RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q4QEG5_LEIMA

TriTrypDb:

LmjF.17.0290 , LMJLV39_170008500 , LMJSD75_170008200

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEG5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.774
CLV_C14_Caspase3-7	486	490	PF00656	0.736
CLV_MEL_PAP_1	239	245	PF00089	0.740
CLV_MEL_PAP_1	402	408	PF00089	0.452
CLV_NRD_NRD_1	140	142	PF00675	0.779
CLV_NRD_NRD_1	348	350	PF00675	0.591
CLV_NRD_NRD_1	700	702	PF00675	0.598
CLV_NRD_NRD_1	723	725	PF00675	0.600
CLV_PCSK_FUR_1	138	142	PF00082	0.772
CLV_PCSK_KEX2_1	116	118	PF00082	0.752
CLV_PCSK_KEX2_1	140	142	PF00082	0.779
CLV_PCSK_KEX2_1	348	350	PF00082	0.619
CLV_PCSK_KEX2_1	599	601	PF00082	0.630
CLV_PCSK_KEX2_1	699	701	PF00082	0.731
CLV_PCSK_KEX2_1	722	724	PF00082	0.564
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.752
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.595
CLV_PCSK_PC1ET2_1	699	701	PF00082	0.692
CLV_PCSK_SKI1_1	119	123	PF00082	0.764
CLV_PCSK_SKI1_1	151	155	PF00082	0.731
CLV_PCSK_SKI1_1	617	621	PF00082	0.587
CLV_Separin_Metazoa	187	191	PF03568	0.646
DEG_APCC_DBOX_1	422	430	PF00400	0.527
DEG_SCF_FBW7_1	290	297	PF00400	0.705
DEG_SPOP_SBC_1	388	392	PF00917	0.635
DOC_CDC14_PxL_1	8	16	PF14671	0.558
DOC_CKS1_1	256	261	PF01111	0.728
DOC_CKS1_1	272	277	PF01111	0.645
DOC_CKS1_1	613	618	PF01111	0.570
DOC_CYCLIN_yCln2_LP_2	295	301	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	558	564	PF00134	0.544
DOC_MAPK_DCC_7	68	78	PF00069	0.526
DOC_PP1_RVXF_1	30	37	PF00149	0.397
DOC_PP2B_LxvP_1	144	147	PF13499	0.796
DOC_PP2B_LxvP_1	358	361	PF13499	0.494
DOC_PP4_FxxP_1	272	275	PF00568	0.775
DOC_PP4_FxxP_1	30	33	PF00568	0.411
DOC_USP7_MATH_1	139	143	PF00917	0.842
DOC_USP7_MATH_1	159	163	PF00917	0.793
DOC_USP7_MATH_1	223	227	PF00917	0.792
DOC_USP7_MATH_1	314	318	PF00917	0.800
DOC_USP7_MATH_1	323	327	PF00917	0.672
DOC_USP7_MATH_1	367	371	PF00917	0.473
DOC_USP7_MATH_1	388	392	PF00917	0.706
DOC_USP7_MATH_1	567	571	PF00917	0.617
DOC_USP7_MATH_1	666	670	PF00917	0.492
DOC_USP7_MATH_1	685	689	PF00917	0.688
DOC_WW_Pin1_4	101	106	PF00397	0.746
DOC_WW_Pin1_4	142	147	PF00397	0.808
DOC_WW_Pin1_4	200	205	PF00397	0.672
DOC_WW_Pin1_4	255	260	PF00397	0.704
DOC_WW_Pin1_4	263	268	PF00397	0.724
DOC_WW_Pin1_4	271	276	PF00397	0.537
DOC_WW_Pin1_4	290	295	PF00397	0.509
DOC_WW_Pin1_4	356	361	PF00397	0.492
DOC_WW_Pin1_4	429	434	PF00397	0.542
DOC_WW_Pin1_4	612	617	PF00397	0.543
DOC_WW_Pin1_4	629	634	PF00397	0.683
DOC_WW_Pin1_4	686	691	PF00397	0.680
LIG_14-3-3_CanoR_1	119	127	PF00244	0.617
LIG_14-3-3_CanoR_1	138	148	PF00244	0.778
LIG_14-3-3_CanoR_1	151	157	PF00244	0.685
LIG_14-3-3_CanoR_1	198	207	PF00244	0.749
