Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEL5_LEIMA

TriTrypDb:

LmjF.16.1500 , LMJLV39_160021900 , LMJSD75_160021600

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEL5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	414	418	PF00656	0.417
CLV_C14_Caspase3-7	457	461	PF00656	0.388
CLV_NRD_NRD_1	139	141	PF00675	0.371
CLV_NRD_NRD_1	147	149	PF00675	0.343
CLV_NRD_NRD_1	216	218	PF00675	0.502
CLV_NRD_NRD_1	267	269	PF00675	0.429
CLV_NRD_NRD_1	473	475	PF00675	0.481
CLV_NRD_NRD_1	48	50	PF00675	0.379
CLV_NRD_NRD_1	554	556	PF00675	0.482
CLV_NRD_NRD_1	565	567	PF00675	0.468
CLV_PCSK_KEX2_1	11	13	PF00082	0.489
CLV_PCSK_KEX2_1	139	141	PF00082	0.476
CLV_PCSK_KEX2_1	147	149	PF00082	0.402
CLV_PCSK_KEX2_1	216	218	PF00082	0.560
CLV_PCSK_KEX2_1	267	269	PF00082	0.429
CLV_PCSK_KEX2_1	31	33	PF00082	0.389
CLV_PCSK_KEX2_1	473	475	PF00082	0.481
CLV_PCSK_KEX2_1	48	50	PF00082	0.364
CLV_PCSK_KEX2_1	554	556	PF00082	0.482
CLV_PCSK_KEX2_1	565	567	PF00082	0.468
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.510
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.389
CLV_PCSK_SKI1_1	186	190	PF00082	0.487
CLV_PCSK_SKI1_1	267	271	PF00082	0.379
CLV_PCSK_SKI1_1	309	313	PF00082	0.348
CLV_PCSK_SKI1_1	459	463	PF00082	0.590
CLV_PCSK_SKI1_1	473	477	PF00082	0.412
CLV_PCSK_SKI1_1	543	547	PF00082	0.529
CLV_PCSK_SKI1_1	66	70	PF00082	0.452
CLV_PCSK_SKI1_1	74	78	PF00082	0.438
CLV_Separin_Metazoa	223	227	PF03568	0.346
DEG_APCC_DBOX_1	472	480	PF00400	0.462
DEG_Nend_Nbox_1	1	3	PF02207	0.523
DOC_ANK_TNKS_1	326	333	PF00023	0.299
DOC_CKS1_1	343	348	PF01111	0.462
DOC_CYCLIN_RxL_1	61	72	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.414
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.456
DOC_MAPK_gen_1	147	153	PF00069	0.479
DOC_MAPK_gen_1	84	94	PF00069	0.349
DOC_MAPK_MEF2A_6	293	302	PF00069	0.481
DOC_MAPK_MEF2A_6	87	95	PF00069	0.328
DOC_USP7_MATH_1	394	398	PF00917	0.591
DOC_WW_Pin1_4	10	15	PF00397	0.503
DOC_WW_Pin1_4	173	178	PF00397	0.395
DOC_WW_Pin1_4	193	198	PF00397	0.369
DOC_WW_Pin1_4	315	320	PF00397	0.356
DOC_WW_Pin1_4	342	347	PF00397	0.482
DOC_WW_Pin1_4	371	376	PF00397	0.666
DOC_WW_Pin1_4	377	382	PF00397	0.638
LIG_14-3-3_CanoR_1	170	178	PF00244	0.440
LIG_14-3-3_CanoR_1	20	25	PF00244	0.429
LIG_14-3-3_CanoR_1	283	289	PF00244	0.336
LIG_14-3-3_CanoR_1	293	299	PF00244	0.387
LIG_14-3-3_CanoR_1	554	564	PF00244	0.552
LIG_APCC_ABBA_1	326	331	PF00400	0.341
LIG_APCC_ABBA_1	432	437	PF00400	0.376
