LeishMANIAdb
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Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Non-specific serine/threonine protein kinase
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QEG8_LEIMA
TriTrypDb:
LmjF.17.0260 * , LMJLV39_170008200 * , LMJSD75_170007900 *
Length:
785

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEG8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEG8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 34 38 PF00656 0.601
CLV_NRD_NRD_1 230 232 PF00675 0.702
CLV_NRD_NRD_1 248 250 PF00675 0.589
CLV_NRD_NRD_1 337 339 PF00675 0.755
CLV_NRD_NRD_1 523 525 PF00675 0.639
CLV_NRD_NRD_1 536 538 PF00675 0.504
CLV_NRD_NRD_1 610 612 PF00675 0.596
CLV_PCSK_KEX2_1 188 190 PF00082 0.650
CLV_PCSK_KEX2_1 248 250 PF00082 0.589
CLV_PCSK_KEX2_1 337 339 PF00082 0.755
CLV_PCSK_KEX2_1 536 538 PF00082 0.550
CLV_PCSK_KEX2_1 610 612 PF00082 0.596
CLV_PCSK_PC1ET2_1 188 190 PF00082 0.611
CLV_PCSK_PC7_1 333 339 PF00082 0.613
CLV_PCSK_SKI1_1 17 21 PF00082 0.584
CLV_PCSK_SKI1_1 232 236 PF00082 0.737
CLV_PCSK_SKI1_1 524 528 PF00082 0.639
CLV_PCSK_SKI1_1 536 540 PF00082 0.482
CLV_PCSK_SKI1_1 596 600 PF00082 0.594
CLV_PCSK_SKI1_1 743 747 PF00082 0.539
CLV_PCSK_SKI1_1 764 768 PF00082 0.533
CLV_Separin_Metazoa 521 525 PF03568 0.652
DEG_APCC_KENBOX_2 531 535 PF00400 0.462
DEG_COP1_1 78 86 PF00400 0.675
DEG_SCF_FBW7_1 346 353 PF00400 0.758
DEG_SCF_FBW7_1 381 388 PF00400 0.683
DEG_SCF_FBW7_2 83 89 PF00400 0.739
DEG_SPOP_SBC_1 122 126 PF00917 0.592
DEG_SPOP_SBC_1 364 368 PF00917 0.567
DEG_SPOP_SBC_1 700 704 PF00917 0.522
DOC_CKS1_1 647 652 PF01111 0.705
DOC_CKS1_1 77 82 PF01111 0.732
DOC_CKS1_1 83 88 PF01111 0.718
DOC_CYCLIN_RxL_1 532 545 PF00134 0.635
DOC_MAPK_gen_1 14 22 PF00069 0.620
DOC_MAPK_gen_1 337 343 PF00069 0.752
DOC_MAPK_gen_1 456 465 PF00069 0.813
DOC_PP1_RVXF_1 259 265 PF00149 0.528
DOC_PP1_RVXF_1 767 774 PF00149 0.637
DOC_PP2B_LxvP_1 120 123 PF13499 0.741
DOC_PP2B_LxvP_1 20 23 PF13499 0.604
DOC_PP2B_LxvP_1 325 328 PF13499 0.742
DOC_PP2B_LxvP_1 343 346 PF13499 0.605
DOC_PP4_FxxP_1 710 713 PF00568 0.561
DOC_USP7_MATH_1 121 125 PF00917 0.739
DOC_USP7_MATH_1 193 197 PF00917 0.688
DOC_USP7_MATH_1 227 231 PF00917 0.609
DOC_USP7_MATH_1 257 261 PF00917 0.634
DOC_USP7_MATH_1 27 31 PF00917 0.690
DOC_USP7_MATH_1 294 298 PF00917 0.780
DOC_USP7_MATH_1 3 7 PF00917 0.613
DOC_USP7_MATH_1 350 354 PF00917 0.776
DOC_USP7_MATH_1 364 368 PF00917 0.551
DOC_USP7_MATH_1 375 379 PF00917 0.560
DOC_USP7_MATH_1 438 442 PF00917 0.844
DOC_USP7_MATH_1 510 514 PF00917 0.782
DOC_USP7_MATH_1 55 59 PF00917 0.758
DOC_USP7_MATH_1 554 558 PF00917 0.687
DOC_USP7_MATH_1 564 568 PF00917 0.809
