Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEH7_LEIMA

TriTrypDb:

LmjF.17.0110 , LMJLV39_170007300 , LMJSD75_170007000

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	2
GO:0005814	centriole	5	2
GO:0005815	microtubule organizing center	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QEH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEH7

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007098	centrosome cycle	3	2
GO:0009987	cellular process	1	2
GO:0010564	regulation of cell cycle process	5	2
GO:0010638	positive regulation of organelle organization	6	2
GO:0010824	regulation of centrosome duplication	6	2
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0031023	microtubule organizing center organization	3	2
GO:0032886	regulation of microtubule-based process	4	2
GO:0033043	regulation of organelle organization	5	2
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0044089	positive regulation of cellular component biogenesis	5	2
GO:0045787	positive regulation of cell cycle	5	2
GO:0046599	regulation of centriole replication	6	2
GO:0046601	positive regulation of centriole replication	7	2
GO:0046605	regulation of centrosome cycle	5	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051130	positive regulation of cellular component organization	5	2
GO:0051493	regulation of cytoskeleton organization	6	2
GO:0051495	positive regulation of cytoskeleton organization	7	2
GO:0051726	regulation of cell cycle	4	2
GO:0065007	biological regulation	1	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090068	positive regulation of cell cycle process	6	2
GO:1902115	regulation of organelle assembly	5	2
GO:1902117	positive regulation of organelle assembly	6	2
GO:1903722	regulation of centriole elongation	6	2
GO:1903724	positive regulation of centriole elongation	7	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	500	504	PF00656	0.415
CLV_C14_Caspase3-7	508	512	PF00656	0.455
CLV_NRD_NRD_1	14	16	PF00675	0.587
CLV_NRD_NRD_1	160	162	PF00675	0.459
CLV_NRD_NRD_1	181	183	PF00675	0.503
CLV_NRD_NRD_1	226	228	PF00675	0.474
CLV_NRD_NRD_1	273	275	PF00675	0.483
CLV_NRD_NRD_1	367	369	PF00675	0.502
CLV_NRD_NRD_1	376	378	PF00675	0.499
CLV_NRD_NRD_1	381	383	PF00675	0.515
CLV_NRD_NRD_1	45	47	PF00675	0.708
CLV_NRD_NRD_1	515	517	PF00675	0.433
CLV_PCSK_KEX2_1	14	16	PF00082	0.582
CLV_PCSK_KEX2_1	180	182	PF00082	0.499
CLV_PCSK_KEX2_1	226	228	PF00082	0.476
CLV_PCSK_KEX2_1	273	275	PF00082	0.442
CLV_PCSK_KEX2_1	367	369	PF00082	0.487
CLV_PCSK_KEX2_1	375	377	PF00082	0.519
CLV_PCSK_KEX2_1	381	383	PF00082	0.533
CLV_PCSK_KEX2_1	44	46	PF00082	0.730
CLV_PCSK_KEX2_1	515	517	PF00082	0.454
CLV_PCSK_KEX2_1	92	94	PF00082	0.538
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.506
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.538
CLV_PCSK_PC7_1	177	183	PF00082	0.493
CLV_PCSK_PC7_1	377	383	PF00082	0.571
CLV_PCSK_PC7_1	40	46	PF00082	0.705
CLV_PCSK_SKI1_1	177	181	PF00082	0.418
