WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEK3_LEIMA

TriTrypDb:

LmjF.16.1620 , LMJLV39_160023100 , LMJSD75_160022800

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.611
CLV_NRD_NRD_1	111	113	PF00675	0.518
CLV_NRD_NRD_1	246	248	PF00675	0.580
CLV_NRD_NRD_1	443	445	PF00675	0.460
CLV_PCSK_KEX2_1	111	113	PF00082	0.518
CLV_PCSK_KEX2_1	246	248	PF00082	0.580
CLV_PCSK_SKI1_1	111	115	PF00082	0.579
CLV_PCSK_SKI1_1	36	40	PF00082	0.518
CLV_PCSK_SKI1_1	439	443	PF00082	0.519
DEG_SCF_FBW7_2	410	416	PF00400	0.527
DEG_SCF_TRCP1_1	21	27	PF00400	0.437
DOC_CKS1_1	223	228	PF01111	0.586
DOC_CKS1_1	410	415	PF01111	0.529
DOC_CKS1_1	59	64	PF01111	0.636
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.574
DOC_MAPK_MEF2A_6	4	12	PF00069	0.705
DOC_PP2B_LxvP_1	49	52	PF13499	0.385
DOC_PP4_FxxP_1	249	252	PF00568	0.671
DOC_USP7_MATH_1	199	203	PF00917	0.723
DOC_USP7_MATH_1	206	210	PF00917	0.671
DOC_USP7_MATH_1	219	223	PF00917	0.690
DOC_USP7_MATH_1	242	246	PF00917	0.693
DOC_USP7_MATH_1	343	347	PF00917	0.726
DOC_USP7_MATH_1	390	394	PF00917	0.717
DOC_USP7_MATH_1	397	401	PF00917	0.675
DOC_USP7_MATH_1	77	81	PF00917	0.382
DOC_WW_Pin1_4	222	227	PF00397	0.679
DOC_WW_Pin1_4	347	352	PF00397	0.762
DOC_WW_Pin1_4	369	374	PF00397	0.664
DOC_WW_Pin1_4	377	382	PF00397	0.729
DOC_WW_Pin1_4	409	414	PF00397	0.556
DOC_WW_Pin1_4	58	63	PF00397	0.612
LIG_14-3-3_CanoR_1	124	133	PF00244	0.550
LIG_14-3-3_CanoR_1	190	195	PF00244	0.675
LIG_14-3-3_CanoR_1	258	263	PF00244	0.508
LIG_14-3-3_CanoR_1	297	306	PF00244	0.573
LIG_14-3-3_CanoR_1	382	389	PF00244	0.782
LIG_AP2alpha_2	205	207	PF02296	0.524
LIG_APCC_ABBA_1	60	65	PF00400	0.630
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_BRCT_BRCA1_1	92	96	PF00533	0.469
LIG_EVH1_2	252	256	PF00568	0.538
LIG_EVH1_2	353	357	PF00568	0.712
LIG_FHA_1	115	121	PF00498	0.441
LIG_FHA_1	128	134	PF00498	0.327
LIG_FHA_1	25	31	PF00498	0.459
LIG_FHA_1	278	284	PF00498	0.639
LIG_FHA_1	328	334	PF00498	0.641
LIG_FHA_1	378	384	PF00498	0.730
LIG_FHA_1	5	11	PF00498	0.535
LIG_FHA_2	296	302	PF00498	0.704
LIG_FHA_2	410	416	PF00498	0.692
LIG_GBD_Chelix_1	434	442	PF00786	0.504
LIG_Integrin_isoDGR_2	366	368	PF01839	0.726
LIG_LIR_Apic_2	400	406	PF02991	0.585
LIG_LIR_Gen_1	205	215	PF02991	0.717
LIG_LIR_Gen_1	225	233	PF02991	0.551
LIG_LIR_Nem_3	205	210	PF02991	0.711
LIG_LIR_Nem_3	225	231	PF02991	0.549
LIG_NRBOX	151	157	PF00104	0.484
LIG_Pex14_1	228	232	PF04695	0.492
LIG_REV1ctd_RIR_1	99	107	PF16727	0.361
LIG_SH2_CRK	370	374	PF00017	0.681
LIG_SH2_CRK	403	407	PF00017	0.761
LIG_SH2_NCK_1	370	374	PF00017	0.696
LIG_SH2_STAP1	74	78	PF00017	0.433
LIG_SH3_1	348	354	PF00018	0.723
LIG_SH3_3	348	354	PF00018	0.723
LIG_SH3_3	407	413	PF00018	0.662
LIG_SH3_3	56	62	PF00018	0.657
LIG_SH3_CIN85_PxpxPR_1	406	411	PF14604	0.743
LIG_SUMO_SIM_anti_2	27	35	PF11976	0.534
LIG_SUMO_SIM_par_1	10	16	PF11976	0.619
LIG_TRAF2_1	233	236	PF00917	0.643
LIG_TRAF2_1	413	416	PF00917	0.611
LIG_WRC_WIRS_1	438	443	PF05994	0.383
LIG_WRC_WIRS_1	98	103	PF05994	0.336
MOD_CDK_SPK_2	377	382	PF00069	0.729
MOD_CK1_1	127	133	PF00069	0.432
MOD_CK1_1	179	185	PF00069	0.571
MOD_CK1_1	193	199	PF00069	0.603
MOD_CK1_1	209	215	PF00069	0.716
MOD_CK1_1	22	28	PF00069	0.570
MOD_CK1_1	222	228	PF00069	0.491