LIG_BRCT_BRCA1_1	313	317	PF00533	0.473
LIG_CtBP_PxDLS_1	177	181	PF00389	0.341
LIG_CtBP_PxDLS_1	375	379	PF00389	0.471
LIG_DLG_GKlike_1	20	27	PF00625	0.605
LIG_FHA_1	179	185	PF00498	0.409
LIG_FHA_1	187	193	PF00498	0.580
LIG_FHA_1	204	210	PF00498	0.359
LIG_FHA_1	283	289	PF00498	0.417
LIG_FHA_1	293	299	PF00498	0.502
LIG_FHA_1	343	349	PF00498	0.670
LIG_FHA_1	357	363	PF00498	0.513
LIG_FHA_1	371	377	PF00498	0.647
LIG_FHA_1	460	466	PF00498	0.420
LIG_FHA_1	522	528	PF00498	0.535
LIG_FHA_1	556	562	PF00498	0.422
LIG_FHA_1	75	81	PF00498	0.484
LIG_FHA_2	159	165	PF00498	0.436
LIG_FHA_2	174	180	PF00498	0.295
LIG_FHA_2	23	29	PF00498	0.477
LIG_FHA_2	316	322	PF00498	0.335
LIG_GBD_Chelix_1	298	306	PF00786	0.391
LIG_LIR_Gen_1	115	125	PF02991	0.448
LIG_LIR_Gen_1	205	214	PF02991	0.453
LIG_LIR_Gen_1	420	429	PF02991	0.448
LIG_LIR_Nem_3	115	120	PF02991	0.429
LIG_LIR_Nem_3	143	149	PF02991	0.371
LIG_LIR_Nem_3	205	210	PF02991	0.459
LIG_LIR_Nem_3	420	425	PF02991	0.473
LIG_LIR_Nem_3	72	76	PF02991	0.349
LIG_LYPXL_SIV_4	421	429	PF13949	0.415
LIG_NRBOX	491	497	PF00104	0.372
LIG_PCNA_PIPBox_1	428	437	PF02747	0.445
LIG_PCNA_yPIPBox_3	215	228	PF02747	0.368
LIG_Pex14_2	100	104	PF04695	0.340
LIG_SH2_CRK	146	150	PF00017	0.455
LIG_SH2_SRC	329	332	PF00017	0.435
LIG_SH2_SRC	435	438	PF00017	0.391
LIG_SH2_STAT5	16	19	PF00017	0.487
LIG_SH2_STAT5	329	332	PF00017	0.353
LIG_SH2_STAT5	34	37	PF00017	0.487
LIG_SH2_STAT5	422	425	PF00017	0.388
LIG_SH2_STAT5	435	438	PF00017	0.335
LIG_SH2_STAT5	75	78	PF00017	0.462
LIG_SH3_3	152	158	PF00018	0.400
LIG_SH3_3	218	224	PF00018	0.379
LIG_SH3_3	343	349	PF00018	0.581
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.379
LIG_SUMO_SIM_anti_2	240	246	PF11976	0.329
LIG_SUMO_SIM_anti_2	427	433	PF11976	0.511
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.432
LIG_SUMO_SIM_par_1	331	337	PF11976	0.364
LIG_SUMO_SIM_par_1	373	380	PF11976	0.446
LIG_TRAF2_1	161	164	PF00917	0.444
LIG_TRAF2_1	518	521	PF00917	0.344
LIG_UBA3_1	483	488	PF00899	0.416
MOD_CK1_1	10	16	PF00069	0.499
MOD_CK1_1	22	28	PF00069	0.471
MOD_CK1_1	337	343	PF00069	0.464
MOD_CK1_1	365	371	PF00069	0.696
MOD_CK1_1	374	380	PF00069	0.607
MOD_CK1_1	397	403	PF00069	0.378
MOD_CK1_1	424	430	PF00069	0.398
MOD_CK2_1	158	164	PF00069	0.375
MOD_CK2_1	173	179	PF00069	0.356
MOD_CK2_1	20	26	PF00069	0.474
MOD_CK2_1	315	321	PF00069	0.349
MOD_CK2_1	424	430	PF00069	0.465
MOD_CK2_1	488	494	PF00069	0.397
MOD_CK2_1	52	58	PF00069	0.433
