LeishMANIAdb
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Isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Isomerase
Gene product:
Phenazine biosynthesis-like protein, putative
Species:
Leishmania major
UniProt:
Q4QEE6_LEIMA
TriTrypDb:
LmjF.17.0480 , LMJLV39_170010500 * , LMJSD75_170010200 *
Length:
537

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4QEE6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEE6

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 7
GO:0009058 biosynthetic process 2 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016853 isomerase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 410 414 PF00656 0.362
CLV_NRD_NRD_1 145 147 PF00675 0.576
CLV_NRD_NRD_1 230 232 PF00675 0.721
CLV_NRD_NRD_1 233 235 PF00675 0.473
CLV_NRD_NRD_1 309 311 PF00675 0.291
CLV_NRD_NRD_1 403 405 PF00675 0.430
CLV_NRD_NRD_1 509 511 PF00675 0.332
CLV_NRD_NRD_1 65 67 PF00675 0.634
CLV_PCSK_FUR_1 231 235 PF00082 0.575
CLV_PCSK_KEX2_1 144 146 PF00082 0.528
CLV_PCSK_KEX2_1 230 232 PF00082 0.721
CLV_PCSK_KEX2_1 233 235 PF00082 0.473
CLV_PCSK_KEX2_1 309 311 PF00082 0.291
CLV_PCSK_KEX2_1 403 405 PF00082 0.430
CLV_PCSK_KEX2_1 498 500 PF00082 0.352
CLV_PCSK_PC1ET2_1 498 500 PF00082 0.312
CLV_PCSK_SKI1_1 243 247 PF00082 0.312
CLV_PCSK_SKI1_1 403 407 PF00082 0.331
CLV_PCSK_SKI1_1 514 518 PF00082 0.312
CLV_PCSK_SKI1_1 66 70 PF00082 0.623
CLV_PCSK_SKI1_1 84 88 PF00082 0.424
DEG_SPOP_SBC_1 405 409 PF00917 0.340
DOC_CKS1_1 12 17 PF01111 0.531
DOC_CKS1_1 244 249 PF01111 0.326
DOC_CKS1_1 386 391 PF01111 0.311
DOC_MAPK_DCC_7 346 354 PF00069 0.243
DOC_MAPK_gen_1 346 354 PF00069 0.243
DOC_MAPK_gen_1 510 517 PF00069 0.312
DOC_MAPK_MEF2A_6 346 354 PF00069 0.243
DOC_PP2B_LxvP_1 160 163 PF13499 0.622
DOC_PP4_FxxP_1 288 291 PF00568 0.312
DOC_PP4_FxxP_1 452 455 PF00568 0.339
DOC_USP7_MATH_1 180 184 PF00917 0.752
DOC_USP7_MATH_1 200 204 PF00917 0.596
DOC_USP7_MATH_1 218 222 PF00917 0.674
DOC_USP7_MATH_1 316 320 PF00917 0.243
DOC_USP7_MATH_1 405 409 PF00917 0.374
DOC_USP7_MATH_1 48 52 PF00917 0.573
DOC_USP7_UBL2_3 482 486 PF12436 0.265
DOC_USP7_UBL2_3 67 71 PF12436 0.623
DOC_WW_Pin1_4 11 16 PF00397 0.450
DOC_WW_Pin1_4 176 181 PF00397 0.582
DOC_WW_Pin1_4 192 197 PF00397 0.587
DOC_WW_Pin1_4 243 248 PF00397 0.314
DOC_WW_Pin1_4 326 331 PF00397 0.352
DOC_WW_Pin1_4 385 390 PF00397 0.328
DOC_WW_Pin1_4 60 65 PF00397 0.599
LIG_14-3-3_CanoR_1 165 174 PF00244 0.661
LIG_14-3-3_CanoR_1 217 223 PF00244 0.542
LIG_14-3-3_CanoR_1 233 242 PF00244 0.334
LIG_14-3-3_CanoR_1 270 280 PF00244 0.312
LIG_14-3-3_CanoR_1 317 322 PF00244 0.251
LIG_14-3-3_CanoR_1 385 389 PF00244 0.322