LIG_14-3-3_CanoR_1	368	372	PF00244	0.488
LIG_14-3-3_CanoR_1	96	100	PF00244	0.792
LIG_Actin_WH2_2	74	91	PF00022	0.656
LIG_BRCT_BRCA1_1	631	635	PF00533	0.673
LIG_FHA_1	194	200	PF00498	0.732
LIG_FHA_1	230	236	PF00498	0.805
LIG_FHA_1	291	297	PF00498	0.808
LIG_FHA_1	46	52	PF00498	0.286
LIG_FHA_1	483	489	PF00498	0.777
LIG_FHA_1	547	553	PF00498	0.574
LIG_FHA_1	81	87	PF00498	0.528
LIG_FHA_2	120	126	PF00498	0.809
LIG_FHA_2	128	134	PF00498	0.750
LIG_FHA_2	482	488	PF00498	0.763
LIG_FHA_2	527	533	PF00498	0.591
LIG_FHA_2	601	607	PF00498	0.591
LIG_LIR_Apic_2	28	33	PF02991	0.411
LIG_LIR_Apic_2	494	498	PF02991	0.672
LIG_LIR_Gen_1	302	312	PF02991	0.550
LIG_LIR_Gen_1	401	411	PF02991	0.516
LIG_LIR_Nem_3	302	307	PF02991	0.589
LIG_LIR_Nem_3	401	406	PF02991	0.560
LIG_LIR_Nem_3	708	713	PF02991	0.351
LIG_MYND_1	263	267	PF01753	0.778
LIG_MYND_1	294	298	PF01753	0.724
LIG_NRBOX	425	431	PF00104	0.530
LIG_NRBOX	449	455	PF00104	0.487
LIG_PCNA_yPIPBox_3	68	82	PF02747	0.507
LIG_SH2_CRK	495	499	PF00017	0.669
LIG_SH2_CRK	658	662	PF00017	0.480
LIG_SH2_STAT5	483	486	PF00017	0.647
LIG_SH2_STAT5	495	498	PF00017	0.672
LIG_SH2_STAT5	543	546	PF00017	0.681
LIG_SH3_3	201	207	PF00018	0.694
LIG_SH3_3	253	259	PF00018	0.748
LIG_SH3_3	31	37	PF00018	0.513
LIG_SH3_3	52	58	PF00018	0.411
LIG_SH3_3	630	636	PF00018	0.587
LIG_SH3_3	700	706	PF00018	0.522
LIG_Sin3_3	303	310	PF02671	0.568
LIG_SUMO_SIM_anti_2	446	454	PF11976	0.487
LIG_SUMO_SIM_par_1	207	213	PF11976	0.828
LIG_TRAF2_1	126	129	PF00917	0.692
LIG_TRAF2_1	591	594	PF00917	0.612
MOD_CDK_SPK_2	612	617	PF00069	0.499
MOD_CDK_SPxK_1	686	692	PF00069	0.684
MOD_CK1_1	142	148	PF00069	0.763
MOD_CK1_1	234	240	PF00069	0.788
MOD_CK1_1	342	348	PF00069	0.587
MOD_CK1_1	389	395	PF00069	0.711
MOD_CK1_1	474	480	PF00069	0.643
MOD_CK1_1	604	610	PF00069	0.735
MOD_CK1_1	686	692	PF00069	0.723
MOD_CK2_1	127	133	PF00069	0.620
MOD_CK2_1	152	158	PF00069	0.766
MOD_CK2_1	181	187	PF00069	0.614
MOD_CK2_1	474	480	PF00069	0.732
MOD_CK2_1	481	487	PF00069	0.722
MOD_CK2_1	526	532	PF00069	0.576
MOD_CK2_1	600	606	PF00069	0.706
MOD_CMANNOS	344	347	PF00535	0.529
MOD_Cter_Amidation	597	600	PF01082	0.585
MOD_Cter_Amidation	697	700	PF01082	0.743
MOD_GlcNHglycan	236	239	PF01048	0.761
MOD_GlcNHglycan	245	248	PF01048	0.629
MOD_GlcNHglycan	321	324	PF01048	0.697
MOD_GlcNHglycan	391	394	PF01048	0.710
MOD_GlcNHglycan	569	572	PF01048	0.572
MOD_GlcNHglycan	603	606	PF01048	0.740
MOD_GlcNHglycan	668	671	PF01048	0.489
MOD_GlcNHglycan	684	688	PF01048	0.700
MOD_GlcNHglycan	693	697	PF01048	0.781
MOD_GlcNHglycan	90	93	PF01048	0.725
MOD_GSK3_1	169	176	PF00069	0.850
MOD_GSK3_1	230	237	PF00069	0.806
MOD_GSK3_1	290	297	PF00069	0.705
MOD_GSK3_1	310	317	PF00069	0.464
