Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEL7_LEIMA

TriTrypDb:

LmjF.16.1480 , LMJLV39_160021700 , LMJSD75_160021400

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QEL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEL7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008483	transaminase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016769	transferase activity, transferring nitrogenous groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.712
CLV_MEL_PAP_1	629	635	PF00089	0.440
CLV_NRD_NRD_1	241	243	PF00675	0.645
CLV_NRD_NRD_1	269	271	PF00675	0.472
CLV_NRD_NRD_1	292	294	PF00675	0.691
CLV_PCSK_FUR_1	267	271	PF00082	0.525
CLV_PCSK_FUR_1	559	563	PF00082	0.493
CLV_PCSK_KEX2_1	160	162	PF00082	0.486
CLV_PCSK_KEX2_1	241	243	PF00082	0.643
CLV_PCSK_KEX2_1	269	271	PF00082	0.463
CLV_PCSK_KEX2_1	292	294	PF00082	0.686
CLV_PCSK_KEX2_1	50	52	PF00082	0.648
CLV_PCSK_KEX2_1	561	563	PF00082	0.523
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.486
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.686
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.609
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.523
CLV_PCSK_SKI1_1	168	172	PF00082	0.369
CLV_PCSK_SKI1_1	201	205	PF00082	0.745
CLV_PCSK_SKI1_1	277	281	PF00082	0.759
CLV_PCSK_SKI1_1	294	298	PF00082	0.564
CLV_PCSK_SKI1_1	410	414	PF00082	0.475
CLV_PCSK_SKI1_1	480	484	PF00082	0.510
CLV_PCSK_SKI1_1	520	524	PF00082	0.515
CLV_PCSK_SKI1_1	574	578	PF00082	0.350
DEG_APCC_DBOX_1	200	208	PF00400	0.661
DEG_Nend_UBRbox_4	1	3	PF02207	0.592
DOC_CYCLIN_RxL_1	550	560	PF00134	0.408
DOC_MAPK_DCC_7	445	454	PF00069	0.487
DOC_MAPK_DCC_7	469	479	PF00069	0.349
DOC_MAPK_gen_1	292	299	PF00069	0.640
DOC_MAPK_MEF2A_6	16	25	PF00069	0.430
DOC_MAPK_MEF2A_6	249	257	PF00069	0.475
DOC_MAPK_MEF2A_6	292	299	PF00069	0.640
DOC_MAPK_MEF2A_6	445	454	PF00069	0.539
DOC_MAPK_MEF2A_6	520	529	PF00069	0.438
DOC_USP7_MATH_1	275	279	PF00917	0.706
DOC_USP7_MATH_1	352	356	PF00917	0.727
DOC_USP7_MATH_1	357	361	PF00917	0.710
DOC_USP7_MATH_1	615	619	PF00917	0.527
DOC_USP7_UBL2_3	480	484	PF12436	0.533
DOC_WW_Pin1_4	16	21	PF00397	0.580
DOC_WW_Pin1_4	320	325	PF00397	0.688
DOC_WW_Pin1_4	96	101	PF00397	0.700
LIG_14-3-3_CanoR_1	134	142	PF00244	0.694
LIG_14-3-3_CanoR_1	354	360	PF00244	0.747
LIG_14-3-3_CanoR_1	513	519	PF00244	0.425
LIG_14-3-3_CanoR_1	520	526	PF00244	0.478
LIG_Actin_WH2_2	226	243	PF00022	0.571
LIG_Actin_WH2_2	464	482	PF00022	0.504
LIG_FAT_LD_1	250	258	PF03623	0.506
LIG_FHA_1	127	133	PF00498	0.703
LIG_FHA_1	425	431	PF00498	0.469
LIG_FHA_1	481	487	PF00498	0.456
LIG_FHA_1	509	515	PF00498	0.474
