Histone H2A

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H2A

Gene product:

histone H2A variant Z

Species:

Leishmania major

UniProt:

Q4QEG6_LEIMA

TriTrypDb:

LmjF.17.0280 , LMJLV39_170008400 , LMJSD75_170008100

Length:

177

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, Histone H2A

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	10
GO:0005654	nucleoplasm	2	2
GO:0032991	protein-containing complex	1	10
GO:0032993	protein-DNA complex	2	10
GO:0044815	DNA packaging complex	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005634	nucleus	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

Q4QEG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEG6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006352	DNA-templated transcription initiation	6	2
GO:0006367	transcription initiation at RNA polymerase II promoter	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0032774	RNA biosynthetic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0051276	chromosome organization	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0005198	structural molecule activity	1	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0030527	structural constituent of chromatin	2	10
GO:0046982	protein heterodimerization activity	4	10
GO:0046983	protein dimerization activity	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	60	62	PF00675	0.209
CLV_NRD_NRD_1	88	90	PF00675	0.186
CLV_PCSK_KEX2_1	174	176	PF00082	0.486
CLV_PCSK_KEX2_1	49	51	PF00082	0.194
CLV_PCSK_KEX2_1	60	62	PF00082	0.207
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.486
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.179
CLV_PCSK_SKI1_1	131	135	PF00082	0.179
CLV_PCSK_SKI1_1	171	175	PF00082	0.262
DEG_APCC_DBOX_1	130	138	PF00400	0.379
DOC_MAPK_gen_1	127	135	PF00069	0.379
DOC_MAPK_gen_1	66	74	PF00069	0.406
DOC_MAPK_JIP1_4	129	135	PF00069	0.379
DOC_MAPK_MEF2A_6	129	137	PF00069	0.379
DOC_USP7_UBL2_3	162	166	PF12436	0.379
DOC_USP7_UBL2_3	167	171	PF12436	0.379
DOC_USP7_UBL2_3	35	39	PF12436	0.526
DOC_USP7_UBL2_3	41	45	PF12436	0.216
DOC_USP7_UBL2_3	49	53	PF12436	0.286
LIG_14-3-3_CanoR_1	92	100	PF00244	0.389
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_FHA_1	107	113	PF00498	0.379
LIG_FHA_1	123	129	PF00498	0.381
LIG_FHA_1	26	32	PF00498	0.598
LIG_FHA_2	2	8	PF00498	0.535
LIG_Integrin_RGD_1	138	140	PF01839	0.179
LIG_SH2_STAT3	88	91	PF00017	0.433
LIG_SH2_STAT5	100	103	PF00017	0.379
LIG_SH2_STAT5	107	110	PF00017	0.379
LIG_SH2_STAT5	3	6	PF00017	0.630
LIG_SH3_3	9	15	PF00018	0.535
LIG_SUMO_SIM_par_1	109	116	PF11976	0.462
LIG_TRAF2_1	4	7	PF00917	0.624
MOD_CK1_1	29	35	PF00069	0.539
MOD_CK2_1	1	7	PF00069	0.571
MOD_Cter_Amidation	47	50	PF01082	0.190
MOD_Cter_Amidation	58	61	PF01082	0.183
MOD_GlcNHglycan	114	118	PF01048	0.262
MOD_GlcNHglycan	171	174	PF01048	0.262
MOD_GlcNHglycan	21	24	PF01048	0.503
MOD_GlcNHglycan	31	34	PF01048	0.522
MOD_GlcNHglycan	95	98	PF01048	0.191
MOD_GSK3_1	1	8	PF00069	0.628
MOD_GSK3_1	165	172	PF00069	0.472
MOD_GSK3_1	21	28	PF00069	0.579
MOD_PKA_1	169	175	PF00069	0.462
MOD_PKA_2	62	68	PF00069	0.464
MOD_Plk_1	25	31	PF00069	0.528
MOD_Plk_4	26	32	PF00069	0.564
TRG_NLS_MonoExtN_4	166	173	PF00514	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA7	Leptomonas seymouri	94%	99%
A0A0S4KEA6	Bodo saltans	57%	98%
A0A1X0NTG5	Trypanosomatidae	78%	99%
A0A381MJI1	Leishmania infantum	43%	100%
A0A3Q8IHC3	Leishmania donovani	44%	100%
A0A3Q8IL41	Leishmania donovani	43%	100%
A0A3S5H701	Leishmania donovani	100%	100%
A0A3S5IQH1	Trypanosoma rangeli	81%	100%
A1A4R1	Bos taurus	53%	100%
A2YMC6	Oryza sativa subsp. indica	47%	100%
A3LXE7	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	50%	100%
A3LZZ0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	52%	100%
A4H8X1	Leishmania braziliensis	89%	97%
A4HBV1	Leishmania braziliensis	49%	100%
A4HBV2	Leishmania braziliensis	48%	100%
A4HBV3	Leishmania braziliensis	48%	100%
A4HHI4	Leishmania braziliensis	46%	100%
A4HK98	Leishmania braziliensis	48%	100%
A4HX95	Leishmania infantum	100%	100%
A5DBG4	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	53%	100%
A5DWF1	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	50%	100%
