RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QEJ5_LEIMA

TriTrypDb:

LmjF.17.0030 , LMJLV39_170005400 , LMJSD75_170005500

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEJ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.568
CLV_NRD_NRD_1	145	147	PF00675	0.606
CLV_NRD_NRD_1	206	208	PF00675	0.540
CLV_PCSK_FUR_1	139	143	PF00082	0.618
CLV_PCSK_KEX2_1	141	143	PF00082	0.557
CLV_PCSK_SKI1_1	158	162	PF00082	0.609
DEG_Nend_Nbox_1	1	3	PF02207	0.624
DEG_SCF_FBW7_1	161	167	PF00400	0.534
DOC_CKS1_1	161	166	PF01111	0.732
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.411
DOC_PP4_FxxP_1	3	6	PF00568	0.601
DOC_USP7_MATH_1	164	168	PF00917	0.607
DOC_USP7_MATH_1	36	40	PF00917	0.685
DOC_USP7_MATH_1	44	48	PF00917	0.564
DOC_USP7_MATH_1	6	10	PF00917	0.496
DOC_WW_Pin1_4	160	165	PF00397	0.732
DOC_WW_Pin1_4	2	7	PF00397	0.609
LIG_14-3-3_CanoR_1	112	118	PF00244	0.411
LIG_14-3-3_CanoR_1	131	138	PF00244	0.687
LIG_FHA_1	68	74	PF00498	0.578
LIG_FHA_1	78	84	PF00498	0.411
LIG_Rb_LxCxE_1	100	116	PF01857	0.411
LIG_SH2_GRB2like	58	61	PF00017	0.719
LIG_SH2_STAT5	2	5	PF00017	0.612
LIG_SH2_STAT5	58	61	PF00017	0.719
LIG_SH3_1	146	152	PF00018	0.538
LIG_SH3_2	149	154	PF14604	0.541
LIG_SH3_3	146	152	PF00018	0.655
LIG_SUMO_SIM_anti_2	184	191	PF11976	0.697
LIG_SUMO_SIM_par_1	188	194	PF11976	0.649
MOD_CK1_1	39	45	PF00069	0.683
MOD_CK2_1	11	17	PF00069	0.519
MOD_CK2_1	170	176	PF00069	0.655
MOD_GlcNHglycan	193	196	PF01048	0.518
MOD_GSK3_1	160	167	PF00069	0.613
MOD_GSK3_1	191	198	PF00069	0.606
MOD_GSK3_1	2	9	PF00069	0.609
MOD_GSK3_1	44	51	PF00069	0.647
MOD_N-GLC_1	53	58	PF02516	0.625
MOD_NEK2_2	195	200	PF00069	0.490
MOD_PIKK_1	11	17	PF00454	0.743
MOD_PIKK_1	164	170	PF00454	0.527
MOD_PKA_2	113	119	PF00069	0.411
MOD_PKA_2	21	27	PF00069	0.667
MOD_Plk_1	60	66	PF00069	0.627
MOD_Plk_2-3	178	184	PF00069	0.772
MOD_Plk_2-3	67	73	PF00069	0.693
MOD_Plk_2-3	86	92	PF00069	0.411
MOD_Plk_4	21	27	PF00069	0.697
MOD_Plk_4	60	66	PF00069	0.651
MOD_ProDKin_1	160	166	PF00069	0.731
MOD_ProDKin_1	2	8	PF00069	0.609
MOD_SUMO_for_1	97	100	PF00179	0.411
TRG_DiLeu_BaEn_1	157	162	PF01217	0.670
TRG_ER_diArg_1	111	114	PF00400	0.411
TRG_ER_diArg_1	138	141	PF00400	0.554
TRG_ER_diArg_1	142	144	PF00400	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S1	Leptomonas seymouri	61%	100%
A0A3S7WU93	Leishmania donovani	91%	100%
A4H8U9	Leishmania braziliensis	74%	100%
A4HX68	Leishmania infantum	90%	100%
E9ARC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%