Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

STE/STE11 serine/threonine-protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QEE5_LEIMA

TriTrypDb:

LmjF.17.0490 , LMJLV39_170010600 , LMJSD75_170010300

Length:

906

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QEE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEE5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004672	protein kinase activity	3	10
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.657
CLV_C14_Caspase3-7	64	68	PF00656	0.722
CLV_C14_Caspase3-7	95	99	PF00656	0.665
CLV_MEL_PAP_1	284	290	PF00089	0.510
CLV_MEL_PAP_1	834	840	PF00089	0.191
CLV_NRD_NRD_1	207	209	PF00675	0.640
CLV_NRD_NRD_1	210	212	PF00675	0.607
CLV_NRD_NRD_1	278	280	PF00675	0.522
CLV_NRD_NRD_1	290	292	PF00675	0.457
CLV_NRD_NRD_1	450	452	PF00675	0.537
CLV_NRD_NRD_1	52	54	PF00675	0.663
CLV_NRD_NRD_1	588	590	PF00675	0.372
CLV_NRD_NRD_1	682	684	PF00675	0.289
CLV_NRD_NRD_1	74	76	PF00675	0.679
CLV_NRD_NRD_1	870	872	PF00675	0.322
CLV_NRD_NRD_1	92	94	PF00675	0.765
CLV_PCSK_FUR_1	208	212	PF00082	0.721
CLV_PCSK_KEX2_1	207	209	PF00082	0.675
CLV_PCSK_KEX2_1	210	212	PF00082	0.649
CLV_PCSK_KEX2_1	213	215	PF00082	0.606
CLV_PCSK_KEX2_1	278	280	PF00082	0.520
CLV_PCSK_KEX2_1	450	452	PF00082	0.535
CLV_PCSK_KEX2_1	588	590	PF00082	0.372
CLV_PCSK_KEX2_1	682	684	PF00082	0.289
CLV_PCSK_KEX2_1	74	76	PF00082	0.681
CLV_PCSK_KEX2_1	743	745	PF00082	0.289
CLV_PCSK_KEX2_1	869	871	PF00082	0.330
CLV_PCSK_KEX2_1	92	94	PF00082	0.625
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.556
CLV_PCSK_PC1ET2_1	743	745	PF00082	0.289
CLV_PCSK_PC1ET2_1	869	871	PF00082	0.330
CLV_PCSK_PC7_1	274	280	PF00082	0.629
CLV_PCSK_PC7_1	866	872	PF00082	0.384
CLV_PCSK_SKI1_1	225	229	PF00082	0.742
CLV_PCSK_SKI1_1	266	270	PF00082	0.579
CLV_PCSK_SKI1_1	279	283	PF00082	0.532
CLV_PCSK_SKI1_1	291	295	PF00082	0.633
CLV_PCSK_SKI1_1	517	521	PF00082	0.659
CLV_PCSK_SKI1_1	631	635	PF00082	0.349
CLV_PCSK_SKI1_1	684	688	PF00082	0.446
CLV_PCSK_SKI1_1	702	706	PF00082	0.211
CLV_PCSK_SKI1_1	719	723	PF00082	0.289
CLV_PCSK_SKI1_1	829	833	PF00082	0.322
CLV_PCSK_SKI1_1	866	870	PF00082	0.340
CLV_Separin_Metazoa	794	798	PF03568	0.322
DEG_APCC_DBOX_1	701	709	PF00400	0.349
DEG_SCF_FBW7_1	24	30	PF00400	0.546
DEG_SPOP_SBC_1	190	194	PF00917	0.707
DOC_CKS1_1	24	29	PF01111	0.788
DOC_CYCLIN_RxL_1	572	583	PF00134	0.512
DOC_MAPK_gen_1	256	265	PF00069	0.712
DOC_MAPK_gen_1	631	639	PF00069	0.372
