Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania major

UniProt:

Q4QEL8_LEIMA

TriTrypDb:

LmjF.16.1470 , LMJLV39_160021400 , LMJLV39_290016200 , LMJSD75_160021200

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005871	kinesin complex	3	3
GO:0005874	microtubule	6	5
GO:0005875	microtubule associated complex	2	3
GO:0020016	ciliary pocket	2	2
GO:0030863	cortical cytoskeleton	6	2
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	5
GO:0099081	supramolecular polymer	3	5
GO:0099512	supramolecular fiber	4	5
GO:0099513	polymeric cytoskeletal fiber	5	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1

Expansion

Sequence features

Q4QEL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEL8

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	17
GO:0007018	microtubule-based movement	3	17
GO:0009987	cellular process	1	17

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003774	cytoskeletal motor activity	1	17
GO:0003777	microtubule motor activity	2	17
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	17
GO:0005515	protein binding	2	17
GO:0005524	ATP binding	5	17
GO:0008017	microtubule binding	5	17
GO:0008092	cytoskeletal protein binding	3	17
GO:0015631	tubulin binding	4	17
GO:0016462	pyrophosphatase activity	5	3
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	3
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	3
GO:0016887	ATP hydrolysis activity	7	3
GO:0017076	purine nucleotide binding	4	17
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	3
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:0140657	ATP-dependent activity	1	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.345
CLV_C14_Caspase3-7	507	511	PF00656	0.544
CLV_NRD_NRD_1	170	172	PF00675	0.291
CLV_NRD_NRD_1	2	4	PF00675	0.602
CLV_NRD_NRD_1	384	386	PF00675	0.480
CLV_NRD_NRD_1	524	526	PF00675	0.577
CLV_NRD_NRD_1	755	757	PF00675	0.470
CLV_NRD_NRD_1	777	779	PF00675	0.593
CLV_NRD_NRD_1	788	790	PF00675	0.503
CLV_NRD_NRD_1	801	803	PF00675	0.579
CLV_PCSK_KEX2_1	2	4	PF00082	0.571
CLV_PCSK_KEX2_1	495	497	PF00082	0.521
CLV_PCSK_KEX2_1	524	526	PF00082	0.506
CLV_PCSK_KEX2_1	755	757	PF00082	0.470
CLV_PCSK_KEX2_1	777	779	PF00082	0.593
CLV_PCSK_KEX2_1	788	790	PF00082	0.513
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.545
CLV_PCSK_SKI1_1	146	150	PF00082	0.319
CLV_PCSK_SKI1_1	246	250	PF00082	0.318
CLV_PCSK_SKI1_1	313	317	PF00082	0.305
CLV_PCSK_SKI1_1	352	356	PF00082	0.326
