Cytidine deaminase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytidine deaminase-like protein

Species:

Leishmania major

UniProt:

Q4QEF8_LEIMA

TriTrypDb:

LmjF.17.0360 , LMJLV39_170009200 , LMJSD75_170008900

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QEF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEF8

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006213	pyrimidine nucleoside metabolic process	5	2
GO:0006216	cytidine catabolic process	8	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009116	nucleoside metabolic process	4	2
GO:0009119	ribonucleoside metabolic process	5	2
GO:0009164	nucleoside catabolic process	5	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004126	cytidine deaminase activity	4	3
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0016787	hydrolase activity	2	3
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	3
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	3
GO:0019239	deaminase activity	3	3
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	89	91	PF00675	0.284
CLV_PCSK_KEX2_1	89	91	PF00082	0.286
CLV_PCSK_SKI1_1	123	127	PF00082	0.267
DEG_APCC_DBOX_1	11	19	PF00400	0.425
DEG_APCC_DBOX_1	122	130	PF00400	0.436
DOC_ANK_TNKS_1	81	88	PF00023	0.498
DOC_CYCLIN_RxL_1	120	128	PF00134	0.484
DOC_MAPK_gen_1	89	96	PF00069	0.461
DOC_PP2B_LxvP_1	115	118	PF13499	0.488
DOC_WW_Pin1_4	102	107	PF00397	0.483

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P973	Leptomonas seymouri	76%	100%
A0A0S4JP63	Bodo saltans	55%	90%
A0A1X0NSY6	Trypanosomatidae	61%	98%
A0A3Q8IAT7	Leishmania donovani	97%	100%
A0A422NXF1	Trypanosoma rangeli	61%	98%
A4H8X9	Leishmania braziliensis	83%	100%
A4HXA3	Leishmania infantum	97%	100%
C9ZXD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	70%
E9AR05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P19079	Bacillus subtilis (strain 168)	37%	100%

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