Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QEH5_LEIMA

TriTrypDb:

LmjF.17.0130 , LMJLV39_170007500 , LMJSD75_170007200

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	511	515	PF00656	0.583
CLV_C14_Caspase3-7	579	583	PF00656	0.534
CLV_C14_Caspase3-7	615	619	PF00656	0.661
CLV_C14_Caspase3-7	818	822	PF00656	0.628
CLV_C14_Caspase3-7	9	13	PF00656	0.472
CLV_MEL_PAP_1	500	506	PF00089	0.568
CLV_NRD_NRD_1	141	143	PF00675	0.503
CLV_NRD_NRD_1	390	392	PF00675	0.440
CLV_NRD_NRD_1	435	437	PF00675	0.586
CLV_NRD_NRD_1	537	539	PF00675	0.562
CLV_NRD_NRD_1	720	722	PF00675	0.562
CLV_NRD_NRD_1	733	735	PF00675	0.430
CLV_NRD_NRD_1	741	743	PF00675	0.544
CLV_NRD_NRD_1	791	793	PF00675	0.628
CLV_NRD_NRD_1	807	809	PF00675	0.632
CLV_NRD_NRD_1	833	835	PF00675	0.526
CLV_PCSK_FUR_1	739	743	PF00082	0.630
CLV_PCSK_FUR_1	830	834	PF00082	0.544
CLV_PCSK_KEX2_1	141	143	PF00082	0.503
CLV_PCSK_KEX2_1	390	392	PF00082	0.478
CLV_PCSK_KEX2_1	435	437	PF00082	0.586
CLV_PCSK_KEX2_1	536	538	PF00082	0.594
CLV_PCSK_KEX2_1	720	722	PF00082	0.539
CLV_PCSK_KEX2_1	731	733	PF00082	0.451
CLV_PCSK_KEX2_1	741	743	PF00082	0.531
CLV_PCSK_KEX2_1	791	793	PF00082	0.628
CLV_PCSK_KEX2_1	807	809	PF00082	0.632
CLV_PCSK_KEX2_1	830	832	PF00082	0.541
CLV_PCSK_KEX2_1	833	835	PF00082	0.526
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.579
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.451
CLV_PCSK_SKI1_1	2	6	PF00082	0.522
CLV_PCSK_SKI1_1	249	253	PF00082	0.472
CLV_PCSK_SKI1_1	410	414	PF00082	0.386
CLV_PCSK_SKI1_1	571	575	PF00082	0.573
CLV_PCSK_SKI1_1	658	662	PF00082	0.595
CLV_PCSK_SKI1_1	8	12	PF00082	0.459
CLV_PCSK_SKI1_1	851	855	PF00082	0.655
DEG_APCC_DBOX_1	791	799	PF00400	0.567
DEG_Nend_UBRbox_1	1	4	PF02207	0.506
DEG_SPOP_SBC_1	312	316	PF00917	0.478
DOC_CDC14_PxL_1	217	225	PF14671	0.438
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	4	7	PF00134	0.529
DOC_MAPK_gen_1	141	149	PF00069	0.503
DOC_MAPK_gen_1	390	398	PF00069	0.394
DOC_MAPK_gen_1	536	544	PF00069	0.496
DOC_MAPK_MEF2A_6	141	148	PF00069	0.595
DOC_MAPK_MEF2A_6	536	544	PF00069	0.496
DOC_MAPK_MEF2A_6	87	96	PF00069	0.551
DOC_MAPK_NFAT4_5	141	149	PF00069	0.599
DOC_PP1_RVXF_1	408	414	PF00149	0.392
DOC_PP2B_LxvP_1	11	14	PF13499	0.536
DOC_PP2B_LxvP_1	336	339	PF13499	0.549
DOC_PP2B_LxvP_1	4	7	PF13499	0.529
DOC_PP2B_PxIxI_1	539	545	PF00149	0.425
DOC_PP4_FxxP_1	180	183	PF00568	0.663
DOC_PP4_FxxP_1	53	56	PF00568	0.510
DOC_USP7_MATH_1	102	106	PF00917	0.408
DOC_USP7_MATH_1	190	194	PF00917	0.567
DOC_USP7_MATH_1	245	249	PF00917	0.577
DOC_USP7_MATH_1	254	258	PF00917	0.328
DOC_USP7_MATH_1	274	278	PF00917	0.336
DOC_USP7_MATH_1	312	316	PF00917	0.409
DOC_USP7_MATH_1	42	46	PF00917	0.717
DOC_USP7_MATH_1	499	503	PF00917	0.503
DOC_USP7_MATH_1	527	531	PF00917	0.684