LIG_FHA_1	568	574	PF00498	0.393
LIG_FHA_1	590	596	PF00498	0.357
LIG_FHA_1	619	625	PF00498	0.445
LIG_FHA_2	115	121	PF00498	0.600
LIG_FHA_2	123	129	PF00498	0.512
LIG_FHA_2	179	185	PF00498	0.639
LIG_FHA_2	223	229	PF00498	0.527
LIG_LIR_Gen_1	392	402	PF02991	0.378
LIG_LIR_LC3C_4	483	488	PF02991	0.489
LIG_LIR_Nem_3	152	158	PF02991	0.565
LIG_LIR_Nem_3	392	397	PF02991	0.367
LIG_NRBOX	21	27	PF00104	0.346
LIG_Pex14_2	151	155	PF04695	0.558
LIG_PTB_Apo_2	145	152	PF02174	0.593
LIG_PTB_Phospho_1	150	156	PF10480	0.360
LIG_SH2_CRK	472	476	PF00017	0.489
LIG_SH2_PTP2	463	466	PF00017	0.358
LIG_SH2_STAP1	369	373	PF00017	0.509
LIG_SH2_STAT3	628	631	PF00017	0.426
LIG_SH2_STAT5	219	222	PF00017	0.450
LIG_SH2_STAT5	463	466	PF00017	0.358
LIG_SH2_STAT5	628	631	PF00017	0.411
LIG_SH3_3	14	20	PF00018	0.592
LIG_SH3_3	321	327	PF00018	0.731
LIG_SH3_3	84	90	PF00018	0.498
LIG_SUMO_SIM_anti_2	19	25	PF11976	0.524
LIG_SUMO_SIM_par_1	128	133	PF11976	0.658
LIG_SUMO_SIM_par_1	21	27	PF11976	0.502
LIG_SUMO_SIM_par_1	370	375	PF11976	0.375
LIG_SUMO_SIM_par_1	553	558	PF11976	0.369
LIG_SUMO_SIM_par_1	591	598	PF11976	0.417
LIG_TYR_ITIM	577	582	PF00017	0.341
LIG_UBA3_1	473	480	PF00899	0.504
LIG_WRC_WIRS_1	437	442	PF05994	0.461
MOD_CDC14_SPxK_1	99	102	PF00782	0.750
MOD_CDK_SPxK_1	96	102	PF00069	0.748
MOD_CK1_1	119	125	PF00069	0.587
MOD_CK1_1	135	141	PF00069	0.487
MOD_CK1_1	147	153	PF00069	0.432
MOD_CK1_1	186	192	PF00069	0.629
MOD_CK1_1	27	33	PF00069	0.509
MOD_CK1_1	282	288	PF00069	0.756
MOD_CK1_1	309	315	PF00069	0.672
MOD_CK1_1	320	326	PF00069	0.757
MOD_CK1_1	328	334	PF00069	0.695
MOD_CK1_1	355	361	PF00069	0.752
MOD_CK1_1	532	538	PF00069	0.462
MOD_CK1_1	618	624	PF00069	0.517
MOD_CK2_1	178	184	PF00069	0.630
MOD_CK2_1	49	55	PF00069	0.714
MOD_DYRK1A_RPxSP_1	16	20	PF00069	0.470
MOD_GlcNHglycan	114	117	PF01048	0.690
MOD_GlcNHglycan	133	137	PF01048	0.424
MOD_GlcNHglycan	188	191	PF01048	0.715
MOD_GlcNHglycan	277	280	PF01048	0.731
MOD_GlcNHglycan	36	39	PF01048	0.684
MOD_GlcNHglycan	385	388	PF01048	0.599
MOD_GlcNHglycan	488	491	PF01048	0.457
MOD_GSK3_1	112	119	PF00069	0.720
MOD_GSK3_1	122	129	PF00069	0.588
MOD_GSK3_1	147	154	PF00069	0.554
MOD_GSK3_1	199	206	PF00069	0.663
MOD_GSK3_1	240	247	PF00069	0.596
MOD_GSK3_1	275	282	PF00069	0.729
MOD_GSK3_1	29	36	PF00069	0.532
MOD_GSK3_1	309	316	PF00069	0.684
MOD_GSK3_1	357	364	PF00069	0.664
MOD_GSK3_1	508	515	PF00069	0.489
MOD_GSK3_1	618	625	PF00069	0.457
MOD_N-GLC_1	112	117	PF02516	0.648
MOD_N-GLC_1	142	147	PF02516	0.599
MOD_N-GLC_1	168	173	PF02516	0.550
MOD_N-GLC_1	199	204	PF02516	0.654
MOD_N-GLC_1	207	212	PF02516	0.633
