N6-adenine methyltransferase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Probable N6-adenine methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QEF2_LEIMA

TriTrypDb:

LmjF.17.0420 , LMJLV39_170009900 , LMJSD75_170009600

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QEF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEF2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	9
GO:0008168	methyltransferase activity	4	12
GO:0008170	N-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016278	lysine N-methyltransferase activity	6	12
GO:0016279	protein-lysine N-methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.520
CLV_NRD_NRD_1	246	248	PF00675	0.586
CLV_NRD_NRD_1	346	348	PF00675	0.452
CLV_NRD_NRD_1	531	533	PF00675	0.456
CLV_NRD_NRD_1	77	79	PF00675	0.355
CLV_NRD_NRD_1	93	95	PF00675	0.302
CLV_PCSK_KEX2_1	248	250	PF00082	0.624
CLV_PCSK_KEX2_1	346	348	PF00082	0.353
CLV_PCSK_KEX2_1	531	533	PF00082	0.565
CLV_PCSK_KEX2_1	77	79	PF00082	0.355
CLV_PCSK_KEX2_1	93	95	PF00082	0.302
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.666
CLV_PCSK_SKI1_1	153	157	PF00082	0.251
CLV_PCSK_SKI1_1	161	165	PF00082	0.236
CLV_PCSK_SKI1_1	180	184	PF00082	0.350
CLV_PCSK_SKI1_1	381	385	PF00082	0.603
CLV_PCSK_SKI1_1	531	535	PF00082	0.483
CLV_PCSK_SKI1_1	542	546	PF00082	0.366
CLV_PCSK_SKI1_1	549	553	PF00082	0.342
DEG_Nend_Nbox_1	1	3	PF02207	0.481
DOC_CKS1_1	65	70	PF01111	0.465
DOC_CYCLIN_RxL_1	147	158	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.479
DOC_MAPK_FxFP_2	533	536	PF00069	0.514
DOC_MAPK_gen_1	371	379	PF00069	0.573
DOC_MAPK_gen_1	434	443	PF00069	0.537
DOC_MAPK_RevD_3	63	78	PF00069	0.550
DOC_PIKK_1	169	177	PF02985	0.550
DOC_PP1_RVXF_1	159	165	PF00149	0.465
DOC_PP1_RVXF_1	33	39	PF00149	0.288
DOC_PP4_FxxP_1	116	119	PF00568	0.465
DOC_PP4_FxxP_1	533	536	PF00568	0.532
DOC_USP7_MATH_1	24	28	PF00917	0.514
DOC_USP7_MATH_1	354	358	PF00917	0.437
DOC_USP7_MATH_1	483	487	PF00917	0.698
DOC_USP7_MATH_1	511	515	PF00917	0.488
DOC_USP7_UBL2_3	153	157	PF12436	0.501
DOC_USP7_UBL2_3	387	391	PF12436	0.649
DOC_WW_Pin1_4	402	407	PF00397	0.509
DOC_WW_Pin1_4	464	469	PF00397	0.638
DOC_WW_Pin1_4	487	492	PF00397	0.661
DOC_WW_Pin1_4	64	69	PF00397	0.474
LIG_14-3-3_CanoR_1	234	242	PF00244	0.579
LIG_14-3-3_CanoR_1	26	30	PF00244	0.547
LIG_14-3-3_CanoR_1	45	49	PF00244	0.479
LIG_Actin_WH2_2	220	236	PF00022	0.477
LIG_APCC_ABBA_1	302	307	PF00400	0.642
LIG_BRCT_BRCA1_1	68	72	PF00533	0.454
LIG_BRCT_BRCA1_1	95	99	PF00533	0.454
LIG_FHA_1	139	145	PF00498	0.457
LIG_FHA_1	149	155	PF00498	0.473
LIG_FHA_1	163	169	PF00498	0.456
LIG_FHA_1	285	291	PF00498	0.712
LIG_FHA_1	422	428	PF00498	0.482
LIG_FHA_1	504	510	PF00498	0.495
LIG_FHA_1	65	71	PF00498	0.465
LIG_FHA_2	164	170	PF00498	0.475
LIG_FHA_2	321	327	PF00498	0.785
LIG_FHA_2	80	86	PF00498	0.556
LIG_LIR_Apic_2	115	119	PF02991	0.454
LIG_LIR_Apic_2	495	500	PF02991	0.551
LIG_LIR_Apic_2	530	536	PF02991	0.422
LIG_LIR_Gen_1	195	206	PF02991	0.454
LIG_LIR_Nem_3	108	114	PF02991	0.454
LIG_LIR_Nem_3	143	148	PF02991	0.464
LIG_LIR_Nem_3	195	201	PF02991	0.435
LIG_LIR_Nem_3	294	298	PF02991	0.680
LIG_LIR_Nem_3	37	41	PF02991	0.465
