Nop domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative snoRNA binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QEK2_LEIMA

TriTrypDb:

LmjF.16.1630 , LMJLV39_160023200 , LMJSD75_160022900

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0005687	U4 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	12
GO:0071011	precatalytic spliceosome	4	2
GO:0097525	spliceosomal snRNP complex	4	12
GO:0097526	spliceosomal tri-snRNP complex	5	12
GO:0120114	Sm-like protein family complex	2	12
GO:0140513	nuclear protein-containing complex	2	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4QEK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEK2

Function

Biological processes
Term	Name	Level	Count
GO:0000244	spliceosomal tri-snRNP complex assembly	8	12
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000387	spliceosomal snRNP assembly	7	12
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0022607	cellular component assembly	4	12
GO:0022618	ribonucleoprotein complex assembly	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043933	protein-containing complex organization	4	12
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0065003	protein-containing complex assembly	5	12
GO:0071704	organic substance metabolic process	2	2
GO:0071826	ribonucleoprotein complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.526
CLV_NRD_NRD_1	163	165	PF00675	0.486
CLV_NRD_NRD_1	219	221	PF00675	0.512
CLV_NRD_NRD_1	81	83	PF00675	0.255
CLV_NRD_NRD_1	93	95	PF00675	0.219
CLV_PCSK_FUR_1	164	168	PF00082	0.580
CLV_PCSK_KEX2_1	157	159	PF00082	0.463
CLV_PCSK_KEX2_1	166	168	PF00082	0.424
CLV_PCSK_KEX2_1	221	223	PF00082	0.532
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.458
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.532
CLV_PCSK_SKI1_1	95	99	PF00082	0.291
DEG_SCF_FBXO31_1	233	239	PF12014	0.638
DOC_ANK_TNKS_1	126	133	PF00023	0.571
DOC_CKS1_1	1	6	PF01111	0.326
DOC_CYCLIN_yClb5_NLxxxL_5	1	10	PF00134	0.409
DOC_CYCLIN_yCln2_LP_2	10	16	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.600
DOC_PP2B_LxvP_1	10	13	PF13499	0.442
DOC_PP2B_LxvP_1	142	145	PF13499	0.438
DOC_PP2B_LxvP_1	62	65	PF13499	0.527
DOC_USP7_MATH_1	223	227	PF00917	0.491
DOC_USP7_MATH_1	48	52	PF00917	0.501
DOC_USP7_UBL2_3	162	166	PF12436	0.525
DOC_USP7_UBL2_3	217	221	PF12436	0.535
DOC_USP7_UBL2_3	83	87	PF12436	0.534
LIG_14-3-3_CanoR_1	179	186	PF00244	0.430
LIG_APCC_ABBA_1	147	152	PF00400	0.418
LIG_APCC_ABBAyCdc20_2	224	230	PF00400	0.510
LIG_BIR_II_1	1	5	PF00653	0.390
LIG_FHA_1	1	7	PF00498	0.326
LIG_FHA_1	124	130	PF00498	0.435
LIG_FHA_1	137	143	PF00498	0.430
LIG_FHA_1	179	185	PF00498	0.565
LIG_FHA_2	133	139	PF00498	0.620
LIG_LIR_Gen_1	229	239	PF02991	0.509
LIG_LIR_Gen_1	41	48	PF02991	0.534
LIG_LIR_Nem_3	229	234	PF02991	0.502
LIG_LIR_Nem_3	41	47	PF02991	0.534
LIG_NRBOX	5	11	PF00104	0.534
LIG_PDZ_Class_2	234	239	PF00595	0.511
LIG_Pex14_2	67	71	PF04695	0.440
LIG_SH2_SRC	148	151	PF00017	0.419
LIG_SH2_STAT5	148	151	PF00017	0.572
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.478
LIG_TRAF2_1	169	172	PF00917	0.596
LIG_TRAF2_1	189	192	PF00917	0.453
LIG_UBA3_1	25	30	PF00899	0.474
MOD_CK1_1	109	115	PF00069	0.468
MOD_CK1_1	46	52	PF00069	0.583
MOD_CK2_1	109	115	PF00069	0.530
MOD_CK2_1	166	172	PF00069	0.469
MOD_CK2_1	186	192	PF00069	0.458
MOD_Cter_Amidation	92	95	PF01082	0.334
MOD_GSK3_1	132	139	PF00069	0.551
MOD_GSK3_1	166	173	PF00069	0.432
MOD_GSK3_1	43	50	PF00069	0.534
MOD_NEK2_1	216	221	PF00069	0.626
MOD_NEK2_2	223	228	PF00069	0.456
MOD_PIKK_1	136	142	PF00454	0.466
MOD_PIKK_1	166	172	PF00454	0.560
MOD_PIKK_1	178	184	PF00454	0.511
MOD_PKA_1	166	172	PF00069	0.433
MOD_PKA_2	166	172	PF00069	0.620
MOD_PKA_2	178	184	PF00069	0.519
MOD_PKA_2	223	229	PF00069	0.452
MOD_SUMO_rev_2	75	85	PF00179	0.474
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.434
TRG_ENDOCYTIC_2	231	234	PF00928	0.495
TRG_ER_diArg_1	183	186	PF00400	0.488
TRG_NLS_MonoExtC_3	219	224	PF00514	0.491
TRG_NLS_MonoExtN_4	217	224	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE4	Leptomonas seymouri	72%	100%
A0A0S4JJR8	Bodo saltans	29%	85%
A0A1X0P0A6	Trypanosomatidae	50%	100%
A0A3S7WU78	Leishmania donovani	96%	100%
A0A422NE48	Trypanosoma rangeli	50%	100%
A4H8U1	Leishmania braziliensis	91%	100%
A4HX61	Leishmania infantum	96%	100%
C9ZVT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	81%
E9AQX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BSA7	Trypanosoma cruzi	49%	100%