RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QEF4_LEIMA

TriTrypDb:

LmjF.17.0400 , LMJLV39_170009600 , LMJSD75_170009300

Length:

1054

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.603
CLV_C14_Caspase3-7	312	316	PF00656	0.524
CLV_C14_Caspase3-7	511	515	PF00656	0.746
CLV_C14_Caspase3-7	610	614	PF00656	0.769
CLV_C14_Caspase3-7	71	75	PF00656	0.663
CLV_C14_Caspase3-7	93	97	PF00656	0.810
CLV_C14_Caspase3-7	963	967	PF00656	0.588
CLV_NRD_NRD_1	196	198	PF00675	0.864
CLV_NRD_NRD_1	291	293	PF00675	0.626
CLV_NRD_NRD_1	490	492	PF00675	0.796
CLV_NRD_NRD_1	52	54	PF00675	0.605
CLV_NRD_NRD_1	608	610	PF00675	0.796
CLV_NRD_NRD_1	715	717	PF00675	0.663
CLV_NRD_NRD_1	85	87	PF00675	0.708
CLV_PCSK_FUR_1	291	295	PF00082	0.720
CLV_PCSK_KEX2_1	196	198	PF00082	0.858
CLV_PCSK_KEX2_1	241	243	PF00082	0.751
CLV_PCSK_KEX2_1	291	293	PF00082	0.622
CLV_PCSK_KEX2_1	383	385	PF00082	0.606
CLV_PCSK_KEX2_1	45	47	PF00082	0.677
CLV_PCSK_KEX2_1	490	492	PF00082	0.795
CLV_PCSK_KEX2_1	52	54	PF00082	0.590
CLV_PCSK_KEX2_1	608	610	PF00082	0.796
CLV_PCSK_KEX2_1	715	717	PF00082	0.663
CLV_PCSK_KEX2_1	85	87	PF00082	0.708
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.751
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.714
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.708
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.642
CLV_PCSK_SKI1_1	29	33	PF00082	0.715
CLV_PCSK_SKI1_1	380	384	PF00082	0.711
CLV_PCSK_SKI1_1	435	439	PF00082	0.494
CLV_PCSK_SKI1_1	460	464	PF00082	0.610
CLV_PCSK_SKI1_1	553	557	PF00082	0.733
CLV_PCSK_SKI1_1	883	887	PF00082	0.646
CLV_PCSK_SKI1_1	975	979	PF00082	0.552
CLV_Separin_Metazoa	429	433	PF03568	0.640
DEG_APCC_DBOX_1	28	36	PF00400	0.707
DEG_Nend_UBRbox_3	1	3	PF02207	0.752
DEG_ODPH_VHL_1	618	629	PF01847	0.752
DEG_SCF_TRCP1_1	724	729	PF00400	0.716
DEG_SPOP_SBC_1	225	229	PF00917	0.697
DOC_CKS1_1	113	118	PF01111	0.769
DOC_CYCLIN_RxL_1	241	254	PF00134	0.749
DOC_CYCLIN_RxL_1	26	34	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	694	700	PF00134	0.700
DOC_CYCLIN_yCln2_LP_2	769	775	PF00134	0.638
DOC_MAPK_gen_1	241	250	PF00069	0.757
DOC_MAPK_gen_1	380	390	PF00069	0.619
DOC_MAPK_MEF2A_6	383	390	PF00069	0.604
DOC_MAPK_MEF2A_6	676	684	PF00069	0.588
DOC_MAPK_RevD_3	30	45	PF00069	0.613
DOC_MAPK_RevD_3	700	716	PF00069	0.689
DOC_PP1_RVXF_1	713	720	PF00149	0.566
DOC_PP2B_LxvP_1	769	772	PF13499	0.649
DOC_PP2B_LxvP_1	847	850	PF13499	0.537
DOC_PP2B_LxvP_1	978	981	PF13499	0.591
DOC_PP4_FxxP_1	113	116	PF00568	0.768
DOC_PP4_FxxP_1	162	165	PF00568	0.738
DOC_PP4_FxxP_1	555	558	PF00568	0.746
DOC_PP4_MxPP_1	479	482	PF00568	0.704
DOC_USP7_MATH_1	107	111	PF00917	0.819
DOC_USP7_MATH_1	122	126	PF00917	0.832
