SMP-LTD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEK8_LEIMA

TriTrypDb:

LmjF.16.1570 , LMJLV39_160022600 , LMJSD75_160022300

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032865	ERMES complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0098796	membrane protein complex	2	12
GO:0098798	mitochondrial protein-containing complex	2	12
GO:0098799	outer mitochondrial membrane protein complex	3	12
GO:0140534	endoplasmic reticulum protein-containing complex	2	12

Expansion

Sequence features

Q4QEK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEK8

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0007005	mitochondrion organization	5	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0071840	cellular component organization or biogenesis	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	213	215	PF00675	0.570
CLV_NRD_NRD_1	285	287	PF00675	0.416
CLV_PCSK_KEX2_1	213	215	PF00082	0.570
CLV_PCSK_KEX2_1	278	280	PF00082	0.458
CLV_PCSK_KEX2_1	284	286	PF00082	0.401
CLV_PCSK_KEX2_1	297	299	PF00082	0.442
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.481
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.427
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.465
CLV_PCSK_SKI1_1	19	23	PF00082	0.542
CLV_PCSK_SKI1_1	285	289	PF00082	0.372
DEG_APCC_DBOX_1	268	276	PF00400	0.579
DEG_Nend_Nbox_1	1	3	PF02207	0.417
DEG_SPOP_SBC_1	186	190	PF00917	0.639
DOC_ANK_TNKS_1	328	335	PF00023	0.479
DOC_MAPK_gen_1	283	291	PF00069	0.375
DOC_MAPK_gen_1	36	46	PF00069	0.529
DOC_MAPK_gen_1	84	92	PF00069	0.432
DOC_MAPK_MEF2A_6	15	22	PF00069	0.460
DOC_MAPK_MEF2A_6	283	291	PF00069	0.389
DOC_MAPK_MEF2A_6	39	46	PF00069	0.521
DOC_MAPK_MEF2A_6	84	92	PF00069	0.392
DOC_PP2B_LxvP_1	107	110	PF13499	0.599
DOC_PP4_FxxP_1	111	114	PF00568	0.390
DOC_PP4_FxxP_1	292	295	PF00568	0.385
DOC_PP4_MxPP_1	216	219	PF00568	0.581
DOC_USP7_MATH_1	185	189	PF00917	0.647
DOC_USP7_MATH_1	245	249	PF00917	0.711
DOC_USP7_MATH_1	268	272	PF00917	0.523
DOC_USP7_UBL2_3	284	288	PF12436	0.409
DOC_USP7_UBL2_3	32	36	PF12436	0.598
DOC_WW_Pin1_4	146	151	PF00397	0.674
DOC_WW_Pin1_4	156	161	PF00397	0.443
DOC_WW_Pin1_4	233	238	PF00397	0.698
DOC_WW_Pin1_4	49	54	PF00397	0.503
LIG_14-3-3_CanoR_1	173	183	PF00244	0.620
LIG_14-3-3_CanoR_1	269	273	PF00244	0.540
LIG_APCC_ABBA_1	130	135	PF00400	0.393
LIG_APCC_ABBA_1	289	294	PF00400	0.380
LIG_APCC_ABBAyCdc20_2	288	294	PF00400	0.393
LIG_APCC_ABBAyCdc20_2	39	45	PF00400	0.441
LIG_Clathr_ClatBox_1	41	45	PF01394	0.430
LIG_CtBP_PxDLS_1	114	118	PF00389	0.494
LIG_CtBP_PxDLS_1	218	222	PF00389	0.586
LIG_deltaCOP1_diTrp_1	5	10	PF00928	0.403
LIG_FHA_1	151	157	PF00498	0.741
LIG_FHA_1	160	166	PF00498	0.769
LIG_FHA_1	334	340	PF00498	0.530
LIG_FHA_1	7	13	PF00498	0.568
LIG_FHA_2	116	122	PF00498	0.396
LIG_LIR_Gen_1	131	140	PF02991	0.414
LIG_LIR_Nem_3	131	136	PF02991	0.419
LIG_LIR_Nem_3	201	207	PF02991	0.623
LIG_SH2_CRK	204	208	PF00017	0.545
LIG_SH2_STAT5	112	115	PF00017	0.487
LIG_SH2_STAT5	181	184	PF00017	0.563
LIG_SH3_3	226	232	PF00018	0.754
LIG_SH3_3	262	268	PF00018	0.716
LIG_SH3_3	303	309	PF00018	0.584
LIG_SH3_3	41	47	PF00018	0.505
LIG_SUMO_SIM_par_1	271	277	PF11976	0.494
LIG_SUMO_SIM_par_1	335	340	PF11976	0.489
LIG_UBA3_1	272	278	PF00899	0.577
MOD_CDK_SPK_2	156	161	PF00069	0.654
MOD_CK1_1	149	155	PF00069	0.686
MOD_CK1_1	167	173	PF00069	0.696
MOD_CK1_1	177	183	PF00069	0.596
MOD_CK1_1	193	199	PF00069	0.621
MOD_CK1_1	241	247	PF00069	0.660
MOD_CK1_1	252	258	PF00069	0.663
MOD_CK1_1	99	105	PF00069	0.556
MOD_Cter_Amidation	211	214	PF01082	0.552
MOD_Cter_Amidation	311	314	PF01082	0.572
MOD_GlcNHglycan	176	179	PF01048	0.686
MOD_GlcNHglycan	183	186	PF01048	0.671
MOD_GlcNHglycan	192	195	PF01048	0.609
MOD_GlcNHglycan	201	204	PF01048	0.599
MOD_GlcNHglycan	252	255	PF01048	0.730
MOD_GlcNHglycan	257	260	PF01048	0.633
MOD_GSK3_1	146	153	PF00069	0.667
MOD_GSK3_1	177	184	PF00069	0.690
MOD_GSK3_1	186	193	PF00069	0.537
MOD_GSK3_1	241	248	PF00069	0.683
MOD_GSK3_1	250	257	PF00069	0.703
MOD_GSK3_1	259	266	PF00069	0.547
MOD_GSK3_1	333	340	PF00069	0.593
MOD_GSK3_1	62	69	PF00069	0.376
MOD_GSK3_1	96	103	PF00069	0.596
MOD_N-GLC_1	97	102	PF02516	0.486
MOD_NEK2_1	115	120	PF00069	0.381
MOD_NEK2_1	154	159	PF00069	0.697
MOD_NEK2_1	66	71	PF00069	0.478
MOD_NEK2_2	79	84	PF00069	0.367
MOD_PIKK_1	263	269	PF00454	0.671
MOD_PKA_2	268	274	PF00069	0.498
MOD_Plk_1	115	121	PF00069	0.353
MOD_Plk_1	150	156	PF00069	0.720
MOD_Plk_1	245	251	PF00069	0.672
MOD_Plk_1	62	68	PF00069	0.392
MOD_Plk_1	79	85	PF00069	0.378
MOD_Plk_1	97	103	PF00069	0.537
MOD_Plk_2-3	333	339	PF00069	0.476
MOD_Plk_4	268	274	PF00069	0.567
MOD_ProDKin_1	146	152	PF00069	0.677
MOD_ProDKin_1	156	162	PF00069	0.441
MOD_ProDKin_1	233	239	PF00069	0.697
MOD_ProDKin_1	49	55	PF00069	0.507
MOD_SUMO_for_1	31	34	PF00179	0.593
TRG_DiLeu_BaEn_1	143	148	PF01217	0.584
TRG_DiLeu_BaEn_1	67	72	PF01217	0.395
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.481
TRG_ENDOCYTIC_2	112	115	PF00928	0.502
TRG_ENDOCYTIC_2	204	207	PF00928	0.546
TRG_ER_diArg_1	285	287	PF00400	0.418
TRG_NES_CRM1_1	55	67	PF08389	0.522
TRG_NLS_Bipartite_1	283	301	PF00514	0.524
TRG_NLS_MonoCore_2	282	287	PF00514	0.524
TRG_NLS_MonoExtC_3	283	288	PF00514	0.524
TRG_NLS_MonoExtC_3	296	302	PF00514	0.530
TRG_NLS_MonoExtN_4	283	288	PF00514	0.509
TRG_NLS_MonoExtN_4	295	301	PF00514	0.391
TRG_Pf-PMV_PEXEL_1	62	67	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY6	Leptomonas seymouri	65%	100%
A0A0S4IYB8	Bodo saltans	33%	93%
A0A1X0NYR1	Trypanosomatidae	43%	100%
A0A3R7LUZ6	Trypanosoma rangeli	42%	100%
A0A3S7WU79	Leishmania donovani	96%	100%
A4H8T6	Leishmania braziliensis	86%	100%
A4HX55	Leishmania infantum	96%	100%
C9ZVT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AQX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BSA1	Trypanosoma cruzi	41%	100%