LeishMANIAdb
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Monocyte to macrophage differentiation factor 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Monocyte to macrophage differentiation factor 2
Gene product:
Protein of unknown function (DUF3522), putative
Species:
Leishmania major
UniProt:
Q4QEJ6_LEIMA
TriTrypDb:
LmjF.17.0025 , LMJLV39_170005300 , LMJSD75_170005400
Length:
225

Annotations

LeishMANIAdb annotations

Very distantly similar to animal TMEM8 and MMD2 proteins. Its function is obscure, although gene fusions with lipid hydrolases suggest a related function

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 20
NetGPI no yes: 0, no: 21
Cellular components
TermNameLevelCount
GO:0005886 plasma membrane 3 22
GO:0016020 membrane 2 22
GO:0110165 cellular anatomical entity 1 22
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Expansion

Sequence features

Q4QEJ6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEJ6

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 143 145 PF00675 0.283
CLV_NRD_NRD_1 204 206 PF00675 0.430
CLV_NRD_NRD_1 207 209 PF00675 0.459
CLV_NRD_NRD_1 32 34 PF00675 0.281
CLV_PCSK_FUR_1 205 209 PF00082 0.327
CLV_PCSK_KEX2_1 142 144 PF00082 0.268
CLV_PCSK_KEX2_1 206 208 PF00082 0.476
CLV_PCSK_KEX2_1 32 34 PF00082 0.264
CLV_PCSK_PC1ET2_1 206 208 PF00082 0.468
CLV_PCSK_SKI1_1 9 13 PF00082 0.418
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I1L8 Leptomonas seymouri 59% 100%
A0A0N1IHQ2 Leptomonas seymouri 36% 100%
A0A0S4J3W8 Bodo saltans 36% 100%
A0A0S4J4A1 Bodo saltans 36% 100%
A0A1X0NUH8 Trypanosomatidae 41% 100%
A0A1X0NUR6 Trypanosomatidae 35% 100%
A0A3Q8ICP7 Leishmania donovani 34% 100%
A0A3R7NKX5 Trypanosoma rangeli 33% 100%
A0A3S5H6Z5 Leishmania donovani 96% 100%
A4H8U8 Leishmania braziliensis 34% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS