	PF00069	0.604
MOD_CK1_1	167	173	PF00069	0.672
MOD_CK1_1	218	224	PF00069	0.717
MOD_CK1_1	5	11	PF00069	0.737
MOD_CK1_1	69	75	PF00069	0.594
MOD_CK2_1	162	168	PF00069	0.750
MOD_CK2_1	173	179	PF00069	0.641
MOD_CK2_1	231	237	PF00069	0.593
MOD_CK2_1	253	259	PF00069	0.587
MOD_CK2_1	56	62	PF00069	0.633
MOD_CK2_1	76	82	PF00069	0.327
MOD_Cter_Amidation	100	103	PF01082	0.604
MOD_GlcNHglycan	135	138	PF01048	0.672
MOD_GlcNHglycan	144	147	PF01048	0.703
MOD_GlcNHglycan	168	172	PF01048	0.825
MOD_GlcNHglycan	4	7	PF01048	0.715
MOD_GSK3_1	144	151	PF00069	0.680
MOD_GSK3_1	160	167	PF00069	0.717
MOD_GSK3_1	198	205	PF00069	0.649
MOD_GSK3_1	218	225	PF00069	0.707
MOD_GSK3_1	227	234	PF00069	0.663
MOD_GSK3_1	52	59	PF00069	0.523
MOD_GSK3_1	69	76	PF00069	0.424
MOD_N-GLC_1	131	136	PF02516	0.764
MOD_N-GLC_2	242	244	PF02516	0.536
MOD_NEK2_1	105	110	PF00069	0.589
MOD_NEK2_1	144	149	PF00069	0.711
MOD_NEK2_1	56	61	PF00069	0.532
MOD_NEK2_2	52	57	PF00069	0.462
MOD_PIKK_1	125	131	PF00454	0.727
MOD_PIKK_1	173	179	PF00454	0.802
MOD_PIKK_1	76	82	PF00454	0.528
MOD_PK_1	198	204	PF00069	0.614
MOD_PKA_1	142	148	PF00069	0.759
MOD_PKA_2	105	111	PF00069	0.581
MOD_PKA_2	142	148	PF00069	0.759
MOD_PKA_2	269	275	PF00069	0.553
MOD_PKA_2	56	62	PF00069	0.552
MOD_Plk_1	52	58	PF00069	0.504
MOD_Plk_1	80	86	PF00069	0.434
MOD_Plk_2-3	82	88	PF00069	0.658
MOD_Plk_4	13	19	PF00069	0.672
MOD_Plk_4	269	275	PF00069	0.623
MOD_Plk_4	82	88	PF00069	0.658
MOD_ProDKin_1	11	17	PF00069	0.645
MOD_ProDKin_1	131	137	PF00069	0.724
MOD_ProDKin_1	191	197	PF00069	0.602
MOD_ProDKin_1	215	221	PF00069	0.756
MOD_SUMO_for_1	159	162	PF00179	0.736
TRG_DiLeu_BaEn_2	81	87	PF01217	0.510
TRG_ENDOCYTIC_2	112	115	PF00928	0.485
TRG_ER_diArg_1	105	107	PF00400	0.602
TRG_ER_diArg_1	142	144	PF00400	0.678
TRG_ER_diArg_1	157	159	PF00400	0.710
TRG_ER_diArg_1	56	58	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.739
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT54	Leptomonas seymouri	33%	94%
A0A3S5H6Z1	Leishmania donovani	87%	100%
A4HX42	Leishmania infantum	87%	100%
E9AQV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%