Clu domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Clustered mitochondria, putative

Species:

Leishmania major

UniProt:

Q4QEK0_LEIMA

TriTrypDb:

LmjF.16.1650 , LMJLV39_160023400 , LMJSD75_160023100

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEK0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0071840	cellular component organization or biogenesis	2	9

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003743	translation initiation factor activity	4	1
GO:0005488	binding	1	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.598
CLV_MEL_PAP_1	378	384	PF00089	0.559
CLV_NRD_NRD_1	241	243	PF00675	0.555
CLV_NRD_NRD_1	371	373	PF00675	0.486
CLV_NRD_NRD_1	503	505	PF00675	0.529
CLV_NRD_NRD_1	588	590	PF00675	0.383
CLV_PCSK_KEX2_1	209	211	PF00082	0.433
CLV_PCSK_KEX2_1	241	243	PF00082	0.545
CLV_PCSK_KEX2_1	314	316	PF00082	0.492
CLV_PCSK_KEX2_1	371	373	PF00082	0.488
CLV_PCSK_KEX2_1	380	382	PF00082	0.434
CLV_PCSK_KEX2_1	648	650	PF00082	0.542
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.433
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.502
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.506
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.542
CLV_PCSK_SKI1_1	104	108	PF00082	0.301
CLV_PCSK_SKI1_1	110	114	PF00082	0.301
CLV_PCSK_SKI1_1	241	245	PF00082	0.566
CLV_PCSK_SKI1_1	301	305	PF00082	0.372
CLV_PCSK_SKI1_1	332	336	PF00082	0.516
CLV_PCSK_SKI1_1	345	349	PF00082	0.370
CLV_PCSK_SKI1_1	375	379	PF00082	0.496
CLV_PCSK_SKI1_1	450	454	PF00082	0.440
CLV_PCSK_SKI1_1	492	496	PF00082	0.479
CLV_PCSK_SKI1_1	61	65	PF00082	0.337
CLV_PCSK_SKI1_1	75	79	PF00082	0.308
CLV_PCSK_SKI1_1	83	87	PF00082	0.335
DEG_APCC_DBOX_1	109	117	PF00400	0.510
DEG_Nend_UBRbox_2	1	3	PF02207	0.528
DOC_ANK_TNKS_1	87	94	PF00023	0.598
DOC_CKS1_1	166	171	PF01111	0.534
DOC_CYCLIN_RxL_1	488	499	PF00134	0.497
DOC_CYCLIN_RxL_1	71	82	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	231	237	PF00134	0.462
DOC_MAPK_gen_1	209	216	PF00069	0.456
DOC_MAPK_gen_1	301	311	PF00069	0.358
DOC_MAPK_gen_1	314	320	PF00069	0.505
DOC_MAPK_gen_1	380	388	PF00069	0.479
DOC_MAPK_gen_1	473	481	PF00069	0.446
DOC_MAPK_gen_1	526	533	PF00069	0.434
DOC_MAPK_gen_1	589	596	PF00069	0.371
DOC_MAPK_gen_1	648	657	PF00069	0.510
DOC_MAPK_gen_1	659	667	PF00069	0.478
DOC_MAPK_JIP1_4	210	216	PF00069	0.594
DOC_MAPK_MEF2A_6	110	118	PF00069	0.525
DOC_MAPK_MEF2A_6	488	495	PF00069	0.483
DOC_MAPK_NFAT4_5	488	496	PF00069	0.490
DOC_PP1_RVXF_1	399	406	PF00149	0.578
DOC_PP1_RVXF_1	490	496	PF00149	0.484
DOC_PP2B_LxvP_1	114	117	PF13499	0.501
DOC_USP7_MATH_1	117	121	PF00917	0.560
DOC_USP7_MATH_1	334	338	PF00917	0.588
DOC_USP7_MATH_1	678	682	PF00917	0.565
DOC_WW_Pin1_4	124	129	PF00397	0.536
DOC_WW_Pin1_4	165	170	PF00397	0.524
DOC_WW_Pin1_4	411	416	PF00397	0.502
LIG_14-3-3_CanoR_1	253	262	PF00244	0.465
LIG_14-3-3_CanoR_1	431	441	PF00244	0.458
LIG_14-3-3_CanoR_1	492	498	PF00244	0.514
LIG_14-3-3_CanoR_1	566	574	PF00244	0.458