CLV_PCSK_SKI1_1	187	191	PF00082	0.477
CLV_PCSK_SKI1_1	367	371	PF00082	0.436
CLV_PCSK_SKI1_1	51	55	PF00082	0.621
DEG_APCC_DBOX_1	491	499	PF00400	0.450
DEG_SPOP_SBC_1	319	323	PF00917	0.611
DEG_SPOP_SBC_1	418	422	PF00917	0.662
DOC_ANK_TNKS_1	506	513	PF00023	0.457
DOC_CKS1_1	87	92	PF01111	0.728
DOC_MAPK_gen_1	180	190	PF00069	0.459
DOC_MAPK_gen_1	71	79	PF00069	0.609
DOC_MAPK_MEF2A_6	475	484	PF00069	0.469
DOC_MAPK_MEF2A_6	71	79	PF00069	0.609
DOC_PP1_RVXF_1	166	173	PF00149	0.385
DOC_PP4_FxxP_1	105	108	PF00568	0.539
DOC_USP7_MATH_1	319	323	PF00917	0.587
DOC_USP7_MATH_1	412	416	PF00917	0.742
DOC_USP7_MATH_1	418	422	PF00917	0.705
DOC_USP7_MATH_1	497	501	PF00917	0.336
DOC_USP7_MATH_1	80	84	PF00917	0.571
DOC_USP7_MATH_1	97	101	PF00917	0.603
DOC_USP7_UBL2_3	162	166	PF12436	0.609
DOC_WW_Pin1_4	116	121	PF00397	0.710
DOC_WW_Pin1_4	125	130	PF00397	0.594
DOC_WW_Pin1_4	300	305	PF00397	0.622
DOC_WW_Pin1_4	385	390	PF00397	0.666
DOC_WW_Pin1_4	421	426	PF00397	0.737
DOC_WW_Pin1_4	86	91	PF00397	0.608
LIG_14-3-3_CanoR_1	193	199	PF00244	0.412
LIG_14-3-3_CanoR_1	295	304	PF00244	0.581
LIG_14-3-3_CanoR_1	45	55	PF00244	0.675
LIG_14-3-3_CanoR_1	463	467	PF00244	0.444
LIG_14-3-3_CanoR_1	82	87	PF00244	0.694
LIG_ActinCP_TwfCPI_2	105	112	PF01115	0.543
LIG_BRCT_BRCA1_1	168	172	PF00533	0.470
LIG_BRCT_BRCA1_1	320	324	PF00533	0.538
LIG_FHA_1	117	123	PF00498	0.648
LIG_FHA_1	192	198	PF00498	0.456
LIG_FHA_1	296	302	PF00498	0.467
LIG_FHA_1	368	374	PF00498	0.548
LIG_FHA_1	431	437	PF00498	0.638
LIG_FHA_1	475	481	PF00498	0.498
LIG_FHA_2	329	335	PF00498	0.366
LIG_FHA_2	442	448	PF00498	0.483
LIG_FHA_2	450	456	PF00498	0.586
LIG_LIR_Apic_2	104	108	PF02991	0.539
LIG_LIR_Gen_1	169	179	PF02991	0.472
LIG_LIR_Gen_1	285	293	PF02991	0.459
LIG_LIR_Nem_3	150	155	PF02991	0.425
LIG_LIR_Nem_3	169	175	PF02991	0.432
LIG_LIR_Nem_3	285	289	PF02991	0.439
LIG_LIR_Nem_3	291	296	PF02991	0.439
LIG_RPA_C_Plants	227	238	PF08784	0.523
LIG_SH2_STAT3	296	299	PF00017	0.537
LIG_SH2_STAT5	286	289	PF00017	0.391
LIG_SH3_2	87	92	PF14604	0.590
LIG_SH3_3	387	393	PF00018	0.601
LIG_SH3_3	49	55	PF00018	0.691
LIG_SH3_3	84	90	PF00018	0.635
LIG_TRAF2_1	282	285	PF00917	0.457
LIG_WRC_WIRS_1	102	107	PF05994	0.544
LIG_WW_2	390	393	PF00397	0.581
MOD_CDK_SPxK_1	86	92	PF00069	0.721
MOD_CDK_SPxxK_3	86	93	PF00069	0.591
MOD_CK1_1	10	16	PF00069	0.644
MOD_CK1_1	123	129	PF00069	0.625
MOD_CK1_1	18	24	PF00069	0.674
MOD_CK1_1	303	309	PF00069	0.617
MOD_CK1_1	31	37	PF00069	0.729
MOD_CK1_1	322	328	PF00069	0.644
MOD_CK1_1	420	426	PF00069	0.696
MOD_CK1_1	65	71	PF00069	0.680
MOD_CK2_1	216	222	PF00069	0.453
MOD_CK2_1	285	291	PF00069	0.602
MOD_CK2_1	328	334	PF00069	0.369
MOD_CK2_1	449	455	PF00069	0.597
MOD_CK2_1	462	468	PF00069	0.446
MOD_GlcNHglycan	122	125	PF01048	0.642
MOD_GlcNHglycan	17	20	PF01048	0.723
MOD_GlcNHglycan	2	5	PF01048	0.612
MOD_GlcNHglycan	22	25	PF01048	0.658
MOD_GlcNHglycan	305	308	PF01048	0.704
MOD_GlcNHglycan	385	388	PF01048	0.589