CLV_PCSK_SKI1_1	387	391	PF00082	0.420
CLV_PCSK_SKI1_1	435	439	PF00082	0.459
CLV_PCSK_SKI1_1	448	452	PF00082	0.488
CLV_PCSK_SKI1_1	755	759	PF00082	0.463
CLV_Separin_Metazoa	209	213	PF03568	0.338
DEG_APCC_DBOX_1	754	762	PF00400	0.463
DEG_Nend_UBRbox_1	1	4	PF02207	0.538
DOC_CYCLIN_RxL_1	246	254	PF00134	0.293
DOC_MAPK_MEF2A_6	8	17	PF00069	0.565
DOC_MAPK_RevD_3	157	172	PF00069	0.305
DOC_MIT_MIM_1	543	551	PF04212	0.438
DOC_PP4_FxxP_1	115	118	PF00568	0.420
DOC_PP4_FxxP_1	238	241	PF00568	0.420
DOC_USP7_MATH_1	140	144	PF00917	0.305
DOC_USP7_MATH_1	194	198	PF00917	0.345
DOC_USP7_MATH_1	215	219	PF00917	0.400
DOC_USP7_MATH_1	284	288	PF00917	0.353
DOC_USP7_MATH_1	504	508	PF00917	0.523
DOC_USP7_MATH_1	593	597	PF00917	0.613
DOC_USP7_MATH_1	67	71	PF00917	0.338
DOC_USP7_MATH_1	718	722	PF00917	0.377
DOC_USP7_MATH_1	73	77	PF00917	0.318
DOC_WW_Pin1_4	329	334	PF00397	0.386
DOC_WW_Pin1_4	783	788	PF00397	0.597
LIG_14-3-3_CanoR_1	139	148	PF00244	0.305
LIG_14-3-3_CanoR_1	171	177	PF00244	0.420
LIG_14-3-3_CanoR_1	225	230	PF00244	0.317
LIG_14-3-3_CanoR_1	307	312	PF00244	0.305
LIG_14-3-3_CanoR_1	503	513	PF00244	0.563
LIG_14-3-3_CanoR_1	52	56	PF00244	0.305
LIG_14-3-3_CanoR_1	547	555	PF00244	0.544
LIG_14-3-3_CanoR_1	777	785	PF00244	0.506
LIG_14-3-3_CanoR_1	802	807	PF00244	0.524
LIG_Actin_WH2_2	192	208	PF00022	0.267
LIG_Actin_WH2_2	704	722	PF00022	0.428
LIG_APCC_ABBA_1	157	162	PF00400	0.342
LIG_APCC_ABBAyCdc20_2	387	393	PF00400	0.409
LIG_APCC_ABBAyCdc20_2	448	454	PF00400	0.530
LIG_BRCT_BRCA1_1	181	185	PF00533	0.316
LIG_Clathr_ClatBox_1	229	233	PF01394	0.305
LIG_FHA_1	147	153	PF00498	0.351
LIG_FHA_1	182	188	PF00498	0.370
LIG_FHA_1	190	196	PF00498	0.383
LIG_FHA_1	310	316	PF00498	0.326
LIG_FHA_1	324	330	PF00498	0.326
LIG_FHA_1	425	431	PF00498	0.524
LIG_FHA_1	515	521	PF00498	0.527
LIG_FHA_1	778	784	PF00498	0.579
LIG_FHA_2	121	127	PF00498	0.329
LIG_FHA_2	234	240	PF00498	0.288
LIG_FHA_2	25	31	PF00498	0.310
LIG_FHA_2	426	432	PF00498	0.463
LIG_FHA_2	436	442	PF00498	0.503
LIG_FHA_2	598	604	PF00498	0.603
LIG_FHA_2	612	618	PF00498	0.634
LIG_FHA_2	626	632	PF00498	0.518
LIG_FHA_2	640	646	PF00498	0.493
LIG_FHA_2	671	677	PF00498	0.450
LIG_GBD_Chelix_1	526	534	PF00786	0.555
LIG_KLC1_Yacidic_2	158	162	PF13176	0.305
LIG_LIR_Apic_2	113	118	PF02991	0.420
LIG_LIR_Apic_2	236	241	PF02991	0.420
LIG_LIR_Gen_1	111	118	PF02991	0.342
LIG_LIR_Gen_1	182	193	PF02991	0.298
LIG_LIR_Gen_1	197	205	PF02991	0.301
LIG_LIR_Gen_1	454	462	PF02991	0.579
LIG_LIR_Gen_1	735	744	PF02991	0.462