LIG_14-3-3_CanoR_1	61	66	PF00244	0.598
LIG_14-3-3_CanoR_1	649	657	PF00244	0.479
LIG_14-3-3_CanoR_1	659	668	PF00244	0.469
LIG_14-3-3_CanoR_1	94	100	PF00244	0.578
LIG_Actin_WH2_2	257	272	PF00022	0.378
LIG_Actin_WH2_2	316	334	PF00022	0.490
LIG_APCC_ABBA_1	142	147	PF00400	0.597
LIG_APCC_ABBAyCdc20_2	332	338	PF00400	0.550
LIG_APCC_ABBAyCdc20_2	350	356	PF00400	0.307
LIG_BIR_III_4	545	549	PF00653	0.318
LIG_FHA_1	113	119	PF00498	0.506
LIG_FHA_1	125	131	PF00498	0.512
LIG_FHA_1	193	199	PF00498	0.504
LIG_FHA_1	225	231	PF00498	0.545
LIG_FHA_1	289	295	PF00498	0.435
LIG_FHA_1	31	37	PF00498	0.560
LIG_FHA_1	412	418	PF00498	0.555
LIG_FHA_1	421	427	PF00498	0.412
LIG_FHA_1	509	515	PF00498	0.471
LIG_FHA_1	615	621	PF00498	0.465
LIG_FHA_1	635	641	PF00498	0.214
LIG_FHA_1	662	668	PF00498	0.495
LIG_FHA_1	9	15	PF00498	0.492
LIG_FHA_2	221	227	PF00498	0.582
LIG_FHA_2	244	250	PF00498	0.515
LIG_FHA_2	395	401	PF00498	0.502
LIG_FHA_2	465	471	PF00498	0.569
LIG_FHA_2	651	657	PF00498	0.625
LIG_GBD_Chelix_1	99	107	PF00786	0.360
LIG_LIR_Gen_1	306	316	PF02991	0.434
LIG_LIR_Gen_1	340	351	PF02991	0.466
LIG_LIR_Gen_1	489	497	PF02991	0.451
LIG_LIR_Gen_1	569	579	PF02991	0.450
LIG_LIR_Nem_3	177	182	PF02991	0.382
LIG_LIR_Nem_3	258	264	PF02991	0.495
LIG_LIR_Nem_3	306	311	PF02991	0.389
LIG_LIR_Nem_3	340	346	PF02991	0.444
LIG_LIR_Nem_3	427	433	PF02991	0.513
LIG_LIR_Nem_3	489	493	PF02991	0.447
LIG_LIR_Nem_3	569	575	PF02991	0.409
LIG_LIR_Nem_3	674	679	PF02991	0.549
LIG_LYPXL_SIV_4	506	514	PF13949	0.513
LIG_PAM2_1	10	22	PF00658	0.481
LIG_Pex14_1	19	23	PF04695	0.501
LIG_SH2_CRK	430	434	PF00017	0.526
LIG_SH2_CRK	507	511	PF00017	0.487
LIG_SH2_CRK	87	91	PF00017	0.598
LIG_SH2_NCK_1	507	511	PF00017	0.515
LIG_SH2_SRC	351	354	PF00017	0.499
LIG_SH2_SRC	633	636	PF00017	0.427
LIG_SH2_STAP1	327	331	PF00017	0.485
LIG_SH2_STAP1	517	521	PF00017	0.368
LIG_SH2_STAT3	285	288	PF00017	0.485
LIG_SH2_STAT3	445	448	PF00017	0.476
LIG_SH2_STAT5	187	190	PF00017	0.375
LIG_SH2_STAT5	440	443	PF00017	0.550
LIG_SH2_STAT5	5	8	PF00017	0.480
LIG_SH2_STAT5	574	577	PF00017	0.406
LIG_SH2_STAT5	605	608	PF00017	0.454
LIG_SH2_STAT5	615	618	PF00017	0.312
LIG_SH2_STAT5	619	622	PF00017	0.274
LIG_SH2_STAT5	679	682	PF00017	0.467
LIG_SH3_3	401	407	PF00018	0.514
LIG_SH3_3	606	612	PF00018	0.476
LIG_SH3_3	64	70	PF00018	0.598
LIG_SH3_3	667	673	PF00018	0.479
LIG_SUMO_SIM_anti_2	158	164	PF11976	0.502
LIG_SUMO_SIM_anti_2	225	232	PF11976	0.461
LIG_SUMO_SIM_par_1	194	201	PF11976	0.587
LIG_SUMO_SIM_par_1	291	297	PF11976	0.460
LIG_SUMO_SIM_par_1	662	669	PF11976	0.475
LIG_TRAF2_1	50	53	PF00917	0.583
LIG_TRFH_1	87	91	PF08558	0.431
LIG_TYR_ITIM	85	90	PF00017	0.598
MOD_CDK_SPK_2	411	416	PF00069	0.409
MOD_CK1_1	10	16	PF00069	0.535
MOD_CK1_1	432	438	PF00069	0.489
MOD_CK1_1	480	486	PF00069	0.407
MOD_CK1_1	564	570	PF00069	0.476
MOD_CK1_1	666	672	PF00069	0.538
MOD_CK1_1	681	687	PF00069	0.499
MOD_CK1_1	95	101	PF00069	0.548
MOD_CK2_1	394	400	PF00069	0.544
MOD_CK2_1	464	470	PF00069	0.510
MOD_CK2_1	509	515	PF00069	0.434
MOD_GlcNHglycan	110	113	PF01048	0.301
MOD_GlcNHglycan	375	378	PF01048	0.562
MOD_GlcNHglycan	389	392	PF01048	0.527
MOD_GlcNHglycan	540	543	PF01048	0.550
MOD_GlcNHglycan	568	571	PF01048	0.398
MOD_GlcNHglycan	590	593	PF01048	0.556
MOD_GlcNHglycan	680	683	PF01048	0.525
MOD_GlcNHglycan	685	688	PF01048	0.544
MOD_GlcNHglycan	94	97	PF01048	0.301
MOD_GSK3_1	108	115	PF00069	0.515
MOD_GSK3_1	188	195	PF00069	0.400
MOD_GSK3_1	220	227	PF00069	0.589
MOD_GSK3_1	418	425	PF00069	0.525
MOD_GSK3_1	561	568	PF00069	0.440
MOD_GSK3_1	634	641	PF00069	0.468
MOD_GSK3_1	659	666	PF00069	0.527
MOD_N-GLC_1	191	196	PF02516	0.410
MOD_N-GLC_2	265	267	PF02516	0.420
MOD_N-GLC_2	324	326	PF02516	0.499
MOD_NEK2_1	186	191	PF00069	0.443
MOD_NEK2_1	198	203	PF00069	0.506
MOD_NEK2_1	255	260	PF00069	0.440
MOD_NEK2_1	29	34	PF00069	0.536
MOD_NEK2_1	299	304	PF00069	0.394
MOD_NEK2_1	363	368	PF00069	0.454
MOD_NEK2_1	429	434	PF00069	0.544
MOD_NEK2_1	464	469	PF00069	0.458
MOD_NEK2_1	493	498	PF00069	0.507
MOD_NEK2_1	509	514	PF00069	0.491
MOD_NEK2_1	538	543	PF00069	0.458
MOD_NEK2_1	565	570	PF00069	0.478
MOD_NEK2_1	604	609	PF00069	0.548
MOD_NEK2_2	477	482	PF00069	0.583
MOD_OFUCOSY	217	224	PF10250	0.570
MOD_OFUCOSY	418	424	PF10250	0.321
MOD_PIKK_1	634	640	PF00454	0.451
MOD_PIKK_1	647	653	PF00454	0.524
MOD_PKA_1	380	386	PF00069	0.479
MOD_PKA_2	380	386	PF00069	0.527
MOD_PKA_2	565	571	PF00069	0.476
MOD_PKA_2	588	594	PF00069	0.376
MOD_PKB_1	659	667	PF00069	0.374
MOD_Plk_1	191	197	PF00069	0.422
MOD_Plk_1	198	204	PF00069	0.547
MOD_Plk_1	224	230	PF00069	0.582
MOD_Plk_1	30	36	PF00069	0.560
MOD_Plk_1	399	405	PF00069	0.558
MOD_Plk_1	477	483	PF00069	0.590
MOD_Plk_1	634	640	PF00069	0.473
MOD_Plk_4	117	123	PF00069	0.551
MOD_Plk_4	198	204	PF00069	0.591
MOD_Plk_4	226	232	PF00069	0.473
MOD_Plk_4	363	369	PF00069	0.468
MOD_Plk_4	509	515	PF00069	0.446
MOD_ProDKin_1	124	130	PF00069	0.536
MOD_ProDKin_1	165	171	PF00069	0.527
MOD_ProDKin_1	411	417	PF00069	0.500
MOD_SUMO_for_1	303	306	PF00179	0.381
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.317
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.461
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.431
TRG_ENDOCYTIC_2	179	182	PF00928	0.387
TRG_ENDOCYTIC_2	308	311	PF00928	0.395
TRG_ENDOCYTIC_2	430	433	PF00928	0.514
TRG_ENDOCYTIC_2	476	479	PF00928	0.571
TRG_ENDOCYTIC_2	507	510	PF00928	0.527
TRG_ENDOCYTIC_2	87	90	PF00928	0.579
TRG_ER_diArg_1	240	242	PF00400	0.462
TRG_ER_diArg_1	370	372	PF00400	0.555
TRG_ER_diArg_1	473	476	PF00400	0.528
TRG_ER_diArg_1	582	585	PF00400	0.532
TRG_NES_CRM1_1	297	310	PF08389	0.387
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR4	Leptomonas seymouri	64%	98%
A0A1X0NZ67	Trypanosomatidae	40%	98%
A0A3S7WUD5	Leishmania donovani	93%	100%
A4H8U2	Leishmania braziliensis	77%	100%
A4HX63	Leishmania infantum	93%	100%
E9AQX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BI85	Trypanosoma cruzi	34%	100%