Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEH8_LEIMA

TriTrypDb:

LmjF.17.0100 , LMJLV39_170007200 , LMJSD75_170006900

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.693
CLV_C14_Caspase3-7	312	316	PF00656	0.748
CLV_C14_Caspase3-7	319	323	PF00656	0.555
CLV_C14_Caspase3-7	636	640	PF00656	0.630
CLV_C14_Caspase3-7	88	92	PF00656	0.559
CLV_MEL_PAP_1	121	127	PF00089	0.567
CLV_NRD_NRD_1	116	118	PF00675	0.500
CLV_NRD_NRD_1	176	178	PF00675	0.515
CLV_NRD_NRD_1	333	335	PF00675	0.667
CLV_NRD_NRD_1	402	404	PF00675	0.380
CLV_PCSK_KEX2_1	116	118	PF00082	0.500
CLV_PCSK_KEX2_1	176	178	PF00082	0.569
CLV_PCSK_KEX2_1	333	335	PF00082	0.667
CLV_PCSK_KEX2_1	402	404	PF00082	0.403
CLV_PCSK_KEX2_1	595	597	PF00082	0.743
CLV_PCSK_KEX2_1	630	632	PF00082	0.561
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.743
CLV_PCSK_PC1ET2_1	630	632	PF00082	0.561
CLV_PCSK_PC7_1	329	335	PF00082	0.455
CLV_PCSK_SKI1_1	247	251	PF00082	0.523
CLV_PCSK_SKI1_1	329	333	PF00082	0.687
CLV_PCSK_SKI1_1	631	635	PF00082	0.382
CLV_Separin_Metazoa	330	334	PF03568	0.452
DEG_APCC_DBOX_1	328	336	PF00400	0.641
DEG_SPOP_SBC_1	380	384	PF00917	0.695
DEG_SPOP_SBC_1	419	423	PF00917	0.717
DEG_SPOP_SBC_1	502	506	PF00917	0.540
DOC_CDC14_PxL_1	290	298	PF14671	0.575
DOC_MAPK_gen_1	231	238	PF00069	0.495
DOC_MAPK_HePTP_8	66	78	PF00069	0.554
DOC_MAPK_MEF2A_6	231	238	PF00069	0.512
DOC_MAPK_MEF2A_6	69	78	PF00069	0.527
DOC_PP2B_LxvP_1	468	471	PF13499	0.796
DOC_PP4_FxxP_1	613	616	PF00568	0.706
DOC_SPAK_OSR1_1	69	73	PF12202	0.398
DOC_USP7_MATH_1	11	15	PF00917	0.735
DOC_USP7_MATH_1	256	260	PF00917	0.527
DOC_USP7_MATH_1	30	34	PF00917	0.519
DOC_USP7_MATH_1	380	384	PF00917	0.693
DOC_USP7_MATH_1	420	424	PF00917	0.702
DOC_USP7_MATH_1	471	475	PF00917	0.795
DOC_USP7_MATH_1	50	54	PF00917	0.671
DOC_USP7_MATH_1	502	506	PF00917	0.620
DOC_USP7_MATH_1	93	97	PF00917	0.672
DOC_USP7_UBL2_3	568	572	PF12436	0.653
DOC_WW_Pin1_4	294	299	PF00397	0.529
DOC_WW_Pin1_4	408	413	PF00397	0.537
DOC_WW_Pin1_4	44	49	PF00397	0.639
LIG_14-3-3_CanoR_1	102	111	PF00244	0.629
LIG_14-3-3_CanoR_1	243	249	PF00244	0.443
LIG_14-3-3_CanoR_1	333	342	PF00244	0.593
LIG_14-3-3_CanoR_1	486	496	PF00244	0.702
LIG_14-3-3_CanoR_1	563	570	PF00244	0.514
LIG_14-3-3_CanoR_1	578	586	PF00244	0.474
LIG_14-3-3_CanoR_1	631	636	PF00244	0.395
LIG_BIR_III_4	542	546	PF00653	0.549
LIG_BIR_III_4	600	604	PF00653	0.554
LIG_BIR_III_4	91	95	PF00653	0.617
LIG_BRCT_BRCA1_1	351	355	PF00533	0.393
LIG_BRCT_BRCA1_1	621	625	PF00533	0.569
LIG_Clathr_ClatBox_1	226	230	PF01394	0.446
LIG_Clathr_ClatBox_1	632	636	PF01394	0.569
LIG_Dynein_DLC8_1	332	338	PF01221	0.531
LIG_EH1_1	435	443	PF00400	0.461
LIG_FHA_1	207	213	PF00498	0.398
LIG_FHA_1	411	417	PF00498	0.530
LIG_FHA_1	44	50	PF00498	0.678
LIG_FHA_1	463	469	PF00498	0.714