DOC_USP7_MATH_1 582 586 PF00917 0.753
DOC_USP7_MATH_1 587 591 PF00917 0.760
DOC_USP7_MATH_1 700 704 PF00917 0.753
DOC_WW_Pin1_4 103 108 PF00397 0.731
DOC_WW_Pin1_4 127 132 PF00397 0.795
DOC_WW_Pin1_4 158 163 PF00397 0.710
DOC_WW_Pin1_4 341 346 PF00397 0.811
DOC_WW_Pin1_4 381 386 PF00397 0.685
DOC_WW_Pin1_4 471 476 PF00397 0.727
DOC_WW_Pin1_4 500 505 PF00397 0.772
DOC_WW_Pin1_4 572 577 PF00397 0.735
DOC_WW_Pin1_4 625 630 PF00397 0.591
DOC_WW_Pin1_4 639 644 PF00397 0.663
DOC_WW_Pin1_4 646 651 PF00397 0.683
DOC_WW_Pin1_4 685 690 PF00397 0.744
DOC_WW_Pin1_4 696 701 PF00397 0.712
DOC_WW_Pin1_4 726 731 PF00397 0.477
DOC_WW_Pin1_4 76 81 PF00397 0.762
DOC_WW_Pin1_4 82 87 PF00397 0.652
DOC_WW_Pin1_4 96 101 PF00397 0.513
LIG_14-3-3_CanoR_1 105 111 PF00244 0.753
LIG_14-3-3_CanoR_1 408 412 PF00244 0.743
LIG_14-3-3_CanoR_1 459 464 PF00244 0.735
LIG_14-3-3_CanoR_1 546 553 PF00244 0.693
LIG_14-3-3_CanoR_1 610 614 PF00244 0.625
LIG_14-3-3_CanoR_1 627 637 PF00244 0.653
LIG_BIR_II_1 1 5 PF00653 0.572
LIG_BIR_III_4 154 158 PF00653 0.838
LIG_BIR_III_4 39 43 PF00653 0.711
LIG_BRCT_BRCA1_1 566 570 PF00533 0.753
LIG_BRCT_BRCA1_1 633 637 PF00533 0.690
LIG_CaM_IQ_9 538 554 PF13499 0.684
LIG_eIF4E_1 110 116 PF01652 0.635
LIG_EVH1_1 325 329 PF00568 0.577
LIG_FHA_1 202 208 PF00498 0.668
LIG_FHA_1 553 559 PF00498 0.739
LIG_FHA_1 640 646 PF00498 0.718
LIG_FHA_1 68 74 PF00498 0.768
LIG_FHA_1 700 706 PF00498 0.626
LIG_FHA_1 731 737 PF00498 0.653
LIG_FHA_2 32 38 PF00498 0.665
LIG_FHA_2 666 672 PF00498 0.800
LIG_LIR_Gen_1 384 393 PF02991 0.662
LIG_LIR_Nem_3 263 267 PF02991 0.652
LIG_LIR_Nem_3 384 390 PF02991 0.674
LIG_LIR_Nem_3 740 745 PF02991 0.647
LIG_LIR_Nem_3 760 766 PF02991 0.309
LIG_LIR_Nem_3 772 776 PF02991 0.553
LIG_SH2_CRK 742 746 PF00017 0.649
LIG_SH2_CRK 763 767 PF00017 0.565
LIG_SH3_2 184 189 PF14604 0.627
LIG_SH3_2 270 275 PF14604 0.706
LIG_SH3_2 332 337 PF14604 0.840
LIG_SH3_2 576 581 PF14604 0.752
LIG_SH3_3 172 178 PF00018 0.758
LIG_SH3_3 179 185 PF00018 0.640
LIG_SH3_3 267 273 PF00018 0.700
LIG_SH3_3 321 327 PF00018 0.729
LIG_SH3_3 329 335 PF00018 0.692
LIG_SH3_3 469 475 PF00018 0.723
LIG_SH3_3 49 55 PF00018 0.781
LIG_SH3_3 498 504 PF00018 0.741
LIG_SH3_3 573 579 PF00018 0.734
LIG_SH3_3 80 86 PF00018 0.736
LIG_SH3_4 299 306 PF00018 0.733
LIG_SH3_CIN85_PxpxPR_1 328 333 PF14604 0.587
LIG_SUMO_SIM_anti_2 461 469 PF11976 0.689
LIG_SUMO_SIM_par_1 18 25 PF11976 0.679
LIG_SUMO_SIM_par_1 665 673 PF11976 0.727
LIG_TRAF2_1 484 487 PF00917 0.707
LIG_TRAF2_1 612 615 PF00917 0.694
LIG_TRAF2_1 713 716 PF00917 0.584
LIG_TRAF2_1 754 757 PF00917 0.565
LIG_WW_3 688 692 PF00397 0.590
LIG_WW_3 93 97 PF00397 0.715
MOD_CDC14_SPxK_1 578 581 PF00782 0.812
