Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QEF7_LEIMA

TriTrypDb:

LmjF.17.0370 , LMJLV39_170009300 , LMJSD75_170009000

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QEF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	519	523	PF00656	0.758
CLV_C14_Caspase3-7	55	59	PF00656	0.773
CLV_C14_Caspase3-7	595	599	PF00656	0.716
CLV_C14_Caspase3-7	754	758	PF00656	0.700
CLV_NRD_NRD_1	208	210	PF00675	0.565
CLV_NRD_NRD_1	321	323	PF00675	0.501
CLV_NRD_NRD_1	330	332	PF00675	0.451
CLV_NRD_NRD_1	37	39	PF00675	0.516
CLV_NRD_NRD_1	525	527	PF00675	0.591
CLV_PCSK_FUR_1	206	210	PF00082	0.553
CLV_PCSK_FUR_1	319	323	PF00082	0.521
CLV_PCSK_KEX2_1	208	210	PF00082	0.562
CLV_PCSK_KEX2_1	321	323	PF00082	0.501
CLV_PCSK_KEX2_1	330	332	PF00082	0.451
CLV_PCSK_KEX2_1	37	39	PF00082	0.516
CLV_PCSK_KEX2_1	524	526	PF00082	0.590
CLV_PCSK_SKI1_1	101	105	PF00082	0.509
CLV_PCSK_SKI1_1	14	18	PF00082	0.525
CLV_PCSK_SKI1_1	150	154	PF00082	0.494
CLV_PCSK_SKI1_1	244	248	PF00082	0.601
CLV_PCSK_SKI1_1	333	337	PF00082	0.458
CLV_PCSK_SKI1_1	399	403	PF00082	0.479
DEG_APCC_DBOX_1	100	108	PF00400	0.712
DEG_APCC_DBOX_1	116	124	PF00400	0.636
DEG_SCF_FBW7_1	510	516	PF00400	0.774
DEG_SPOP_SBC_1	284	288	PF00917	0.724
DOC_CKS1_1	510	515	PF01111	0.777
DOC_CYCLIN_RxL_1	11	21	PF00134	0.795
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.779
DOC_CYCLIN_yCln2_LP_2	485	491	PF00134	0.831
DOC_MAPK_DCC_7	761	770	PF00069	0.460
DOC_MAPK_MEF2A_6	761	770	PF00069	0.469
DOC_PP2B_LxvP_1	248	251	PF13499	0.734
DOC_PP2B_LxvP_1	485	488	PF13499	0.831
DOC_PP2B_LxvP_1	77	80	PF13499	0.814
DOC_PP4_FxxP_1	290	293	PF00568	0.787
DOC_USP7_MATH_1	266	270	PF00917	0.796
DOC_USP7_MATH_1	276	280	PF00917	0.838
DOC_USP7_MATH_1	462	466	PF00917	0.813
DOC_USP7_MATH_1	473	477	PF00917	0.758
DOC_USP7_MATH_1	478	482	PF00917	0.703
DOC_USP7_MATH_1	513	517	PF00917	0.770
DOC_USP7_MATH_1	52	56	PF00917	0.817
DOC_USP7_MATH_1	580	584	PF00917	0.816
DOC_USP7_MATH_1	59	63	PF00917	0.815
DOC_USP7_MATH_1	69	73	PF00917	0.655
DOC_USP7_MATH_1	8	12	PF00917	0.680
DOC_USP7_MATH_1	86	90	PF00917	0.727
DOC_USP7_MATH_2	370	376	PF00917	0.825
DOC_WW_Pin1_4	218	223	PF00397	0.734
DOC_WW_Pin1_4	272	277	PF00397	0.737
DOC_WW_Pin1_4	391	396	PF00397	0.843
DOC_WW_Pin1_4	431	436	PF00397	0.834
DOC_WW_Pin1_4	443	448	PF00397	0.675
DOC_WW_Pin1_4	458	463	PF00397	0.786
DOC_WW_Pin1_4	474	479	PF00397	0.670
DOC_WW_Pin1_4	480	485	PF00397	0.791
DOC_WW_Pin1_4	500	505	PF00397	0.775
DOC_WW_Pin1_4	509	514	PF00397	0.808
DOC_WW_Pin1_4	535	540	PF00397	0.771
DOC_WW_Pin1_4	571	576	PF00397	0.747
