Putative endoplasmic reticulum oxidoreductin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endoplasmic reticulum oxidoreductin, putative

Species:

Leishmania major

UniProt:

Q4QEL2_LEIMA

TriTrypDb:

LmjF.16.1530 , LMJLV39_160022200 , LMJSD75_160021900

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 4
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	13
GO:0016020	membrane	2	13
GO:0031090	organelle membrane	3	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

Q4QEL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEL2

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	13
GO:0009987	cellular process	1	13
GO:0034975	protein folding in endoplasmic reticulum	3	13

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0015035	protein-disulfide reductase activity	3	13
GO:0015036	disulfide oxidoreductase activity	4	13
GO:0016491	oxidoreductase activity	2	13
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	13
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	4	13
GO:0016972	thiol oxidase activity	5	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0050660	flavin adenine dinucleotide binding	4	13
GO:0071949	FAD binding	5	13
GO:0097159	organic cyclic compound binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003756	protein disulfide isomerase activity	3	1
GO:0016853	isomerase activity	2	1
GO:0016860	intramolecular oxidoreductase activity	3	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	264	266	PF00082	0.336
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.426
CLV_PCSK_SKI1_1	145	149	PF00082	0.370
CLV_PCSK_SKI1_1	214	218	PF00082	0.404
CLV_PCSK_SKI1_1	291	295	PF00082	0.325
CLV_PCSK_SKI1_1	321	325	PF00082	0.345
CLV_PCSK_SKI1_1	71	75	PF00082	0.419
CLV_PCSK_SKI1_1	87	91	PF00082	0.249
DEG_APCC_DBOX_1	213	221	PF00400	0.426
DEG_Nend_UBRbox_4	1	3	PF02207	0.552
DEG_ODPH_VHL_1	266	278	PF01847	0.370
DEG_SCF_FBW7_1	136	142	PF00400	0.447
DOC_CKS1_1	136	141	PF01111	0.426
DOC_CYCLIN_RxL_1	211	218	PF00134	0.431
DOC_CYCLIN_RxL_1	409	417	PF00134	0.367
DOC_CYCLIN_yClb5_NLxxxL_5	405	414	PF00134	0.345
DOC_MAPK_DCC_7	145	153	PF00069	0.370
DOC_MAPK_MEF2A_6	11	20	PF00069	0.584
DOC_MAPK_MEF2A_6	30	39	PF00069	0.582
DOC_PP1_RVXF_1	410	417	PF00149	0.426
DOC_PP1_SILK_1	210	215	PF00149	0.447
DOC_PP4_FxxP_1	39	42	PF00568	0.685
DOC_USP7_MATH_1	139	143	PF00917	0.447
DOC_USP7_UBL2_3	376	380	PF12436	0.426
DOC_WW_Pin1_4	135	140	PF00397	0.402
DOC_WW_Pin1_4	237	242	PF00397	0.312
DOC_WW_Pin1_4	328	333	PF00397	0.340
DOC_WW_Pin1_4	59	64	PF00397	0.531
DOC_WW_Pin1_4	80	85	PF00397	0.375
LIG_14-3-3_CanoR_1	396	400	PF00244	0.449
LIG_14-3-3_CanoR_1	79	83	PF00244	0.458
LIG_APCC_ABBA_1	266	271	PF00400	0.415
LIG_BRCT_BRCA1_1	289	293	PF00533	0.370
LIG_BRCT_BRCA1_1	330	334	PF00533	0.303
LIG_BRCT_BRCA1_1	82	86	PF00533	0.332
LIG_Clathr_ClatBox_1	46	50	PF01394	0.330
LIG_deltaCOP1_diTrp_1	154	159	PF00928	0.345
LIG_eIF4E_1	99	105	PF01652	0.327
LIG_FHA_1	110	116	PF00498	0.426
LIG_FHA_1	293	299	PF00498	0.435
LIG_FHA_1	377	383	PF00498	0.310
LIG_FHA_1	49	55	PF00498	0.503
LIG_FHA_1	68	74	PF00498	0.219
LIG_FHA_2	105	111	PF00498	0.385
LIG_FHA_2	204	210	PF00498	0.464
LIG_FHA_2	308	314	PF00498	0.327
LIG_FHA_2	331	337	PF00498	0.312
LIG_FHA_2	50	56	PF00498	0.521
LIG_LIR_Apic_2	179	184	PF02991	0.312
LIG_LIR_Apic_2	230	236	PF02991	0.426
LIG_LIR_Apic_2	38	42	PF02991	0.687
LIG_LIR_Gen_1	167	175	PF02991	0.304
LIG_LIR_Nem_3	167	171	PF02991	0.304
LIG_LIR_Nem_3	83	89	PF02991	0.315
LIG_MLH1_MIPbox_1	82	86	PF16413	0.393
LIG_NRBOX	212	218	PF00104	0.393
LIG_Pex14_1	190	194	PF04695	0.298
LIG_SH2_CRK	181	185	PF00017	0.327
LIG_SH2_CRK	248	252	PF00017	0.429
LIG_SH2_NCK_1	248	252	PF00017	0.447
LIG_SH2_PTP2	168	171	PF00017	0.312
LIG_SH2_STAT5	168	171	PF00017	0.298
LIG_SH2_STAT5	277	280	PF00017	0.331
LIG_SH2_STAT5	58	61	PF00017	0.533
LIG_SH2_STAT5	85	88	PF00017	0.360
LIG_SH3_3	144	150	PF00018	0.426
