Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEK9_LEIMA

TriTrypDb:

LmjF.16.1560 , LMJLV39_160022500 , LMJSD75_160022200

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QEK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.537
CLV_C14_Caspase3-7	390	394	PF00656	0.397
CLV_C14_Caspase3-7	449	453	PF00656	0.332
CLV_C14_Caspase3-7	509	513	PF00656	0.501
CLV_MEL_PAP_1	656	662	PF00089	0.408
CLV_NRD_NRD_1	658	660	PF00675	0.447
CLV_PCSK_KEX2_1	121	123	PF00082	0.364
CLV_PCSK_KEX2_1	363	365	PF00082	0.406
CLV_PCSK_KEX2_1	658	660	PF00082	0.431
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.364
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.406
CLV_PCSK_SKI1_1	144	148	PF00082	0.333
CLV_PCSK_SKI1_1	431	435	PF00082	0.363
CLV_PCSK_SKI1_1	546	550	PF00082	0.348
CLV_PCSK_SKI1_1	642	646	PF00082	0.581
CLV_PCSK_SKI1_1	67	71	PF00082	0.387
DEG_APCC_DBOX_1	168	176	PF00400	0.473
DEG_Nend_Nbox_1	1	3	PF02207	0.578
DEG_SCF_FBW7_1	304	311	PF00400	0.430
DEG_SPOP_SBC_1	322	326	PF00917	0.526
DEG_SPOP_SBC_1	69	73	PF00917	0.530
DOC_CKS1_1	139	144	PF01111	0.368
DOC_CKS1_1	305	310	PF01111	0.432
DOC_CKS1_1	634	639	PF01111	0.456
DOC_MAPK_gen_1	121	129	PF00069	0.345
DOC_MAPK_gen_1	166	174	PF00069	0.377
DOC_MAPK_MEF2A_6	292	299	PF00069	0.439
DOC_MAPK_MEF2A_6	576	585	PF00069	0.475
DOC_PP2B_LxvP_1	379	382	PF13499	0.529
DOC_PP2B_LxvP_1	581	584	PF13499	0.456
DOC_USP7_MATH_1	15	19	PF00917	0.443
DOC_USP7_MATH_1	157	161	PF00917	0.342
DOC_USP7_MATH_1	238	242	PF00917	0.387
DOC_USP7_MATH_1	285	289	PF00917	0.421
DOC_USP7_MATH_1	308	312	PF00917	0.683
DOC_USP7_MATH_1	313	317	PF00917	0.700
DOC_USP7_MATH_1	323	327	PF00917	0.707
DOC_USP7_MATH_1	506	510	PF00917	0.471
DOC_USP7_MATH_1	530	534	PF00917	0.377
DOC_USP7_MATH_1	564	568	PF00917	0.363
DOC_USP7_MATH_1	619	623	PF00917	0.612
DOC_WW_Pin1_4	103	108	PF00397	0.544
DOC_WW_Pin1_4	138	143	PF00397	0.366
DOC_WW_Pin1_4	304	309	PF00397	0.404
DOC_WW_Pin1_4	326	331	PF00397	0.711
DOC_WW_Pin1_4	469	474	PF00397	0.361
DOC_WW_Pin1_4	633	638	PF00397	0.599
DOC_WW_Pin1_4	682	687	PF00397	0.445
LIG_14-3-3_CanoR_1	144	151	PF00244	0.335
LIG_14-3-3_CanoR_1	180	185	PF00244	0.360
LIG_14-3-3_CanoR_1	364	372	PF00244	0.371
LIG_14-3-3_CanoR_1	374	379	PF00244	0.350
LIG_14-3-3_CanoR_1	431	440	PF00244	0.425
LIG_14-3-3_CanoR_1	551	557	PF00244	0.327
LIG_14-3-3_CanoR_1	576	581	PF00244	0.451
LIG_14-3-3_CanoR_1	67	77	PF00244	0.529
LIG_14-3-3_CanoR_1	9	15	PF00244	0.416
LIG_APCC_ABBA_1	463	468	PF00400	0.486
LIG_BIR_III_4	239	243	PF00653	0.446
LIG_BIR_III_4	331	335	PF00653	0.519
LIG_BRCT_BRCA1_1	310	314	PF00533	0.594
LIG_Clathr_ClatBox_1	126	130	PF01394	0.396
LIG_deltaCOP1_diTrp_1	177	184	PF00928	0.369
LIG_deltaCOP1_diTrp_1	221	226	PF00928	0.495
LIG_deltaCOP1_diTrp_1	352	359	PF00928	0.312
LIG_FHA_1	145	151	PF00498	0.329
LIG_FHA_1	249	255	PF00498	0.383
LIG_FHA_1	291	297	PF00498	0.444
LIG_FHA_1	351	357	PF00498	0.386
LIG_FHA_1	38	44	PF00498	0.535
LIG_FHA_1	381	387	PF00498	0.484
LIG_FHA_1	547	553	PF00498	0.338