LIG_FHA_1	624	630	PF00498	0.469
LIG_FHA_2	134	140	PF00498	0.547
LIG_FHA_2	197	203	PF00498	0.660
LIG_FHA_2	548	554	PF00498	0.620
LIG_FHA_2	632	638	PF00498	0.428
LIG_LIR_Apic_2	610	616	PF02991	0.701
LIG_LIR_Gen_1	209	218	PF02991	0.550
LIG_LIR_Gen_1	359	368	PF02991	0.515
LIG_LIR_Gen_1	551	561	PF02991	0.620
LIG_LIR_Nem_3	123	128	PF02991	0.521
LIG_LIR_Nem_3	163	167	PF02991	0.386
LIG_LIR_Nem_3	173	178	PF02991	0.384
LIG_LIR_Nem_3	209	214	PF02991	0.537
LIG_LIR_Nem_3	219	223	PF02991	0.391
LIG_LIR_Nem_3	359	364	PF02991	0.511
LIG_LIR_Nem_3	551	557	PF02991	0.544
LIG_LIR_Nem_3	56	61	PF02991	0.538
LIG_LYPXL_yS_3	4	7	PF13949	0.682
LIG_MYND_1	294	298	PF01753	0.613
LIG_NRBOX	222	228	PF00104	0.490
LIG_PDZ_Class_2	635	640	PF00595	0.617
LIG_Pex14_1	619	623	PF04695	0.497
LIG_Rb_LxCxE_1	222	242	PF01857	0.499
LIG_REV1ctd_RIR_1	434	444	PF16727	0.543
LIG_SH2_CRK	64	68	PF00017	0.540
LIG_SH2_NCK_1	119	123	PF00017	0.571
LIG_SH2_PTP2	211	214	PF00017	0.394
LIG_SH2_SRC	35	38	PF00017	0.503
LIG_SH2_STAT5	167	170	PF00017	0.417
LIG_SH2_STAT5	211	214	PF00017	0.394
LIG_SH2_STAT5	35	38	PF00017	0.503
LIG_SH2_STAT5	404	407	PF00017	0.516
LIG_SH3_3	138	144	PF00018	0.655
LIG_SH3_3	266	272	PF00018	0.400
LIG_SH3_3	288	294	PF00018	0.452
LIG_SH3_3	56	62	PF00018	0.526
LIG_SUMO_SIM_par_1	631	637	PF11976	0.556
LIG_TRAF2_1	375	378	PF00917	0.520
LIG_TYR_ITIM	2	7	PF00017	0.574
LIG_TYR_ITIM	61	66	PF00017	0.606
LIG_Vh1_VBS_1	238	256	PF01044	0.354
MOD_CK1_1	15	21	PF00069	0.743
MOD_CK1_1	154	160	PF00069	0.668
MOD_CK1_1	242	248	PF00069	0.426
MOD_CK1_1	297	303	PF00069	0.667
MOD_CK1_1	340	346	PF00069	0.535
MOD_CK1_1	348	354	PF00069	0.418
MOD_CK1_1	381	387	PF00069	0.662
MOD_CK1_1	411	417	PF00069	0.686
MOD_CK1_1	423	429	PF00069	0.486
MOD_CK1_1	472	478	PF00069	0.754
MOD_CK1_1	491	497	PF00069	0.448
MOD_CK1_1	503	509	PF00069	0.415
MOD_CK1_1	511	517	PF00069	0.470
MOD_CK1_1	53	59	PF00069	0.623
MOD_CK1_1	585	591	PF00069	0.739
MOD_CK2_1	133	139	PF00069	0.569
MOD_CK2_1	547	553	PF00069	0.631
MOD_CK2_1	65	71	PF00069	0.540
MOD_CMANNOS	284	287	PF00535	0.488
MOD_GlcNHglycan	153	156	PF01048	0.658
MOD_GlcNHglycan	192	195	PF01048	0.723
MOD_GlcNHglycan	26	29	PF01048	0.700
MOD_GlcNHglycan	311	314	PF01048	0.748
MOD_GlcNHglycan	324	327	PF01048	0.564
MOD_GlcNHglycan	339	342	PF01048	0.443
MOD_GlcNHglycan	385	388	PF01048	0.713
MOD_GlcNHglycan	423	426	PF01048	0.726
MOD_GlcNHglycan	471	474	PF01048	0.747
MOD_GlcNHglycan	479	482	PF01048	0.748
MOD_GlcNHglycan	490	493	PF01048	0.551
MOD_GlcNHglycan	513	516	PF01048	0.550
MOD_GlcNHglycan	52	55	PF01048	0.760
MOD_GlcNHglycan	587	590	PF01048	0.684
MOD_GlcNHglycan	8	11	PF01048	0.633
MOD_GlcNHglycan	95	98	PF01048	0.659
MOD_GSK3_1	11	18	PF00069	0.625
MOD_GSK3_1	129	136	PF00069	0.530
MOD_GSK3_1	150	157	PF00069	0.663