LIG_SH3_3	39	45	PF00018	0.628
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.600
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.426
LIG_SUMO_SIM_anti_2	402	409	PF11976	0.303
LIG_SUMO_SIM_anti_2	72	78	PF11976	0.395
LIG_SUMO_SIM_par_1	44	52	PF11976	0.450
LIG_SxIP_EBH_1	344	355	PF03271	0.447
LIG_TRAF2_1	206	209	PF00917	0.433
LIG_UBA3_1	46	53	PF00899	0.344
MOD_CDC14_SPxK_1	240	243	PF00782	0.333
MOD_CDK_SPxK_1	237	243	PF00069	0.333
MOD_CDK_SPxxK_3	80	87	PF00069	0.375
MOD_CK1_1	292	298	PF00069	0.331
MOD_CK2_1	104	110	PF00069	0.385
MOD_CK2_1	119	125	PF00069	0.368
MOD_CK2_1	170	176	PF00069	0.447
MOD_CK2_1	203	209	PF00069	0.398
MOD_CK2_1	330	336	PF00069	0.314
MOD_CK2_1	59	65	PF00069	0.489
MOD_CMANNOS	156	159	PF00535	0.345
MOD_GlcNHglycan	107	110	PF01048	0.117
MOD_GlcNHglycan	181	184	PF01048	0.312
MOD_GlcNHglycan	217	220	PF01048	0.292
MOD_GlcNHglycan	92	95	PF01048	0.464
MOD_GSK3_1	100	107	PF00069	0.371
MOD_GSK3_1	131	138	PF00069	0.331
MOD_GSK3_1	139	146	PF00069	0.405
MOD_GSK3_1	208	215	PF00069	0.352
MOD_GSK3_1	292	299	PF00069	0.380
MOD_GSK3_1	395	402	PF00069	0.426
MOD_N-GLC_1	251	256	PF02516	0.326
MOD_N-GLC_1	296	301	PF02516	0.358
MOD_N-GLC_1	357	362	PF02516	0.298
MOD_N-GLC_2	111	113	PF02516	0.345
MOD_NEK2_1	104	109	PF00069	0.393
MOD_NEK2_1	220	225	PF00069	0.298
MOD_NEK2_1	287	292	PF00069	0.326
MOD_NEK2_1	323	328	PF00069	0.306
MOD_NEK2_1	357	362	PF00069	0.415
MOD_NEK2_1	414	419	PF00069	0.340
MOD_NEK2_1	49	54	PF00069	0.493
MOD_NEK2_2	251	256	PF00069	0.426
MOD_NEK2_2	280	285	PF00069	0.370
MOD_OFUCOSY	106	113	PF10250	0.363
MOD_PKA_2	395	401	PF00069	0.447
MOD_PKA_2	78	84	PF00069	0.447
MOD_Plk_1	119	125	PF00069	0.402
MOD_Plk_1	208	214	PF00069	0.447
MOD_Plk_1	251	257	PF00069	0.330
MOD_Plk_1	296	302	PF00069	0.364
MOD_Plk_1	307	313	PF00069	0.302
MOD_Plk_1	357	363	PF00069	0.302
MOD_Plk_1	6	12	PF00069	0.614
MOD_Plk_2-3	119	125	PF00069	0.464
MOD_Plk_2-3	395	401	PF00069	0.447
MOD_Plk_4	100	106	PF00069	0.426
MOD_Plk_4	12	18	PF00069	0.632
MOD_Plk_4	143	149	PF00069	0.432
MOD_Plk_4	208	214	PF00069	0.404
MOD_Plk_4	228	234	PF00069	0.117
MOD_Plk_4	296	302	PF00069	0.380
MOD_Plk_4	403	409	PF00069	0.337
MOD_Plk_4	69	75	PF00069	0.450
MOD_ProDKin_1	135	141	PF00069	0.402
MOD_ProDKin_1	237	243	PF00069	0.312
MOD_ProDKin_1	328	334	PF00069	0.340
MOD_ProDKin_1	59	65	PF00069	0.527
MOD_ProDKin_1	80	86	PF00069	0.375
TRG_DiLeu_BaEn_1	403	408	PF01217	0.298
TRG_DiLeu_BaLyEn_6	324	329	PF01217	0.393
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.387
TRG_ENDOCYTIC_2	168	171	PF00928	0.298
TRG_ENDOCYTIC_2	88	91	PF00928	0.333
TRG_ENDOCYTIC_2	99	102	PF00928	0.253
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYQ4	Leptomonas seymouri	74%	100%
A0A0S4JAH9	Bodo saltans	33%	90%
A0A0S4JHX0	Bodo saltans	40%	87%
A0A1X0P0B6	Trypanosomatidae	51%	97%
A0A3S7WU69	Leishmania donovani	95%	98%
A0A422NE38	Trypanosoma rangeli	53%	94%
A4H8T2	Leishmania braziliensis	85%	100%
A4HX51	Leishmania infantum	95%	98%
A5PJN2	Bos taurus	31%	92%
B1H1F9	Xenopus tropicalis	30%	91%
B6CVD7	Sus scrofa	31%	92%
C9ZVU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
E9AQW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O74401	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	93%
Q03103	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	77%
Q6DD71	Xenopus laevis	30%	93%
Q75BB5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	79%
Q7T3D1	Danio rerio	30%	88%
Q7X9I4	Arabidopsis thaliana	31%	92%
Q7YTU4	Caenorhabditis elegans	29%	90%
Q86YB8	Homo sapiens	30%	93%
Q8NIP5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	77%
Q8R180	Mus musculus	31%	93%
Q8R2E9	Mus musculus	30%	93%
Q8R4A1	Rattus norvegicus	31%	93%
Q96HE7	Homo sapiens	31%	92%
Q9C7S7	Arabidopsis thaliana	33%	92%
Q9V3A6	Drosophila melanogaster	28%	89%
Q9Y7P1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	76%
V5BI75	Trypanosoma cruzi	51%	98%