DOC_MAPK_gen_1	687	696	PF00069	0.289
DOC_MAPK_gen_1	719	728	PF00069	0.289
DOC_MAPK_gen_1	850	857	PF00069	0.318
DOC_MAPK_gen_1	869	877	PF00069	0.202
DOC_MAPK_MEF2A_6	259	267	PF00069	0.606
DOC_MAPK_MEF2A_6	850	859	PF00069	0.338
DOC_PP1_RVXF_1	264	270	PF00149	0.539
DOC_PP4_FxxP_1	790	793	PF00568	0.275
DOC_USP7_MATH_1	186	190	PF00917	0.709
DOC_USP7_MATH_1	231	235	PF00917	0.679
DOC_USP7_MATH_1	27	31	PF00917	0.743
DOC_USP7_MATH_1	270	274	PF00917	0.579
DOC_USP7_MATH_1	359	363	PF00917	0.587
DOC_USP7_MATH_1	400	404	PF00917	0.760
DOC_USP7_MATH_1	536	540	PF00917	0.813
DOC_USP7_MATH_1	554	558	PF00917	0.585
DOC_USP7_MATH_2	201	207	PF00917	0.611
DOC_USP7_UBL2_3	213	217	PF12436	0.516
DOC_WW_Pin1_4	108	113	PF00397	0.633
DOC_WW_Pin1_4	12	17	PF00397	0.805
DOC_WW_Pin1_4	23	28	PF00397	0.695
DOC_WW_Pin1_4	335	340	PF00397	0.782
DOC_WW_Pin1_4	341	346	PF00397	0.725
DOC_WW_Pin1_4	36	41	PF00397	0.653
DOC_WW_Pin1_4	404	409	PF00397	0.580
DOC_WW_Pin1_4	47	52	PF00397	0.599
DOC_WW_Pin1_4	486	491	PF00397	0.771
DOC_WW_Pin1_4	504	509	PF00397	0.536
DOC_WW_Pin1_4	510	515	PF00397	0.598
DOC_WW_Pin1_4	766	771	PF00397	0.436
DOC_WW_Pin1_4	784	789	PF00397	0.209
DOC_WW_Pin1_4	893	898	PF00397	0.534
DOC_WW_Pin1_4	900	905	PF00397	0.624
LIG_14-3-3_CanoR_1	291	299	PF00244	0.554
LIG_14-3-3_CanoR_1	384	389	PF00244	0.604
LIG_14-3-3_CanoR_1	495	502	PF00244	0.592
LIG_14-3-3_CanoR_1	517	523	PF00244	0.478
LIG_14-3-3_CanoR_1	588	593	PF00244	0.490
LIG_14-3-3_CanoR_1	7	16	PF00244	0.602
LIG_14-3-3_CanoR_1	870	878	PF00244	0.279
LIG_APCC_ABBA_1	666	671	PF00400	0.289
LIG_BRCT_BRCA1_1	561	565	PF00533	0.613
LIG_BRCT_BRCA1_1	786	790	PF00533	0.338
LIG_CtBP_PxDLS_1	347	351	PF00389	0.514
LIG_DLG_GKlike_1	384	392	PF00625	0.617
LIG_FHA_1	197	203	PF00498	0.615
LIG_FHA_1	41	47	PF00498	0.659
LIG_FHA_1	462	468	PF00498	0.443
LIG_FHA_1	496	502	PF00498	0.670
LIG_FHA_1	522	528	PF00498	0.678
LIG_FHA_1	574	580	PF00498	0.625
LIG_FHA_1	654	660	PF00498	0.336
LIG_FHA_1	699	705	PF00498	0.404
LIG_FHA_2	174	180	PF00498	0.660
LIG_FHA_2	292	298	PF00498	0.624
LIG_FHA_2	310	316	PF00498	0.641
LIG_FHA_2	598	604	PF00498	0.409
LIG_FHA_2	871	877	PF00498	0.267
LIG_FHA_2	882	888	PF00498	0.386
LIG_LIR_Apic_2	787	793	PF02991	0.275
LIG_LIR_Gen_1	313	323	PF02991	0.568
LIG_LIR_Nem_3	294	299	PF02991	0.529
LIG_LIR_Nem_3	313	319	PF02991	0.656
LIG_LIR_Nem_3	542	546	PF02991	0.569
LIG_LIR_Nem_3	597	601	PF02991	0.339
LIG_LIR_Nem_3	667	672	PF02991	0.372
LIG_LRP6_Inhibitor_1	19	25	PF00058	0.654
