Monocyte to macrophage differentiation factor 2

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3522), putative

Species:

Leishmania major

UniProt:

Q4QEJ6_LEIMA

TriTrypDb:

LmjF.17.0025 , LMJLV39_170005300 , LMJSD75_170005400

Length:

225

Annotations

LeishMANIAdb annotations

Very distantly similar to animal TMEM8 and MMD2 proteins. Its function is obscure, although gene fusions with lipid hydrolases suggest a related function

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 20
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	22
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

Q4QEJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.283
CLV_NRD_NRD_1	204	206	PF00675	0.430
CLV_NRD_NRD_1	207	209	PF00675	0.459
CLV_NRD_NRD_1	32	34	PF00675	0.281
CLV_PCSK_FUR_1	205	209	PF00082	0.327
CLV_PCSK_KEX2_1	142	144	PF00082	0.268
CLV_PCSK_KEX2_1	206	208	PF00082	0.476
CLV_PCSK_KEX2_1	32	34	PF00082	0.264
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.468
CLV_PCSK_SKI1_1	9	13	PF00082	0.418
CLV_PCSK_SKI1_1	94	98	PF00082	0.242
DEG_APCC_DBOX_1	93	101	PF00400	0.418
DOC_CYCLIN_RxL_1	205	216	PF00134	0.539
DOC_MAPK_DCC_7	120	128	PF00069	0.346
DOC_MAPK_gen_1	205	212	PF00069	0.648
DOC_MAPK_MEF2A_6	120	128	PF00069	0.355
DOC_MAPK_RevD_3	128	143	PF00069	0.450
DOC_PP1_RVXF_1	31	38	PF00149	0.418
DOC_PP2B_LxvP_1	210	213	PF13499	0.675
DOC_PP4_FxxP_1	147	150	PF00568	0.576
DOC_USP7_MATH_1	133	137	PF00917	0.337
DOC_USP7_MATH_1	5	9	PF00917	0.396
DOC_USP7_MATH_1	77	81	PF00917	0.309
LIG_14-3-3_CanoR_1	205	211	PF00244	0.630
LIG_Actin_WH2_2	185	202	PF00022	0.232
LIG_BIR_II_1	1	5	PF00653	0.448
LIG_FHA_1	13	19	PF00498	0.315
LIG_FHA_1	187	193	PF00498	0.474
LIG_FHA_1	45	51	PF00498	0.230
LIG_LIR_Gen_1	118	128	PF02991	0.242
LIG_LIR_Gen_1	7	18	PF02991	0.222
LIG_LIR_Nem_3	118	124	PF02991	0.203
LIG_LIR_Nem_3	191	197	PF02991	0.321
LIG_LIR_Nem_3	34	40	PF02991	0.493
LIG_LIR_Nem_3	7	13	PF02991	0.222
LIG_LIR_Nem_3	98	102	PF02991	0.258
LIG_PCNA_PIPBox_1	23	32	PF02747	0.465
LIG_PDZ_Class_2	220	225	PF00595	0.616
LIG_Pex14_1	117	121	PF04695	0.249
LIG_Rb_LxCxE_1	84	98	PF01857	0.335
LIG_SH2_CRK	121	125	PF00017	0.273
LIG_SH2_NCK_1	121	125	PF00017	0.282
LIG_SH2_PTP2	102	105	PF00017	0.274
LIG_SH2_STAP1	10	14	PF00017	0.457
LIG_SH2_STAP1	44	48	PF00017	0.296
LIG_SH2_STAT5	121	124	PF00017	0.285
LIG_SH2_STAT5	99	102	PF00017	0.294
LIG_SUMO_SIM_anti_2	216	223	PF11976	0.598
LIG_SUMO_SIM_anti_2	47	52	PF11976	0.183
LIG_SUMO_SIM_par_1	107	113	PF11976	0.307
LIG_TRFH_1	197	201	PF08558	0.280
LIG_TYR_ITIM	100	105	PF00017	0.307
LIG_TYR_ITIM	119	124	PF00017	0.161
MOD_GlcNHglycan	201	204	PF01048	0.435
MOD_GSK3_1	12	19	PF00069	0.319
MOD_GSK3_1	42	49	PF00069	0.431
MOD_GSK3_1	58	65	PF00069	0.349
MOD_GSK3_1	77	84	PF00069	0.173
MOD_NEK2_1	12	17	PF00069	0.353
MOD_NEK2_1	58	63	PF00069	0.287
MOD_PIKK_1	62	68	PF00454	0.171
MOD_PKA_1	206	212	PF00069	0.676
MOD_PKA_2	119	125	PF00069	0.372
MOD_PKA_2	199	205	PF00069	0.642
MOD_PKA_2	206	212	PF00069	0.665
MOD_Plk_1	58	64	PF00069	0.325
MOD_Plk_4	119	125	PF00069	0.236
MOD_Plk_4	46	52	PF00069	0.312
MOD_Plk_4	58	64	PF00069	0.279
MOD_SUMO_rev_2	6	11	PF00179	0.283
TRG_DiLeu_BaEn_1	92	97	PF01217	0.531
TRG_DiLeu_BaEn_2	58	64	PF01217	0.218
TRG_ENDOCYTIC_2	10	13	PF00928	0.465
TRG_ENDOCYTIC_2	102	105	PF00928	0.276
TRG_ENDOCYTIC_2	121	124	PF00928	0.181
TRG_ENDOCYTIC_2	180	183	PF00928	0.233
TRG_ER_diArg_1	141	144	PF00400	0.485
TRG_ER_diArg_1	205	208	PF00400	0.607
TRG_ER_diArg_1	31	33	PF00400	0.481
TRG_NES_CRM1_1	98	113	PF08389	0.420
TRG_NLS_MonoExtN_4	205	210	PF00514	0.541
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L8	Leptomonas seymouri	59%	100%
A0A0N1IHQ2	Leptomonas seymouri	36%	100%
A0A0S4J3W8	Bodo saltans	36%	100%
A0A0S4J4A1	Bodo saltans	36%	100%
A0A1X0NUH8	Trypanosomatidae	41%	100%
A0A1X0NUR6	Trypanosomatidae	35%	100%
A0A3Q8ICP7	Leishmania donovani	34%	100%
A0A3R7NKX5	Trypanosoma rangeli	33%	100%
A0A3S5H6Z5	Leishmania donovani	96%	100%
A4H8U8	Leishmania braziliensis	34%	100%
A4HX66	Leishmania infantum	34%	100%
A4HX67	Leishmania infantum	96%	100%
C9ZTT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZTT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZTT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ARC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ARC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QEJ7	Leishmania major	34%	100%
V5ASR1	Trypanosoma cruzi	33%	100%
V5BCQ2	Trypanosoma cruzi	40%	100%