Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEG2_LEIMA

TriTrypDb:

LmjF.17.0320 , LMJLV39_170008800 , LMJSD75_170008500

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	305	307	PF00675	0.728
CLV_NRD_NRD_1	31	33	PF00675	0.684
CLV_NRD_NRD_1	311	313	PF00675	0.635
CLV_NRD_NRD_1	47	49	PF00675	0.612
CLV_NRD_NRD_1	5	7	PF00675	0.746
CLV_NRD_NRD_1	66	68	PF00675	0.523
CLV_PCSK_FUR_1	306	310	PF00082	0.712
CLV_PCSK_FUR_1	75	79	PF00082	0.654
CLV_PCSK_KEX2_1	305	307	PF00082	0.773
CLV_PCSK_KEX2_1	308	310	PF00082	0.782
CLV_PCSK_KEX2_1	31	33	PF00082	0.684
CLV_PCSK_KEX2_1	311	313	PF00082	0.762
CLV_PCSK_KEX2_1	47	49	PF00082	0.551
CLV_PCSK_KEX2_1	5	7	PF00082	0.746
CLV_PCSK_KEX2_1	66	68	PF00082	0.537
CLV_PCSK_KEX2_1	77	79	PF00082	0.648
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.648
CLV_PCSK_PC7_1	305	311	PF00082	0.801
CLV_PCSK_SKI1_1	112	116	PF00082	0.483
CLV_PCSK_SKI1_1	15	19	PF00082	0.537
CLV_PCSK_SKI1_1	212	216	PF00082	0.617
CLV_PCSK_SKI1_1	48	52	PF00082	0.583
DEG_COP1_1	242	252	PF00400	0.579
DOC_CYCLIN_RxL_1	12	21	PF00134	0.532
DOC_MAPK_gen_1	75	84	PF00069	0.513
DOC_PP1_RVXF_1	13	19	PF00149	0.530
DOC_PP1_RVXF_1	171	177	PF00149	0.545
DOC_PP2B_LxvP_1	10	13	PF13499	0.522
DOC_SPAK_OSR1_1	60	64	PF12202	0.487
DOC_USP7_MATH_1	186	190	PF00917	0.649
DOC_USP7_MATH_1	56	60	PF00917	0.570
DOC_WW_Pin1_4	217	222	PF00397	0.666
DOC_WW_Pin1_4	225	230	PF00397	0.754
DOC_WW_Pin1_4	237	242	PF00397	0.701
DOC_WW_Pin1_4	24	29	PF00397	0.691
DOC_WW_Pin1_4	49	54	PF00397	0.666
LIG_14-3-3_CanoR_1	173	177	PF00244	0.602
LIG_14-3-3_CanoR_1	231	238	PF00244	0.628
LIG_14-3-3_CanoR_1	309	315	PF00244	0.655
LIG_14-3-3_CanoR_1	47	53	PF00244	0.544
LIG_FHA_1	261	267	PF00498	0.564
LIG_FHA_2	21	27	PF00498	0.666
LIG_FHA_2	240	246	PF00498	0.746
LIG_LIR_Gen_1	59	65	PF02991	0.485
LIG_LIR_Nem_3	322	328	PF02991	0.573
LIG_LIR_Nem_3	59	64	PF02991	0.486
LIG_PDZ_Class_3	324	329	PF00595	0.573
LIG_Pex14_2	61	65	PF04695	0.483
LIG_PTAP_UEV_1	281	286	PF05743	0.589
LIG_Rb_pABgroove_1	86	94	PF01858	0.495
LIG_RPA_C_Fungi	55	67	PF08784	0.502
LIG_SH2_SRC	152	155	PF00017	0.658
LIG_SH2_STAP1	152	156	PF00017	0.639
LIG_SH2_STAP1	20	24	PF00017	0.661
LIG_SH2_STAT3	253	256	PF00017	0.570
LIG_SH2_STAT5	20	23	PF00017	0.545