LIG_MLH1_MIPbox_1	786	790	PF16413	0.338
LIG_Pex14_2	832	836	PF04695	0.338
LIG_Pex14_2	860	864	PF04695	0.268
LIG_PROFILIN_1	477	483	PF00235	0.515
LIG_PTB_Apo_2	440	447	PF02174	0.599
LIG_PTB_Phospho_1	440	446	PF10480	0.598
LIG_REV1ctd_RIR_1	857	866	PF16727	0.269
LIG_SH2_GRB2like	441	444	PF00017	0.590
LIG_SH2_NCK_1	441	445	PF00017	0.590
LIG_SH2_SRC	710	713	PF00017	0.289
LIG_SH2_STAP1	441	445	PF00017	0.590
LIG_SH2_STAP1	700	704	PF00017	0.289
LIG_SH2_STAT3	652	655	PF00017	0.289
LIG_SH2_STAT3	700	703	PF00017	0.289
LIG_SH2_STAT5	280	283	PF00017	0.588
LIG_SH2_STAT5	299	302	PF00017	0.456
LIG_SH2_STAT5	438	441	PF00017	0.554
LIG_SH2_STAT5	446	449	PF00017	0.562
LIG_SH2_STAT5	463	466	PF00017	0.430
LIG_SH2_STAT5	700	703	PF00017	0.329
LIG_SH2_STAT5	710	713	PF00017	0.246
LIG_SH2_STAT5	802	805	PF00017	0.338
LIG_SH3_1	14	20	PF00018	0.721
LIG_SH3_3	14	20	PF00018	0.679
LIG_SH3_3	333	339	PF00018	0.712
LIG_SH3_3	342	348	PF00018	0.691
LIG_SH3_3	43	49	PF00018	0.741
LIG_SH3_3	474	480	PF00018	0.626
LIG_SH3_3	508	514	PF00018	0.705
LIG_SH3_3	78	84	PF00018	0.665
LIG_SH3_3	782	788	PF00018	0.275
LIG_SH3_3	891	897	PF00018	0.501
LIG_SUMO_SIM_anti_2	430	436	PF11976	0.423
LIG_SUMO_SIM_anti_2	693	699	PF11976	0.289
LIG_SUMO_SIM_anti_2	873	879	PF11976	0.300
LIG_SUMO_SIM_par_1	197	206	PF11976	0.615
LIG_SUMO_SIM_par_1	42	50	PF11976	0.644
LIG_TRAF2_1	144	147	PF00917	0.832
LIG_TRAF2_1	162	165	PF00917	0.496
LIG_TRAF2_1	769	772	PF00917	0.322
LIG_TRAF2_1	889	892	PF00917	0.557
LIG_TRFH_1	404	408	PF08558	0.627
LIG_TYR_ITSM	598	605	PF00017	0.372
LIG_UBA3_1	639	646	PF00899	0.289
LIG_UBA3_1	727	735	PF00899	0.313
LIG_UBA3_1	831	840	PF00899	0.312
LIG_WRC_WIRS_1	519	524	PF05994	0.476
MOD_CDC14_SPxK_1	111	114	PF00782	0.505
MOD_CDC14_SPxK_1	50	53	PF00782	0.607
MOD_CDK_SPK_2	404	409	PF00069	0.578
MOD_CDK_SPxK_1	108	114	PF00069	0.510
MOD_CDK_SPxK_1	47	53	PF00069	0.610
MOD_CDK_SPxxK_3	47	54	PF00069	0.643
MOD_CDK_SPxxK_3	486	493	PF00069	0.637
MOD_CDK_SPxxK_3	510	517	PF00069	0.610
MOD_CK1_1	110	116	PF00069	0.702
MOD_CK1_1	12	18	PF00069	0.547
MOD_CK1_1	122	128	PF00069	0.738
MOD_CK1_1	189	195	PF00069	0.709
MOD_CK1_1	206	212	PF00069	0.492
MOD_CK1_1	219	225	PF00069	0.536
MOD_CK1_1	234	240	PF00069	0.738
MOD_CK1_1	30	36	PF00069	0.625
MOD_CK1_1	338	344	PF00069	0.681
MOD_CK1_1	362	368	PF00069	0.712
MOD_CK1_1	39	45	PF00069	0.625
MOD_CK1_1	416	422	PF00069	0.667
MOD_CK1_1	430	436	PF00069	0.495
MOD_CK1_1	470	476	PF00069	0.613
