Cilia- and flagella-associated protein 206

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEH3_LEIMA

TriTrypDb:

LmjF.17.0150 , LMJLV39_170007700 , LMJSD75_170007400

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0005815	microtubule organizing center	2	2
GO:0005930	axoneme	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	9
GO:0005856	cytoskeleton	5	7
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

Q4QEH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEH3

Function

Biological processes
Term	Name	Level	Count
GO:0003352	regulation of cilium movement	6	2
GO:0003356	regulation of cilium beat frequency	7	2
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0030030	cell projection organization	4	9
GO:0032886	regulation of microtubule-based process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0060632	regulation of microtubule-based movement	5	2
GO:0065007	biological regulation	1	2
GO:0071840	cellular component organization or biogenesis	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	363	367	PF00656	0.403
CLV_NRD_NRD_1	201	203	PF00675	0.323
CLV_NRD_NRD_1	521	523	PF00675	0.536
CLV_NRD_NRD_1	629	631	PF00675	0.402
CLV_NRD_NRD_1	654	656	PF00675	0.507
CLV_NRD_NRD_1	663	665	PF00675	0.507
CLV_NRD_NRD_1	700	702	PF00675	0.449
CLV_PCSK_KEX2_1	201	203	PF00082	0.335
CLV_PCSK_KEX2_1	521	523	PF00082	0.532
CLV_PCSK_KEX2_1	629	631	PF00082	0.404
CLV_PCSK_KEX2_1	654	656	PF00082	0.517
CLV_PCSK_SKI1_1	255	259	PF00082	0.454
CLV_PCSK_SKI1_1	355	359	PF00082	0.464
CLV_PCSK_SKI1_1	386	390	PF00082	0.447
CLV_PCSK_SKI1_1	522	526	PF00082	0.449
CLV_PCSK_SKI1_1	630	634	PF00082	0.406
CLV_Separin_Metazoa	573	577	PF03568	0.428
DEG_APCC_DBOX_1	74	82	PF00400	0.347
DEG_Nend_UBRbox_2	1	3	PF02207	0.370
DEG_SCF_FBW7_2	229	235	PF00400	0.391
DOC_CKS1_1	229	234	PF01111	0.385
DOC_CYCLIN_RxL_1	250	262	PF00134	0.495
DOC_CYCLIN_RxL_1	521	535	PF00134	0.450
DOC_CYCLIN_RxL_1	570	581	PF00134	0.470
DOC_CYCLIN_yCln2_LP_2	525	531	PF00134	0.466
DOC_MAPK_DCC_7	439	448	PF00069	0.362
DOC_MAPK_gen_1	107	115	PF00069	0.428
DOC_MAPK_gen_1	201	209	PF00069	0.356
DOC_MAPK_gen_1	250	259	PF00069	0.298
DOC_MAPK_gen_1	439	448	PF00069	0.481
DOC_MAPK_gen_1	449	456	PF00069	0.508
DOC_MAPK_gen_1	629	635	PF00069	0.362
DOC_MAPK_MEF2A_6	107	115	PF00069	0.410
DOC_MAPK_MEF2A_6	439	448	PF00069	0.362
DOC_PP1_RVXF_1	199	206	PF00149	0.289
DOC_PP1_RVXF_1	352	359	PF00149	0.477
DOC_PP1_RVXF_1	525	532	PF00149	0.396
DOC_PP2B_LxvP_1	491	494	PF13499	0.442
DOC_USP7_MATH_1	118	122	PF00917	0.465
DOC_USP7_MATH_1	23	27	PF00917	0.477
DOC_USP7_MATH_1	308	312	PF00917	0.528
DOC_USP7_MATH_1	329	333	PF00917	0.647
DOC_USP7_MATH_1	388	392	PF00917	0.447
DOC_USP7_MATH_1	418	422	PF00917	0.497
DOC_USP7_UBL2_3	103	107	PF12436	0.494
DOC_WW_Pin1_4	228	233	PF00397	0.490
DOC_WW_Pin1_4	257	262	PF00397	0.314
DOC_WW_Pin1_4	337	342	PF00397	0.618
DOC_WW_Pin1_4	500	505	PF00397	0.676
