Isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Isomerase

Gene product:

Phenazine biosynthesis-like protein, putative

Species:

Leishmania major

UniProt:

Q4QEE6_LEIMA

TriTrypDb:

LmjF.17.0480 , LMJLV39_170010500 , LMJSD75_170010200

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QEE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEE6

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016853	isomerase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.362
CLV_NRD_NRD_1	145	147	PF00675	0.576
CLV_NRD_NRD_1	230	232	PF00675	0.721
CLV_NRD_NRD_1	233	235	PF00675	0.473
CLV_NRD_NRD_1	309	311	PF00675	0.291
CLV_NRD_NRD_1	403	405	PF00675	0.430
CLV_NRD_NRD_1	509	511	PF00675	0.332
CLV_NRD_NRD_1	65	67	PF00675	0.634
CLV_PCSK_FUR_1	231	235	PF00082	0.575
CLV_PCSK_KEX2_1	144	146	PF00082	0.528
CLV_PCSK_KEX2_1	230	232	PF00082	0.721
CLV_PCSK_KEX2_1	233	235	PF00082	0.473
CLV_PCSK_KEX2_1	309	311	PF00082	0.291
CLV_PCSK_KEX2_1	403	405	PF00082	0.430
CLV_PCSK_KEX2_1	498	500	PF00082	0.352
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.312
CLV_PCSK_SKI1_1	243	247	PF00082	0.312
CLV_PCSK_SKI1_1	403	407	PF00082	0.331
CLV_PCSK_SKI1_1	514	518	PF00082	0.312
CLV_PCSK_SKI1_1	66	70	PF00082	0.623
CLV_PCSK_SKI1_1	84	88	PF00082	0.424
DEG_SPOP_SBC_1	405	409	PF00917	0.340
DOC_CKS1_1	12	17	PF01111	0.531
DOC_CKS1_1	244	249	PF01111	0.326
DOC_CKS1_1	386	391	PF01111	0.311
DOC_MAPK_DCC_7	346	354	PF00069	0.243
DOC_MAPK_gen_1	346	354	PF00069	0.243
DOC_MAPK_gen_1	510	517	PF00069	0.312
DOC_MAPK_MEF2A_6	346	354	PF00069	0.243
DOC_PP2B_LxvP_1	160	163	PF13499	0.622
DOC_PP4_FxxP_1	288	291	PF00568	0.312
DOC_PP4_FxxP_1	452	455	PF00568	0.339
DOC_USP7_MATH_1	180	184	PF00917	0.752
DOC_USP7_MATH_1	200	204	PF00917	0.596
DOC_USP7_MATH_1	218	222	PF00917	0.674
DOC_USP7_MATH_1	316	320	PF00917	0.243
DOC_USP7_MATH_1	405	409	PF00917	0.374
DOC_USP7_MATH_1	48	52	PF00917	0.573
DOC_USP7_UBL2_3	482	486	PF12436	0.265
DOC_USP7_UBL2_3	67	71	PF12436	0.623
DOC_WW_Pin1_4	11	16	PF00397	0.450
DOC_WW_Pin1_4	176	181	PF00397	0.582
DOC_WW_Pin1_4	192	197	PF00397	0.587
DOC_WW_Pin1_4	243	248	PF00397	0.314
DOC_WW_Pin1_4	326	331	PF00397	0.352
DOC_WW_Pin1_4	385	390	PF00397	0.328
DOC_WW_Pin1_4	60	65	PF00397	0.599
LIG_14-3-3_CanoR_1	165	174	PF00244	0.661
LIG_14-3-3_CanoR_1	217	223	PF00244	0.542
LIG_14-3-3_CanoR_1	233	242	PF00244	0.334
LIG_14-3-3_CanoR_1	270	280	PF00244	0.312
LIG_14-3-3_CanoR_1	317	322	PF00244	0.251
LIG_14-3-3_CanoR_1	385	389	PF00244	0.322
LIG_14-3-3_CanoR_1	403	412	PF00244	0.332
LIG_14-3-3_CanoR_1	526	532	PF00244	0.539
LIG_BRCT_BRCA1_1	200	204	PF00533	0.604