MOD_CK1_1	486	492	PF00069	0.666
MOD_CK1_1	526	532	PF00069	0.625
MOD_CK1_1	557	563	PF00069	0.583
MOD_CK1_1	597	603	PF00069	0.404
MOD_CK1_1	677	683	PF00069	0.372
MOD_CK1_1	896	902	PF00069	0.585
MOD_CK2_1	131	137	PF00069	0.663
MOD_CK2_1	141	147	PF00069	0.615
MOD_CK2_1	159	165	PF00069	0.607
MOD_CK2_1	419	425	PF00069	0.601
MOD_CK2_1	536	542	PF00069	0.685
MOD_CK2_1	597	603	PF00069	0.404
MOD_CK2_1	766	772	PF00069	0.464
MOD_CK2_1	870	876	PF00069	0.260
MOD_CK2_1	896	902	PF00069	0.585
MOD_Cter_Amidation	215	218	PF01082	0.642
MOD_GlcNHglycan	133	136	PF01048	0.530
MOD_GlcNHglycan	188	191	PF01048	0.702
MOD_GlcNHglycan	194	197	PF01048	0.615
MOD_GlcNHglycan	214	217	PF01048	0.467
MOD_GlcNHglycan	234	237	PF01048	0.538
MOD_GlcNHglycan	245	248	PF01048	0.557
MOD_GlcNHglycan	29	32	PF01048	0.616
MOD_GlcNHglycan	377	380	PF01048	0.615
MOD_GlcNHglycan	388	391	PF01048	0.626
MOD_GlcNHglycan	418	421	PF01048	0.662
MOD_GlcNHglycan	469	472	PF01048	0.649
MOD_GlcNHglycan	502	505	PF01048	0.598
MOD_GlcNHglycan	528	531	PF01048	0.665
MOD_GlcNHglycan	556	559	PF01048	0.615
MOD_GlcNHglycan	56	59	PF01048	0.698
MOD_GlcNHglycan	728	731	PF01048	0.347
MOD_GSK3_1	106	113	PF00069	0.652
MOD_GSK3_1	169	176	PF00069	0.668
MOD_GSK3_1	184	191	PF00069	0.584
MOD_GSK3_1	192	199	PF00069	0.617
MOD_GSK3_1	212	219	PF00069	0.614
MOD_GSK3_1	227	234	PF00069	0.568
MOD_GSK3_1	23	30	PF00069	0.610
MOD_GSK3_1	3	10	PF00069	0.814
MOD_GSK3_1	32	39	PF00069	0.776
MOD_GSK3_1	331	338	PF00069	0.672
MOD_GSK3_1	375	382	PF00069	0.596
MOD_GSK3_1	384	391	PF00069	0.589
MOD_GSK3_1	400	407	PF00069	0.609
MOD_GSK3_1	410	417	PF00069	0.582
MOD_GSK3_1	457	464	PF00069	0.605
MOD_GSK3_1	500	507	PF00069	0.629
MOD_GSK3_1	54	61	PF00069	0.745
MOD_GSK3_1	692	699	PF00069	0.293
MOD_GSK3_1	780	787	PF00069	0.275
MOD_GSK3_1	896	903	PF00069	0.591
MOD_N-GLC_1	359	364	PF02516	0.584
MOD_N-GLC_1	392	397	PF02516	0.643
MOD_N-GLC_1	457	462	PF02516	0.573
MOD_N-GLC_1	565	570	PF02516	0.560
MOD_NEK2_1	3	8	PF00069	0.744
MOD_NEK2_1	375	380	PF00069	0.701
MOD_NEK2_1	386	391	PF00069	0.688
MOD_NEK2_1	410	415	PF00069	0.583
MOD_NEK2_1	457	462	PF00069	0.584
MOD_NEK2_1	520	525	PF00069	0.651
MOD_NEK2_1	565	570	PF00069	0.545
MOD_NEK2_1	573	578	PF00069	0.535
MOD_NEK2_1	639	644	PF00069	0.272
MOD_NEK2_1	692	697	PF00069	0.289
MOD_NEK2_1	739	744	PF00069	0.319
MOD_NEK2_1	780	785	PF00069	0.338
MOD_PIKK_1	119	125	PF00454	0.707
MOD_PIKK_1	217	223	PF00454	0.629
MOD_PIKK_1	30	36	PF00454	0.753