LIG_14-3-3_CanoR_1	386	395	PF00244	0.508
LIG_14-3-3_CanoR_1	449	456	PF00244	0.413
LIG_14-3-3_CanoR_1	642	651	PF00244	0.432
LIG_14-3-3_CanoR_1	690	700	PF00244	0.403
LIG_14-3-3_CanoR_1	75	79	PF00244	0.512
LIG_Actin_WH2_2	81	96	PF00022	0.412
LIG_AP2alpha_2	545	547	PF02296	0.355
LIG_Clathr_ClatBox_1	119	123	PF01394	0.473
LIG_deltaCOP1_diTrp_1	130	140	PF00928	0.355
LIG_eIF4E_1	277	283	PF01652	0.322
LIG_eIF4E_1	477	483	PF01652	0.281
LIG_FHA_1	181	187	PF00498	0.490
LIG_FHA_1	215	221	PF00498	0.528
LIG_FHA_1	252	258	PF00498	0.453
LIG_FHA_1	260	266	PF00498	0.524
LIG_FHA_1	27	33	PF00498	0.363
LIG_FHA_1	308	314	PF00498	0.460
LIG_FHA_1	486	492	PF00498	0.416
LIG_FHA_1	608	614	PF00498	0.499
LIG_FHA_1	646	652	PF00498	0.452
LIG_FHA_1	692	698	PF00498	0.418
LIG_FHA_1	81	87	PF00498	0.270
LIG_FHA_2	225	231	PF00498	0.449
LIG_FHA_2	400	406	PF00498	0.385
LIG_FHA_2	657	663	PF00498	0.571
LIG_FHA_2	93	99	PF00498	0.330
LIG_GBD_Chelix_1	585	593	PF00786	0.489
LIG_HCF-1_HBM_1	618	621	PF13415	0.461
LIG_KLC1_Yacidic_2	577	581	PF13176	0.400
LIG_LIR_Gen_1	130	141	PF02991	0.398
LIG_LIR_Gen_1	275	283	PF02991	0.399
LIG_LIR_Nem_3	130	136	PF02991	0.318
LIG_LIR_Nem_3	275	280	PF02991	0.403
LIG_LIR_Nem_3	545	550	PF02991	0.328
LIG_NRBOX	31	37	PF00104	0.396
LIG_NRBOX	68	74	PF00104	0.337
LIG_Pex14_2	622	626	PF04695	0.495
LIG_SH2_CRK	144	148	PF00017	0.352
LIG_SH2_CRK	309	313	PF00017	0.362
LIG_SH2_CRK	477	481	PF00017	0.405
LIG_SH2_SRC	549	552	PF00017	0.429
LIG_SH2_SRC	579	582	PF00017	0.431
LIG_SH2_SRC	616	619	PF00017	0.524
LIG_SH2_STAP1	309	313	PF00017	0.346
LIG_SH2_STAP1	395	399	PF00017	0.490
LIG_SH2_STAP1	693	697	PF00017	0.421
LIG_SH2_STAT3	15	18	PF00017	0.409
LIG_SH2_STAT5	309	312	PF00017	0.265
LIG_SH2_STAT5	477	480	PF00017	0.399
LIG_SH2_STAT5	530	533	PF00017	0.320
LIG_SH2_STAT5	549	552	PF00017	0.338
LIG_SH2_STAT5	579	582	PF00017	0.403
LIG_SH2_STAT5	616	619	PF00017	0.468
LIG_SH2_STAT5	621	624	PF00017	0.433
LIG_SH2_STAT5	685	688	PF00017	0.399
LIG_SH2_STAT5	693	696	PF00017	0.425
LIG_SH2_STAT5	71	74	PF00017	0.326
LIG_SH3_3	226	232	PF00018	0.476
LIG_SH3_3	258	264	PF00018	0.468
LIG_SH3_3	302	308	PF00018	0.483
LIG_SH3_3	353	359	PF00018	0.420
LIG_SH3_3	412	418	PF00018	0.479
LIG_SH3_3	495	501	PF00018	0.514
LIG_TRAF2_1	403	406	PF00917	0.495
LIG_TRAF2_1	96	99	PF00917	0.381
LIG_UBA3_1	35	43	PF00899	0.333
MOD_CK1_1	149	155	PF00069	0.626
MOD_CK1_1	159	165	PF00069	0.643
MOD_CK1_1	171	177	PF00069	0.392
MOD_CK1_1	224	230	PF00069	0.393
MOD_CK1_1	26	32	PF00069	0.369
MOD_CK1_1	334	340	PF00069	0.645
MOD_CK1_1	435	441	PF00069	0.463
MOD_CK1_1	499	505	PF00069	0.669
MOD_CK1_1	507	513	PF00069	0.560
MOD_CK1_1	605	611	PF00069	0.596
MOD_CK1_1	645	651	PF00069	0.446
MOD_CK1_1	77	83	PF00069	0.425
MOD_CK2_1	162	168	PF00069	0.497
MOD_CK2_1	399	405	PF00069	0.375
MOD_CK2_1	692	698	PF00069	0.418
MOD_CK2_1	92	98	PF00069	0.472
MOD_CMANNOS	623	626	PF00535	0.366
MOD_GlcNHglycan	127	130	PF01048	0.509