LIG_FHA_1	569	575	PF00498	0.342
LIG_FHA_1	629	635	PF00498	0.622
LIG_FHA_2	206	212	PF00498	0.321
LIG_FHA_2	313	319	PF00498	0.494
LIG_FHA_2	447	453	PF00498	0.441
LIG_FHA_2	456	462	PF00498	0.259
LIG_FHA_2	482	488	PF00498	0.392
LIG_FHA_2	600	606	PF00498	0.442
LIG_FHA_2	622	628	PF00498	0.571
LIG_FHA_2	630	636	PF00498	0.580
LIG_LIR_Apic_2	543	547	PF02991	0.508
LIG_LIR_Gen_1	148	157	PF02991	0.339
LIG_LIR_Gen_1	177	184	PF02991	0.424
LIG_LIR_Gen_1	188	199	PF02991	0.288
LIG_LIR_Gen_1	252	263	PF02991	0.286
LIG_LIR_Gen_1	370	379	PF02991	0.375
LIG_LIR_Gen_1	434	445	PF02991	0.369
LIG_LIR_Gen_1	458	465	PF02991	0.389
LIG_LIR_Nem_3	115	120	PF02991	0.429
LIG_LIR_Nem_3	148	154	PF02991	0.343
LIG_LIR_Nem_3	177	181	PF02991	0.472
LIG_LIR_Nem_3	223	229	PF02991	0.346
LIG_LIR_Nem_3	252	258	PF02991	0.281
LIG_LIR_Nem_3	342	346	PF02991	0.438
LIG_LIR_Nem_3	352	357	PF02991	0.252
LIG_LIR_Nem_3	358	362	PF02991	0.253
LIG_LIR_Nem_3	434	440	PF02991	0.362
LIG_LIR_Nem_3	458	463	PF02991	0.463
LIG_LIR_Nem_3	532	538	PF02991	0.474
LIG_LIR_Nem_3	59	65	PF02991	0.393
LIG_NRBOX	552	558	PF00104	0.337
LIG_NRBOX	576	582	PF00104	0.344
LIG_PCNA_yPIPBox_3	137	150	PF02747	0.474
LIG_Pex14_2	440	444	PF04695	0.311
LIG_Rb_pABgroove_1	512	520	PF01858	0.429
LIG_SH2_CRK	151	155	PF00017	0.374
LIG_SH2_CRK	255	259	PF00017	0.341
LIG_SH2_CRK	535	539	PF00017	0.508
LIG_SH2_CRK	544	548	PF00017	0.525
LIG_SH2_CRK	578	582	PF00017	0.574
LIG_SH2_STAP1	255	259	PF00017	0.341
LIG_SH2_STAP1	460	464	PF00017	0.374
LIG_SH2_STAP1	518	522	PF00017	0.291
LIG_SH2_STAT5	114	117	PF00017	0.361
LIG_SH2_STAT5	119	122	PF00017	0.346
LIG_SH2_STAT5	229	232	PF00017	0.394
LIG_SH2_STAT5	253	256	PF00017	0.318
LIG_SH2_STAT5	346	349	PF00017	0.504
LIG_SH2_STAT5	420	423	PF00017	0.357
LIG_SH2_STAT5	437	440	PF00017	0.402
LIG_SH3_3	151	157	PF00018	0.362
LIG_SH3_3	631	637	PF00018	0.589
LIG_SH3_3	91	97	PF00018	0.388
LIG_SH3_4	488	495	PF00018	0.360
LIG_SUMO_SIM_anti_2	170	177	PF11976	0.396
LIG_SUMO_SIM_par_1	125	130	PF11976	0.341
LIG_SUMO_SIM_par_1	293	298	PF11976	0.435
LIG_SUMO_SIM_par_1	382	387	PF11976	0.408
LIG_SxIP_EBH_1	673	684	PF03271	0.470
LIG_TRAF2_1	300	303	PF00917	0.396
LIG_TRAF2_1	52	55	PF00917	0.428
LIG_UBA3_1	126	131	PF00899	0.351
LIG_WRC_WIRS_1	181	186	PF05994	0.399
LIG_WRC_WIRS_1	606	611	PF05994	0.497
MOD_CDK_SPxK_1	138	144	PF00069	0.372
MOD_CDK_SPxxK_3	103	110	PF00069	0.538
MOD_CDK_SPxxK_3	633	640	PF00069	0.417
MOD_CDK_SPxxK_3	682	689	PF00069	0.495
MOD_CK1_1	18	24	PF00069	0.499
MOD_CK1_1	25	31	PF00069	0.616
MOD_CK1_1	312	318	PF00069	0.682
MOD_CK1_1	324	330	PF00069	0.644
MOD_CK1_1	569	575	PF00069	0.388
MOD_CK2_1	205	211	PF00069	0.327
MOD_CK2_1	312	318	PF00069	0.554
MOD_CK2_1	455	461	PF00069	0.441
MOD_CK2_1	599	605	PF00069	0.510
MOD_CK2_1	621	627	PF00069	0.574
MOD_CK2_1	682	688	PF00069	0.446
MOD_GlcNHglycan	17	20	PF01048	0.479
MOD_GlcNHglycan	239	243	PF01048	0.515
MOD_GlcNHglycan	311	314	PF01048	0.697
MOD_GlcNHglycan	315	318	PF01048	0.707
MOD_GlcNHglycan	326	329	PF01048	0.708
MOD_GlcNHglycan	336	339	PF01048	0.720