DOC_USP7_MATH_1	133	137	PF00917	0.612
DOC_USP7_MATH_1	179	183	PF00917	0.665
DOC_USP7_MATH_1	223	227	PF00917	0.606
DOC_USP7_MATH_1	346	350	PF00917	0.660
DOC_USP7_MATH_1	592	596	PF00917	0.579
DOC_USP7_MATH_1	81	85	PF00917	0.766
DOC_USP7_MATH_1	879	883	PF00917	0.663
DOC_USP7_UBL2_3	662	666	PF12436	0.722
DOC_WW_Pin1_4	1047	1052	PF00397	0.765
DOC_WW_Pin1_4	112	117	PF00397	0.753
DOC_WW_Pin1_4	161	166	PF00397	0.737
DOC_WW_Pin1_4	207	212	PF00397	0.731
DOC_WW_Pin1_4	219	224	PF00397	0.581
DOC_WW_Pin1_4	251	256	PF00397	0.482
DOC_WW_Pin1_4	506	511	PF00397	0.800
DOC_WW_Pin1_4	572	577	PF00397	0.636
DOC_WW_Pin1_4	578	583	PF00397	0.585
DOC_WW_Pin1_4	667	672	PF00397	0.661
DOC_WW_Pin1_4	804	809	PF00397	0.492
LIG_14-3-3_CanoR_1	279	285	PF00244	0.561
LIG_14-3-3_CanoR_1	324	329	PF00244	0.646
LIG_14-3-3_CanoR_1	331	338	PF00244	0.578
LIG_14-3-3_CanoR_1	435	441	PF00244	0.605
LIG_14-3-3_CanoR_1	608	612	PF00244	0.791
LIG_14-3-3_CanoR_1	715	720	PF00244	0.556
LIG_14-3-3_CanoR_1	954	962	PF00244	0.537
LIG_Actin_WH2_2	383	400	PF00022	0.700
LIG_AP2alpha_1	611	615	PF02296	0.768
LIG_BIR_III_4	9	13	PF00653	0.609
LIG_BRCT_BRCA1_1	109	113	PF00533	0.716
LIG_CtBP_PxDLS_1	444	448	PF00389	0.756
LIG_EH1_1	472	480	PF00400	0.630
LIG_eIF4E_1	16	22	PF01652	0.727
LIG_EVH1_1	847	851	PF00568	0.642
LIG_FHA_1	309	315	PF00498	0.586
LIG_FHA_1	327	333	PF00498	0.509
LIG_FHA_1	409	415	PF00498	0.462
LIG_FHA_1	679	685	PF00498	0.735
LIG_FHA_1	797	803	PF00498	0.519
LIG_FHA_1	838	844	PF00498	0.700
LIG_FHA_2	1034	1040	PF00498	0.476
LIG_FHA_2	15	21	PF00498	0.700
LIG_FHA_2	199	205	PF00498	0.664
LIG_FHA_2	558	564	PF00498	0.627
LIG_FHA_2	608	614	PF00498	0.662
LIG_FHA_2	91	97	PF00498	0.716
LIG_FHA_2	961	967	PF00498	0.673
LIG_LIR_Apic_2	110	116	PF02991	0.759
LIG_LIR_Apic_2	160	165	PF02991	0.739
LIG_LIR_Apic_2	956	961	PF02991	0.659
LIG_LIR_Gen_1	407	414	PF02991	0.496
LIG_LIR_Gen_1	613	622	PF02991	0.666
LIG_LIR_Gen_1	718	727	PF02991	0.583
LIG_LIR_Nem_3	1024	1029	PF02991	0.502
LIG_LIR_Nem_3	275	281	PF02991	0.695
LIG_LIR_Nem_3	407	412	PF02991	0.482
LIG_LIR_Nem_3	439	443	PF02991	0.732
LIG_LIR_Nem_3	613	618	PF02991	0.666
LIG_LIR_Nem_3	718	722	PF02991	0.504
LIG_LIR_Nem_3	748	752	PF02991	0.579
LIG_Pex14_1	258	262	PF04695	0.529
LIG_Pex14_2	3	7	PF04695	0.628
LIG_Pex14_2	462	466	PF04695	0.588
LIG_Pex14_2	611	615	PF04695	0.768
LIG_PTB_Apo_2	400	407	PF02174	0.530
LIG_Rb_LxCxE_1	595	613	PF01857	0.726
LIG_SH2_CRK	287	291	PF00017	0.708
LIG_SH2_CRK	409	413	PF00017	0.632
LIG_SH2_CRK	958	962	PF00017	0.655
LIG_SH2_GRB2like	1014	1017	PF00017	0.566
LIG_SH2_STAP1	328	332	PF00017	0.536
LIG_SH2_STAP1	409	413	PF00017	0.632
LIG_SH2_STAP1	741	745	PF00017	0.634
LIG_SH2_STAT5	16	19	PF00017	0.639
LIG_SH2_STAT5	277	280	PF00017	0.598