DOC_WW_Pin1_4	88	93	PF00397	0.814
LIG_14-3-3_CanoR_1	117	121	PF00244	0.637
LIG_14-3-3_CanoR_1	131	141	PF00244	0.661
LIG_14-3-3_CanoR_1	330	336	PF00244	0.715
LIG_14-3-3_CanoR_1	350	355	PF00244	0.601
LIG_14-3-3_CanoR_1	361	370	PF00244	0.707
LIG_14-3-3_CanoR_1	37	42	PF00244	0.729
LIG_14-3-3_CanoR_1	454	462	PF00244	0.787
LIG_14-3-3_CanoR_1	524	533	PF00244	0.793
LIG_14-3-3_CanoR_1	556	561	PF00244	0.827
LIG_14-3-3_CanoR_1	606	613	PF00244	0.642
LIG_14-3-3_CanoR_1	734	739	PF00244	0.738
LIG_APCC_ABBA_1	223	228	PF00400	0.688
LIG_BRCT_BRCA1_1	439	443	PF00533	0.844
LIG_BRCT_BRCA1_2	439	445	PF00533	0.790
LIG_CaM_IQ_9	311	327	PF13499	0.710
LIG_DLG_GKlike_1	37	45	PF00625	0.725
LIG_EH1_1	639	647	PF00400	0.772
LIG_EVH1_1	77	81	PF00568	0.815
LIG_FHA_1	259	265	PF00498	0.775
LIG_FHA_1	293	299	PF00498	0.711
LIG_FHA_1	344	350	PF00498	0.805
LIG_FHA_1	535	541	PF00498	0.840
LIG_FHA_1	713	719	PF00498	0.709
LIG_FHA_2	335	341	PF00498	0.802
LIG_FHA_2	94	100	PF00498	0.789
LIG_HP1_1	86	90	PF01393	0.822
LIG_Integrin_RGD_1	755	757	PF01839	0.528
LIG_KLC1_Yacidic_2	668	673	PF13176	0.683
LIG_LIR_Apic_2	287	293	PF02991	0.792
LIG_LIR_Apic_2	677	683	PF02991	0.693
LIG_LIR_Gen_1	109	120	PF02991	0.669
LIG_LIR_Gen_1	237	246	PF02991	0.728
LIG_LIR_Gen_1	598	608	PF02991	0.758
LIG_LIR_Gen_1	650	658	PF02991	0.681
LIG_LIR_Gen_1	668	676	PF02991	0.622
LIG_LIR_Gen_1	686	694	PF02991	0.750
LIG_LIR_Gen_1	772	782	PF02991	0.407
LIG_LIR_LC3C_4	383	387	PF02991	0.816
LIG_LIR_Nem_3	109	115	PF02991	0.629
LIG_LIR_Nem_3	163	167	PF02991	0.657
LIG_LIR_Nem_3	237	241	PF02991	0.731
LIG_LIR_Nem_3	598	604	PF02991	0.776
LIG_LIR_Nem_3	650	656	PF02991	0.633
LIG_LIR_Nem_3	668	674	PF02991	0.623
LIG_LIR_Nem_3	686	690	PF02991	0.749
LIG_LIR_Nem_3	772	777	PF02991	0.407
LIG_LIR_Nem_3	91	97	PF02991	0.726
LIG_Pex14_1	112	116	PF04695	0.637
LIG_Pex14_2	139	143	PF04695	0.654
LIG_Pex14_2	243	247	PF04695	0.799
LIG_Pex14_2	779	783	PF04695	0.407
LIG_SH2_CRK	164	168	PF00017	0.654
LIG_SH2_CRK	680	684	PF00017	0.689
LIG_SH2_CRK	774	778	PF00017	0.407
LIG_SH2_NCK_1	774	778	PF00017	0.308
LIG_SH2_SRC	7	10	PF00017	0.720
LIG_SH2_STAP1	774	778	PF00017	0.494
LIG_SH2_STAT3	354	357	PF00017	0.826
LIG_SH2_STAT5	106	109	PF00017	0.662
LIG_SH2_STAT5	354	357	PF00017	0.754
LIG_SH2_STAT5	671	674	PF00017	0.635
LIG_SH2_STAT5	680	683	PF00017	0.649
LIG_SH2_STAT5	774	777	PF00017	0.407
LIG_SH2_STAT5	95	98	PF00017	0.760
LIG_SH3_3	219	225	PF00018	0.683
LIG_SH3_3	253	259	PF00018	0.746
LIG_SH3_3	425	431	PF00018	0.799
LIG_SH3_3	466	472	PF00018	0.790
LIG_SH3_3	72	78	PF00018	0.785
LIG_Sin3_3	710	717	PF02671	0.689