MOD_GlcNHglycan	532	535	PF01048	0.356
MOD_GlcNHglycan	58	61	PF01048	0.481
MOD_GlcNHglycan	602	605	PF01048	0.466
MOD_GlcNHglycan	621	624	PF01048	0.518
MOD_GlcNHglycan	72	75	PF01048	0.481
MOD_GSK3_1	18	25	PF00069	0.527
MOD_GSK3_1	28	35	PF00069	0.461
MOD_GSK3_1	304	311	PF00069	0.552
MOD_GSK3_1	312	319	PF00069	0.623
MOD_GSK3_1	322	329	PF00069	0.549
MOD_GSK3_1	358	365	PF00069	0.399
MOD_GSK3_1	564	571	PF00069	0.404
MOD_GSK3_1	629	636	PF00069	0.498
MOD_GSK3_1	671	678	PF00069	0.472
MOD_N-GLC_1	103	108	PF02516	0.399
MOD_NEK2_1	1	6	PF00069	0.568
MOD_NEK2_1	112	117	PF00069	0.483
MOD_NEK2_1	194	199	PF00069	0.368
MOD_NEK2_1	22	27	PF00069	0.446
MOD_NEK2_1	248	253	PF00069	0.423
MOD_NEK2_1	290	295	PF00069	0.455
MOD_NEK2_1	438	443	PF00069	0.446
MOD_NEK2_1	455	460	PF00069	0.392
MOD_NEK2_1	675	680	PF00069	0.449
MOD_NEK2_1	70	75	PF00069	0.508
MOD_NEK2_2	407	412	PF00069	0.410
MOD_PIKK_1	426	432	PF00454	0.360
MOD_PIKK_1	446	452	PF00454	0.320
MOD_PKA_1	363	369	PF00069	0.392
MOD_PKA_2	112	118	PF00069	0.435
MOD_PKA_2	285	291	PF00069	0.353
MOD_PKA_2	363	369	PF00069	0.343
MOD_PKA_2	652	658	PF00069	0.543
MOD_Plk_1	586	592	PF00069	0.459
MOD_Plk_1	629	635	PF00069	0.400
MOD_Plk_2-3	352	358	PF00069	0.403
MOD_Plk_2-3	387	393	PF00069	0.416
MOD_Plk_4	170	176	PF00069	0.423
MOD_Plk_4	18	24	PF00069	0.499
MOD_Plk_4	249	255	PF00069	0.322
MOD_Plk_4	285	291	PF00069	0.360
MOD_Plk_4	37	43	PF00069	0.493
MOD_Plk_4	374	380	PF00069	0.348
MOD_Plk_4	455	461	PF00069	0.355
MOD_Plk_4	506	512	PF00069	0.437
MOD_Plk_4	552	558	PF00069	0.318
MOD_Plk_4	576	582	PF00069	0.426
MOD_Plk_4	629	635	PF00069	0.607
MOD_Plk_4	652	658	PF00069	0.536
MOD_Plk_4	671	677	PF00069	0.467
MOD_ProDKin_1	103	109	PF00069	0.541
MOD_ProDKin_1	138	144	PF00069	0.372
MOD_ProDKin_1	304	310	PF00069	0.419
MOD_ProDKin_1	326	332	PF00069	0.707
MOD_ProDKin_1	469	475	PF00069	0.357
MOD_ProDKin_1	633	639	PF00069	0.598
MOD_ProDKin_1	682	688	PF00069	0.446
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.327
TRG_ENDOCYTIC_2	117	120	PF00928	0.350
TRG_ENDOCYTIC_2	151	154	PF00928	0.375
TRG_ENDOCYTIC_2	255	258	PF00928	0.341
TRG_ENDOCYTIC_2	372	375	PF00928	0.307
TRG_ENDOCYTIC_2	437	440	PF00928	0.402
TRG_ENDOCYTIC_2	460	463	PF00928	0.468
TRG_ENDOCYTIC_2	535	538	PF00928	0.514
TRG_ENDOCYTIC_2	578	581	PF00928	0.426
TRG_ENDOCYTIC_2	62	65	PF00928	0.389
TRG_ER_diArg_1	283	286	PF00400	0.359
TRG_ER_diArg_1	650	653	PF00400	0.463
TRG_ER_diArg_1	657	659	PF00400	0.432
TRG_NES_CRM1_1	454	468	PF08389	0.364
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	431	436	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T2	Leptomonas seymouri	74%	100%
A0A0S4IYN7	Bodo saltans	39%	100%
A0A1X0NYU0	Trypanosomatidae	56%	100%
A0A3S5H6Z3	Leishmania donovani	97%	100%
A0A422NE62	Trypanosoma rangeli	58%	100%
A4H8T5	Leishmania braziliensis	89%	100%
A4HX54	Leishmania infantum	97%	100%
C9ZVT7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AQW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BMQ0	Trypanosoma cruzi	58%	97%