MOD_GlcNHglycan	144	147	PF01048	0.491
MOD_GlcNHglycan	151	154	PF01048	0.551
MOD_GlcNHglycan	158	161	PF01048	0.640
MOD_GlcNHglycan	170	173	PF01048	0.432
MOD_GlcNHglycan	25	28	PF01048	0.495
MOD_GlcNHglycan	333	336	PF01048	0.558
MOD_GlcNHglycan	390	393	PF01048	0.515
MOD_GlcNHglycan	420	423	PF01048	0.580
MOD_GlcNHglycan	515	519	PF01048	0.484
MOD_GlcNHglycan	694	697	PF01048	0.441
MOD_GSK3_1	142	149	PF00069	0.525
MOD_GSK3_1	158	165	PF00069	0.589
MOD_GSK3_1	221	228	PF00069	0.440
MOD_GSK3_1	330	337	PF00069	0.565
MOD_GSK3_1	395	402	PF00069	0.393
MOD_GSK3_1	455	462	PF00069	0.491
MOD_GSK3_1	496	503	PF00069	0.612
MOD_GSK3_1	664	671	PF00069	0.673
MOD_GSK3_1	89	96	PF00069	0.470
MOD_LATS_1	447	453	PF00433	0.314
MOD_NEK2_1	223	228	PF00069	0.407
MOD_NEK2_1	380	385	PF00069	0.296
MOD_NEK2_1	506	511	PF00069	0.423
MOD_NEK2_1	514	519	PF00069	0.312
MOD_NEK2_1	689	694	PF00069	0.424
MOD_PIKK_1	605	611	PF00454	0.517
MOD_PIKK_1	643	649	PF00454	0.440
MOD_PIKK_1	656	662	PF00454	0.513
MOD_PIKK_1	674	680	PF00454	0.563
MOD_PKA_1	664	670	PF00069	0.521
MOD_PKA_2	251	257	PF00069	0.411
MOD_PKA_2	602	608	PF00069	0.613
MOD_PKA_2	689	695	PF00069	0.435
MOD_PKA_2	74	80	PF00069	0.409
MOD_PKA_2	93	99	PF00069	0.416
MOD_Plk_1	395	401	PF00069	0.401
MOD_Plk_4	308	314	PF00069	0.353
MOD_Plk_4	380	386	PF00069	0.322
MOD_Plk_4	54	60	PF00069	0.426
MOD_Plk_4	562	568	PF00069	0.389
MOD_Plk_4	612	618	PF00069	0.558
MOD_ProDKin_1	228	234	PF00069	0.494
MOD_ProDKin_1	257	263	PF00069	0.315
MOD_ProDKin_1	337	343	PF00069	0.620
MOD_ProDKin_1	500	506	PF00069	0.677
MOD_SUMO_for_1	106	109	PF00179	0.428
MOD_SUMO_for_1	238	241	PF00179	0.342
MOD_SUMO_for_1	273	276	PF00179	0.340
MOD_SUMO_rev_2	235	240	PF00179	0.391
TRG_DiLeu_BaEn_1	276	281	PF01217	0.353
TRG_DiLeu_BaEn_1	428	433	PF01217	0.389
TRG_DiLeu_BaEn_4	405	411	PF01217	0.369
TRG_ENDOCYTIC_2	144	147	PF00928	0.404
TRG_ENDOCYTIC_2	277	280	PF00928	0.400
TRG_ENDOCYTIC_2	309	312	PF00928	0.442
TRG_ENDOCYTIC_2	477	480	PF00928	0.399
TRG_ENDOCYTIC_2	530	533	PF00928	0.320
TRG_ER_diArg_1	200	202	PF00400	0.332
TRG_ER_diArg_1	249	252	PF00400	0.473
TRG_ER_diArg_1	439	442	PF00400	0.505
TRG_ER_diArg_1	45	48	PF00400	0.352
TRG_ER_diArg_1	520	522	PF00400	0.529
TRG_ER_diArg_1	628	630	PF00400	0.399
TRG_ER_diArg_1	653	655	PF00400	0.556
TRG_NES_CRM1_1	199	213	PF08389	0.425
TRG_NES_CRM1_1	31	44	PF08389	0.413
TRG_Pf-PMV_PEXEL_1	576	581	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWJ8	Leptomonas seymouri	60%	96%
A0A0S4J344	Bodo saltans	29%	100%
A0A1X0NSZ8	Trypanosomatidae	35%	100%
A0A3Q8IAK5	Leishmania donovani	94%	100%
A1A5Q4	Rattus norvegicus	24%	100%
A4H8W4	Leishmania braziliensis	80%	84%
C9ZTV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q23H79	Tetrahymena thermophila (strain SB210)	21%	100%
Q29RL1	Bos taurus	23%	100%
Q6PE87	Mus musculus	25%	100%
Q8IYR0	Homo sapiens	24%	100%
Q95JU3	Macaca fascicularis	24%	100%
V5BH83	Trypanosoma cruzi	36%	100%