DOC_USP7_MATH_1	57	61	PF00917	0.399
DOC_USP7_MATH_1	578	582	PF00917	0.583
DOC_USP7_MATH_1	589	593	PF00917	0.437
DOC_USP7_MATH_1	623	627	PF00917	0.661
DOC_USP7_MATH_1	83	87	PF00917	0.626
DOC_WW_Pin1_4	175	180	PF00397	0.644
DOC_WW_Pin1_4	186	191	PF00397	0.504
DOC_WW_Pin1_4	225	230	PF00397	0.516
DOC_WW_Pin1_4	334	339	PF00397	0.472
DOC_WW_Pin1_4	384	389	PF00397	0.469
DOC_WW_Pin1_4	461	466	PF00397	0.539
DOC_WW_Pin1_4	662	667	PF00397	0.607
DOC_WW_Pin1_4	696	701	PF00397	0.674
DOC_WW_Pin1_4	79	84	PF00397	0.640
LIG_14-3-3_CanoR_1	116	126	PF00244	0.508
LIG_14-3-3_CanoR_1	435	444	PF00244	0.581
LIG_14-3-3_CanoR_1	610	620	PF00244	0.569
LIG_14-3-3_CanoR_1	693	700	PF00244	0.720
LIG_14-3-3_CanoR_1	851	856	PF00244	0.651
LIG_Actin_WH2_2	395	412	PF00022	0.461
LIG_Actin_WH2_2	540	556	PF00022	0.558
LIG_AP2alpha_2	539	541	PF02296	0.531
LIG_APCC_ABBA_1	94	99	PF00400	0.442
LIG_BRCT_BRCA1_1	221	225	PF00533	0.425
LIG_BRCT_BRCA1_1	325	329	PF00533	0.588
LIG_BRCT_BRCA1_1	44	48	PF00533	0.662
LIG_BRCT_BRCA1_1	589	593	PF00533	0.496
LIG_BRCT_BRCA1_1	602	606	PF00533	0.471
LIG_CaM_IQ_9	402	418	PF13499	0.434
LIG_eIF4E_1	444	450	PF01652	0.455
LIG_FHA_1	154	160	PF00498	0.556
LIG_FHA_1	186	192	PF00498	0.579
LIG_FHA_1	214	220	PF00498	0.614
LIG_FHA_1	233	239	PF00498	0.440
LIG_FHA_1	340	346	PF00498	0.437
LIG_FHA_1	384	390	PF00498	0.616
LIG_FHA_1	438	444	PF00498	0.501
LIG_FHA_1	445	451	PF00498	0.509
LIG_FHA_1	80	86	PF00498	0.691
LIG_FHA_1	88	94	PF00498	0.548
LIG_FHA_2	342	348	PF00498	0.651
LIG_FHA_2	70	76	PF00498	0.614
LIG_FHA_2	792	798	PF00498	0.612
LIG_FHA_2	852	858	PF00498	0.656
LIG_GBD_Chelix_1	429	437	PF00786	0.446
LIG_HCF-1_HBM_1	638	641	PF13415	0.496
LIG_LIR_Apic_2	131	135	PF02991	0.489
LIG_LIR_Apic_2	178	183	PF02991	0.658
LIG_LIR_Apic_2	50	56	PF02991	0.634
LIG_LIR_Gen_1	216	225	PF02991	0.460
LIG_LIR_Gen_1	603	613	PF02991	0.469
LIG_LIR_Nem_3	193	199	PF02991	0.519
LIG_LIR_Nem_3	216	220	PF02991	0.474
LIG_LIR_Nem_3	257	263	PF02991	0.375
LIG_LIR_Nem_3	539	544	PF02991	0.494
LIG_LIR_Nem_3	603	609	PF02991	0.451
LIG_LIR_Nem_3	638	644	PF02991	0.593
LIG_MYND_1	334	338	PF01753	0.400
LIG_NRBOX	142	148	PF00104	0.589
LIG_PTB_Apo_2	628	635	PF02174	0.537
LIG_PTB_Phospho_1	628	634	PF10480	0.537
LIG_RPA_C_Fungi	729	741	PF08784	0.437
LIG_SH2_CRK	550	554	PF00017	0.578
LIG_SH2_GRB2like	320	323	PF00017	0.544
LIG_SH2_PTP2	132	135	PF00017	0.530
LIG_SH2_PTP2	211	214	PF00017	0.488
LIG_SH2_PTP2	260	263	PF00017	0.320
LIG_SH2_SRC	132	135	PF00017	0.530
LIG_SH2_SRC	211	214	PF00017	0.488
LIG_SH2_SRC	320	323	PF00017	0.488
LIG_SH2_STAT3	656	659	PF00017	0.574
LIG_SH2_STAT5	132	135	PF00017	0.530
LIG_SH2_STAT5	196	199	PF00017	0.626
LIG_SH2_STAT5	211	214	PF00017	0.397
LIG_SH2_STAT5	260	263	PF00017	0.338
LIG_SH2_STAT5	320	323	PF00017	0.448
