Prohibitin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prohibitin

Gene product:

prohibitin

Species:

Leishmania major

UniProt:

Q4QEK4_LEIMA

TriTrypDb:

LmjF.16.1610 , LMJLV39_160023000 , LMJSD75_160022700

Length:

268

Annotations

LeishMANIAdb annotations

Homologous to other Eukaryotic mitochondrial prohibitins, although no distinct transit signal can be discerned in this protein. A rather conserved family of proteins. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005743	mitochondrial inner membrane	5	11
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	11
GO:0020016	ciliary pocket	2	2
GO:0031090	organelle membrane	3	11
GO:0031966	mitochondrial membrane	4	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0060187	cell pole	2	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QEK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEK4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0007005	mitochondrion organization	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005543	phospholipid binding	3	2
GO:0008289	lipid binding	2	2
GO:0030544	Hsp70 protein binding	4	2
GO:0031072	heat shock protein binding	3	2
GO:0034235	GPI anchor binding	4	2
GO:0035091	phosphatidylinositol binding	4	2
GO:0051861	glycolipid binding	3	2
GO:0097367	carbohydrate derivative binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	203	205	PF00675	0.315
CLV_NRD_NRD_1	235	237	PF00675	0.365
CLV_PCSK_KEX2_1	138	140	PF00082	0.237
CLV_PCSK_KEX2_1	202	204	PF00082	0.281
CLV_PCSK_KEX2_1	235	237	PF00082	0.384
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.237
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.317
CLV_PCSK_SKI1_1	89	93	PF00082	0.292
CLV_Separin_Metazoa	59	63	PF03568	0.350
DOC_MAPK_gen_1	235	243	PF00069	0.348
DOC_MAPK_MEF2A_6	79	88	PF00069	0.237
DOC_PP1_RVXF_1	87	93	PF00149	0.237
DOC_SPAK_OSR1_1	62	66	PF12202	0.369
DOC_USP7_MATH_1	116	120	PF00917	0.369
DOC_USP7_UBL2_3	3	7	PF12436	0.440
LIG_14-3-3_CanoR_1	68	73	PF00244	0.275
LIG_APCC_ABBAyCdc20_2	42	48	PF00400	0.255
LIG_BIR_II_1	1	5	PF00653	0.408
LIG_BRCT_BRCA1_1	20	24	PF00533	0.404
LIG_eIF4E_1	130	136	PF01652	0.237
LIG_FHA_1	103	109	PF00498	0.277
LIG_FHA_1	76	82	PF00498	0.237
LIG_FHA_2	175	181	PF00498	0.369
LIG_LIR_Nem_3	190	195	PF02991	0.255
LIG_LIR_Nem_3	21	27	PF02991	0.444
LIG_PCNA_yPIPBox_3	113	127	PF02747	0.237
LIG_Pex14_2	171	175	PF04695	0.237
LIG_PTB_Apo_2	249	256	PF02174	0.420
LIG_RPA_C_Fungi	213	225	PF08784	0.438
LIG_SH2_CRK	192	196	PF00017	0.369
LIG_SH2_CRK	35	39	PF00017	0.255
LIG_SH2_NCK_1	35	39	PF00017	0.255
LIG_SH2_STAP1	110	114	PF00017	0.237
LIG_SH2_STAP1	20	24	PF00017	0.361
LIG_SH2_STAT5	194	197	PF00017	0.255
LIG_SH3_3	22	28	PF00018	0.255
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.237
LIG_TRAF2_1	185	188	PF00917	0.237
LIG_TYR_ITIM	33	38	PF00017	0.255
LIG_WRC_WIRS_1	103	108	PF05994	0.298
MOD_CK1_1	18	24	PF00069	0.476
MOD_CK2_1	174	180	PF00069	0.369
MOD_GlcNHglycan	142	145	PF01048	0.244