LIG_SH2_STAT5	90	93	PF00017	0.515
LIG_SH3_3	211	217	PF00018	0.724
LIG_SH3_3	235	241	PF00018	0.829
LIG_SH3_3	274	280	PF00018	0.739
LIG_SH3_3	8	14	PF00018	0.626
LIG_TRAF2_1	151	154	PF00917	0.732
LIG_TRFH_1	213	217	PF08558	0.602
LIG_WW_3	12	16	PF00397	0.523
LIG_WW_3	228	232	PF00397	0.715
MOD_CDC14_SPxK_1	52	55	PF00782	0.497
MOD_CDK_SPxK_1	225	231	PF00069	0.710
MOD_CDK_SPxK_1	49	55	PF00069	0.521
MOD_CDK_SPxxK_3	24	31	PF00069	0.677
MOD_CK1_1	180	186	PF00069	0.709
MOD_CK1_1	189	195	PF00069	0.690
MOD_CK1_1	239	245	PF00069	0.741
MOD_CK1_1	267	273	PF00069	0.662
MOD_CK1_1	313	319	PF00069	0.632
MOD_CK1_1	68	74	PF00069	0.635
MOD_CK2_1	239	245	PF00069	0.749
MOD_Cter_Amidation	3	6	PF01082	0.750
MOD_Cter_Amidation	45	48	PF01082	0.599
MOD_GlcNHglycan	179	182	PF01048	0.762
MOD_GlcNHglycan	184	187	PF01048	0.720
MOD_GlcNHglycan	188	191	PF01048	0.671
MOD_GlcNHglycan	68	71	PF01048	0.511
MOD_GSK3_1	18	25	PF00069	0.651
MOD_GSK3_1	182	189	PF00069	0.678
MOD_GSK3_1	260	267	PF00069	0.629
MOD_N-GLC_1	160	165	PF02516	0.652
MOD_NEK2_1	18	23	PF00069	0.543
MOD_NEK2_1	65	70	PF00069	0.516
MOD_PIKK_1	18	24	PF00454	0.630
MOD_PK_1	262	268	PF00069	0.740
MOD_PK_1	310	316	PF00069	0.623
MOD_PKA_1	310	316	PF00069	0.740
MOD_PKA_1	66	72	PF00069	0.534
MOD_PKA_2	172	178	PF00069	0.604
MOD_PKA_2	230	236	PF00069	0.706
MOD_PKA_2	310	316	PF00069	0.601
MOD_PKA_2	65	71	PF00069	0.535
MOD_PKB_1	308	316	PF00069	0.754
MOD_Plk_1	291	297	PF00069	0.590
MOD_Plk_1	86	92	PF00069	0.476
MOD_Plk_4	248	254	PF00069	0.647
MOD_Plk_4	291	297	PF00069	0.641
MOD_Plk_4	86	92	PF00069	0.466
MOD_ProDKin_1	217	223	PF00069	0.669
MOD_ProDKin_1	225	231	PF00069	0.758
MOD_ProDKin_1	237	243	PF00069	0.697
MOD_ProDKin_1	24	30	PF00069	0.695
MOD_ProDKin_1	49	55	PF00069	0.658
MOD_SUMO_for_1	76	79	PF00179	0.649
TRG_DiLeu_BaEn_4	142	148	PF01217	0.501
TRG_ER_diArg_1	210	213	PF00400	0.623
TRG_ER_diArg_1	305	308	PF00400	0.766
TRG_ER_diArg_1	309	312	PF00400	0.763
TRG_ER_diArg_1	65	67	PF00400	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9Y1	Leptomonas seymouri	36%	100%
A0A3S7WUB2	Leishmania donovani	83%	100%
A4H8X5	Leishmania braziliensis	64%	100%
A4HX99	Leishmania infantum	84%	100%
E9AR01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%