MOD_N-GLC_1	344	349	PF02516	0.740
MOD_N-GLC_1	390	395	PF02516	0.511
MOD_N-GLC_1	435	440	PF02516	0.398
MOD_N-GLC_1	589	594	PF02516	0.384
MOD_N-GLC_1	595	600	PF02516	0.410
MOD_N-GLC_2	137	139	PF02516	0.508
MOD_NEK2_1	114	119	PF00069	0.621
MOD_NEK2_1	142	147	PF00069	0.549
MOD_NEK2_1	149	154	PF00069	0.489
MOD_NEK2_1	183	188	PF00069	0.607
MOD_NEK2_1	203	208	PF00069	0.685
MOD_NEK2_1	29	34	PF00069	0.642
MOD_NEK2_1	350	355	PF00069	0.744
MOD_NEK2_1	372	377	PF00069	0.360
MOD_NEK2_1	397	402	PF00069	0.506
MOD_NEK2_1	508	513	PF00069	0.449
MOD_NEK2_1	514	519	PF00069	0.405
MOD_NEK2_1	521	526	PF00069	0.414
MOD_NEK2_1	557	562	PF00069	0.387
MOD_NEK2_1	595	600	PF00069	0.419
MOD_NEK2_1	633	638	PF00069	0.446
MOD_PIKK_1	277	283	PF00454	0.735
MOD_PIKK_1	424	430	PF00454	0.521
MOD_PIKK_1	609	615	PF00454	0.431
MOD_PKA_2	126	132	PF00069	0.731
MOD_PKA_2	240	246	PF00069	0.601
MOD_PKA_2	355	361	PF00069	0.766
MOD_PKA_2	512	518	PF00069	0.472
MOD_Plk_1	119	125	PF00069	0.547
MOD_Plk_1	142	148	PF00069	0.636
MOD_Plk_1	168	174	PF00069	0.515
MOD_Plk_1	183	189	PF00069	0.584
MOD_Plk_1	199	205	PF00069	0.571
MOD_Plk_1	207	213	PF00069	0.630
MOD_Plk_1	328	334	PF00069	0.686
MOD_Plk_1	344	350	PF00069	0.691
MOD_Plk_1	389	395	PF00069	0.488
MOD_Plk_1	435	441	PF00069	0.412
MOD_Plk_1	508	514	PF00069	0.517
MOD_Plk_1	589	595	PF00069	0.383
MOD_Plk_2-3	128	134	PF00069	0.662
MOD_Plk_2-3	390	396	PF00069	0.461
MOD_Plk_4	151	157	PF00069	0.478
MOD_Plk_4	178	184	PF00069	0.592
MOD_Plk_4	208	214	PF00069	0.663
MOD_Plk_4	249	255	PF00069	0.461
MOD_Plk_4	29	35	PF00069	0.385
MOD_Plk_4	306	312	PF00069	0.654
MOD_Plk_4	344	350	PF00069	0.783
MOD_Plk_4	514	520	PF00069	0.433
MOD_Plk_4	589	595	PF00069	0.399
MOD_ProDKin_1	16	22	PF00069	0.570
MOD_ProDKin_1	320	326	PF00069	0.688
MOD_ProDKin_1	96	102	PF00069	0.701
MOD_SUMO_rev_2	438	446	PF00179	0.542
MOD_SUMO_rev_2	47	52	PF00179	0.611
MOD_SUMO_rev_2	499	503	PF00179	0.584
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.563
TRG_ENDOCYTIC_2	369	372	PF00928	0.407
TRG_ENDOCYTIC_2	463	466	PF00928	0.346
TRG_ENDOCYTIC_2	579	582	PF00928	0.342
TRG_ER_diArg_1	240	242	PF00400	0.649
TRG_ER_diArg_1	266	269	PF00400	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX36	Leptomonas seymouri	52%	100%
A0A0S4IMR2	Bodo saltans	33%	96%
A0A1X0P052	Trypanosomatidae	39%	100%
A0A3R7K490	Trypanosoma rangeli	37%	100%
A0A3S7WU54	Leishmania donovani	93%	100%
A4H8S7	Leishmania braziliensis	73%	100%
A4HX46	Leishmania infantum	92%	100%
C9ZVU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AQW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BS91	Trypanosoma cruzi	40%	100%