J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QEJ4_LEIMA

TriTrypDb:

LmjF.17.0040 , LMJLV39_170005500 , LMJSD75_170005600

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	10
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QEJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.458
CLV_NRD_NRD_1	2	4	PF00675	0.515
CLV_NRD_NRD_1	219	221	PF00675	0.632
CLV_NRD_NRD_1	241	243	PF00675	0.695
CLV_NRD_NRD_1	259	261	PF00675	0.743
CLV_NRD_NRD_1	56	58	PF00675	0.431
CLV_PCSK_KEX2_1	164	166	PF00082	0.433
CLV_PCSK_KEX2_1	2	4	PF00082	0.514
CLV_PCSK_KEX2_1	221	223	PF00082	0.638
CLV_PCSK_KEX2_1	233	235	PF00082	0.621
CLV_PCSK_KEX2_1	241	243	PF00082	0.481
CLV_PCSK_KEX2_1	259	261	PF00082	0.692
CLV_PCSK_KEX2_1	55	57	PF00082	0.427
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.666
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.585
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.455
CLV_PCSK_SKI1_1	153	157	PF00082	0.401
CLV_PCSK_SKI1_1	23	27	PF00082	0.492
CLV_PCSK_SKI1_1	241	245	PF00082	0.628
CLV_PCSK_SKI1_1	43	47	PF00082	0.231
DEG_Nend_UBRbox_1	1	4	PF02207	0.749
DOC_AGCK_PIF_1	172	177	PF00069	0.378
DOC_CYCLIN_RxL_1	101	111	PF00134	0.562
DOC_CYCLIN_RxL_1	150	159	PF00134	0.622
DOC_CYCLIN_RxL_1	40	50	PF00134	0.637
DOC_MAPK_gen_1	101	109	PF00069	0.482
DOC_MAPK_gen_1	160	171	PF00069	0.682
DOC_MAPK_MEF2A_6	55	62	PF00069	0.677
DOC_PP1_RVXF_1	239	246	PF00149	0.428
DOC_PP1_RVXF_1	72	79	PF00149	0.664
DOC_PP4_FxxP_1	202	205	PF00568	0.409
DOC_USP7_MATH_1	41	45	PF00917	0.634
DOC_WW_Pin1_4	145	150	PF00397	0.644
DOC_WW_Pin1_4	47	52	PF00397	0.595
DOC_WW_Pin1_4	81	86	PF00397	0.546
LIG_14-3-3_CanoR_1	103	108	PF00244	0.562
LIG_14-3-3_CanoR_1	15	22	PF00244	0.725
LIG_14-3-3_CanoR_1	2	10	PF00244	0.748
LIG_Actin_WH2_2	148	166	PF00022	0.520
LIG_FHA_1	187	193	PF00498	0.405
LIG_FHA_1	24	30	PF00498	0.689
LIG_FHA_1	67	73	PF00498	0.649
LIG_FHA_2	109	115	PF00498	0.496
LIG_FHA_2	117	123	PF00498	0.496
LIG_FHA_2	62	68	PF00498	0.682
LIG_LIR_Gen_1	122	132	PF02991	0.484
LIG_LIR_Gen_1	174	185	PF02991	0.348
LIG_LIR_Gen_1	206	212	PF02991	0.380
LIG_LIR_Gen_1	44	54	PF02991	0.603
LIG_LIR_Nem_3	122	128	PF02991	0.484
LIG_LIR_Nem_3	204	210	PF02991	0.376
LIG_LIR_Nem_3	44	49	PF02991	0.604
LIG_NBox_RRM_1	175	185	PF00076	0.363
LIG_Pex14_2	203	207	PF04695	0.395
LIG_Pex14_2	245	249	PF04695	0.427
LIG_SH2_CRK	104	108	PF00017	0.562
LIG_SH2_CRK	125	129	PF00017	0.496
LIG_SH2_STAP1	177	181	PF00017	0.434
LIG_SUMO_SIM_par_1	188	193	PF11976	0.447
LIG_SUMO_SIM_par_1	38	44	PF11976	0.584
LIG_WRC_WIRS_1	172	177	PF05994	0.402
MOD_CK2_1	116	122	PF00069	0.586
MOD_CK2_1	61	67	PF00069	0.689
MOD_GlcNHglycan	6	9	PF01048	0.503
MOD_GSK3_1	108	115	PF00069	0.507
MOD_GSK3_1	116	123	PF00069	0.496
MOD_GSK3_1	186	193	PF00069	0.463
MOD_GSK3_1	41	48	PF00069	0.636
MOD_N-GLC_1	117	122	PF02516	0.330
MOD_NEK2_1	156	161	PF00069	0.613
MOD_NEK2_1	186	191	PF00069	0.449
MOD_NEK2_1	45	50	PF00069	0.588
MOD_NEK2_2	41	46	PF00069	0.643
MOD_PKA_1	2	8	PF00069	0.736
MOD_PKA_2	14	20	PF00069	0.711
MOD_PKA_2	156	162	PF00069	0.566
MOD_PKA_2	2	8	PF00069	0.736
MOD_PKB_1	101	109	PF00069	0.562
MOD_Plk_4	137	143	PF00069	0.531
MOD_Plk_4	186	192	PF00069	0.480
MOD_ProDKin_1	145	151	PF00069	0.639
MOD_ProDKin_1	47	53	PF00069	0.597
MOD_ProDKin_1	81	87	PF00069	0.551
MOD_SUMO_rev_2	215	223	PF00179	0.458
MOD_SUMO_rev_2	226	235	PF00179	0.386
TRG_DiLeu_BaEn_2	205	211	PF01217	0.393
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.427
TRG_ENDOCYTIC_2	104	107	PF00928	0.482
TRG_ENDOCYTIC_2	125	128	PF00928	0.471
TRG_ENDOCYTIC_2	177	180	PF00928	0.331
TRG_ENDOCYTIC_2	208	211	PF00928	0.374
TRG_ER_diArg_1	1	3	PF00400	0.720
TRG_ER_diArg_1	100	103	PF00400	0.482
TRG_ER_diArg_1	163	165	PF00400	0.663
TRG_ER_diArg_1	240	242	PF00400	0.510
TRG_ER_diArg_1	56	58	PF00400	0.614
TRG_NLS_MonoExtC_3	159	164	PF00514	0.670
TRG_NLS_MonoExtN_4	157	164	PF00514	0.653
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P361	Leptomonas seymouri	71%	100%
A0A0S4J092	Bodo saltans	47%	80%
A0A1X0NT05	Trypanosomatidae	61%	96%
A0A3Q8IJ96	Leishmania donovani	97%	100%
A0A3R7LVM9	Trypanosoma rangeli	56%	98%
A4H8V0	Leishmania braziliensis	83%	100%
A4HX69	Leishmania infantum	97%	100%
C9ZTU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	92%
E9ARC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%