LIG_BRCT_BRCA1_1	407	411	PF00533	0.312
LIG_BRCT_BRCA1_1	449	453	PF00533	0.312
LIG_BRCT_BRCA1_1	527	531	PF00533	0.329
LIG_deltaCOP1_diTrp_1	398	406	PF00928	0.340
LIG_EH1_1	265	273	PF00400	0.388
LIG_FHA_1	102	108	PF00498	0.415
LIG_FHA_1	275	281	PF00498	0.305
LIG_FHA_1	292	298	PF00498	0.416
LIG_FHA_1	330	336	PF00498	0.340
LIG_FHA_1	338	344	PF00498	0.277
LIG_FHA_1	463	469	PF00498	0.312
LIG_FHA_1	502	508	PF00498	0.312
LIG_FHA_1	528	534	PF00498	0.515
LIG_FHA_2	115	121	PF00498	0.535
LIG_FHA_2	150	156	PF00498	0.565
LIG_FHA_2	222	228	PF00498	0.644
LIG_FHA_2	67	73	PF00498	0.551
LIG_LIR_Apic_2	287	291	PF02991	0.345
LIG_LIR_Apic_2	450	455	PF02991	0.338
LIG_LIR_Gen_1	372	383	PF02991	0.340
LIG_LIR_Gen_1	398	406	PF02991	0.397
LIG_LIR_Gen_1	45	54	PF02991	0.531
LIG_LIR_Nem_3	237	242	PF02991	0.291
LIG_LIR_Nem_3	372	378	PF02991	0.243
LIG_LIR_Nem_3	398	402	PF02991	0.397
LIG_LIR_Nem_3	45	49	PF02991	0.501
LIG_MLH1_MIPbox_1	449	453	PF16413	0.312
LIG_MYND_1	196	200	PF01753	0.585
LIG_Pex14_2	240	244	PF04695	0.312
LIG_Pex14_2	452	456	PF04695	0.312
LIG_SH2_CRK	108	112	PF00017	0.420
LIG_SH2_CRK	375	379	PF00017	0.346
LIG_SH2_NCK_1	215	219	PF00017	0.598
LIG_SH2_STAP1	133	137	PF00017	0.499
LIG_SH2_STAP1	333	337	PF00017	0.312
LIG_SH2_STAT5	215	218	PF00017	0.556
LIG_SH2_STAT5	326	329	PF00017	0.388
LIG_SH2_STAT5	382	385	PF00017	0.312
LIG_SH2_STAT5	42	45	PF00017	0.432
LIG_SH3_1	58	64	PF00018	0.547
LIG_SH3_2	61	66	PF14604	0.653
LIG_SH3_3	190	196	PF00018	0.594
LIG_SH3_3	332	338	PF00018	0.324
LIG_SH3_3	418	424	PF00018	0.279
LIG_SH3_3	58	64	PF00018	0.655
LIG_SH3_3	9	15	PF00018	0.592
LIG_SUMO_SIM_anti_2	513	519	PF11976	0.312
LIG_TYR_ITIM	373	378	PF00017	0.340
LIG_WRC_WIRS_1	521	526	PF05994	0.302
MOD_CDC14_SPxK_1	63	66	PF00782	0.541
MOD_CDK_SPxK_1	243	249	PF00069	0.312
MOD_CDK_SPxK_1	60	66	PF00069	0.615
MOD_CDK_SPxxK_3	60	67	PF00069	0.575
MOD_CK1_1	176	182	PF00069	0.629
MOD_CK1_1	202	208	PF00069	0.562
MOD_CK1_1	209	215	PF00069	0.476
MOD_CK1_1	221	227	PF00069	0.632
MOD_CK1_1	274	280	PF00069	0.312
MOD_CK1_1	329	335	PF00069	0.340
MOD_CK1_1	376	382	PF00069	0.446
MOD_CK1_1	467	473	PF00069	0.340
MOD_CK1_1	47	53	PF00069	0.550
MOD_CK2_1	114	120	PF00069	0.531
MOD_CK2_1	149	155	PF00069	0.484
MOD_CK2_1	221	227	PF00069	0.634
MOD_CK2_1	47	53	PF00069	0.542
MOD_Cter_Amidation	228	231	PF01082	0.651
MOD_Cter_Amidation	508	511	PF01082	0.324
MOD_GlcNHglycan	147	150	PF01048	0.655
MOD_GlcNHglycan	154	160	PF01048	0.665
MOD_GlcNHglycan	168	171	PF01048	0.596
MOD_GlcNHglycan	182	185	PF01048	0.750
MOD_GlcNHglycan	208	211	PF01048	0.556