LIG_LIR_Gen_1	78	89	PF02991	0.319
LIG_LIR_Nem_3	111	115	PF02991	0.320
LIG_LIR_Nem_3	162	168	PF02991	0.285
LIG_LIR_Nem_3	182	188	PF02991	0.298
LIG_LIR_Nem_3	197	201	PF02991	0.301
LIG_LIR_Nem_3	388	394	PF02991	0.417
LIG_LIR_Nem_3	454	458	PF02991	0.580
LIG_LIR_Nem_3	735	740	PF02991	0.473
LIG_LIR_Nem_3	78	84	PF02991	0.322
LIG_MYND_1	241	245	PF01753	0.420
LIG_NRBOX	310	316	PF00104	0.342
LIG_PCNA_PIPBox_1	231	240	PF02747	0.316
LIG_PCNA_yPIPBox_3	301	315	PF02747	0.331
LIG_PDZ_Class_1	802	807	PF00595	0.526
LIG_Pex14_1	379	383	PF04695	0.594
LIG_Pex14_2	53	57	PF04695	0.318
LIG_PTB_Apo_2	131	138	PF02174	0.420
LIG_SH2_GRB2like	681	684	PF00017	0.469
LIG_SH2_NCK_1	737	741	PF00017	0.454
LIG_SH2_PTP2	16	19	PF00017	0.474
LIG_SH2_STAP1	150	154	PF00017	0.420
LIG_SH2_STAP1	498	502	PF00017	0.485
LIG_SH2_STAT3	681	684	PF00017	0.469
LIG_SH2_STAT5	112	115	PF00017	0.270
LIG_SH2_STAT5	150	153	PF00017	0.327
LIG_SH2_STAT5	16	19	PF00017	0.474
LIG_SH2_STAT5	160	163	PF00017	0.265
LIG_SH2_STAT5	318	321	PF00017	0.305
LIG_SH2_STAT5	383	386	PF00017	0.486
LIG_SH2_STAT5	688	691	PF00017	0.474
LIG_SH3_3	42	48	PF00018	0.329
LIG_SH3_3	81	87	PF00018	0.420
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.379
LIG_SUMO_SIM_par_1	149	155	PF11976	0.234
LIG_SUMO_SIM_par_1	230	236	PF11976	0.365
LIG_SUMO_SIM_par_1	281	287	PF11976	0.305
LIG_SUMO_SIM_par_1	325	332	PF11976	0.420
LIG_TRAF2_1	123	126	PF00917	0.329
LIG_TRAF2_1	600	603	PF00917	0.620
LIG_TRAF2_1	614	617	PF00917	0.692
LIG_TRAF2_1	628	631	PF00917	0.512
LIG_TRAF2_1	642	645	PF00917	0.486
LIG_TRAF2_1	75	78	PF00917	0.305
LIG_UBA3_1	753	760	PF00899	0.464
LIG_WRC_WIRS_1	112	117	PF05994	0.420
LIG_WRC_WIRS_1	211	216	PF05994	0.305
MOD_CDK_SPK_2	783	788	PF00069	0.568
MOD_CDK_SPxK_1	783	789	PF00069	0.597
MOD_CDK_SPxxK_3	329	336	PF00069	0.287
MOD_CK1_1	108	114	PF00069	0.326
MOD_CK1_1	120	126	PF00069	0.326
MOD_CK1_1	309	315	PF00069	0.337
MOD_CK1_1	323	329	PF00069	0.326
MOD_CK1_1	341	347	PF00069	0.326
MOD_CK2_1	120	126	PF00069	0.330
MOD_CK2_1	152	158	PF00069	0.362
MOD_CK2_1	284	290	PF00069	0.317
MOD_CK2_1	329	335	PF00069	0.424
MOD_CK2_1	38	44	PF00069	0.507
MOD_CK2_1	425	431	PF00069	0.487
MOD_CK2_1	513	519	PF00069	0.549
MOD_CK2_1	593	599	PF00069	0.633
MOD_CK2_1	611	617	PF00069	0.702
MOD_CK2_1	625	631	PF00069	0.517
MOD_CK2_1	639	645	PF00069	0.476
MOD_CK2_1	660	666	PF00069	0.525
MOD_CK2_1	670	676	PF00069	0.468
MOD_CK2_1	791	797	PF00069	0.606
MOD_GlcNHglycan	107	110	PF01048	0.326