LIG_SH2_STAT5	599	602	PF00017	0.549
LIG_SH2_STAT5	634	637	PF00017	0.664
LIG_SH2_STAT5	656	659	PF00017	0.596
LIG_SH3_3	223	229	PF00018	0.511
LIG_SH3_3	35	41	PF00018	0.694
LIG_SH3_3	561	567	PF00018	0.613
LIG_SH3_3	572	578	PF00018	0.536
LIG_SH3_3	787	793	PF00018	0.631
LIG_SH3_3	86	92	PF00018	0.625
LIG_SUMO_SIM_anti_2	145	150	PF11976	0.605
LIG_SUMO_SIM_anti_2	493	499	PF11976	0.407
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.491
LIG_SUMO_SIM_par_1	285	293	PF11976	0.397
LIG_SUMO_SIM_par_1	92	101	PF11976	0.460
LIG_TRAF2_1	529	532	PF00917	0.717
LIG_TRAF2_1	646	649	PF00917	0.614
LIG_TRAF2_1	712	715	PF00917	0.543
LIG_TRFH_1	217	221	PF08558	0.494
LIG_UBA3_1	398	403	PF00899	0.447
LIG_WW_3	5	9	PF00397	0.454
MOD_CDC14_SPxK_1	387	390	PF00782	0.431
MOD_CDK_SPxK_1	384	390	PF00069	0.465
MOD_CDK_SPxxK_3	384	391	PF00069	0.459
MOD_CDK_SPxxK_3	461	468	PF00069	0.522
MOD_CK1_1	173	179	PF00069	0.581
MOD_CK1_1	277	283	PF00069	0.459
MOD_CK1_1	341	347	PF00069	0.558
MOD_CK1_1	43	49	PF00069	0.735
MOD_CK1_1	530	536	PF00069	0.640
MOD_CK1_1	672	678	PF00069	0.682
MOD_CK1_1	862	868	PF00069	0.647
MOD_CK2_1	134	140	PF00069	0.479
MOD_CK2_1	192	198	PF00069	0.518
MOD_CK2_1	225	231	PF00069	0.519
MOD_CK2_1	341	347	PF00069	0.665
MOD_CK2_1	454	460	PF00069	0.772
MOD_CK2_1	566	572	PF00069	0.631
MOD_CK2_1	672	678	PF00069	0.658
MOD_CK2_1	69	75	PF00069	0.583
MOD_CK2_1	696	702	PF00069	0.744
MOD_CK2_1	780	786	PF00069	0.765
MOD_CK2_1	851	857	PF00069	0.559
MOD_CK2_1	862	868	PF00069	0.581
MOD_Cter_Amidation	805	808	PF01082	0.696
MOD_DYRK1A_RPxSP_1	461	465	PF00069	0.538
MOD_GlcNHglycan	136	139	PF01048	0.573
MOD_GlcNHglycan	175	178	PF01048	0.584
MOD_GlcNHglycan	192	195	PF01048	0.452
MOD_GlcNHglycan	292	295	PF01048	0.404
MOD_GlcNHglycan	325	328	PF01048	0.632
MOD_GlcNHglycan	354	357	PF01048	0.633
MOD_GlcNHglycan	393	396	PF01048	0.476
MOD_GlcNHglycan	42	45	PF01048	0.656
MOD_GlcNHglycan	568	571	PF01048	0.680
MOD_GlcNHglycan	589	592	PF01048	0.604
MOD_GlcNHglycan	602	605	PF01048	0.420
MOD_GlcNHglycan	625	628	PF01048	0.678
MOD_GlcNHglycan	687	690	PF01048	0.759
MOD_GlcNHglycan	696	699	PF01048	0.596
MOD_GlcNHglycan	780	783	PF01048	0.607
MOD_GlcNHglycan	99	103	PF01048	0.423
MOD_GSK3_1	117	124	PF00069	0.502
MOD_GSK3_1	149	156	PF00069	0.677
MOD_GSK3_1	186	193	PF00069	0.636
MOD_GSK3_1	198	205	PF00069	0.416
MOD_GSK3_1	243	250	PF00069	0.687
MOD_GSK3_1	261	268	PF00069	0.420
MOD_GSK3_1	273	280	PF00069	0.475
MOD_GSK3_1	334	341	PF00069	0.497
MOD_GSK3_1	36	43	PF00069	0.719
MOD_GSK3_1	450	457	PF00069	0.644
MOD_GSK3_1	459	466	PF00069	0.664
MOD_GSK3_1	486	493	PF00069	0.546
MOD_GSK3_1	600	607	PF00069	0.574
MOD_GSK3_1	65	72	PF00069	0.621
MOD_GSK3_1	692	699	PF00069	0.711
MOD_GSK3_1	77	84	PF00069	0.594
MOD_GSK3_1	98	105	PF00069	0.488