MOD_GlcNHglycan	215	218	PF01048	0.354
MOD_GlcNHglycan	226	229	PF01048	0.376
MOD_GlcNHglycan	38	41	PF01048	0.262
MOD_GSK3_1	71	78	PF00069	0.237
MOD_N-GLC_1	251	256	PF02516	0.429
MOD_NEK2_1	41	46	PF00069	0.255
MOD_NEK2_2	15	20	PF00069	0.425
MOD_PKB_1	66	74	PF00069	0.369
MOD_Plk_1	162	168	PF00069	0.251
MOD_Plk_1	251	257	PF00069	0.429
MOD_Plk_2-3	162	168	PF00069	0.237
MOD_Plk_4	15	21	PF00069	0.423
MOD_Plk_4	162	168	PF00069	0.275
MOD_Plk_4	251	257	PF00069	0.429
MOD_Plk_4	41	47	PF00069	0.255
MOD_SUMO_rev_2	174	184	PF00179	0.237
TRG_DiLeu_BaEn_1	162	167	PF01217	0.237
TRG_DiLeu_BaEn_1	215	220	PF01217	0.360
TRG_DiLeu_LyEn_5	215	220	PF01217	0.379
TRG_ENDOCYTIC_2	103	106	PF00928	0.264
TRG_ENDOCYTIC_2	147	150	PF00928	0.255
TRG_ENDOCYTIC_2	192	195	PF00928	0.319
TRG_ENDOCYTIC_2	35	38	PF00928	0.255
TRG_ER_diArg_1	234	236	PF00400	0.368
TRG_ER_diArg_1	65	68	PF00400	0.237
TRG_ER_diArg_1	86	89	PF00400	0.288
TRG_NES_CRM1_1	148	163	PF08389	0.277
TRG_NES_CRM1_1	233	246	PF08389	0.369
TRG_NES_CRM1_1	97	112	PF08389	0.255
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M3	Leptomonas seymouri	40%	88%
A0A0N1IKI8	Leptomonas seymouri	92%	100%
A0A0S4IYJ7	Bodo saltans	75%	100%
A0A0S4JRD4	Bodo saltans	39%	86%
A0A1X0NJ09	Trypanosomatidae	39%	90%
A0A1X0NYS7	Trypanosomatidae	79%	99%
A0A3R7K7X6	Trypanosoma rangeli	38%	88%
A0A3S7WU67	Leishmania donovani	99%	100%
A0A3S7X8M7	Leishmania donovani	40%	92%
A4H8T9	Leishmania braziliensis	96%	100%
A4HM46	Leishmania braziliensis	40%	92%
A4HX59	Leishmania infantum	99%	100%
A4IAQ8	Leishmania infantum	40%	92%
A9UMS3	Xenopus tropicalis	41%	89%
C9ZVT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	97%
D0A2F6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	91%
E9AEI4	Leishmania major	40%	92%
E9AQX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
E9B5P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	92%
O04331	Arabidopsis thaliana	45%	97%
O35129	Mus musculus	41%	90%
O49460	Arabidopsis thaliana	45%	93%
O94550	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	93%
P24156	Drosophila melanogaster	44%	97%
P35232	Homo sapiens	43%	99%
P40961	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	93%
P50085	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	86%
P50093	Caenorhabditis elegans	42%	91%
P67778	Mus musculus	43%	99%
P67779	Rattus norvegicus	43%	99%
P84173	Gallus gallus	43%	99%
Q2HJ97	Bos taurus	41%	90%
Q3T165	Bos taurus	43%	99%
Q54GI9	Dictyostelium discoideum	45%	99%
Q54Q31	Dictyostelium discoideum	41%	91%
Q5RB19	Pongo abelii	41%	90%
Q5XIH7	Rattus norvegicus	41%	90%
Q5ZMN3	Gallus gallus	41%	89%
Q99623	Homo sapiens	41%	90%
Q9BKU4	Caenorhabditis elegans	45%	97%
Q9FFH5	Arabidopsis thaliana	44%	96%
Q9LK25	Arabidopsis thaliana	46%	96%
Q9LY99	Arabidopsis thaliana	39%	100%
Q9P7H3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	95%
Q9SIL6	Arabidopsis thaliana	44%	94%
Q9ZNT7	Arabidopsis thaliana	44%	94%
V5DJ73	Trypanosoma cruzi	81%	99%
V5DJR3	Trypanosoma cruzi	38%	88%