LIG_SUMO_SIM_anti_2	425	430	PF11976	0.764
LIG_SUMO_SIM_anti_2	643	648	PF11976	0.765
LIG_SUMO_SIM_par_1	383	390	PF11976	0.818
LIG_SUMO_SIM_par_1	86	91	PF11976	0.820
LIG_TRAF2_1	44	47	PF00917	0.737
LIG_TRAF2_1	666	669	PF00917	0.677
LIG_TRAF2_1	675	678	PF00917	0.690
LIG_TRAF2_1	719	722	PF00917	0.682
LIG_TYR_ITIM	651	656	PF00017	0.690
LIG_UBA3_1	16	20	PF00899	0.728
LIG_WRC_WIRS_1	235	240	PF05994	0.738
LIG_WRC_WIRS_1	684	689	PF05994	0.746
MOD_CK1_1	234	240	PF00069	0.821
MOD_CK1_1	269	275	PF00069	0.756
MOD_CK1_1	279	285	PF00069	0.799
MOD_CK1_1	334	340	PF00069	0.713
MOD_CK1_1	40	46	PF00069	0.806
MOD_CK1_1	458	464	PF00069	0.772
MOD_CK1_1	476	482	PF00069	0.633
MOD_CK1_1	498	504	PF00069	0.733
MOD_CK1_1	516	522	PF00069	0.833
MOD_CK1_1	599	605	PF00069	0.760
MOD_CK1_1	609	615	PF00069	0.783
MOD_CK1_1	630	636	PF00069	0.736
MOD_CK1_1	772	778	PF00069	0.407
MOD_CK2_1	3	9	PF00069	0.695
MOD_CK2_1	40	46	PF00069	0.802
MOD_CK2_1	93	99	PF00069	0.719
MOD_Cter_Amidation	522	525	PF01082	0.558
MOD_GlcNHglycan	364	367	PF01048	0.623
MOD_GlcNHglycan	377	381	PF01048	0.525
MOD_GlcNHglycan	46	50	PF01048	0.570
MOD_GlcNHglycan	507	510	PF01048	0.577
MOD_GlcNHglycan	515	518	PF01048	0.627
MOD_GlcNHglycan	548	551	PF01048	0.637
MOD_GlcNHglycan	582	585	PF01048	0.567
MOD_GlcNHglycan	60	64	PF01048	0.531
MOD_GlcNHglycan	608	611	PF01048	0.520
MOD_GlcNHglycan	629	632	PF01048	0.545
MOD_GlcNHglycan	67	70	PF01048	0.551
MOD_GlcNHglycan	694	697	PF01048	0.451
MOD_GlcNHglycan	71	74	PF01048	0.525
MOD_GlcNHglycan	715	718	PF01048	0.468
MOD_GSK3_1	131	138	PF00069	0.663
MOD_GSK3_1	258	265	PF00069	0.727
MOD_GSK3_1	266	273	PF00069	0.727
MOD_GSK3_1	279	286	PF00069	0.790
MOD_GSK3_1	3	10	PF00069	0.692
MOD_GSK3_1	364	371	PF00069	0.771
MOD_GSK3_1	37	44	PF00069	0.791
MOD_GSK3_1	372	379	PF00069	0.722
MOD_GSK3_1	387	394	PF00069	0.707
MOD_GSK3_1	437	444	PF00069	0.761
MOD_GSK3_1	457	464	PF00069	0.779
MOD_GSK3_1	473	480	PF00069	0.695
MOD_GSK3_1	483	490	PF00069	0.803
MOD_GSK3_1	494	501	PF00069	0.760
MOD_GSK3_1	505	512	PF00069	0.756
MOD_GSK3_1	552	559	PF00069	0.725
MOD_GSK3_1	576	583	PF00069	0.717
MOD_GSK3_1	608	615	PF00069	0.735
MOD_GSK3_1	65	72	PF00069	0.736
MOD_N-GLC_1	391	396	PF02516	0.596
MOD_N-GLC_1	494	499	PF02516	0.560
MOD_N-GLC_1	596	601	PF02516	0.568
MOD_N-GLC_2	605	607	PF02516	0.501
MOD_N-GLC_2	748	750	PF02516	0.530
MOD_NEK2_1	111	116	PF00069	0.691
MOD_NEK2_1	262	267	PF00069	0.768
MOD_NEK2_1	283	288	PF00069	0.702
MOD_NEK2_1	343	348	PF00069	0.772
MOD_NEK2_1	349	354	PF00069	0.735
MOD_NEK2_1	362	367	PF00069	0.593
MOD_NEK2_1	385	390	PF00069	0.822