MOD_GSK3_1	202	209	PF00069	0.540
MOD_GSK3_1	238	245	PF00069	0.441
MOD_GSK3_1	333	340	PF00069	0.535
MOD_GSK3_1	345	352	PF00069	0.340
MOD_GSK3_1	379	386	PF00069	0.731
MOD_GSK3_1	419	426	PF00069	0.673
MOD_GSK3_1	471	478	PF00069	0.736
MOD_GSK3_1	487	494	PF00069	0.522
MOD_GSK3_1	50	57	PF00069	0.724
MOD_GSK3_1	562	569	PF00069	0.580
MOD_GSK3_1	619	626	PF00069	0.565
MOD_N-GLC_1	322	327	PF02516	0.629
MOD_NEK2_1	137	142	PF00069	0.581
MOD_NEK2_1	238	243	PF00069	0.420
MOD_NEK2_1	345	350	PF00069	0.410
MOD_NEK2_1	385	390	PF00069	0.756
MOD_NEK2_1	436	441	PF00069	0.494
MOD_NEK2_1	487	492	PF00069	0.708
MOD_NEK2_1	508	513	PF00069	0.591
MOD_NEK2_1	623	628	PF00069	0.534
MOD_PIKK_1	13	19	PF00454	0.647
MOD_PIKK_1	157	163	PF00454	0.583
MOD_PIKK_1	242	248	PF00454	0.428
MOD_PIKK_1	333	339	PF00454	0.521
MOD_PK_1	124	130	PF00069	0.477
MOD_PKA_1	333	339	PF00069	0.643
MOD_PKA_2	242	248	PF00069	0.447
MOD_PKA_2	308	314	PF00069	0.731
MOD_PKA_2	333	339	PF00069	0.654
MOD_PKA_2	378	384	PF00069	0.662
MOD_PKA_2	511	517	PF00069	0.554
MOD_PKA_2	523	529	PF00069	0.506
MOD_PKA_2	562	568	PF00069	0.493
MOD_Plk_1	74	80	PF00069	0.604
MOD_Plk_2-3	547	553	PF00069	0.615
MOD_Plk_2-3	566	572	PF00069	0.490
MOD_Plk_4	124	130	PF00069	0.475
MOD_Plk_4	137	143	PF00069	0.513
MOD_Plk_4	206	212	PF00069	0.559
MOD_Plk_4	31	37	PF00069	0.652
MOD_Plk_4	491	497	PF00069	0.687
MOD_ProDKin_1	294	300	PF00069	0.546
MOD_ProDKin_1	408	414	PF00069	0.551
MOD_ProDKin_1	44	50	PF00069	0.639
MOD_SUMO_rev_2	562	570	PF00179	0.609
TRG_AP2beta_CARGO_1	173	182	PF09066	0.431
TRG_DiLeu_BaEn_1	230	235	PF01217	0.507
TRG_DiLeu_BaEn_1	271	276	PF01217	0.530
TRG_DiLeu_BaEn_1	447	452	PF01217	0.586
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.657
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.498
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.508
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.486
TRG_DiLeu_BaLyEn_6	628	633	PF01217	0.554
TRG_DiLeu_LyEn_5	230	235	PF01217	0.485
TRG_ENDOCYTIC_2	211	214	PF00928	0.538
TRG_ENDOCYTIC_2	4	7	PF00928	0.682
TRG_ENDOCYTIC_2	63	66	PF00928	0.445
TRG_ER_diArg_1	116	118	PF00400	0.500
TRG_ER_diArg_1	175	177	PF00400	0.554
TRG_ER_diArg_1	332	334	PF00400	0.688
TRG_ER_diArg_1	402	404	PF00400	0.384
TRG_ER_diArg_1	596	599	PF00400	0.698
TRG_NLS_MonoExtC_3	594	600	PF00514	0.778
TRG_NLS_MonoExtN_4	593	599	PF00514	0.734
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTE1	Leptomonas seymouri	36%	100%
A0A3S5H6Z9	Leishmania donovani	88%	96%
A0A3S5IR37	Trypanosoma rangeli	30%	100%
A4H8V9	Leishmania braziliensis	67%	94%
A4HXA6	Leishmania infantum	88%	100%
C9ZTV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AQY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	96%
V5D8P0	Trypanosoma cruzi	28%	100%