Putative Qa-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qa-SNARE protein, putative

Species:

Leishmania major

UniProt:

Q4QEF6_LEIMA

TriTrypDb:

LmjF.17.0380 , LMJLV39_170009400 , LMJSD75_170009100

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0005794	Golgi apparatus	5	3
GO:0010008	endosome membrane	5	2
GO:0012506	vesicle membrane	4	2
GO:0012507	ER to Golgi transport vesicle membrane	6	2
GO:0016020	membrane	2	11
GO:0030658	transport vesicle membrane	5	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0030662	coated vesicle membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0031201	SNARE complex	3	3
GO:0031902	late endosome membrane	6	2
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0098588	bounding membrane of organelle	4	2
GO:0098796	membrane protein complex	2	3
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4QEF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEF6

Function

Biological processes
Term	Name	Level	Count
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0048284	organelle fusion	5	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0006810	transport	3	4
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	3
GO:0016192	vesicle-mediated transport	4	4
GO:0048193	Golgi vesicle transport	5	3
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	3
GO:0015031	protein transport	4	3
GO:0033036	macromolecule localization	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046907	intracellular transport	3	1
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	6
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	6
GO:0060090	molecular adaptor activity	1	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.746
CLV_NRD_NRD_1	242	244	PF00675	0.396
CLV_NRD_NRD_1	70	72	PF00675	0.448
CLV_PCSK_KEX2_1	242	244	PF00082	0.399
CLV_PCSK_KEX2_1	273	275	PF00082	0.543
CLV_PCSK_KEX2_1	70	72	PF00082	0.389
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.543
CLV_PCSK_SKI1_1	243	247	PF00082	0.331
CLV_PCSK_SKI1_1	58	62	PF00082	0.442
CLV_PCSK_SKI1_1	9	13	PF00082	0.390
DEG_APCC_DBOX_1	242	250	PF00400	0.679
DEG_SPOP_SBC_1	132	136	PF00917	0.577
DEG_SPOP_SBC_1	36	40	PF00917	0.731
DEG_SPOP_SBC_1	52	56	PF00917	0.637
DOC_CYCLIN_RxL_1	6	15	PF00134	0.632
DOC_MAPK_gen_1	70	81	PF00069	0.661
DOC_MAPK_MEF2A_6	74	83	PF00069	0.664
DOC_MAPK_RevD_3	259	274	PF00069	0.320
DOC_USP7_MATH_1	119	123	PF00917	0.690
DOC_USP7_MATH_1	132	136	PF00917	0.717
DOC_USP7_MATH_1	162	166	PF00917	0.691
LIG_14-3-3_CanoR_1	118	127	PF00244	0.724
LIG_14-3-3_CanoR_1	232	241	PF00244	0.668
LIG_14-3-3_CanoR_1	58	63	PF00244	0.659
LIG_BIR_II_1	1	5	PF00653	0.528
LIG_BIR_III_3	1	5	PF00653	0.533
LIG_Clathr_ClatBox_1	11	15	PF01394	0.635
LIG_EH1_1	252	260	PF00400	0.390
LIG_FHA_1	196	202	PF00498	0.636
LIG_FHA_1	211	217	PF00498	0.626
LIG_FHA_1	218	224	PF00498	0.632
LIG_FHA_1	262	268	PF00498	0.372
LIG_FHA_1	31	37	PF00498	0.704
LIG_FHA_2	217	223	PF00498	0.727
LIG_NRBOX	71	77	PF00104	0.651
LIG_NRP_CendR_1	273	275	PF00754	0.655
LIG_SH2_STAP1	94	98	PF00017	0.678
LIG_SH3_3	141	147	PF00018	0.718
LIG_SH3_3	22	28	PF00018	0.768
LIG_SUMO_SIM_par_1	10	15	PF11976	0.631
LIG_SUMO_SIM_par_1	219	225	PF11976	0.704
LIG_WW_3	146	150	PF00397	0.695
MOD_CK1_1	38	44	PF00069	0.763
MOD_CK2_1	104	110	PF00069	0.669
MOD_CK2_1	216	222	PF00069	0.696
MOD_GlcNHglycan	41	44	PF01048	0.583
MOD_GlcNHglycan	55	58	PF01048	0.502
MOD_GlcNHglycan	98	101	PF01048	0.344
MOD_GSK3_1	119	126	PF00069	0.680
MOD_GSK3_1	128	135	PF00069	0.647
MOD_GSK3_1	180	187	PF00069	0.599
MOD_GSK3_1	35	42	PF00069	0.718
MOD_N-GLC_1	195	200	PF02516	0.405
MOD_N-GLC_1	52	57	PF02516	0.495
MOD_NEK2_2	205	210	PF00069	0.636
MOD_PIKK_1	133	139	PF00454	0.752
MOD_PKA_2	139	145	PF00069	0.730
MOD_PKA_2	231	237	PF00069	0.681
MOD_SUMO_rev_2	234	240	PF00179	0.684
TRG_DiLeu_BaEn_2	235	241	PF01217	0.613
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.637
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.647
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.609
TRG_ER_diArg_1	241	243	PF00400	0.606
TRG_ER_diArg_1	69	71	PF00400	0.651
TRG_ER_diLys_1	271	275	PF00400	0.440
TRG_NES_CRM1_1	13	24	PF08389	0.668
TRG_NES_CRM1_1	236	247	PF08389	0.556
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H7	Leptomonas seymouri	58%	100%
A0A0S4JPW8	Bodo saltans	36%	100%
A0A1X0NUE9	Trypanosomatidae	37%	100%
A0A1X0NY79	Trypanosomatidae	26%	95%
A0A3S5IS79	Trypanosoma rangeli	34%	100%
A0A3S7WUJ1	Leishmania donovani	91%	100%
A4H8Y1	Leishmania braziliensis	65%	75%
A4HXA5	Leishmania infantum	91%	100%
C9ZTX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AR07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%