J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QEE8_LEIMA

TriTrypDb:

LmjF.17.0460 , LMJLV39_170010300 , LMJSD75_170010000

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	11
GO:0031207	Sec62/Sec63 complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	11
GO:0140534	endoplasmic reticulum protein-containing complex	2	2

Expansion

Sequence features

Q4QEE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEE8

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006613	cotranslational protein targeting to membrane	6	2
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	2
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0045047	protein targeting to ER	6	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0070972	protein localization to endoplasmic reticulum	6	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0008320	protein transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022884	macromolecule transmembrane transporter activity	3	2
GO:0140318	protein transporter activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.489
CLV_NRD_NRD_1	211	213	PF00675	0.369
CLV_NRD_NRD_1	96	98	PF00675	0.447
CLV_PCSK_KEX2_1	10	12	PF00082	0.470
CLV_PCSK_KEX2_1	211	213	PF00082	0.358
CLV_PCSK_KEX2_1	96	98	PF00082	0.422
CLV_PCSK_PC7_1	7	13	PF00082	0.463
CLV_PCSK_SKI1_1	207	211	PF00082	0.346
CLV_Separin_Metazoa	123	127	PF03568	0.572
DEG_Nend_UBRbox_2	1	3	PF02207	0.551
DOC_CKS1_1	133	138	PF01111	0.561
DOC_USP7_MATH_1	194	198	PF00917	0.604
DOC_USP7_MATH_1	45	49	PF00917	0.477
DOC_WW_Pin1_4	132	137	PF00397	0.555
DOC_WW_Pin1_4	202	207	PF00397	0.569
DOC_WW_Pin1_4	88	93	PF00397	0.572
LIG_14-3-3_CanoR_1	10	15	PF00244	0.562
LIG_14-3-3_CanoR_1	126	131	PF00244	0.561
LIG_14-3-3_CanoR_1	134	140	PF00244	0.450
LIG_14-3-3_CanoR_1	99	109	PF00244	0.581
LIG_BRCT_BRCA1_1	162	166	PF00533	0.343
LIG_deltaCOP1_diTrp_1	199	209	PF00928	0.563
LIG_FHA_1	47	53	PF00498	0.483
LIG_FHA_2	17	23	PF00498	0.672
LIG_LIR_Gen_1	137	145	PF02991	0.471
LIG_LIR_Gen_1	163	174	PF02991	0.348
LIG_LIR_Nem_3	104	110	PF02991	0.584
LIG_LIR_Nem_3	137	142	PF02991	0.471
LIG_LIR_Nem_3	163	169	PF02991	0.345
LIG_LIR_Nem_3	95	101	PF02991	0.604
LIG_MLH1_MIPbox_1	162	166	PF16413	0.387
LIG_NRBOX	170	176	PF00104	0.346
LIG_Pex14_2	108	112	PF04695	0.565
LIG_Pex14_2	154	158	PF04695	0.310
LIG_SH2_CRK	110	114	PF00017	0.550
LIG_SH2_CRK	98	102	PF00017	0.593
LIG_SH2_NCK_1	85	89	PF00017	0.450
LIG_SH2_SRC	14	17	PF00017	0.597
LIG_SH2_STAP1	190	194	PF00017	0.364
LIG_SH2_STAP1	198	202	PF00017	0.556
LIG_SH2_STAT5	107	110	PF00017	0.574
LIG_SH2_STAT5	14	17	PF00017	0.567
LIG_SH2_STAT5	149	152	PF00017	0.386
LIG_TYR_ITAM	82	101	PF00017	0.574
LIG_TYR_ITIM	54	59	PF00017	0.461
MOD_CDK_SPK_2	202	207	PF00069	0.558
MOD_CK1_1	48	54	PF00069	0.493
MOD_CMANNOS	130	133	PF00535	0.362
MOD_GlcNHglycan	32	35	PF01048	0.523
MOD_GSK3_1	26	33	PF00069	0.752
MOD_GSK3_1	86	93	PF00069	0.450
MOD_NEK2_1	160	165	PF00069	0.324
MOD_NEK2_1	174	179	PF00069	0.285
MOD_NEK2_1	188	193	PF00069	0.312
MOD_PIKK_1	102	108	PF00454	0.575
MOD_PIKK_1	46	52	PF00454	0.544
MOD_PKA_1	10	16	PF00069	0.695
MOD_PKA_2	10	16	PF00069	0.679
MOD_Plk_4	160	166	PF00069	0.333
MOD_Plk_4	174	180	PF00069	0.245
MOD_Plk_4	188	194	PF00069	0.242
MOD_ProDKin_1	132	138	PF00069	0.552
MOD_ProDKin_1	202	208	PF00069	0.564
MOD_ProDKin_1	88	94	PF00069	0.579
TRG_ENDOCYTIC_2	109	112	PF00928	0.564
TRG_ENDOCYTIC_2	155	158	PF00928	0.312
TRG_ENDOCYTIC_2	190	193	PF00928	0.310
TRG_ENDOCYTIC_2	56	59	PF00928	0.461
TRG_ENDOCYTIC_2	85	88	PF00928	0.450
TRG_ENDOCYTIC_2	98	101	PF00928	0.602
TRG_ER_diArg_1	10	12	PF00400	0.674
TRG_ER_diArg_1	210	212	PF00400	0.565
TRG_ER_diArg_1	52	55	PF00400	0.461
TRG_ER_diArg_1	96	98	PF00400	0.643
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	99	104	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK95	Leptomonas seymouri	89%	73%
A0A0S4J1V7	Bodo saltans	62%	77%
A0A1X0NSX2	Trypanosomatidae	68%	77%
A0A3R7MRU2	Trypanosoma rangeli	69%	80%
A4H8Y9	Leishmania braziliensis	95%	66%
A4HXB9	Leishmania infantum	96%	67%
C9ZU12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	84%
E9AR15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	66%
V5D6J3	Trypanosoma cruzi	76%	100%