LIG_SH2_STAT5	301	304	PF00017	0.747
LIG_SH2_STAT5	328	331	PF00017	0.694
LIG_SH2_STAT5	377	380	PF00017	0.706
LIG_SH3_2	186	191	PF14604	0.608
LIG_SH3_3	103	109	PF00018	0.784
LIG_SH3_3	1048	1054	PF00018	0.591
LIG_SH3_3	183	189	PF00018	0.615
LIG_SH3_3	385	391	PF00018	0.712
LIG_SH3_3	438	444	PF00018	0.567
LIG_SH3_3	479	485	PF00018	0.794
LIG_SH3_3	544	550	PF00018	0.587
LIG_SH3_3	570	576	PF00018	0.558
LIG_SH3_3	845	851	PF00018	0.560
LIG_SUMO_SIM_anti_2	626	632	PF11976	0.741
LIG_SUMO_SIM_anti_2	679	684	PF11976	0.629
LIG_SUMO_SIM_anti_2	799	804	PF11976	0.587
LIG_TRAF2_1	306	309	PF00917	0.674
LIG_TRAF2_1	350	353	PF00917	0.575
LIG_TRAF2_1	68	71	PF00917	0.650
LIG_TRAF2_1	790	793	PF00917	0.570
LIG_TYR_ITIM	285	290	PF00017	0.704
LIG_UBA3_1	284	293	PF00899	0.712
MOD_CDC14_SPxK_1	254	257	PF00782	0.459
MOD_CDK_SPK_2	207	212	PF00069	0.731
MOD_CDK_SPxK_1	251	257	PF00069	0.479
MOD_CDK_SPxxK_3	578	585	PF00069	0.651
MOD_CK1_1	111	117	PF00069	0.768
MOD_CK1_1	136	142	PF00069	0.831
MOD_CK1_1	152	158	PF00069	0.676
MOD_CK1_1	164	170	PF00069	0.758
MOD_CK1_1	177	183	PF00069	0.738
MOD_CK1_1	224	230	PF00069	0.807
MOD_CK1_1	231	237	PF00069	0.631
MOD_CK1_1	327	333	PF00069	0.642
MOD_CK1_1	508	514	PF00069	0.757
MOD_CK1_1	595	601	PF00069	0.741
MOD_CK1_1	66	72	PF00069	0.731
MOD_CK1_1	84	90	PF00069	0.635
MOD_CK2_1	14	20	PF00069	0.700
MOD_CK2_1	198	204	PF00069	0.670
MOD_CK2_1	346	352	PF00069	0.792
MOD_CK2_1	530	536	PF00069	0.717
MOD_CK2_1	557	563	PF00069	0.623
MOD_CK2_1	61	67	PF00069	0.828
MOD_CK2_1	620	626	PF00069	0.646
MOD_CK2_1	653	659	PF00069	0.539
MOD_CK2_1	786	792	PF00069	0.588
MOD_Cter_Amidation	488	491	PF01082	0.647
MOD_GlcNHglycan	100	103	PF01048	0.794
MOD_GlcNHglycan	158	162	PF01048	0.789
MOD_GlcNHglycan	169	172	PF01048	0.644
MOD_GlcNHglycan	223	226	PF01048	0.815
MOD_GlcNHglycan	348	351	PF01048	0.675
MOD_GlcNHglycan	54	57	PF01048	0.728
MOD_GlcNHglycan	724	727	PF01048	0.680
MOD_GlcNHglycan	788	791	PF01048	0.516
MOD_GlcNHglycan	825	829	PF01048	0.674
MOD_GSK3_1	1015	1022	PF00069	0.621
MOD_GSK3_1	1033	1040	PF00069	0.408
MOD_GSK3_1	107	114	PF00069	0.763
MOD_GSK3_1	133	140	PF00069	0.827
MOD_GSK3_1	157	164	PF00069	0.765
MOD_GSK3_1	174	181	PF00069	0.557
MOD_GSK3_1	219	226	PF00069	0.816
MOD_GSK3_1	326	333	PF00069	0.703
MOD_GSK3_1	404	411	PF00069	0.508
MOD_GSK3_1	501	508	PF00069	0.751
MOD_GSK3_1	61	68	PF00069	0.728
MOD_GSK3_1	722	729	PF00069	0.707
MOD_GSK3_1	778	785	PF00069	0.426
MOD_GSK3_1	86	93	PF00069	0.699
MOD_N-GLC_1	1015	1020	PF02516	0.551
MOD_N-GLC_1	501	506	PF02516	0.853
MOD_N-GLC_1	861	866	PF02516	0.518
MOD_N-GLC_2	948	950	PF02516	0.411
MOD_NEK2_1	1033	1038	PF00069	0.554
MOD_NEK2_1	149	154	PF00069	0.811
MOD_NEK2_1	31	36	PF00069	0.630