MOD_PIKK_1	388	394	PF00454	0.703
MOD_PIKK_1	461	467	PF00454	0.483
MOD_PIKK_1	603	609	PF00454	0.372
MOD_PIKK_1	896	902	PF00454	0.585
MOD_PIKK_1	9	15	PF00454	0.525
MOD_PK_1	588	594	PF00069	0.372
MOD_PKA_1	217	223	PF00069	0.667
MOD_PKA_1	291	297	PF00069	0.584
MOD_PKA_1	588	594	PF00069	0.372
MOD_PKA_1	870	876	PF00069	0.326
MOD_PKA_2	206	212	PF00069	0.670
MOD_PKA_2	331	337	PF00069	0.631
MOD_PKA_2	439	445	PF00069	0.559
MOD_PKA_2	52	58	PF00069	0.668
MOD_PKA_2	588	594	PF00069	0.428
MOD_PKA_2	836	842	PF00069	0.403
MOD_PKA_2	870	876	PF00069	0.277
MOD_Plk_1	410	416	PF00069	0.564
MOD_Plk_1	457	463	PF00069	0.573
MOD_Plk_1	565	571	PF00069	0.572
MOD_Plk_1	617	623	PF00069	0.384
MOD_Plk_2-3	141	147	PF00069	0.720
MOD_Plk_2-3	309	315	PF00069	0.524
MOD_Plk_4	331	337	PF00069	0.693
MOD_Plk_4	394	400	PF00069	0.686
MOD_Plk_4	419	425	PF00069	0.613
MOD_Plk_4	430	436	PF00069	0.482
MOD_Plk_4	457	463	PF00069	0.585
MOD_Plk_4	588	594	PF00069	0.420
MOD_Plk_4	597	603	PF00069	0.363
MOD_Plk_4	647	653	PF00069	0.366
MOD_Plk_4	780	786	PF00069	0.272
MOD_ProDKin_1	108	114	PF00069	0.636
MOD_ProDKin_1	12	18	PF00069	0.803
MOD_ProDKin_1	23	29	PF00069	0.692
MOD_ProDKin_1	335	341	PF00069	0.780
MOD_ProDKin_1	36	42	PF00069	0.654
MOD_ProDKin_1	404	410	PF00069	0.575
MOD_ProDKin_1	47	53	PF00069	0.600
MOD_ProDKin_1	486	492	PF00069	0.768
MOD_ProDKin_1	504	510	PF00069	0.536
MOD_ProDKin_1	766	772	PF00069	0.436
MOD_ProDKin_1	784	790	PF00069	0.209
MOD_ProDKin_1	893	899	PF00069	0.545
MOD_ProDKin_1	900	906	PF00069	0.629
MOD_SUMO_for_1	633	636	PF00179	0.372
MOD_SUMO_rev_2	422	431	PF00179	0.594
MOD_SUMO_rev_2	47	55	PF00179	0.692
MOD_SUMO_rev_2	603	612	PF00179	0.289
MOD_SUMO_rev_2	729	737	PF00179	0.289
TRG_ENDOCYTIC_2	602	605	PF00928	0.308
TRG_ER_diArg_1	207	210	PF00400	0.635
TRG_ER_diArg_1	277	279	PF00400	0.513
TRG_ER_diArg_1	587	589	PF00400	0.482
TRG_ER_diArg_1	681	683	PF00400	0.289
TRG_NES_CRM1_1	317	333	PF08389	0.513
TRG_NES_CRM1_1	567	583	PF08389	0.598
TRG_NES_CRM1_1	807	817	PF08389	0.392
TRG_NLS_MonoExtN_4	866	873	PF00514	0.322
TRG_Pf-PMV_PEXEL_1	888	892	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NSX9	Trypanosomatidae	43%	96%
A0A3R7M724	Trypanosoma rangeli	43%	100%
A0A3S5H705	Leishmania donovani	90%	100%
A4HXC3	Leishmania infantum	93%	100%
C9ZU16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AI55	Leishmania braziliensis	63%	88%
E9AR18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
V5B639	Trypanosoma cruzi	43%	100%