MOD_CDC14_SPxK_1 688 691 PF00782 0.699
MOD_CDK_SPK_2 572 577 PF00069 0.714
MOD_CDK_SPxK_1 575 581 PF00069 0.751
MOD_CDK_SPxK_1 685 691 PF00069 0.705
MOD_CDK_SPxxK_3 341 348 PF00069 0.702
MOD_CDK_SPxxK_3 96 103 PF00069 0.767
MOD_CK1_1 106 112 PF00069 0.701
MOD_CK1_1 136 142 PF00069 0.780
MOD_CK1_1 170 176 PF00069 0.813
MOD_CK1_1 260 266 PF00069 0.617
MOD_CK1_1 280 286 PF00069 0.692
MOD_CK1_1 318 324 PF00069 0.663
MOD_CK1_1 368 374 PF00069 0.693
MOD_CK1_1 439 445 PF00069 0.841
MOD_CK1_1 447 453 PF00069 0.714
MOD_CK1_1 458 464 PF00069 0.786
MOD_CK1_1 528 534 PF00069 0.682
MOD_CK1_1 545 551 PF00069 0.528
MOD_CK1_1 571 577 PF00069 0.735
MOD_CK1_1 580 586 PF00069 0.578
MOD_CK1_1 59 65 PF00069 0.639
MOD_CK1_1 591 597 PF00069 0.652
MOD_CK1_1 609 615 PF00069 0.390
MOD_CK1_1 631 637 PF00069 0.672
MOD_CK1_1 701 707 PF00069 0.555
MOD_CK2_1 227 233 PF00069 0.658
MOD_CK2_1 609 615 PF00069 0.692
MOD_CK2_1 665 671 PF00069 0.728
MOD_DYRK1A_RPxSP_1 502 506 PF00069 0.732
MOD_DYRK1A_RPxSP_1 96 100 PF00069 0.842
MOD_GlcNHglycan 100 103 PF01048 0.630
MOD_GlcNHglycan 127 130 PF01048 0.704
MOD_GlcNHglycan 154 158 PF01048 0.824
MOD_GlcNHglycan 167 172 PF01048 0.543
MOD_GlcNHglycan 305 308 PF01048 0.730
MOD_GlcNHglycan 317 320 PF01048 0.618
MOD_GlcNHglycan 352 355 PF01048 0.732
MOD_GlcNHglycan 373 376 PF01048 0.730
MOD_GlcNHglycan 377 380 PF01048 0.725
MOD_GlcNHglycan 512 515 PF01048 0.709
MOD_GlcNHglycan 564 567 PF01048 0.809
MOD_GlcNHglycan 57 61 PF01048 0.733
MOD_GlcNHglycan 584 587 PF01048 0.685
MOD_GlcNHglycan 630 633 PF01048 0.709
MOD_GlcNHglycan 683 686 PF01048 0.638
MOD_GlcNHglycan 730 733 PF01048 0.567
MOD_GSK3_1 121 128 PF00069 0.772
MOD_GSK3_1 136 143 PF00069 0.772
MOD_GSK3_1 27 34 PF00069 0.806
MOD_GSK3_1 277 284 PF00069 0.808
MOD_GSK3_1 303 310 PF00069 0.688
MOD_GSK3_1 346 353 PF00069 0.765
MOD_GSK3_1 364 371 PF00069 0.710
MOD_GSK3_1 381 388 PF00069 0.500
MOD_GSK3_1 403 410 PF00069 0.729
MOD_GSK3_1 415 422 PF00069 0.654
MOD_GSK3_1 436 443 PF00069 0.785
MOD_GSK3_1 444 451 PF00069 0.689
MOD_GSK3_1 455 462 PF00069 0.760
MOD_GSK3_1 496 503 PF00069 0.717
MOD_GSK3_1 528 535 PF00069 0.573
MOD_GSK3_1 548 555 PF00069 0.520
MOD_GSK3_1 55 62 PF00069 0.696
MOD_GSK3_1 562 569 PF00069 0.719
MOD_GSK3_1 571 578 PF00069 0.755
MOD_GSK3_1 587 594 PF00069 0.700
MOD_GSK3_1 652 659 PF00069 0.792
MOD_GSK3_1 681 688 PF00069 0.636
MOD_GSK3_1 694 701 PF00069 0.717
MOD_GSK3_1 726 733 PF00069 0.521
MOD_N-GLC_1 133 138 PF02516 0.779
MOD_N-GLC_1 447 452 PF02516 0.808
MOD_N-GLC_1 47 52 PF02516 0.752
MOD_N-GLC_1 542 547 PF02516 0.667
MOD_N-GLC_1 68 73 PF02516 0.573
MOD_N-GLC_1 694 699 PF02516 0.763
MOD_NEK2_1 133 138 PF00069 0.721
