Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEL6_LEIMA

TriTrypDb:

LmjF.16.1490 , LMJLV39_160021800 , LMJSD75_160021500

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEL6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016853	isomerase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.696
CLV_NRD_NRD_1	214	216	PF00675	0.462
CLV_NRD_NRD_1	219	221	PF00675	0.425
CLV_PCSK_KEX2_1	76	78	PF00082	0.537
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.572
CLV_PCSK_SKI1_1	329	333	PF00082	0.577
CLV_Separin_Metazoa	128	132	PF03568	0.508
DEG_SPOP_SBC_1	276	280	PF00917	0.735
DOC_CDC14_PxL_1	50	58	PF14671	0.362
DOC_CYCLIN_yClb1_LxF_4	327	332	PF00134	0.600
DOC_MAPK_gen_1	22	31	PF00069	0.545
DOC_MAPK_gen_1	76	85	PF00069	0.448
DOC_MAPK_HePTP_8	19	31	PF00069	0.500
DOC_MAPK_MEF2A_6	22	31	PF00069	0.531
DOC_PP1_RVXF_1	327	333	PF00149	0.598
DOC_PP2B_PxIxI_1	47	53	PF00149	0.488
DOC_PP4_FxxP_1	344	347	PF00568	0.533
DOC_USP7_MATH_1	282	286	PF00917	0.733
DOC_USP7_MATH_1	289	293	PF00917	0.772
DOC_USP7_MATH_1	358	362	PF00917	0.714
DOC_WW_Pin1_4	123	128	PF00397	0.564
DOC_WW_Pin1_4	287	292	PF00397	0.794
LIG_14-3-3_CanoR_1	112	116	PF00244	0.526
LIG_14-3-3_CanoR_1	191	196	PF00244	0.587
LIG_14-3-3_CanoR_1	298	306	PF00244	0.711
LIG_14-3-3_CanoR_1	7	17	PF00244	0.573
LIG_BIR_II_1	1	5	PF00653	0.691
LIG_Clathr_ClatBox_1	330	334	PF01394	0.531
LIG_Clathr_ClatBox_1	82	86	PF01394	0.452
LIG_FHA_1	148	154	PF00498	0.403
LIG_FHA_1	22	28	PF00498	0.493
LIG_FHA_1	249	255	PF00498	0.529
LIG_FHA_1	53	59	PF00498	0.381
LIG_FHA_1	79	85	PF00498	0.484
LIG_FHA_2	192	198	PF00498	0.540
LIG_FHA_2	236	242	PF00498	0.541
LIG_LIR_Apic_2	155	160	PF02991	0.381
LIG_LIR_Gen_1	101	110	PF02991	0.549
LIG_LIR_Gen_1	11	19	PF02991	0.510
LIG_LIR_Gen_1	21	31	PF02991	0.390
LIG_LIR_Gen_1	336	347	PF02991	0.546
LIG_LIR_LC3C_4	14	18	PF02991	0.584
LIG_LIR_Nem_3	101	105	PF02991	0.444
LIG_LIR_Nem_3	11	16	PF02991	0.482
LIG_LIR_Nem_3	21	26	PF02991	0.366
LIG_LIR_Nem_3	210	214	PF02991	0.506
LIG_LIR_Nem_3	336	342	PF02991	0.445
LIG_SH2_CRK	64	68	PF00017	0.355
LIG_SH2_SRC	102	105	PF00017	0.532
LIG_SH2_SRC	70	73	PF00017	0.524
LIG_SH2_STAP1	13	17	PF00017	0.577
LIG_SH2_STAP1	64	68	PF00017	0.371
LIG_SH2_STAT5	157	160	PF00017	0.374
LIG_SH2_STAT5	248	251	PF00017	0.479
LIG_SH2_STAT5	257	260	PF00017	0.509
LIG_SH2_STAT5	70	73	PF00017	0.491
LIG_SH3_3	239	245	PF00018	0.380
LIG_SH3_3	33	39	PF00018	0.673
LIG_SUMO_SIM_anti_2	14	21	PF11976	0.511
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.386
LIG_SUMO_SIM_par_1	14	21	PF11976	0.521
LIG_SUMO_SIM_par_1	24	30	PF11976	0.539
LIG_SUMO_SIM_par_1	80	86	PF11976	0.386
LIG_TYR_ITIM	139	144	PF00017	0.408
LIG_UBA3_1	254	263	PF00899	0.527
LIG_WW_3	326	330	PF00397	0.640
MOD_CDK_SPxxK_3	287	294	PF00069	0.561
MOD_CK1_1	146	152	PF00069	0.527
MOD_CK1_1	21	27	PF00069	0.378
MOD_CK1_1	296	302	PF00069	0.628
MOD_CK2_1	191	197	PF00069	0.579
MOD_CK2_1	235	241	PF00069	0.561
MOD_GlcNHglycan	10	13	PF01048	0.544
MOD_GlcNHglycan	186	191	PF01048	0.376
MOD_GlcNHglycan	265	268	PF01048	0.663
MOD_GlcNHglycan	282	285	PF01048	0.721
MOD_GlcNHglycan	306	309	PF01048	0.686
MOD_GlcNHglycan	317	320	PF01048	0.759
MOD_GSK3_1	143	150	PF00069	0.500
MOD_GSK3_1	199	206	PF00069	0.554
MOD_GSK3_1	276	283	PF00069	0.792
MOD_GSK3_1	289	296	PF00069	0.765
MOD_GSK3_1	315	322	PF00069	0.530
MOD_GSK3_1	357	364	PF00069	0.674
MOD_GSK3_1	48	55	PF00069	0.381
MOD_N-GLC_1	261	266	PF02516	0.546
MOD_NEK2_1	111	116	PF00069	0.500
MOD_NEK2_1	147	152	PF00069	0.463
MOD_NEK2_1	228	233	PF00069	0.566
MOD_NEK2_1	8	13	PF00069	0.516
MOD_PIKK_1	203	209	PF00454	0.535
MOD_PKA_2	111	117	PF00069	0.523
MOD_PKA_2	21	27	PF00069	0.421
MOD_PKA_2	297	303	PF00069	0.712
MOD_Plk_1	120	126	PF00069	0.463
MOD_Plk_1	147	153	PF00069	0.510
MOD_Plk_1	261	267	PF00069	0.558
MOD_Plk_2-3	235	241	PF00069	0.572
MOD_Plk_4	111	117	PF00069	0.472
MOD_Plk_4	120	126	PF00069	0.407
MOD_Plk_4	78	84	PF00069	0.502
MOD_ProDKin_1	123	129	PF00069	0.562
MOD_ProDKin_1	287	293	PF00069	0.794
TRG_DiLeu_BaEn_4	187	193	PF01217	0.563
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.342
TRG_ENDOCYTIC_2	102	105	PF00928	0.434
TRG_ENDOCYTIC_2	13	16	PF00928	0.474
TRG_ENDOCYTIC_2	141	144	PF00928	0.404
TRG_ENDOCYTIC_2	64	67	PF00928	0.371
TRG_ER_diArg_1	4	7	PF00400	0.507
TRG_NES_CRM1_1	128	142	PF08389	0.472
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P676	Leptomonas seymouri	64%	100%
A0A1X0NZ85	Trypanosomatidae	50%	100%
A0A3Q8I9J9	Leishmania donovani	94%	100%
A0A3R7KS20	Trypanosoma rangeli	45%	100%
A4H8S8	Leishmania braziliensis	81%	100%
A4HX47	Leishmania infantum	94%	100%
C9ZVU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AQW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BI68	Trypanosoma cruzi	47%	100%