A9UMV8	Rattus norvegicus	53%	100%
C0HKE1	Mus musculus	52%	100%
C0HKE2	Mus musculus	52%	100%
C0HKE3	Mus musculus	52%	100%
C0HKE4	Mus musculus	52%	100%
C0HKE5	Mus musculus	52%	100%
C0HKE6	Mus musculus	52%	100%
C0HKE7	Mus musculus	52%	100%
C0HKE8	Mus musculus	52%	100%
C0HKE9	Mus musculus	52%	100%
C9ZTW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	99%
E9AE33	Leishmania major	45%	100%
E9AE34	Leishmania major	45%	100%
E9AE35	Leishmania major	45%	100%
E9AGW1	Leishmania infantum	43%	100%
E9ALP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AQZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AV77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
O04848	Arabidopsis thaliana	48%	100%
O62695	Oryctolagus cuniculus	55%	100%
P02262	Rattus norvegicus	54%	100%
P02263	Gallus gallus	53%	100%
P02264	Oncorhynchus mykiss	52%	100%
P02269	Asterias rubens	51%	100%
P02272	Gallus gallus	56%	100%
P02275	Triticum aestivum	48%	100%
P04735	Psammechinus miliaris	48%	100%
P04908	Homo sapiens	52%	100%
P04909	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	100%
P04910	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	100%
P06897	Xenopus laevis	52%	100%
P06898	Xenopus laevis	41%	100%
P0C0S8	Homo sapiens	53%	100%
P0C0S9	Bos taurus	53%	100%
P0C169	Rattus norvegicus	53%	100%
P0C170	Rattus norvegicus	52%	100%
P0CC09	Rattus norvegicus	54%	100%
P13912	Cairina moschata	53%	100%
P16865	Volvox carteri	53%	100%
P16866	Volvox carteri	52%	100%
P16886	Strongylocentrotus purpuratus	49%	100%
P20671	Homo sapiens	53%	100%
P35061	Acropora formosa	48%	100%
P35062	Gallus gallus	52%	100%
P35063	Picea abies	52%	100%
P40280	Zea mays	49%	100%
P40282	Plasmodium falciparum	51%	100%
P50567	Chlamydomonas reinhardtii	52%	100%
P70082	Gallus gallus	53%	100%
P70094	Xenopus laevis	54%	100%
Q00728	Rattus norvegicus	52%	100%
Q12692	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	100%
Q16777	Homo sapiens	53%	100%
Q27511	Caenorhabditis elegans	57%	100%
Q2GUP0	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	52%	100%
Q32LA7	Bos taurus	56%	100%
Q3THW5	Mus musculus	56%	100%
Q3ZBX9	Bos taurus	54%	100%
Q43213	Triticum aestivum	48%	100%
Q43214	Triticum aestivum	47%	100%
Q43312	Triticum aestivum	46%	100%
Q4FZT6	Rattus norvegicus	53%	100%
Q4JHM8	Leishmania donovani	43%	100%
Q4PHE4	Ustilago maydis (strain 521 / FGSC 9021)	52%	100%
Q4QCA4	Leishmania major	43%	100%
Q4R3X5	Macaca fascicularis	53%	100%
Q54LA5	Dictyostelium discoideum	42%	100%
Q59SU5	Candida albicans (strain SC5314 / ATCC MYA-2876)	49%	100%
Q5BJ65	Xenopus tropicalis	56%	100%
Q64522	Mus musculus	52%	100%
Q64523	Mus musculus	53%	100%
Q64598	Rattus norvegicus	52%	100%
Q6BKW8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	52%	100%
Q6BRG3	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	50%	100%
Q6C4I6	Yarrowia lipolytica (strain CLIB 122 / E 150)	52%	100%
Q6CK59	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	49%	100%
Q6CUC8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	53%	100%
Q6DER6	Xenopus tropicalis	54%	100%
Q6FI13	Homo sapiens	54%	100%
Q6GM74	Xenopus laevis	56%	100%
Q6GM86	Xenopus laevis	51%	100%
Q6GSS7	Mus musculus	54%	100%
Q6Y237	Pagrus major	56%	100%
Q6ZL42	Oryza sativa subsp. japonica	47%	100%
Q71PD7	Danio rerio	56%	100%
Q71UI9	Homo sapiens	56%	100%
Q74ZL4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	49%	100%
Q757L4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	49%	100%
Q75CC6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	56%	100%
Q7L7L0	Homo sapiens	53%	100%
Q873G4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	52%	100%
Q8BFU2	Mus musculus	53%	100%
Q8CGP5	Mus musculus	52%	100%
Q8CGP6	Mus musculus	52%	100%
Q8CGP7	Mus musculus	52%	100%
Q8IUE6	Homo sapiens	52%	100%
Q8R1M2	Mus musculus	53%	100%
Q93077	Homo sapiens	53%	100%
Q94F49	Arabidopsis thaliana	48%	100%
Q96KK5	Homo sapiens	53%	100%
Q96QV6	Homo sapiens	52%	100%
Q99878	Homo sapiens	53%	100%
Q9BTM1	Homo sapiens	54%	100%
Q9FJE8	Arabidopsis thaliana	49%	100%
Q9LD75	Lilium longiflorum	40%	100%
Q9M531	Euphorbia esula	50%	100%
Q9S9K7	Arabidopsis thaliana	48%	100%