Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4QEH1_LEIMA

TriTrypDb:

LmjF.17.0170 , LMJLV39_170007900 , LMJSD75_170007600

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13
GO:1990904	ribonucleoprotein complex	2	13

Expansion

Sequence features

Q4QEH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEH1

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	3
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.522
CLV_C14_Caspase3-7	96	100	PF00656	0.513
CLV_NRD_NRD_1	213	215	PF00675	0.551
CLV_NRD_NRD_1	256	258	PF00675	0.623
CLV_PCSK_KEX2_1	481	483	PF00082	0.496
CLV_PCSK_KEX2_1	52	54	PF00082	0.671
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.496
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.559
CLV_PCSK_SKI1_1	274	278	PF00082	0.663
CLV_PCSK_SKI1_1	322	326	PF00082	0.659
CLV_PCSK_SKI1_1	443	447	PF00082	0.460
CLV_PCSK_SKI1_1	604	608	PF00082	0.354
CLV_PCSK_SKI1_1	645	649	PF00082	0.377
CLV_PCSK_SKI1_1	68	72	PF00082	0.568
DEG_SCF_TRCP1_1	269	275	PF00400	0.548
DEG_SPOP_SBC_1	135	139	PF00917	0.509
DOC_CDC14_PxL_1	102	110	PF14671	0.549
DOC_CKS1_1	314	319	PF01111	0.596
DOC_CYCLIN_RxL_1	440	447	PF00134	0.468
DOC_MAPK_DCC_7	569	577	PF00069	0.359
DOC_MAPK_gen_1	353	362	PF00069	0.494
DOC_MAPK_gen_1	528	537	PF00069	0.318
DOC_MAPK_MEF2A_6	356	364	PF00069	0.329
DOC_MAPK_MEF2A_6	530	539	PF00069	0.352
DOC_PP1_RVXF_1	587	593	PF00149	0.395
DOC_PP2B_LxvP_1	162	165	PF13499	0.612
DOC_PP4_FxxP_1	448	451	PF00568	0.526
DOC_USP7_MATH_1	109	113	PF00917	0.772
DOC_USP7_MATH_1	116	120	PF00917	0.716
DOC_USP7_MATH_1	135	139	PF00917	0.603
DOC_USP7_MATH_1	193	197	PF00917	0.744
DOC_USP7_MATH_1	354	358	PF00917	0.541
DOC_USP7_MATH_1	383	387	PF00917	0.357
DOC_USP7_MATH_1	426	430	PF00917	0.465
DOC_USP7_MATH_1	513	517	PF00917	0.529
DOC_USP7_MATH_1	70	74	PF00917	0.537
DOC_USP7_MATH_1	84	88	PF00917	0.660
DOC_USP7_MATH_1	93	97	PF00917	0.602
DOC_USP7_UBL2_3	318	322	PF12436	0.569
DOC_WW_Pin1_4	114	119	PF00397	0.622
DOC_WW_Pin1_4	189	194	PF00397	0.746
DOC_WW_Pin1_4	295	300	PF00397	0.552
DOC_WW_Pin1_4	313	318	PF00397	0.561
DOC_WW_Pin1_4	373	378	PF00397	0.387
DOC_WW_Pin1_4	416	421	PF00397	0.492
DOC_WW_Pin1_4	499	504	PF00397	0.443
DOC_WW_Pin1_4	570	575	PF00397	0.498
LIG_14-3-3_CanoR_1	136	143	PF00244	0.802
LIG_14-3-3_CanoR_1	18	28	PF00244	0.589
LIG_14-3-3_CanoR_1	353	359	PF00244	0.534
LIG_14-3-3_CanoR_1	53	58	PF00244	0.586
LIG_AP2alpha_1	648	652	PF02296	0.349
LIG_APCC_ABBA_1	234	239	PF00400	0.443
LIG_BRCT_BRCA1_1	414	418	PF00533	0.452
LIG_EH1_1	357	365	PF00400	0.416
LIG_FHA_1	192	198	PF00498	0.615
LIG_FHA_1	439	445	PF00498	0.399
LIG_FHA_1	54	60	PF00498	0.598
LIG_FHA_1	578	584	PF00498	0.672
LIG_FHA_1	601	607	PF00498	0.314
LIG_FHA_2	488	494	PF00498	0.368
LIG_FHA_2	620	626	PF00498	0.408
LIG_FXI_DFP_1	282	286	PF00024	0.636
LIG_LIR_Apic_2	447	451	PF02991	0.526
LIG_LIR_Gen_1	281	289	PF02991	0.668
LIG_LIR_Gen_1	601	609	PF02991	0.385
LIG_LIR_Nem_3	281	285	PF02991	0.670
LIG_LIR_Nem_3	291	297	PF02991	0.682
LIG_LIR_Nem_3	485	489	PF02991	0.466
LIG_LIR_Nem_3	527	532	PF02991	0.423
LIG_LIR_Nem_3	601	605	PF02991	0.431
LIG_LIR_Nem_3	650	655	PF02991	0.345
LIG_MAD2	443	451	PF02301	0.286
LIG_PCNA_PIPBox_1	471	480	PF02747	0.459
LIG_PCNA_yPIPBox_3	464	478	PF02747	0.443
LIG_Pex14_2	648	652	PF04695	0.349
LIG_SH2_SRC	237	240	PF00017	0.455
LIG_SH2_STAP1	237	241	PF00017	0.444
LIG_SH2_STAT5	424	427	PF00017	0.459
LIG_SH2_STAT5	489	492	PF00017	0.446
LIG_SH2_STAT5	507	510	PF00017	0.555
LIG_SH2_STAT5	543	546	PF00017	0.343
LIG_SH2_STAT5	616	619	PF00017	0.401
LIG_SH2_STAT5	636	639	PF00017	0.380
LIG_SH2_STAT5	656	659	PF00017	0.382
LIG_SH3_3	293	299	PF00018	0.545
LIG_SH3_3	328	334	PF00018	0.607
LIG_SH3_3	348	354	PF00018	0.526
LIG_SH3_3	78	84	PF00018	0.621
LIG_SUMO_SIM_par_1	137	145	PF11976	0.563
LIG_SUMO_SIM_par_1	226	233	PF11976	0.452
LIG_SUMO_SIM_par_1	616	622	PF11976	0.320
LIG_TRAF2_1	229	232	PF00917	0.493
LIG_WRC_WIRS_1	279	284	PF05994	0.640
LIG_WRC_WIRS_1	355	360	PF05994	0.511
LIG_WRC_WIRS_1	445	450	PF05994	0.391
LIG_WW_3	123	127	PF00397	0.544
MOD_CDK_SPK_2	313	318	PF00069	0.558
MOD_CDK_SPxxK_3	416	423	PF00069	0.297
MOD_CK1_1	119	125	PF00069	0.711
MOD_CK1_1	13	19	PF00069	0.658
MOD_CK1_1	139	145	PF00069	0.618
MOD_CK1_1	166	172	PF00069	0.626
MOD_CK1_1	178	184	PF00069	0.571
MOD_CK1_1	188	194	PF00069	0.559
MOD_CK1_1	267	273	PF00069	0.642
MOD_CK1_1	298	304	PF00069	0.629
MOD_CK1_1	521	527	PF00069	0.389
MOD_CK1_1	542	548	PF00069	0.390
MOD_CK1_1	63	69	PF00069	0.663
MOD_CK1_1	87	93	PF00069	0.717
MOD_CK2_1	226	232	PF00069	0.508
MOD_CK2_1	240	246	PF00069	0.499
MOD_CK2_1	373	379	PF00069	0.386
MOD_CK2_1	426	432	PF00069	0.286
MOD_CK2_1	487	493	PF00069	0.364
MOD_CK2_1	549	555	PF00069	0.353
MOD_CK2_1	59	65	PF00069	0.558
MOD_CK2_1	619	625	PF00069	0.365
MOD_Cter_Amidation	255	258	PF01082	0.603
MOD_GlcNHglycan	111	114	PF01048	0.732
MOD_GlcNHglycan	118	121	PF01048	0.681
MOD_GlcNHglycan	131	134	PF01048	0.633
MOD_GlcNHglycan	168	171	PF01048	0.748
MOD_GlcNHglycan	19	22	PF01048	0.686
MOD_GlcNHglycan	201	204	PF01048	0.795
MOD_GlcNHglycan	269	272	PF01048	0.787
MOD_GlcNHglycan	414	417	PF01048	0.440
MOD_GlcNHglycan	467	470	PF01048	0.324