MOD_NEK2_1	402	407	PF00069	0.631
MOD_NEK2_1	437	442	PF00069	0.802
MOD_NEK2_1	505	510	PF00069	0.769
MOD_NEK2_1	67	72	PF00069	0.779
MOD_NEK2_2	356	361	PF00069	0.823
MOD_NMyristoyl	1	7	PF02799	0.737
MOD_PIKK_1	229	235	PF00454	0.783
MOD_PIKK_1	274	280	PF00454	0.852
MOD_PIKK_1	53	59	PF00454	0.730
MOD_PKA_1	37	43	PF00069	0.718
MOD_PKA_1	524	530	PF00069	0.790
MOD_PKA_2	116	122	PF00069	0.641
MOD_PKA_2	130	136	PF00069	0.656
MOD_PKA_2	349	355	PF00069	0.739
MOD_PKA_2	362	368	PF00069	0.787
MOD_PKA_2	37	43	PF00069	0.726
MOD_PKA_2	524	530	PF00069	0.845
MOD_PKA_2	53	59	PF00069	0.647
MOD_PKA_2	733	739	PF00069	0.653
MOD_PKB_1	331	339	PF00069	0.649
MOD_PKB_1	348	356	PF00069	0.797
MOD_Plk_1	135	141	PF00069	0.664
MOD_Plk_1	270	276	PF00069	0.768
MOD_Plk_1	676	682	PF00069	0.694
MOD_Plk_1	772	778	PF00069	0.407
MOD_Plk_1	8	14	PF00069	0.716
MOD_Plk_2-3	372	378	PF00069	0.663
MOD_Plk_2-3	93	99	PF00069	0.719
MOD_Plk_4	111	117	PF00069	0.699
MOD_Plk_4	234	240	PF00069	0.740
MOD_Plk_4	285	291	PF00069	0.811
MOD_Plk_4	350	356	PF00069	0.773
MOD_Plk_4	364	370	PF00069	0.650
MOD_Plk_4	633	639	PF00069	0.746
MOD_Plk_4	640	646	PF00069	0.765
MOD_Plk_4	772	778	PF00069	0.399
MOD_ProDKin_1	218	224	PF00069	0.734
MOD_ProDKin_1	272	278	PF00069	0.738
MOD_ProDKin_1	391	397	PF00069	0.843
MOD_ProDKin_1	431	437	PF00069	0.836
MOD_ProDKin_1	443	449	PF00069	0.675
MOD_ProDKin_1	458	464	PF00069	0.788
MOD_ProDKin_1	474	480	PF00069	0.670
MOD_ProDKin_1	500	506	PF00069	0.776
MOD_ProDKin_1	509	515	PF00069	0.809
MOD_ProDKin_1	535	541	PF00069	0.770
MOD_ProDKin_1	571	577	PF00069	0.747
MOD_ProDKin_1	88	94	PF00069	0.812
MOD_SUMO_for_1	19	22	PF00179	0.721
MOD_SUMO_rev_2	334	343	PF00179	0.639
TRG_DiLeu_BaEn_4	677	683	PF01217	0.710
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.786
TRG_DiLeu_BaLyEn_6	686	691	PF01217	0.645
TRG_ENDOCYTIC_2	164	167	PF00928	0.654
TRG_ENDOCYTIC_2	653	656	PF00928	0.674
TRG_ENDOCYTIC_2	671	674	PF00928	0.635
TRG_ENDOCYTIC_2	774	777	PF00928	0.407
TRG_ENDOCYTIC_2	787	790	PF00928	0.597
TRG_ENDOCYTIC_2	94	97	PF00928	0.721
TRG_ER_diArg_1	206	209	PF00400	0.767
TRG_ER_diArg_1	325	328	PF00400	0.728
TRG_ER_diArg_1	330	333	PF00400	0.721
TRG_ER_diArg_1	36	38	PF00400	0.714
TRG_ER_diArg_1	360	363	PF00400	0.755
TRG_ER_diArg_1	452	455	PF00400	0.679
TRG_ER_diArg_1	524	526	PF00400	0.790

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRJ8	Leptomonas seymouri	45%	100%
A0A3Q8IAP9	Leishmania donovani	90%	100%
A4H8Y0	Leishmania braziliensis	66%	100%
A4HXA4	Leishmania infantum	91%	100%
E9AR06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%