MOD_NEK2_1	326	331	PF00069	0.691
MOD_NEK2_1	336	341	PF00069	0.573
MOD_NEK2_1	397	402	PF00069	0.658
MOD_NEK2_1	404	409	PF00069	0.515
MOD_NEK2_1	692	697	PF00069	0.570
MOD_NEK2_1	778	783	PF00069	0.408
MOD_NEK2_1	908	913	PF00069	0.280
MOD_NEK2_1	968	973	PF00069	0.551
MOD_PIKK_1	108	114	PF00454	0.781
MOD_PIKK_1	620	626	PF00454	0.677
MOD_PKA_1	52	58	PF00069	0.646
MOD_PKA_1	715	721	PF00069	0.655
MOD_PKA_2	198	204	PF00069	0.787
MOD_PKA_2	316	322	PF00069	0.571
MOD_PKA_2	330	336	PF00069	0.507
MOD_PKA_2	397	403	PF00069	0.661
MOD_PKA_2	52	58	PF00069	0.674
MOD_PKA_2	607	613	PF00069	0.791
MOD_PKA_2	715	721	PF00069	0.655
MOD_PKA_2	776	782	PF00069	0.498
MOD_PKA_2	786	792	PF00069	0.516
MOD_PKA_2	84	90	PF00069	0.815
MOD_PKA_2	953	959	PF00069	0.534
MOD_PKB_1	197	205	PF00069	0.767
MOD_Plk_1	678	684	PF00069	0.627
MOD_Plk_1	796	802	PF00069	0.602
MOD_Plk_1	861	867	PF00069	0.551
MOD_Plk_2-3	607	613	PF00069	0.791
MOD_Plk_2-3	653	659	PF00069	0.539
MOD_Plk_4	1003	1009	PF00069	0.498
MOD_Plk_4	280	286	PF00069	0.702
MOD_Plk_4	408	414	PF00069	0.527
MOD_Plk_4	473	479	PF00069	0.709
MOD_Plk_4	514	520	PF00069	0.743
MOD_Plk_4	595	601	PF00069	0.658
MOD_Plk_4	678	684	PF00069	0.627
MOD_Plk_4	745	751	PF00069	0.565
MOD_Plk_4	862	868	PF00069	0.557
MOD_Plk_4	908	914	PF00069	0.376
MOD_ProDKin_1	1047	1053	PF00069	0.765
MOD_ProDKin_1	112	118	PF00069	0.752
MOD_ProDKin_1	161	167	PF00069	0.736
MOD_ProDKin_1	207	213	PF00069	0.724
MOD_ProDKin_1	219	225	PF00069	0.580
MOD_ProDKin_1	251	257	PF00069	0.479
MOD_ProDKin_1	506	512	PF00069	0.798
MOD_ProDKin_1	572	578	PF00069	0.629
MOD_ProDKin_1	667	673	PF00069	0.652
MOD_ProDKin_1	804	810	PF00069	0.502
MOD_SUMO_rev_2	379	385	PF00179	0.709
TRG_DiLeu_BaEn_1	679	684	PF01217	0.629
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.793
TRG_DiLeu_BaLyEn_6	755	760	PF01217	0.605
TRG_ENDOCYTIC_2	1027	1030	PF00928	0.502
TRG_ENDOCYTIC_2	287	290	PF00928	0.675
TRG_ENDOCYTIC_2	409	412	PF00928	0.520
TRG_ENDOCYTIC_2	570	573	PF00928	0.567
TRG_ENDOCYTIC_2	809	812	PF00928	0.635
TRG_ENDOCYTIC_2	974	977	PF00928	0.547
TRG_ER_diArg_1	196	199	PF00400	0.787
TRG_ER_diArg_1	290	292	PF00400	0.602
TRG_ER_diArg_1	302	305	PF00400	0.650
TRG_ER_diArg_1	395	398	PF00400	0.641
TRG_ER_diArg_1	52	54	PF00400	0.750
TRG_ER_diArg_1	715	717	PF00400	0.663
TRG_NES_CRM1_1	626	640	PF08389	0.754
TRG_NES_CRM1_1	838	853	PF08389	0.681
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	655	659	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H8	Leptomonas seymouri	44%	100%
A0A3Q8IAL8	Leishmania donovani	89%	100%
A4H8Y3	Leishmania braziliensis	74%	100%
A4HXB3	Leishmania infantum	89%	100%
E9AR09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%