MOD_GlcNHglycan	509	512	PF01048	0.303
MOD_GlcNHglycan	520	523	PF01048	0.363
MOD_GlcNHglycan	561	564	PF01048	0.413
MOD_GlcNHglycan	595	598	PF01048	0.406
MOD_GSK3_1	13	20	PF00069	0.705
MOD_GSK3_1	131	138	PF00069	0.705
MOD_GSK3_1	181	188	PF00069	0.576
MOD_GSK3_1	189	196	PF00069	0.628
MOD_GSK3_1	265	272	PF00069	0.645
MOD_GSK3_1	322	329	PF00069	0.594
MOD_GSK3_1	373	380	PF00069	0.387
MOD_GSK3_1	412	419	PF00069	0.323
MOD_GSK3_1	5	12	PF00069	0.687
MOD_GSK3_1	509	516	PF00069	0.391
MOD_GSK3_1	520	527	PF00069	0.345
MOD_GSK3_1	537	544	PF00069	0.374
MOD_GSK3_1	549	556	PF00069	0.352
MOD_GSK3_1	564	571	PF00069	0.394
MOD_GSK3_1	59	66	PF00069	0.622
MOD_GSK3_1	83	90	PF00069	0.755
MOD_LATS_1	161	167	PF00433	0.588
MOD_N-GLC_1	327	332	PF02516	0.543
MOD_N-GLC_1	487	492	PF02516	0.267
MOD_NEK2_1	108	113	PF00069	0.708
MOD_NEK2_1	341	346	PF00069	0.557
MOD_NEK2_1	477	482	PF00069	0.369
MOD_NEK2_1	539	544	PF00069	0.315
MOD_NEK2_1	59	64	PF00069	0.577
MOD_NEK2_1	590	595	PF00069	0.363
MOD_NEK2_1	648	653	PF00069	0.377
MOD_NEK2_2	513	518	PF00069	0.297
MOD_NEK2_2	84	89	PF00069	0.573
MOD_PK_1	136	142	PF00069	0.565
MOD_PKA_2	13	19	PF00069	0.564
MOD_PKA_2	135	141	PF00069	0.703
MOD_PKA_2	175	181	PF00069	0.693
MOD_Plk_1	327	333	PF00069	0.461
MOD_Plk_1	37	43	PF00069	0.538
MOD_Plk_1	388	394	PF00069	0.376
MOD_Plk_1	513	519	PF00069	0.274
MOD_Plk_1	553	559	PF00069	0.405
MOD_Plk_4	136	142	PF00069	0.665
MOD_Plk_4	175	181	PF00069	0.689
MOD_Plk_4	409	415	PF00069	0.348
MOD_Plk_4	553	559	PF00069	0.405
MOD_ProDKin_1	114	120	PF00069	0.623
MOD_ProDKin_1	189	195	PF00069	0.748
MOD_ProDKin_1	295	301	PF00069	0.555
MOD_ProDKin_1	313	319	PF00069	0.562
MOD_ProDKin_1	373	379	PF00069	0.386
MOD_ProDKin_1	416	422	PF00069	0.343
MOD_ProDKin_1	499	505	PF00069	0.274
MOD_ProDKin_1	570	576	PF00069	0.506
MOD_SUMO_rev_2	415	425	PF00179	0.283
TRG_DiLeu_BaEn_2	230	236	PF01217	0.477
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.271
TRG_ENDOCYTIC_2	237	240	PF00928	0.477
TRG_ER_diArg_1	154	157	PF00400	0.656
TRG_NLS_MonoExtN_4	49	56	PF00514	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I384	Leptomonas seymouri	67%	93%
A0A1X0NT03	Trypanosomatidae	50%	100%
A0A3Q8IDW5	Leishmania donovani	92%	95%
A0A3Q8IGX5	Leishmania donovani	27%	100%
A0A3R7NBP1	Trypanosoma rangeli	52%	100%
A4H8W6	Leishmania braziliensis	69%	94%
A4HX90	Leishmania infantum	93%	100%
A4ICS7	Leishmania infantum	27%	100%
C9ZTV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AQZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	95%
E9ASH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%