MOD_GSK3_1	319	326	PF00069	0.688
MOD_GSK3_1	329	336	PF00069	0.500
MOD_GSK3_1	378	385	PF00069	0.661
MOD_GSK3_1	388	395	PF00069	0.755
MOD_GSK3_1	471	478	PF00069	0.691
MOD_GSK3_1	544	551	PF00069	0.577
MOD_GSK3_1	600	607	PF00069	0.725
MOD_GSK3_1	627	634	PF00069	0.678
MOD_N-GLC_1	527	532	PF02516	0.617
MOD_NEK2_1	1	6	PF00069	0.679
MOD_NEK2_1	13	18	PF00069	0.513
MOD_NEK2_1	526	531	PF00069	0.670
MOD_NEK2_1	548	553	PF00069	0.569
MOD_NEK2_1	579	584	PF00069	0.546
MOD_NEK2_1	627	632	PF00069	0.613
MOD_NEK2_1	683	688	PF00069	0.703
MOD_NEK2_1	88	93	PF00069	0.718
MOD_NEK2_1	95	100	PF00069	0.680
MOD_NEK2_2	152	157	PF00069	0.845
MOD_NMyristoyl	1	7	PF02799	0.618
MOD_PIKK_1	127	133	PF00454	0.737
MOD_PIKK_1	193	199	PF00454	0.689
MOD_PIKK_1	471	477	PF00454	0.677
MOD_PKA_1	140	146	PF00069	0.772
MOD_PKA_1	339	345	PF00069	0.593
MOD_PKA_2	139	145	PF00069	0.843
MOD_PKA_2	159	165	PF00069	0.709
MOD_PKA_2	367	373	PF00069	0.483
MOD_PKA_2	567	573	PF00069	0.601
MOD_PKA_2	88	94	PF00069	0.726
MOD_PKA_2	95	101	PF00069	0.682
MOD_PKB_1	117	125	PF00069	0.766
MOD_PKB_1	138	146	PF00069	0.799
MOD_Plk_1	111	117	PF00069	0.758
MOD_Plk_1	446	452	PF00069	0.620
MOD_Plk_1	527	533	PF00069	0.569
MOD_Plk_4	3	9	PF00069	0.605
MOD_Plk_4	367	373	PF00069	0.600
MOD_Plk_4	398	404	PF00069	0.668
MOD_Plk_4	448	454	PF00069	0.478
MOD_Plk_4	74	80	PF00069	0.636
MOD_ProDKin_1	101	107	PF00069	0.745
MOD_ProDKin_1	142	148	PF00069	0.806
MOD_ProDKin_1	200	206	PF00069	0.665
MOD_ProDKin_1	255	261	PF00069	0.703
MOD_ProDKin_1	263	269	PF00069	0.720
MOD_ProDKin_1	271	277	PF00069	0.537
MOD_ProDKin_1	290	296	PF00069	0.665
MOD_ProDKin_1	356	362	PF00069	0.500
MOD_ProDKin_1	429	435	PF00069	0.538
MOD_ProDKin_1	612	618	PF00069	0.526
MOD_ProDKin_1	629	635	PF00069	0.669
MOD_ProDKin_1	686	692	PF00069	0.684
TRG_DiLeu_BaEn_1	448	453	PF01217	0.531
TRG_DiLeu_BaEn_2	148	154	PF01217	0.766
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.579
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.557
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.644
TRG_DiLeu_BaLyEn_6	623	628	PF01217	0.667
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.571
TRG_ER_diArg_1	137	140	PF00400	0.654
TRG_ER_diArg_1	347	349	PF00400	0.576
TRG_ER_diArg_1	422	425	PF00400	0.529
TRG_ER_diArg_1	722	724	PF00400	0.563
TRG_NLS_MonoExtC_3	698	704	PF00514	0.556
TRG_Pf-PMV_PEXEL_1	328	333	PF00026	0.707
TRG_Pf-PMV_PEXEL_1	364	369	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ27	Leptomonas seymouri	41%	100%
A0A3S7WUA7	Leishmania donovani	88%	100%
A4H8X2	Leishmania braziliensis	66%	100%
A4HX96	Leishmania infantum	88%	100%
E9AQZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%