Putative U1 small nuclear ribonucleoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

u1 small nuclear ribonucleoprotein 70 kDa

Species:

Leishmania major

UniProt:

Q4QEK6_LEIMA

TriTrypDb:

LmjF.16.1590 , LMJLV39_160022800 , LMJSD75_160022500

Length:

283

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005681	spliceosomal complex	3	2
GO:0005685	U1 snRNP	5	2
GO:0005689	U12-type spliceosomal complex	4	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

Q4QEK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEK6

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0045292	mRNA cis splicing, via spliceosome	9	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	11
GO:0017069	snRNA binding	5	2
GO:0043021	ribonucleoprotein complex binding	3	2
GO:0044877	protein-containing complex binding	2	2
GO:0070990	snRNP binding	4	2
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:1990446	U1 snRNP binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.455
CLV_NRD_NRD_1	121	123	PF00675	0.481
CLV_NRD_NRD_1	177	179	PF00675	0.256
CLV_NRD_NRD_1	190	192	PF00675	0.330
CLV_NRD_NRD_1	197	199	PF00675	0.274
CLV_NRD_NRD_1	47	49	PF00675	0.615
CLV_PCSK_FUR_1	198	202	PF00082	0.290
CLV_PCSK_KEX2_1	121	123	PF00082	0.495
CLV_PCSK_KEX2_1	14	16	PF00082	0.457
CLV_PCSK_KEX2_1	177	179	PF00082	0.239
CLV_PCSK_KEX2_1	200	202	PF00082	0.285
CLV_PCSK_KEX2_1	223	225	PF00082	0.458
CLV_PCSK_KEX2_1	29	31	PF00082	0.485
CLV_PCSK_KEX2_1	47	49	PF00082	0.487
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.477
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.285
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.443
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.496
CLV_PCSK_PC7_1	10	16	PF00082	0.469
CLV_PCSK_SKI1_1	178	182	PF00082	0.331
CLV_PCSK_SKI1_1	200	204	PF00082	0.392
CLV_PCSK_SKI1_1	223	227	PF00082	0.480
CLV_PCSK_SKI1_1	264	268	PF00082	0.489
CLV_PCSK_SKI1_1	30	34	PF00082	0.515
CLV_PCSK_SKI1_1	79	83	PF00082	0.710
CLV_PCSK_SKI1_1	95	99	PF00082	0.498
DEG_SPOP_SBC_1	88	92	PF00917	0.728
DOC_CKS1_1	231	236	PF01111	0.489
DOC_CYCLIN_RxL_1	220	230	PF00134	0.423
DOC_MAPK_gen_1	175	184	PF00069	0.465
DOC_MAPK_gen_1	198	209	PF00069	0.503
DOC_PP1_RVXF_1	190	197	PF00149	0.531
DOC_PP2B_LxvP_1	267	270	PF13499	0.529
DOC_PP4_FxxP_1	231	234	PF00568	0.468
DOC_USP7_MATH_1	86	90	PF00917	0.658
DOC_USP7_UBL2_3	199	203	PF12436	0.505
DOC_WW_Pin1_4	230	235	PF00397	0.522
LIG_14-3-3_CanoR_1	161	166	PF00244	0.427
LIG_14-3-3_CanoR_1	224	232	PF00244	0.455
LIG_AP2alpha_1	155	159	PF02296	0.549
LIG_CSL_BTD_1	231	234	PF09270	0.468
LIG_EH_1	122	126	PF12763	0.541
LIG_FHA_2	145	151	PF00498	0.448
LIG_FHA_2	241	247	PF00498	0.559
LIG_LIR_Apic_2	229	235	PF02991	0.514
LIG_LIR_Gen_1	176	187	PF02991	0.530
LIG_LIR_Nem_3	157	162	PF02991	0.435
LIG_LIR_Nem_3	176	182	PF02991	0.430
LIG_LIR_Nem_3	183	187	PF02991	0.435
LIG_Pex14_1	28	32	PF04695	0.481
LIG_Pex14_2	155	159	PF04695	0.470
LIG_REV1ctd_RIR_1	30	36	PF16727	0.500
LIG_SH2_CRK	205	209	PF00017	0.427
LIG_SH2_STAP1	205	209	PF00017	0.427
LIG_SH3_3	262	268	PF00018	0.676
LIG_SH3_3	34	40	PF00018	0.493
LIG_SH3_3	80	86	PF00018	0.628
LIG_TRAF2_1	106	109	PF00917	0.573
LIG_TRAF2_1	147	150	PF00917	0.435
MOD_CK1_1	230	236	PF00069	0.578
MOD_CK1_1	240	246	PF00069	0.426
MOD_CK1_1	89	95	PF00069	0.614
MOD_CK2_1	103	109	PF00069	0.625
MOD_CK2_1	144	150	PF00069	0.287
MOD_CK2_1	240	246	PF00069	0.680
MOD_GlcNHglycan	240	243	PF01048	0.604
MOD_GlcNHglycan	254	257	PF01048	0.613
MOD_GlcNHglycan	95	98	PF01048	0.665
MOD_GSK3_1	226	233	PF00069	0.536
MOD_GSK3_1	237	244	PF00069	0.623
MOD_GSK3_1	50	57	PF00069	0.660
MOD_GSK3_1	87	94	PF00069	0.671
MOD_GSK3_1	97	104	PF00069	0.573
MOD_NEK2_1	226	231	PF00069	0.551
MOD_NEK2_1	93	98	PF00069	0.644
MOD_NEK2_2	28	33	PF00069	0.601
MOD_PK_1	161	167	PF00069	0.285
MOD_PK_1	203	209	PF00069	0.433
MOD_Plk_1	6	12	PF00069	0.517
MOD_Plk_4	203	209	PF00069	0.433
MOD_Plk_4	227	233	PF00069	0.564
MOD_ProDKin_1	230	236	PF00069	0.530
MOD_SUMO_rev_2	74	83	PF00179	0.607
TRG_DiLeu_BaEn_4	6	12	PF01217	0.601
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.421
TRG_ENDOCYTIC_2	179	182	PF00928	0.269
TRG_ENDOCYTIC_2	205	208	PF00928	0.436
TRG_ER_diArg_1	13	16	PF00400	0.482
TRG_ER_diArg_1	177	179	PF00400	0.265
TRG_NLS_MonoCore_2	197	202	PF00514	0.347
TRG_NLS_MonoExtC_3	198	203	PF00514	0.402
TRG_NLS_MonoExtN_4	10	17	PF00514	0.583
TRG_NLS_MonoExtN_4	198	204	PF00514	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T1	Leptomonas seymouri	61%	96%
A0A0S4J1P9	Bodo saltans	31%	100%
A0A1X0NYS6	Trypanosomatidae	38%	100%
A0A3Q8IAQ7	Leishmania donovani	91%	100%
A4H8T7	Leishmania braziliensis	80%	100%
A4HX57	Leishmania infantum	91%	75%
C9ZVT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AQX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B2N5	Trypanosoma cruzi	39%	100%