MOD_GlcNHglycan	302	305	PF01048	0.309
MOD_GlcNHglycan	417	421	PF01048	0.513
MOD_GlcNHglycan	45	49	PF01048	0.535
MOD_GSK3_1	110	117	PF00069	0.483
MOD_GSK3_1	145	152	PF00069	0.567
MOD_GSK3_1	166	173	PF00069	0.718
MOD_GSK3_1	174	181	PF00069	0.653
MOD_GSK3_1	198	205	PF00069	0.599
MOD_GSK3_1	209	216	PF00069	0.505
MOD_GSK3_1	218	225	PF00069	0.458
MOD_GSK3_1	300	307	PF00069	0.311
MOD_GSK3_1	322	329	PF00069	0.327
MOD_GSK3_1	337	344	PF00069	0.474
MOD_GSK3_1	44	51	PF00069	0.539
MOD_N-GLC_1	99	104	PF02516	0.408
MOD_NEK2_1	101	106	PF00069	0.399
MOD_NEK2_1	206	211	PF00069	0.546
MOD_NEK2_1	213	218	PF00069	0.525
MOD_NEK2_1	266	271	PF00069	0.488
MOD_NEK2_1	322	327	PF00069	0.368
MOD_NEK2_1	428	433	PF00069	0.334
MOD_NEK2_1	44	49	PF00069	0.490
MOD_NEK2_1	52	57	PF00069	0.581
MOD_NEK2_1	525	530	PF00069	0.335
MOD_NEK2_2	304	309	PF00069	0.312
MOD_PIKK_1	174	180	PF00454	0.657
MOD_PIKK_1	234	240	PF00454	0.291
MOD_PIKK_1	289	295	PF00454	0.279
MOD_PK_1	311	317	PF00069	0.315
MOD_PK_1	499	505	PF00069	0.243
MOD_PKA_1	145	151	PF00069	0.532
MOD_PKA_1	309	315	PF00069	0.291
MOD_PKA_1	66	72	PF00069	0.579
MOD_PKA_2	145	151	PF00069	0.572
MOD_PKA_2	216	222	PF00069	0.550
MOD_PKA_2	309	315	PF00069	0.291
MOD_PKA_2	316	322	PF00069	0.291
MOD_PKA_2	384	390	PF00069	0.322
MOD_PKA_2	525	531	PF00069	0.332
MOD_Plk_1	266	272	PF00069	0.312
MOD_Plk_1	416	422	PF00069	0.497
MOD_Plk_1	44	50	PF00069	0.498
MOD_Plk_1	52	58	PF00069	0.587
MOD_Plk_2-3	78	84	PF00069	0.500
MOD_Plk_4	209	215	PF00069	0.502
MOD_Plk_4	218	224	PF00069	0.638
MOD_Plk_4	317	323	PF00069	0.299
MOD_Plk_4	37	43	PF00069	0.392
MOD_Plk_4	520	526	PF00069	0.341
MOD_ProDKin_1	11	17	PF00069	0.443
MOD_ProDKin_1	176	182	PF00069	0.583
MOD_ProDKin_1	192	198	PF00069	0.588
MOD_ProDKin_1	243	249	PF00069	0.314
MOD_ProDKin_1	326	332	PF00069	0.352
MOD_ProDKin_1	385	391	PF00069	0.328
MOD_ProDKin_1	60	66	PF00069	0.598
MOD_SUMO_for_1	3	6	PF00179	0.494
MOD_SUMO_rev_2	128	137	PF00179	0.468
MOD_SUMO_rev_2	60	69	PF00179	0.672
TRG_DiLeu_BaEn_1	267	272	PF01217	0.388
TRG_DiLeu_BaEn_1	513	518	PF01217	0.312
TRG_DiLeu_BaEn_4	155	161	PF01217	0.529
TRG_ENDOCYTIC_2	375	378	PF00928	0.407
TRG_ER_diArg_1	144	146	PF00400	0.532
TRG_ER_diArg_1	230	233	PF00400	0.685
TRG_ER_diArg_1	308	310	PF00400	0.291
TRG_ER_diArg_1	402	404	PF00400	0.436
TRG_ER_FFAT_1	407	417	PF00635	0.243
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR2	Leptomonas seymouri	68%	100%
A0A3Q8IJD5	Leishmania donovani	94%	100%
A4H8Z1	Leishmania braziliensis	78%	100%
A4HXC2	Leishmania infantum	94%	100%
E9AR17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%