MOD_CK1_1	238	244	PF00069	0.565
MOD_CK1_1	261	267	PF00069	0.585
MOD_CK1_1	300	306	PF00069	0.762
MOD_CK1_1	356	362	PF00069	0.719
MOD_CK1_1	393	399	PF00069	0.766
MOD_CK1_1	43	49	PF00069	0.503
MOD_CK1_1	64	70	PF00069	0.541
MOD_CK2_1	164	170	PF00069	0.449
MOD_CK2_1	278	284	PF00069	0.713
MOD_CK2_1	295	301	PF00069	0.574
MOD_CK2_1	369	375	PF00069	0.687
MOD_CK2_1	409	415	PF00069	0.648
MOD_GlcNHglycan	104	107	PF01048	0.623
MOD_GlcNHglycan	147	150	PF01048	0.459
MOD_GlcNHglycan	201	204	PF01048	0.722
MOD_GlcNHglycan	21	24	PF01048	0.515
MOD_GlcNHglycan	211	214	PF01048	0.659
MOD_GlcNHglycan	27	30	PF01048	0.515
MOD_GlcNHglycan	287	290	PF01048	0.554
MOD_GlcNHglycan	312	315	PF01048	0.681
MOD_GlcNHglycan	341	344	PF01048	0.740
MOD_GlcNHglycan	345	348	PF01048	0.744
MOD_GlcNHglycan	406	409	PF01048	0.669
MOD_GlcNHglycan	55	58	PF01048	0.501
MOD_GSK3_1	124	131	PF00069	0.443
MOD_GSK3_1	164	171	PF00069	0.474
MOD_GSK3_1	238	245	PF00069	0.746
MOD_GSK3_1	24	31	PF00069	0.538
MOD_GSK3_1	252	259	PF00069	0.527
MOD_GSK3_1	291	298	PF00069	0.663
MOD_GSK3_1	318	325	PF00069	0.737
MOD_GSK3_1	339	346	PF00069	0.723
MOD_GSK3_1	353	360	PF00069	0.572
MOD_GSK3_1	377	384	PF00069	0.700
MOD_GSK3_1	389	396	PF00069	0.576
MOD_GSK3_1	39	46	PF00069	0.439
MOD_N-GLC_1	53	58	PF02516	0.633
MOD_NEK2_1	102	107	PF00069	0.453
MOD_NEK2_1	13	18	PF00069	0.560
MOD_NEK2_1	159	164	PF00069	0.451
MOD_NEK2_1	168	173	PF00069	0.249
MOD_NEK2_1	256	261	PF00069	0.543
MOD_NEK2_1	269	274	PF00069	0.409
MOD_NEK2_1	357	362	PF00069	0.703
MOD_NEK2_1	383	388	PF00069	0.715
MOD_NEK2_1	389	394	PF00069	0.602
MOD_NEK2_1	83	88	PF00069	0.395
MOD_NEK2_2	219	224	PF00069	0.653
MOD_NEK2_2	390	395	PF00069	0.767
MOD_NEK2_2	97	102	PF00069	0.514
MOD_OFUCOSY	157	163	PF10250	0.561
MOD_PIKK_1	168	174	PF00454	0.559
MOD_PK_1	258	264	PF00069	0.513
MOD_PKA_1	111	117	PF00069	0.578
MOD_PKA_2	102	108	PF00069	0.607
MOD_PKA_2	111	117	PF00069	0.314
MOD_PKA_2	323	329	PF00069	0.747
MOD_PKA_2	343	349	PF00069	0.723
MOD_PKA_2	381	387	PF00069	0.735
MOD_Plk_1	168	174	PF00069	0.427
MOD_Plk_1	300	306	PF00069	0.730
MOD_Plk_1	390	396	PF00069	0.716
MOD_Plk_1	4	10	PF00069	0.656
MOD_Plk_1	64	70	PF00069	0.539
MOD_Plk_4	128	134	PF00069	0.419
MOD_Plk_4	13	19	PF00069	0.543
MOD_Plk_4	151	157	PF00069	0.487
MOD_Plk_4	252	258	PF00069	0.568
MOD_Plk_4	390	396	PF00069	0.734
MOD_Plk_4	43	49	PF00069	0.464
MOD_Plk_4	437	443	PF00069	0.615
MOD_Plk_4	97	103	PF00069	0.463
MOD_ProDKin_1	222	228	PF00069	0.666
MOD_ProDKin_1	347	353	PF00069	0.761
MOD_ProDKin_1	369	375	PF00069	0.668
MOD_ProDKin_1	377	383	PF00069	0.731
MOD_ProDKin_1	409	415	PF00069	0.553
MOD_ProDKin_1	58	64	PF00069	0.604
TRG_DiLeu_BaEn_1	430	435	PF01217	0.439
TRG_DiLeu_BaEn_1	44	49	PF01217	0.431
TRG_DiLeu_BaEn_2	169	175	PF01217	0.448
TRG_ER_diArg_1	111	113	PF00400	0.525
TRG_ER_diArg_1	333	336	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.277
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX30	Leptomonas seymouri	48%	97%
A0A3R7KLD2	Trypanosoma rangeli	29%	100%
A0A3S7WU83	Leishmania donovani	90%	100%
A4H8U0	Leishmania braziliensis	77%	100%
A4HX60	Leishmania infantum	90%	100%
C9ZVT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AQX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BMQ6	Trypanosoma cruzi	28%	100%