MOD_LATS_1	691	697	PF00433	0.683
MOD_N-GLC_1	321	326	PF02516	0.503
MOD_N-GLC_1	444	449	PF02516	0.516
MOD_N-GLC_1	661	666	PF02516	0.602
MOD_N-GLC_2	850	852	PF02516	0.631
MOD_NEK2_1	160	165	PF00069	0.448
MOD_NEK2_1	185	190	PF00069	0.577
MOD_NEK2_1	321	326	PF00069	0.594
MOD_NEK2_1	383	388	PF00069	0.506
MOD_NEK2_1	437	442	PF00069	0.508
MOD_NEK2_1	443	448	PF00069	0.490
MOD_NEK2_1	486	491	PF00069	0.578
MOD_NEK2_1	587	592	PF00069	0.587
MOD_NEK2_1	597	602	PF00069	0.522
MOD_NEK2_1	65	70	PF00069	0.481
MOD_NEK2_1	661	666	PF00069	0.602
MOD_NEK2_1	97	102	PF00069	0.588
MOD_NEK2_2	362	367	PF00069	0.529
MOD_PIKK_1	277	283	PF00454	0.443
MOD_PIKK_1	486	492	PF00454	0.549
MOD_PIKK_1	780	786	PF00454	0.677
MOD_PIKK_1	819	825	PF00454	0.614
MOD_PKA_1	791	797	PF00069	0.711
MOD_PKA_2	261	267	PF00069	0.491
MOD_PKA_2	415	421	PF00069	0.479
MOD_PKA_2	692	698	PF00069	0.720
MOD_PKA_2	791	797	PF00069	0.693
MOD_Plk_1	304	310	PF00069	0.387
MOD_Plk_1	444	450	PF00069	0.537
MOD_Plk_1	459	465	PF00069	0.637
MOD_Plk_4	122	128	PF00069	0.482
MOD_Plk_4	170	176	PF00069	0.529
MOD_Plk_4	192	198	PF00069	0.518
MOD_Plk_4	254	260	PF00069	0.363
MOD_Plk_4	285	291	PF00069	0.491
MOD_Plk_4	438	444	PF00069	0.592
MOD_Plk_4	445	451	PF00069	0.558
MOD_Plk_4	490	496	PF00069	0.421
MOD_Plk_4	57	63	PF00069	0.466
MOD_Plk_4	589	595	PF00069	0.513
MOD_Plk_4	859	865	PF00069	0.602
MOD_ProDKin_1	175	181	PF00069	0.649
MOD_ProDKin_1	186	192	PF00069	0.506
MOD_ProDKin_1	225	231	PF00069	0.519
MOD_ProDKin_1	334	340	PF00069	0.468
MOD_ProDKin_1	384	390	PF00069	0.465
MOD_ProDKin_1	461	467	PF00069	0.527
MOD_ProDKin_1	662	668	PF00069	0.607
MOD_ProDKin_1	696	702	PF00069	0.671
MOD_ProDKin_1	79	85	PF00069	0.639
MOD_SUMO_for_1	766	769	PF00179	0.648
TRG_DiLeu_BaEn_4	714	720	PF01217	0.546
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.599
TRG_ENDOCYTIC_2	196	199	PF00928	0.512
TRG_ENDOCYTIC_2	260	263	PF00928	0.403
TRG_ENDOCYTIC_2	550	553	PF00928	0.473
TRG_ENDOCYTIC_2	634	637	PF00928	0.568
TRG_ENDOCYTIC_2	641	644	PF00928	0.599
TRG_ER_diArg_1	141	143	PF00400	0.503
TRG_ER_diArg_1	389	391	PF00400	0.482
TRG_ER_diArg_1	435	437	PF00400	0.590
TRG_ER_diArg_1	456	459	PF00400	0.738
TRG_ER_diArg_1	535	538	PF00400	0.588
TRG_ER_diArg_1	710	713	PF00400	0.603
TRG_ER_diArg_1	732	734	PF00400	0.512
TRG_ER_diArg_1	739	742	PF00400	0.545
TRG_ER_diArg_1	790	792	PF00400	0.632
TRG_ER_diArg_1	829	832	PF00400	0.547
TRG_ER_diArg_1	833	836	PF00400	0.551
TRG_ER_diArg_1	845	848	PF00400	0.566
TRG_NES_CRM1_1	477	490	PF08389	0.460
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L9	Leptomonas seymouri	49%	100%
A0A3Q8IAS7	Leishmania donovani	91%	100%
A4H8W2	Leishmania braziliensis	73%	100%
A4HXA9	Leishmania infantum	91%	100%
E9AQY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%