MOD_GlcNHglycan	142	145	PF01048	0.420
MOD_GlcNHglycan	24	30	PF01048	0.400
MOD_GlcNHglycan	39	43	PF01048	0.402
MOD_GlcNHglycan	548	551	PF01048	0.521
MOD_GlcNHglycan	603	607	PF01048	0.567
MOD_GlcNHglycan	617	621	PF01048	0.506
MOD_GlcNHglycan	631	635	PF01048	0.546
MOD_GlcNHglycan	645	649	PF01048	0.522
MOD_GlcNHglycan	657	660	PF01048	0.473
MOD_GlcNHglycan	689	692	PF01048	0.423
MOD_GlcNHglycan	69	72	PF01048	0.408
MOD_GlcNHglycan	73	76	PF01048	0.370
MOD_GSK3_1	117	124	PF00069	0.340
MOD_GSK3_1	146	153	PF00069	0.418
MOD_GSK3_1	179	186	PF00069	0.316
MOD_GSK3_1	210	217	PF00069	0.340
MOD_GSK3_1	221	228	PF00069	0.395
MOD_GSK3_1	323	330	PF00069	0.335
MOD_GSK3_1	593	600	PF00069	0.541
MOD_GSK3_1	611	618	PF00069	0.646
MOD_GSK3_1	625	632	PF00069	0.518
MOD_GSK3_1	639	646	PF00069	0.491
MOD_GSK3_1	67	74	PF00069	0.386
MOD_GSK3_1	779	786	PF00069	0.606
MOD_LATS_1	170	176	PF00433	0.329
MOD_N-GLC_1	278	283	PF02516	0.326
MOD_N-GLC_1	307	312	PF02516	0.278
MOD_N-GLC_1	338	343	PF02516	0.450
MOD_N-GLC_1	693	698	PF02516	0.463
MOD_NEK2_1	135	140	PF00069	0.370
MOD_NEK2_1	214	219	PF00069	0.351
MOD_NEK2_1	306	311	PF00069	0.344
MOD_NEK2_1	327	332	PF00069	0.326
MOD_NEK2_1	38	43	PF00069	0.467
MOD_NEK2_1	601	606	PF00069	0.603
MOD_NEK2_1	615	620	PF00069	0.625
MOD_NEK2_1	629	634	PF00069	0.523
MOD_NEK2_1	643	648	PF00069	0.495
MOD_NEK2_2	215	220	PF00069	0.400
MOD_PIKK_1	121	127	PF00454	0.316
MOD_PIKK_1	73	79	PF00454	0.329
MOD_PK_1	172	178	PF00069	0.365
MOD_PK_1	766	772	PF00069	0.536
MOD_PKA_1	777	783	PF00069	0.595
MOD_PKA_2	306	312	PF00069	0.314
MOD_PKA_2	51	57	PF00069	0.303
MOD_PKA_2	546	552	PF00069	0.605
MOD_PKA_2	777	783	PF00069	0.595
MOD_PKB_1	295	303	PF00069	0.420
MOD_Plk_1	278	284	PF00069	0.334
MOD_Plk_1	307	313	PF00069	0.291
MOD_Plk_1	338	344	PF00069	0.365
MOD_Plk_1	38	44	PF00069	0.334
MOD_Plk_1	611	617	PF00069	0.550
MOD_Plk_1	625	631	PF00069	0.517
MOD_Plk_1	639	645	PF00069	0.477
MOD_Plk_1	653	659	PF00069	0.473
MOD_Plk_1	693	699	PF00069	0.462
MOD_Plk_1	766	772	PF00069	0.536
MOD_Plk_1	796	802	PF00069	0.624
MOD_Plk_2-3	660	666	PF00069	0.497
MOD_Plk_4	152	158	PF00069	0.367
MOD_Plk_4	194	200	PF00069	0.411
MOD_Plk_4	225	231	PF00069	0.305
MOD_Plk_4	278	284	PF00069	0.362
MOD_Plk_4	323	329	PF00069	0.435
MOD_Plk_4	684	690	PF00069	0.410
MOD_ProDKin_1	329	335	PF00069	0.386
MOD_ProDKin_1	783	789	PF00069	0.597
MOD_SUMO_for_1	472	475	PF00179	0.504
MOD_SUMO_rev_2	762	768	PF00179	0.485
MOD_SUMO_rev_2	797	805	PF00179	0.591