MOD_GlcNHglycan	289	292	PF01048	0.414
MOD_GlcNHglycan	336	339	PF01048	0.375
MOD_GlcNHglycan	367	370	PF01048	0.668
MOD_GlcNHglycan	381	384	PF01048	0.465
MOD_GlcNHglycan	408	411	PF01048	0.361
MOD_GlcNHglycan	417	420	PF01048	0.392
MOD_GlcNHglycan	456	459	PF01048	0.614
MOD_GlcNHglycan	506	509	PF01048	0.539
MOD_GlcNHglycan	533	536	PF01048	0.471
MOD_GSK3_1	3	10	PF00069	0.526
MOD_GSK3_1	311	318	PF00069	0.417
MOD_GSK3_1	370	377	PF00069	0.674
MOD_GSK3_1	417	424	PF00069	0.473
MOD_GSK3_1	450	457	PF00069	0.601
MOD_LATS_1	552	558	PF00433	0.505
MOD_NEK2_1	27	32	PF00069	0.499
MOD_NEK2_1	287	292	PF00069	0.388
MOD_NEK2_1	362	367	PF00069	0.656
MOD_NEK2_1	376	381	PF00069	0.486
MOD_NEK2_1	415	420	PF00069	0.472
MOD_NEK2_1	444	449	PF00069	0.581
MOD_NEK2_1	478	483	PF00069	0.323
MOD_NEK2_1	7	12	PF00069	0.517
MOD_PIKK_1	424	430	PF00454	0.414
MOD_PKA_1	554	560	PF00069	0.563
MOD_PKA_2	19	25	PF00069	0.447
MOD_PKA_2	282	288	PF00069	0.329
MOD_PKA_2	292	298	PF00069	0.368
MOD_PKA_2	554	560	PF00069	0.522
MOD_PKB_1	541	549	PF00069	0.448
MOD_Plk_2-3	159	165	PF00069	0.393
MOD_Plk_4	3	9	PF00069	0.653
MOD_ProDKin_1	10	16	PF00069	0.499
MOD_ProDKin_1	173	179	PF00069	0.399
MOD_ProDKin_1	193	199	PF00069	0.364
MOD_ProDKin_1	315	321	PF00069	0.349
MOD_ProDKin_1	342	348	PF00069	0.492
MOD_ProDKin_1	371	377	PF00069	0.664
TRG_DiLeu_BaEn_1	124	129	PF01217	0.478
TRG_DiLeu_BaEn_1	494	499	PF01217	0.363
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.417
TRG_ENDOCYTIC_2	146	149	PF00928	0.371
TRG_ENDOCYTIC_2	422	425	PF00928	0.432
TRG_ENDOCYTIC_2	73	76	PF00928	0.345
TRG_ER_diArg_1	138	140	PF00400	0.462
TRG_ER_diArg_1	146	148	PF00400	0.434
TRG_ER_diArg_1	216	219	PF00400	0.541
TRG_ER_diArg_1	225	228	PF00400	0.505
TRG_ER_diArg_1	267	269	PF00400	0.429
TRG_ER_diArg_1	385	388	PF00400	0.515
TRG_ER_diArg_1	48	50	PF00400	0.364
TRG_ER_diArg_1	554	556	PF00400	0.438
TRG_ER_diArg_1	564	566	PF00400	0.419
TRG_NES_CRM1_1	321	331	PF08389	0.317
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	387	392	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T4	Leptomonas seymouri	66%	98%
A0A1X0NYU8	Trypanosomatidae	41%	100%
A0A3Q8ICN8	Leishmania donovani	94%	100%
A0A422N437	Trypanosoma rangeli	40%	100%
A4H8S9	Leishmania braziliensis	84%	99%
A4HX48	Leishmania infantum	94%	100%
C9ZVU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AQW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
V5B2M3	Trypanosoma cruzi	39%	100%