MOD_GlcNHglycan	412	415	PF01048	0.637
MOD_GlcNHglycan	470	473	PF01048	0.510
MOD_GlcNHglycan	495	498	PF01048	0.317
MOD_GlcNHglycan	94	97	PF01048	0.664
MOD_GlcNHglycan	99	102	PF01048	0.601
MOD_GSK3_1	10	17	PF00069	0.646
MOD_GSK3_1	116	123	PF00069	0.626
MOD_GSK3_1	18	25	PF00069	0.678
MOD_GSK3_1	27	34	PF00069	0.714
MOD_GSK3_1	291	298	PF00069	0.475
MOD_GSK3_1	305	312	PF00069	0.565
MOD_GSK3_1	318	325	PF00069	0.607
MOD_GSK3_1	328	335	PF00069	0.646
MOD_GSK3_1	410	417	PF00069	0.693
MOD_GSK3_1	419	426	PF00069	0.739
MOD_GSK3_1	458	465	PF00069	0.471
MOD_GSK3_1	493	500	PF00069	0.427
MOD_GSK3_1	61	68	PF00069	0.692
MOD_GSK3_1	69	76	PF00069	0.578
MOD_GSK3_1	82	89	PF00069	0.546
MOD_GSK3_1	97	104	PF00069	0.636
MOD_N-GLC_1	250	255	PF02516	0.505
MOD_N-GLC_1	7	12	PF02516	0.604
MOD_NEK2_1	20	25	PF00069	0.722
MOD_PIKK_1	295	301	PF00454	0.540
MOD_PIKK_1	328	334	PF00454	0.398
MOD_PIKK_1	394	400	PF00454	0.653
MOD_PIKK_1	46	52	PF00454	0.587
MOD_PK_1	166	172	PF00069	0.323
MOD_PKA_1	14	20	PF00069	0.586
MOD_PKA_1	367	373	PF00069	0.459
MOD_PKA_1	45	51	PF00069	0.590
MOD_PKA_1	92	98	PF00069	0.594
MOD_PKA_2	137	143	PF00069	0.426
MOD_PKA_2	14	20	PF00069	0.744
MOD_PKA_2	192	198	PF00069	0.496
MOD_PKA_2	31	37	PF00069	0.723
MOD_PKA_2	367	373	PF00069	0.446
MOD_PKA_2	45	51	PF00069	0.607
MOD_PKA_2	450	456	PF00069	0.505
MOD_PKA_2	462	468	PF00069	0.472
MOD_PKA_2	474	480	PF00069	0.512
MOD_PKA_2	81	87	PF00069	0.695
MOD_PKA_2	92	98	PF00069	0.539
MOD_PKB_1	44	52	PF00069	0.589
MOD_PKB_1	518	526	PF00069	0.510
MOD_PKB_1	71	79	PF00069	0.656
MOD_Plk_1	250	256	PF00069	0.506
MOD_Plk_1	461	467	PF00069	0.412
MOD_Plk_2-3	285	291	PF00069	0.453
MOD_Plk_2-3	462	468	PF00069	0.460
MOD_Plk_4	285	291	PF00069	0.574
MOD_Plk_4	462	468	PF00069	0.490
MOD_Plk_4	476	482	PF00069	0.559
MOD_ProDKin_1	116	122	PF00069	0.713
MOD_ProDKin_1	125	131	PF00069	0.592
MOD_ProDKin_1	300	306	PF00069	0.632
MOD_ProDKin_1	385	391	PF00069	0.674
MOD_ProDKin_1	421	427	PF00069	0.737
MOD_ProDKin_1	86	92	PF00069	0.611
TRG_DiLeu_BaEn_1	462	467	PF01217	0.476
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.514
TRG_ENDOCYTIC_2	286	289	PF00928	0.436
TRG_ENDOCYTIC_2	290	293	PF00928	0.435
TRG_ER_diArg_1	225	227	PF00400	0.463
TRG_ER_diArg_1	257	260	PF00400	0.455
TRG_ER_diArg_1	278	281	PF00400	0.431
TRG_ER_diArg_1	367	369	PF00400	0.515
TRG_ER_diArg_1	375	377	PF00400	0.518
TRG_ER_diArg_1	380	382	PF00400	0.505
TRG_ER_diArg_1	44	46	PF00400	0.593
TRG_ER_diArg_1	518	521	PF00400	0.502
TRG_ER_diArg_1	70	73	PF00400	0.658
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	51	56	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9K9	Leptomonas seymouri	54%	100%
A0A1X0NUG8	Trypanosomatidae	36%	100%
A0A3S7WUA9	Leishmania donovani	91%	100%
A0A422NFB5	Trypanosoma rangeli	40%	100%
A4H8W0	Leishmania braziliensis	75%	100%
A4HXA7	Leishmania infantum	91%	100%
C9ZTV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AQY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%