MOD_NEK2_1 140 145 PF00069 0.730
MOD_NEK2_1 407 412 PF00069 0.726
MOD_NEK2_1 415 420 PF00069 0.706
MOD_NEK2_1 496 501 PF00069 0.715
MOD_NEK2_1 547 552 PF00069 0.794
MOD_NEK2_1 553 558 PF00069 0.733
MOD_NEK2_1 637 642 PF00069 0.740
MOD_NEK2_2 403 408 PF00069 0.701
MOD_PIKK_1 284 290 PF00454 0.811
MOD_PIKK_1 496 502 PF00454 0.805
MOD_PIKK_1 548 554 PF00454 0.725
MOD_PIKK_1 588 594 PF00454 0.707
MOD_PIKK_1 730 736 PF00454 0.637
MOD_PIKK_1 757 763 PF00454 0.576
MOD_PK_1 459 465 PF00069 0.816
MOD_PK_1 491 497 PF00069 0.725
MOD_PKA_2 212 218 PF00069 0.528
MOD_PKA_2 336 342 PF00069 0.791
MOD_PKA_2 407 413 PF00069 0.742
MOD_PKA_2 439 445 PF00069 0.771
MOD_PKA_2 455 461 PF00069 0.627
MOD_PKA_2 545 551 PF00069 0.670
MOD_PKA_2 580 586 PF00069 0.757
MOD_PKA_2 609 615 PF00069 0.693
MOD_PKB_1 96 104 PF00069 0.705
MOD_Plk_1 133 139 PF00069 0.731
MOD_Plk_1 307 313 PF00069 0.586
MOD_Plk_1 364 370 PF00069 0.740
MOD_Plk_1 447 453 PF00069 0.796
MOD_Plk_1 47 53 PF00069 0.751
MOD_Plk_1 542 548 PF00069 0.710
MOD_Plk_1 68 74 PF00069 0.572
MOD_Plk_4 111 117 PF00069 0.774
MOD_Plk_4 3 9 PF00069 0.603
MOD_Plk_4 358 364 PF00069 0.753
MOD_Plk_4 368 374 PF00069 0.671
MOD_Plk_4 461 467 PF00069 0.693
MOD_Plk_4 47 53 PF00069 0.595
MOD_Plk_4 491 497 PF00069 0.593
MOD_Plk_4 554 560 PF00069 0.601
MOD_Plk_4 68 74 PF00069 0.805
MOD_ProDKin_1 103 109 PF00069 0.730
MOD_ProDKin_1 127 133 PF00069 0.796
MOD_ProDKin_1 158 164 PF00069 0.711
MOD_ProDKin_1 341 347 PF00069 0.811
MOD_ProDKin_1 381 387 PF00069 0.686
MOD_ProDKin_1 471 477 PF00069 0.732
MOD_ProDKin_1 500 506 PF00069 0.771
MOD_ProDKin_1 572 578 PF00069 0.735
MOD_ProDKin_1 625 631 PF00069 0.598
MOD_ProDKin_1 639 645 PF00069 0.668
MOD_ProDKin_1 646 652 PF00069 0.682
MOD_ProDKin_1 685 691 PF00069 0.745
MOD_ProDKin_1 696 702 PF00069 0.708
MOD_ProDKin_1 726 732 PF00069 0.469
MOD_ProDKin_1 76 82 PF00069 0.763
MOD_ProDKin_1 96 102 PF00069 0.514
MOD_SUMO_rev_2 752 760 PF00179 0.635
TRG_DiLeu_BaEn_1 615 620 PF01217 0.658
TRG_DiLeu_BaLyEn_6 393 398 PF01217 0.738
TRG_DiLeu_BaLyEn_6 476 481 PF01217 0.829
TRG_ENDOCYTIC_2 742 745 PF00928 0.549
TRG_ENDOCYTIC_2 763 766 PF00928 0.537
TRG_ER_diArg_1 248 251 PF00400 0.590
TRG_ER_diArg_1 95 98 PF00400 0.731
TRG_NES_CRM1_1 233 247 PF08389 0.638
TRG_Pf-PMV_PEXEL_1 17 21 PF00026 0.689
TRG_Pf-PMV_PEXEL_1 396 400 PF00026 0.697
TRG_Pf-PMV_PEXEL_1 525 529 PF00026 0.610
TRG_Pf-PMV_PEXEL_1 537 542 PF00026 0.509

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4I6 Leptomonas seymouri 35% 85%
A0A3S7WUB6 Leishmania donovani 90% 100%
A4H8W9 Leishmania braziliensis 62% 96%
A4HX93 Leishmania infantum 90% 100%
E9AQZ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS