RRM_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEJ3_LEIMA

TriTrypDb:

LmjF.17.0050 , LMJLV39_170005600 , LMJSD75_170005700

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEJ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.312
CLV_NRD_NRD_1	21	23	PF00675	0.517
CLV_NRD_NRD_1	227	229	PF00675	0.499
CLV_NRD_NRD_1	89	91	PF00675	0.464
CLV_NRD_NRD_1	98	100	PF00675	0.503
CLV_PCSK_KEX2_1	21	23	PF00082	0.511
CLV_PCSK_KEX2_1	227	229	PF00082	0.414
CLV_PCSK_KEX2_1	84	86	PF00082	0.406
CLV_PCSK_KEX2_1	88	90	PF00082	0.451
CLV_PCSK_KEX2_1	98	100	PF00082	0.499
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.433
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.350
CLV_PCSK_PC7_1	223	229	PF00082	0.441
CLV_PCSK_PC7_1	85	91	PF00082	0.513
CLV_PCSK_SKI1_1	100	104	PF00082	0.422
CLV_PCSK_SKI1_1	168	172	PF00082	0.563
CLV_PCSK_SKI1_1	211	215	PF00082	0.440
CLV_PCSK_SKI1_1	227	231	PF00082	0.377
CLV_PCSK_SKI1_1	59	63	PF00082	0.385
DEG_SCF_FBW7_1	108	115	PF00400	0.389
DOC_CYCLIN_RxL_1	18	29	PF00134	0.491
DOC_CYCLIN_RxL_1	97	106	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.400
DOC_MAPK_MEF2A_6	199	206	PF00069	0.407
DOC_PP1_RVXF_1	19	26	PF00149	0.457
DOC_PP2B_LxvP_1	30	33	PF13499	0.399
DOC_USP7_MATH_1	112	116	PF00917	0.407
DOC_USP7_MATH_1	179	183	PF00917	0.675
DOC_USP7_MATH_1	51	55	PF00917	0.351
DOC_USP7_UBL2_3	205	209	PF12436	0.384
DOC_WW_Pin1_4	108	113	PF00397	0.455
DOC_WW_Pin1_4	36	41	PF00397	0.326
LIG_14-3-3_CanoR_1	22	28	PF00244	0.525
LIG_14-3-3_CterR_2	232	236	PF00244	0.391
LIG_Actin_WH2_2	23	39	PF00022	0.326
LIG_BIR_III_4	189	193	PF00653	0.585
LIG_BRCT_BRCA1_1	53	57	PF00533	0.391
LIG_deltaCOP1_diTrp_1	46	56	PF00928	0.362
LIG_FHA_1	138	144	PF00498	0.566
LIG_FHA_2	120	126	PF00498	0.420
LIG_FHA_2	129	135	PF00498	0.370
LIG_FHA_2	179	185	PF00498	0.729
LIG_LIR_Gen_1	155	164	PF02991	0.425
LIG_LIR_Gen_1	46	57	PF02991	0.348
LIG_LIR_LC3C_4	12	15	PF02991	0.563
LIG_LIR_Nem_3	155	160	PF02991	0.527
LIG_LIR_Nem_3	39	45	PF02991	0.375
LIG_LIR_Nem_3	46	52	PF02991	0.382
LIG_LIR_Nem_3	54	60	PF02991	0.403
LIG_SH2_STAP1	45	49	PF00017	0.456
LIG_SH2_STAT3	45	48	PF00017	0.468
LIG_SUMO_SIM_anti_2	197	204	PF11976	0.356
LIG_WRC_WIRS_1	52	57	PF05994	0.385
MOD_CK2_1	128	134	PF00069	0.372
MOD_CK2_1	178	184	PF00069	0.669
MOD_CK2_1	204	210	PF00069	0.476
MOD_Cter_Amidation	19	22	PF01082	0.528
MOD_GlcNHglycan	105	108	PF01048	0.510
MOD_GlcNHglycan	112	115	PF01048	0.352
MOD_GlcNHglycan	181	184	PF01048	0.773
MOD_GlcNHglycan	63	66	PF01048	0.395
MOD_GSK3_1	108	115	PF00069	0.438
MOD_GSK3_1	116	123	PF00069	0.314
MOD_GSK3_1	175	182	PF00069	0.749
MOD_GSK3_1	32	39	PF00069	0.408
MOD_N-GLC_1	119	124	PF02516	0.372
MOD_NEK2_1	103	108	PF00069	0.498
MOD_NEK2_1	204	209	PF00069	0.452
MOD_NEK2_1	219	224	PF00069	0.354
MOD_NEK2_1	23	28	PF00069	0.423
MOD_NEK2_1	61	66	PF00069	0.493
MOD_Plk_1	119	125	PF00069	0.382
MOD_Plk_1	91	97	PF00069	0.456
MOD_Plk_2-3	191	197	PF00069	0.477
MOD_Plk_4	112	118	PF00069	0.464
MOD_Plk_4	51	57	PF00069	0.391
MOD_Plk_4	9	15	PF00069	0.496
MOD_Plk_4	91	97	PF00069	0.519
MOD_ProDKin_1	108	114	PF00069	0.453
MOD_ProDKin_1	36	42	PF00069	0.319
MOD_SUMO_rev_2	26	33	PF00179	0.481
TRG_DiLeu_BaEn_1	134	139	PF01217	0.493
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.401
TRG_ER_diArg_1	21	23	PF00400	0.552
TRG_ER_diArg_1	227	229	PF00400	0.414
TRG_ER_diArg_1	88	90	PF00400	0.474
TRG_ER_diArg_1	99	102	PF00400	0.476
TRG_NLS_Bipartite_1	84	103	PF00514	0.397
TRG_NLS_MonoCore_2	96	101	PF00514	0.433
TRG_NLS_MonoExtC_3	96	101	PF00514	0.397
TRG_NLS_MonoExtN_4	97	103	PF00514	0.425
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I083	Leptomonas seymouri	61%	96%
A0A1X0NT13	Trypanosomatidae	45%	96%
A0A3R7KLV2	Trypanosoma rangeli	47%	91%
A0A3S5H6Z6	Leishmania donovani	92%	100%
A4H8V1	Leishmania braziliensis	77%	100%
A4HX70	Leishmania infantum	93%	100%
C9ZTU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ARC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%