TRG_ENDOCYTIC_2	112	115	PF00928	0.274
TRG_ENDOCYTIC_2	16	19	PF00928	0.365
TRG_ENDOCYTIC_2	198	201	PF00928	0.305
TRG_ENDOCYTIC_2	452	455	PF00928	0.552
TRG_ENDOCYTIC_2	737	740	PF00928	0.473
TRG_ER_diArg_1	1	3	PF00400	0.792
TRG_ER_diArg_1	17	20	PF00400	0.366
TRG_ER_diArg_1	260	263	PF00400	0.316
TRG_ER_diArg_1	523	525	PF00400	0.460
TRG_ER_diArg_1	564	567	PF00400	0.399
TRG_ER_diArg_1	754	756	PF00400	0.474
TRG_ER_diArg_1	787	789	PF00400	0.550
TRG_NLS_MonoExtN_4	48	53	PF00514	0.370
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	503	508	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	578	582	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	788	792	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5H5	Leptomonas seymouri	27%	68%
A0A0N1IH46	Leptomonas seymouri	78%	100%
A0A0S4IR67	Bodo saltans	28%	100%
A0A0S4JMJ1	Bodo saltans	28%	100%
A0A1X0NDZ3	Trypanosomatidae	30%	72%
A0A1X0NP27	Trypanosomatidae	34%	100%
A0A1X0NPH9	Trypanosomatidae	26%	87%
A0A1X0P0C2	Trypanosomatidae	56%	99%
A0A3Q8IBS7	Leishmania donovani	28%	100%
A0A3Q8IDT2	Leishmania donovani	94%	67%
A0A3Q8IHG6	Leishmania donovani	32%	100%
A0A3R7KM83	Trypanosoma rangeli	29%	73%
A0A3R7MU74	Trypanosoma rangeli	27%	72%
A0A3R7RD86	Trypanosoma rangeli	55%	100%
A0A3S5H5N6	Leishmania donovani	25%	100%
A0A3S7WU64	Leishmania donovani	89%	94%
A0A3S7XBW9	Leishmania donovani	23%	100%
A4H8S6	Leishmania braziliensis	76%	78%
A4HIP0	Leishmania braziliensis	27%	68%
A4HSQ9	Leishmania infantum	25%	100%
A4HX45	Leishmania infantum	91%	100%
A4I4V2	Leishmania infantum	32%	100%
A4I5Y7	Leishmania infantum	28%	68%
A4IDT7	Leishmania infantum	23%	100%
C9ZRB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	73%
D0A9T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	72%
E9AEA0	Leishmania major	32%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AQW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	77%
E9ATU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	97%
Q0DV28	Oryza sativa subsp. japonica	30%	85%
Q2PQA9	Rattus norvegicus	27%	84%
Q4Q0P7	Leishmania major	22%	100%
Q4Q6Y4	Leishmania major	28%	68%
Q4Q7F9	Leishmania major	28%	67%
Q4Q7S4	Leishmania major	27%	100%
Q555I8	Dictyostelium discoideum	25%	66%
Q5R706	Pongo abelii	29%	100%
Q8S905	Arabidopsis thaliana	27%	83%
Q8VWI7	Arabidopsis thaliana	27%	93%
Q9AWM8	Oryza sativa subsp. japonica	27%	85%
V5B325	Trypanosoma cruzi	31%	97%
V5BMP0	Trypanosoma cruzi	58%	100%
V5DNV9	Trypanosoma cruzi	27%	72%