LIG_14-3-3_CanoR_1 403 412 PF00244 0.332
LIG_14-3-3_CanoR_1 526 532 PF00244 0.539
LIG_BRCT_BRCA1_1 200 204 PF00533 0.604
LIG_BRCT_BRCA1_1 407 411 PF00533 0.312
LIG_BRCT_BRCA1_1 449 453 PF00533 0.312
LIG_BRCT_BRCA1_1 527 531 PF00533 0.329
LIG_deltaCOP1_diTrp_1 398 406 PF00928 0.340
LIG_EH1_1 265 273 PF00400 0.388
LIG_FHA_1 102 108 PF00498 0.415
LIG_FHA_1 275 281 PF00498 0.305
LIG_FHA_1 292 298 PF00498 0.416
LIG_FHA_1 330 336 PF00498 0.340
LIG_FHA_1 338 344 PF00498 0.277
LIG_FHA_1 463 469 PF00498 0.312
LIG_FHA_1 502 508 PF00498 0.312
LIG_FHA_1 528 534 PF00498 0.515
LIG_FHA_2 115 121 PF00498 0.535
LIG_FHA_2 150 156 PF00498 0.565
LIG_FHA_2 222 228 PF00498 0.644
LIG_FHA_2 67 73 PF00498 0.551
LIG_LIR_Apic_2 287 291 PF02991 0.345
LIG_LIR_Apic_2 450 455 PF02991 0.338
LIG_LIR_Gen_1 372 383 PF02991 0.340
LIG_LIR_Gen_1 398 406 PF02991 0.397
LIG_LIR_Gen_1 45 54 PF02991 0.531
LIG_LIR_Nem_3 237 242 PF02991 0.291
LIG_LIR_Nem_3 372 378 PF02991 0.243
LIG_LIR_Nem_3 398 402 PF02991 0.397
LIG_LIR_Nem_3 45 49 PF02991 0.501
LIG_MLH1_MIPbox_1 449 453 PF16413 0.312
LIG_MYND_1 196 200 PF01753 0.585
LIG_Pex14_2 240 244 PF04695 0.312
LIG_Pex14_2 452 456 PF04695 0.312
LIG_SH2_CRK 108 112 PF00017 0.420
LIG_SH2_CRK 375 379 PF00017 0.346
LIG_SH2_NCK_1 215 219 PF00017 0.598
LIG_SH2_STAP1 133 137 PF00017 0.499
LIG_SH2_STAP1 333 337 PF00017 0.312
LIG_SH2_STAT5 215 218 PF00017 0.556
LIG_SH2_STAT5 326 329 PF00017 0.388
LIG_SH2_STAT5 382 385 PF00017 0.312
LIG_SH2_STAT5 42 45 PF00017 0.432
LIG_SH3_1 58 64 PF00018 0.547
LIG_SH3_2 61 66 PF14604 0.653
LIG_SH3_3 190 196 PF00018 0.594
LIG_SH3_3 332 338 PF00018 0.324
LIG_SH3_3 418 424 PF00018 0.279
LIG_SH3_3 58 64 PF00018 0.655
LIG_SH3_3 9 15 PF00018 0.592
LIG_SUMO_SIM_anti_2 513 519 PF11976 0.312
LIG_TYR_ITIM 373 378 PF00017 0.340
LIG_WRC_WIRS_1 521 526 PF05994 0.302
MOD_CDC14_SPxK_1 63 66 PF00782 0.541
MOD_CDK_SPxK_1 243 249 PF00069 0.312
MOD_CDK_SPxK_1 60 66 PF00069 0.615
MOD_CDK_SPxxK_3 60 67 PF00069 0.575
MOD_CK1_1 176 182 PF00069 0.629
MOD_CK1_1 202 208 PF00069 0.562
MOD_CK1_1 209 215 PF00069 0.476
MOD_CK1_1 221 227 PF00069 0.632
MOD_CK1_1 274 280 PF00069 0.312
MOD_CK1_1 329 335 PF00069 0.340
MOD_CK1_1 376 382 PF00069 0.446
MOD_CK1_1 467 473 PF00069 0.340
MOD_CK1_1 47 53 PF00069 0.550
MOD_CK2_1 114 120 PF00069 0.531
MOD_CK2_1 149 155 PF00069 0.484
MOD_CK2_1 221 227 PF00069 0.634
MOD_CK2_1 47 53 PF00069 0.542
MOD_Cter_Amidation 228 231 PF01082 0.651
MOD_Cter_Amidation 508 511 PF01082 0.324
MOD_GlcNHglycan 147 150 PF01048 0.655
MOD_GlcNHglycan 154 160 PF01048 0.665
MOD_GlcNHglycan 168 171 PF01048 0.596
MOD_GlcNHglycan 182 185 PF01048 0.750
