Ceramidase

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Ceramidase

Gene product:

Protein of unknown function (DUF3522), putative

Species:

Leishmania major

UniProt:

Q4QEJ7_LEIMA

TriTrypDb:

LmjF.17.0020 , LMJLV39_170005200 , LMJSD75_170005300

Length:

221

Annotations

LeishMANIAdb annotations

Very distantly similar to animal TMEM8 and MMD2 proteins. Its function is obscure, although gene fusions with lipid hydrolases suggest a related function

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 20
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	22
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

Q4QEJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	210	212	PF00675	0.499
CLV_NRD_NRD_1	30	32	PF00675	0.299
CLV_PCSK_KEX2_1	210	212	PF00082	0.521
CLV_PCSK_KEX2_1	30	32	PF00082	0.283
CLV_PCSK_SKI1_1	32	36	PF00082	0.328
DEG_Nend_Nbox_1	1	3	PF02207	0.439
DEG_SCF_FBW7_1	196	203	PF00400	0.557
DOC_CKS1_1	197	202	PF01111	0.563
DOC_MAPK_DCC_7	118	126	PF00069	0.356
DOC_MAPK_MEF2A_6	118	127	PF00069	0.363
DOC_PP4_FxxP_1	89	92	PF00568	0.512
DOC_SPAK_OSR1_1	118	122	PF12202	0.343
DOC_WW_Pin1_4	119	124	PF00397	0.414
DOC_WW_Pin1_4	196	201	PF00397	0.540
LIG_14-3-3_CanoR_1	118	122	PF00244	0.335
LIG_BRCT_BRCA1_1	188	192	PF00533	0.380
LIG_BRCT_BRCA1_1	40	44	PF00533	0.421
LIG_FHA_1	104	110	PF00498	0.342
LIG_FHA_1	11	17	PF00498	0.341
LIG_IBAR_NPY_1	91	93	PF08397	0.428
LIG_Integrin_RGD_1	216	218	PF01839	0.451
LIG_LIR_Gen_1	64	75	PF02991	0.260
LIG_LIR_LC3C_4	106	109	PF02991	0.328
LIG_LIR_Nem_3	128	133	PF02991	0.380
LIG_LIR_Nem_3	173	178	PF02991	0.276
LIG_LIR_Nem_3	41	45	PF02991	0.361
LIG_LIR_Nem_3	64	70	PF02991	0.255
LIG_MLH1_MIPbox_1	188	192	PF16413	0.380
LIG_PDZ_Class_1	216	221	PF00595	0.623
LIG_Pex14_1	115	119	PF04695	0.267
LIG_Pex14_2	101	105	PF04695	0.345
LIG_Pex14_2	126	130	PF04695	0.284
LIG_Pex14_2	155	159	PF04695	0.408
LIG_Pex14_2	44	48	PF04695	0.466
LIG_REV1ctd_RIR_1	25	36	PF16727	0.394
LIG_SH2_PTP2	83	86	PF00017	0.328
LIG_SH2_PTP2	93	96	PF00017	0.467
LIG_SH2_SRC	93	96	PF00017	0.381
LIG_SH2_STAT3	206	209	PF00017	0.572
LIG_SH2_STAT5	33	36	PF00017	0.481
LIG_SH2_STAT5	83	86	PF00017	0.381
LIG_SH2_STAT5	93	96	PF00017	0.469
LIG_SH3_3	194	200	PF00018	0.372
LIG_SUMO_SIM_anti_2	17	24	PF11976	0.342
LIG_TRFH_1	127	131	PF08558	0.464
LIG_TYR_ITIM	81	86	PF00017	0.462
LIG_UBA3_1	103	112	PF00899	0.359
LIG_UBA3_1	125	134	PF00899	0.415
LIG_UBA3_1	162	170	PF00899	0.378
LIG_WRC_WIRS_1	188	193	PF05994	0.391
LIG_WRC_WIRS_1	45	50	PF05994	0.357
MOD_CK1_1	55	61	PF00069	0.291
MOD_GlcNHglycan	145	148	PF01048	0.259
MOD_GlcNHglycan	5	9	PF01048	0.458
MOD_GSK3_1	10	17	PF00069	0.323
MOD_GSK3_1	196	203	PF00069	0.508
MOD_GSK3_1	52	59	PF00069	0.330
MOD_NEK2_1	10	15	PF00069	0.377
MOD_NEK2_1	125	130	PF00069	0.443
MOD_NEK2_1	44	49	PF00069	0.320
MOD_NEK2_1	56	61	PF00069	0.312
MOD_NEK2_2	187	192	PF00069	0.367
MOD_PKA_2	117	123	PF00069	0.372
MOD_Plk_4	11	17	PF00069	0.304
MOD_Plk_4	187	193	PF00069	0.286
MOD_Plk_4	44	50	PF00069	0.328
MOD_Plk_4	56	62	PF00069	0.279
MOD_ProDKin_1	119	125	PF00069	0.414
MOD_ProDKin_1	196	202	PF00069	0.537
TRG_ENDOCYTIC_2	83	86	PF00928	0.431
TRG_ENDOCYTIC_2	93	96	PF00928	0.469
TRG_ER_diArg_1	29	31	PF00400	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L8	Leptomonas seymouri	34%	98%
A0A0N1IHQ2	Leptomonas seymouri	56%	100%
A0A0S4J3W8	Bodo saltans	40%	98%
A0A0S4J4A1	Bodo saltans	42%	100%
A0A1X0NUH8	Trypanosomatidae	38%	100%
A0A1X0NUR6	Trypanosomatidae	45%	100%
A0A3Q8ICP7	Leishmania donovani	94%	100%
A0A3R7NKX5	Trypanosoma rangeli	44%	100%
A0A3S5H6Z5	Leishmania donovani	33%	98%
A4H8U8	Leishmania braziliensis	71%	100%
A4HX66	Leishmania infantum	94%	100%
A4HX67	Leishmania infantum	33%	98%
C9ZTT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZTT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZTT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ARC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9ARC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	98%
Q4QEJ6	Leishmania major	34%	100%
V5ASR1	Trypanosoma cruzi	43%	100%
V5BCQ2	Trypanosoma cruzi	37%	100%