LIG_LIR_Nem_3	495	501	PF02991	0.570
LIG_LIR_Nem_3	69	74	PF02991	0.454
LIG_LYPXL_S_1	187	191	PF13949	0.350
LIG_LYPXL_yS_3	188	191	PF13949	0.550
LIG_MLH1_MIPbox_1	68	72	PF16413	0.454
LIG_NRBOX	173	179	PF00104	0.479
LIG_NRP_CendR_1	552	555	PF00754	0.613
LIG_Pex14_2	183	187	PF04695	0.465
LIG_Pex14_2	38	42	PF04695	0.465
LIG_SH2_CRK	196	200	PF00017	0.465
LIG_SH2_SRC	196	199	PF00017	0.454
LIG_SH2_STAP1	101	105	PF00017	0.550
LIG_SH2_STAP1	148	152	PF00017	0.532
LIG_SH2_STAP1	501	505	PF00017	0.505
LIG_SH2_STAT3	101	104	PF00017	0.511
LIG_SH2_STAT5	111	114	PF00017	0.551
LIG_SH2_STAT5	132	135	PF00017	0.477
LIG_SH2_STAT5	198	201	PF00017	0.462
LIG_SH3_3	131	137	PF00018	0.497
LIG_TRAF2_1	521	524	PF00917	0.572
LIG_TYR_ITIM	194	199	PF00017	0.465
LIG_UBA3_1	544	552	PF00899	0.423
MOD_CK1_1	22	28	PF00069	0.596
MOD_CK1_1	321	327	PF00069	0.648
MOD_CK1_1	402	408	PF00069	0.701
MOD_CK1_1	44	50	PF00069	0.475
MOD_CK1_1	464	470	PF00069	0.715
MOD_CK1_1	492	498	PF00069	0.618
MOD_CK1_1	66	72	PF00069	0.454
MOD_CK2_1	163	169	PF00069	0.454
MOD_CK2_1	233	239	PF00069	0.463
MOD_CK2_1	411	417	PF00069	0.557
MOD_GlcNHglycan	10	13	PF01048	0.751
MOD_GlcNHglycan	14	17	PF01048	0.654
MOD_GlcNHglycan	21	24	PF01048	0.516
MOD_GlcNHglycan	320	323	PF01048	0.679
MOD_GlcNHglycan	400	404	PF01048	0.733
MOD_GlcNHglycan	411	414	PF01048	0.531
MOD_GlcNHglycan	464	467	PF01048	0.599
MOD_GlcNHglycan	485	488	PF01048	0.703
MOD_GlcNHglycan	491	494	PF01048	0.699
MOD_GSK3_1	200	207	PF00069	0.526
MOD_GSK3_1	377	384	PF00069	0.550
MOD_GSK3_1	483	490	PF00069	0.786
MOD_GSK3_1	8	15	PF00069	0.687
MOD_N-GLC_1	169	174	PF02516	0.265
MOD_N-GLC_1	79	84	PF02516	0.202
MOD_NEK2_1	162	167	PF00069	0.459
MOD_NEK2_1	411	416	PF00069	0.366
MOD_PIKK_1	87	93	PF00454	0.492
MOD_PKA_1	93	99	PF00069	0.542
MOD_PKA_2	233	239	PF00069	0.428
MOD_PKA_2	25	31	PF00069	0.544
MOD_PKA_2	44	50	PF00069	0.588
MOD_PKA_2	87	93	PF00069	0.525
MOD_Plk_1	169	175	PF00069	0.465
MOD_Plk_1	381	387	PF00069	0.574
MOD_Plk_1	399	405	PF00069	0.505
MOD_Plk_2-3	169	175	PF00069	0.457
MOD_Plk_4	163	169	PF00069	0.449
MOD_Plk_4	300	306	PF00069	0.558
MOD_Plk_4	66	72	PF00069	0.454
MOD_ProDKin_1	402	408	PF00069	0.503
MOD_ProDKin_1	464	470	PF00069	0.643
MOD_ProDKin_1	487	493	PF00069	0.656
MOD_ProDKin_1	64	70	PF00069	0.474
MOD_SUMO_for_1	34	37	PF00179	0.529
MOD_SUMO_rev_2	215	224	PF00179	0.456
MOD_SUMO_rev_2	514	520	PF00179	0.359
TRG_DiLeu_BaEn_1	158	163	PF01217	0.550
TRG_ENDOCYTIC_2	188	191	PF00928	0.477
TRG_ENDOCYTIC_2	196	199	PF00928	0.435
TRG_ENDOCYTIC_2	512	515	PF00928	0.403
TRG_ER_diArg_1	346	349	PF00400	0.507
TRG_ER_diArg_1	531	533	PF00400	0.542
TRG_ER_diArg_1	92	94	PF00400	0.509
TRG_NES_CRM1_1	360	375	PF08389	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR6	Leptomonas seymouri	64%	100%
A0A0S4KEA9	Bodo saltans	38%	100%
A0A1X0NT88	Trypanosomatidae	41%	100%
A0A3Q8IDX6	Leishmania donovani	92%	100%
A0A422NXL8	Trypanosoma rangeli	43%	100%
A4H8Y5	Leishmania braziliensis	81%	100%
A4HXB5	Leishmania infantum	92%	100%
C9ZU02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AR11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BAJ7	Trypanosoma cruzi	42%	89%