MOD_GlcNHglycan 208 211 PF01048 0.556
MOD_GlcNHglycan 302 305 PF01048 0.309
MOD_GlcNHglycan 417 421 PF01048 0.513
MOD_GlcNHglycan 45 49 PF01048 0.535
MOD_GSK3_1 110 117 PF00069 0.483
MOD_GSK3_1 145 152 PF00069 0.567
MOD_GSK3_1 166 173 PF00069 0.718
MOD_GSK3_1 174 181 PF00069 0.653
MOD_GSK3_1 198 205 PF00069 0.599
MOD_GSK3_1 209 216 PF00069 0.505
MOD_GSK3_1 218 225 PF00069 0.458
MOD_GSK3_1 300 307 PF00069 0.311
MOD_GSK3_1 322 329 PF00069 0.327
MOD_GSK3_1 337 344 PF00069 0.474
MOD_GSK3_1 44 51 PF00069 0.539
MOD_N-GLC_1 99 104 PF02516 0.408
MOD_NEK2_1 101 106 PF00069 0.399
MOD_NEK2_1 206 211 PF00069 0.546
MOD_NEK2_1 213 218 PF00069 0.525
MOD_NEK2_1 266 271 PF00069 0.488
MOD_NEK2_1 322 327 PF00069 0.368
MOD_NEK2_1 428 433 PF00069 0.334
MOD_NEK2_1 44 49 PF00069 0.490
MOD_NEK2_1 52 57 PF00069 0.581
MOD_NEK2_1 525 530 PF00069 0.335
MOD_NEK2_2 304 309 PF00069 0.312
MOD_PIKK_1 174 180 PF00454 0.657
MOD_PIKK_1 234 240 PF00454 0.291
MOD_PIKK_1 289 295 PF00454 0.279
MOD_PK_1 311 317 PF00069 0.315
MOD_PK_1 499 505 PF00069 0.243
MOD_PKA_1 145 151 PF00069 0.532
MOD_PKA_1 309 315 PF00069 0.291
MOD_PKA_1 66 72 PF00069 0.579
MOD_PKA_2 145 151 PF00069 0.572
MOD_PKA_2 216 222 PF00069 0.550
MOD_PKA_2 309 315 PF00069 0.291
MOD_PKA_2 316 322 PF00069 0.291
MOD_PKA_2 384 390 PF00069 0.322
MOD_PKA_2 525 531 PF00069 0.332
MOD_Plk_1 266 272 PF00069 0.312
MOD_Plk_1 416 422 PF00069 0.497
MOD_Plk_1 44 50 PF00069 0.498
MOD_Plk_1 52 58 PF00069 0.587
MOD_Plk_2-3 78 84 PF00069 0.500
MOD_Plk_4 209 215 PF00069 0.502
MOD_Plk_4 218 224 PF00069 0.638
MOD_Plk_4 317 323 PF00069 0.299
MOD_Plk_4 37 43 PF00069 0.392
MOD_Plk_4 520 526 PF00069 0.341
MOD_ProDKin_1 11 17 PF00069 0.443
MOD_ProDKin_1 176 182 PF00069 0.583
MOD_ProDKin_1 192 198 PF00069 0.588
MOD_ProDKin_1 243 249 PF00069 0.314
MOD_ProDKin_1 326 332 PF00069 0.352
MOD_ProDKin_1 385 391 PF00069 0.328
MOD_ProDKin_1 60 66 PF00069 0.598
MOD_SUMO_for_1 3 6 PF00179 0.494
MOD_SUMO_rev_2 128 137 PF00179 0.468
MOD_SUMO_rev_2 60 69 PF00179 0.672
TRG_DiLeu_BaEn_1 267 272 PF01217 0.388
TRG_DiLeu_BaEn_1 513 518 PF01217 0.312
TRG_DiLeu_BaEn_4 155 161 PF01217 0.529
TRG_ENDOCYTIC_2 375 378 PF00928 0.407
TRG_ER_diArg_1 144 146 PF00400 0.532
TRG_ER_diArg_1 230 233 PF00400 0.685
TRG_ER_diArg_1 308 310 PF00400 0.291
TRG_ER_diArg_1 402 404 PF00400 0.436
TRG_ER_FFAT_1 407 417 PF00635 0.243
TRG_Pf-PMV_PEXEL_1 116 120 PF00026 0.462

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCR2 Leptomonas seymouri 68% 100%
A0A3Q8IJD5 Leishmania donovani 94% 100%
A4H8Z1 Leishmania braziliensis 78% 100%
A4HXC2 Leishmania infantum 94% 100%
E9AR17 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS