Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QEE2_LEIMA

TriTrypDb:

LmjF.17.0520 , LMJLV39_170010900 , LMJSD75_170010600

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.598
CLV_C14_Caspase3-7	16	20	PF00656	0.731
CLV_C14_Caspase3-7	304	308	PF00656	0.782
CLV_C14_Caspase3-7	315	319	PF00656	0.655
CLV_C14_Caspase3-7	347	351	PF00656	0.608
CLV_C14_Caspase3-7	659	663	PF00656	0.789
CLV_NRD_NRD_1	258	260	PF00675	0.747
CLV_NRD_NRD_1	269	271	PF00675	0.650
CLV_NRD_NRD_1	51	53	PF00675	0.710
CLV_NRD_NRD_1	570	572	PF00675	0.792
CLV_NRD_NRD_1	60	62	PF00675	0.625
CLV_NRD_NRD_1	9	11	PF00675	0.735
CLV_PCSK_KEX2_1	258	260	PF00082	0.749
CLV_PCSK_KEX2_1	269	271	PF00082	0.648
CLV_PCSK_KEX2_1	51	53	PF00082	0.710
CLV_PCSK_KEX2_1	839	841	PF00082	0.764
CLV_PCSK_KEX2_1	9	11	PF00082	0.718
CLV_PCSK_PC1ET2_1	839	841	PF00082	0.764
CLV_PCSK_SKI1_1	230	234	PF00082	0.718
CLV_PCSK_SKI1_1	567	571	PF00082	0.798
CLV_PCSK_SKI1_1	723	727	PF00082	0.768
DEG_Kelch_Keap1_1	790	795	PF01344	0.707
DEG_Nend_UBRbox_3	1	3	PF02207	0.625
DEG_SPOP_SBC_1	101	105	PF00917	0.603
DEG_SPOP_SBC_1	37	41	PF00917	0.694
DOC_ANK_TNKS_1	50	57	PF00023	0.678
DOC_CKS1_1	354	359	PF01111	0.631
DOC_CKS1_1	382	387	PF01111	0.814
DOC_CKS1_1	761	766	PF01111	0.821
DOC_CYCLIN_RxL_1	236	247	PF00134	0.653
DOC_MAPK_gen_1	594	601	PF00069	0.592
DOC_MAPK_gen_1	839	845	PF00069	0.772
DOC_MAPK_MEF2A_6	359	367	PF00069	0.798
DOC_PP1_RVXF_1	747	754	PF00149	0.616
DOC_PP1_SILK_1	567	572	PF00149	0.785
DOC_PP2B_LxvP_1	23	26	PF13499	0.684
DOC_PP2B_LxvP_1	33	36	PF13499	0.581
DOC_PP2B_LxvP_1	459	462	PF13499	0.688
DOC_PP2B_LxvP_1	78	81	PF13499	0.698
DOC_PP2B_LxvP_1	799	802	PF13499	0.720
DOC_PP4_FxxP_1	371	374	PF00568	0.759
DOC_USP7_MATH_1	108	112	PF00917	0.659
DOC_USP7_MATH_1	138	142	PF00917	0.722
DOC_USP7_MATH_1	152	156	PF00917	0.557
DOC_USP7_MATH_1	185	189	PF00917	0.798
DOC_USP7_MATH_1	244	248	PF00917	0.776
DOC_USP7_MATH_1	263	267	PF00917	0.515
DOC_USP7_MATH_1	27	31	PF00917	0.687
DOC_USP7_MATH_1	298	302	PF00917	0.788
DOC_USP7_MATH_1	36	40	PF00917	0.687
DOC_USP7_MATH_1	374	378	PF00917	0.685
DOC_USP7_MATH_1	392	396	PF00917	0.534
DOC_USP7_MATH_1	397	401	PF00917	0.691
DOC_USP7_MATH_1	482	486	PF00917	0.770
DOC_USP7_MATH_1	513	517	PF00917	0.634
DOC_USP7_MATH_1	550	554	PF00917	0.687
DOC_USP7_MATH_1	679	683	PF00917	0.694
DOC_USP7_MATH_1	742	746	PF00917	0.629
DOC_USP7_MATH_1	86	90	PF00917	0.687
DOC_WW_Pin1_4	200	205	PF00397	0.823
DOC_WW_Pin1_4	206	211	PF00397	0.721
DOC_WW_Pin1_4	268	273	PF00397	0.714
DOC_WW_Pin1_4	293	298	PF00397	0.768
DOC_WW_Pin1_4	308	313	PF00397	0.589
DOC_WW_Pin1_4	353	358	PF00397	0.669
DOC_WW_Pin1_4	369	374	PF00397	0.623
DOC_WW_Pin1_4	376	381	PF00397	0.779
DOC_WW_Pin1_4	38	43	PF00397	0.582
DOC_WW_Pin1_4	388	393	PF00397	0.660
DOC_WW_Pin1_4	490	495	PF00397	0.767
DOC_WW_Pin1_4	544	549	PF00397	0.795
DOC_WW_Pin1_4	617	622	PF00397	0.726
DOC_WW_Pin1_4	639	644	PF00397	0.812
DOC_WW_Pin1_4	673	678	PF00397	0.785
DOC_WW_Pin1_4	738	743	PF00397	0.802
DOC_WW_Pin1_4	757	762	PF00397	0.713
DOC_WW_Pin1_4	765	770	PF00397	0.652
DOC_WW_Pin1_4	832	837	PF00397	0.741
LIG_14-3-3_CanoR_1	168	172	PF00244	0.707
LIG_14-3-3_CanoR_1	187	196	PF00244	0.753
LIG_14-3-3_CanoR_1	258	267	PF00244	0.721
LIG_14-3-3_CanoR_1	332	336	PF00244	0.693
LIG_14-3-3_CanoR_1	560	570	PF00244	0.606
LIG_14-3-3_CanoR_1	61	70	PF00244	0.679
LIG_14-3-3_CanoR_1	622	629	PF00244	0.627
LIG_14-3-3_CanoR_1	636	644	PF00244	0.684
LIG_14-3-3_CanoR_1	657	666	PF00244	0.761
LIG_14-3-3_CanoR_1	683	691	PF00244	0.758
LIG_14-3-3_CanoR_1	821	829	PF00244	0.585
LIG_BIR_III_2	674	678	PF00653	0.759
LIG_BIR_III_2	85	89	PF00653	0.721
LIG_BIR_III_4	450	454	PF00653	0.678
LIG_BRCT_BRCA1_1	552	556	PF00533	0.703
LIG_BRCT_BRCA1_1	749	753	PF00533	0.617
LIG_FHA_1	116	122	PF00498	0.616
LIG_FHA_1	156	162	PF00498	0.718
LIG_FHA_1	167	173	PF00498	0.687
LIG_FHA_1	328	334	PF00498	0.736
LIG_FHA_1	497	503	PF00498	0.827
LIG_FHA_1	561	567	PF00498	0.635
LIG_FHA_1	618	624	PF00498	0.702
LIG_FHA_1	64	70	PF00498	0.724
LIG_FHA_1	794	800	PF00498	0.738
LIG_FHA_1	93	99	PF00498	0.758
LIG_FHA_2	14	20	PF00498	0.728
LIG_FHA_2	158	164	PF00498	0.695
LIG_FHA_2	210	216	PF00498	0.718
LIG_FHA_2	549	555	PF00498	0.768
LIG_FHA_2	657	663	PF00498	0.824
LIG_FHA_2	715	721	PF00498	0.789
LIG_FHA_2	802	808	PF00498	0.750
LIG_FHA_2	821	827	PF00498	0.538
LIG_Integrin_isoDGR_2	634	636	PF01839	0.622
LIG_LIR_Apic_2	370	374	PF02991	0.755
LIG_LIR_Apic_2	692	698	PF02991	0.721
LIG_LIR_Gen_1	424	431	PF02991	0.679
LIG_LIR_LC3C_4	530	535	PF02991	0.586
LIG_LIR_Nem_3	424	429	PF02991	0.748
LIG_LIR_Nem_3	553	559	PF02991	0.699
LIG_LIR_Nem_3	652	656	PF02991	0.779
LIG_MAD2	74	82	PF02301	0.666
LIG_PDZ_Class_2	840	845	PF00595	0.773
LIG_SH2_CRK	483	487	PF00017	0.594
LIG_SH2_GRB2like	443	446	PF00017	0.718
LIG_SH2_NCK_1	483	487	PF00017	0.594
LIG_SH2_SRC	100	103	PF00017	0.721
LIG_SH2_STAP1	117	121	PF00017	0.621
LIG_SH2_STAT5	100	103	PF00017	0.771
LIG_SH2_STAT5	117	120	PF00017	0.545
LIG_SH3_2	354	359	PF14604	0.631
LIG_SH3_3	191	197	PF00018	0.798
LIG_SH3_3	294	300	PF00018	0.723
LIG_SH3_3	351	357	PF00018	0.656
LIG_SH3_3	396	402	PF00018	0.658
LIG_SH3_3	414	420	PF00018	0.625
LIG_SH3_3	451	457	PF00018	0.731
LIG_SH3_3	596	602	PF00018	0.727
LIG_SH3_3	758	764	PF00018	0.749
LIG_SH3_3	795	801	PF00018	0.739
LIG_SUMO_SIM_anti_2	73	79	PF11976	0.571
LIG_WRC_WIRS_1	368	373	PF05994	0.759
MOD_CDC14_SPxK_1	768	771	PF00782	0.668
MOD_CDC14_SPxK_1	837	840	PF00782	0.600
MOD_CDK_SPK_2	617	622	PF00069	0.803
MOD_CDK_SPK_2	834	839	PF00069	0.573
MOD_CDK_SPxK_1	293	299	PF00069	0.715
MOD_CDK_SPxK_1	353	359	PF00069	0.632
MOD_CDK_SPxK_1	765	771	PF00069	0.668
MOD_CDK_SPxK_1	834	840	PF00069	0.606
MOD_CDK_SPxxK_3	376	383	PF00069	0.806
MOD_CDK_SPxxK_3	832	839	PF00069	0.776
MOD_CK1_1	111	117	PF00069	0.768
MOD_CK1_1	126	132	PF00069	0.627
MOD_CK1_1	155	161	PF00069	0.766
MOD_CK1_1	186	192	PF00069	0.726
MOD_CK1_1	209	215	PF00069	0.731
MOD_CK1_1	231	237	PF00069	0.734
MOD_CK1_1	247	253	PF00069	0.558
MOD_CK1_1	262	268	PF00069	0.552
MOD_CK1_1	301	307	PF00069	0.744
MOD_CK1_1	381	387	PF00069	0.861
MOD_CK1_1	391	397	PF00069	0.673
MOD_CK1_1	408	414	PF00069	0.576
MOD_CK1_1	436	442	PF00069	0.774
MOD_CK1_1	484	490	PF00069	0.790
MOD_CK1_1	506	512	PF00069	0.764
MOD_CK1_1	543	549	PF00069	0.696
MOD_CK1_1	573	579	PF00069	0.705
MOD_CK1_1	638	644	PF00069	0.728
MOD_CK1_1	709	715	PF00069	0.771
MOD_CK1_1	760	766	PF00069	0.737
MOD_CK1_1	803	809	PF00069	0.734
MOD_CK2_1	209	215	PF00069	0.716
MOD_CK2_1	486	492	PF00069	0.635
MOD_CK2_1	548	554	PF00069	0.772
MOD_CK2_1	572	578	PF00069	0.623
MOD_CK2_1	714	720	PF00069	0.808
MOD_CK2_1	789	795	PF00069	0.760
MOD_CK2_1	801	807	PF00069	0.670
MOD_CK2_1	820	826	PF00069	0.540
MOD_GlcNHglycan	126	129	PF01048	0.812
MOD_GlcNHglycan	152	155	PF01048	0.574
MOD_GlcNHglycan	244	247	PF01048	0.732
MOD_GlcNHglycan	249	252	PF01048	0.674
MOD_GlcNHglycan	261	264	PF01048	0.538
MOD_GlcNHglycan	286	289	PF01048	0.614
MOD_GlcNHglycan	303	306	PF01048	0.721
MOD_GlcNHglycan	324	327	PF01048	0.828
MOD_GlcNHglycan	394	397	PF01048	0.800
MOD_GlcNHglycan	399	402	PF01048	0.723
MOD_GlcNHglycan	407	410	PF01048	0.662
MOD_GlcNHglycan	435	438	PF01048	0.773
MOD_GlcNHglycan	463	466	PF01048	0.805
MOD_GlcNHglycan	488	491	PF01048	0.679
MOD_GlcNHglycan	515	518	PF01048	0.673
MOD_GlcNHglycan	529	532	PF01048	0.667
MOD_GlcNHglycan	572	575	PF01048	0.706
MOD_GlcNHglycan	626	629	PF01048	0.820
MOD_GlcNHglycan	63	66	PF01048	0.771
MOD_GlcNHglycan	637	640	PF01048	0.670
MOD_GlcNHglycan	668	671	PF01048	0.765
MOD_GlcNHglycan	711	714	PF01048	0.667
MOD_GlcNHglycan	732	735	PF01048	0.647
MOD_GlcNHglycan	744	747	PF01048	0.630
MOD_GlcNHglycan	777	780	PF01048	0.798
MOD_GlcNHglycan	88	91	PF01048	0.710
MOD_GSK3_1	111	118	PF00069	0.636
MOD_GSK3_1	157	164	PF00069	0.771
MOD_GSK3_1	167	174	PF00069	0.718
MOD_GSK3_1	175	182	PF00069	0.624
MOD_GSK3_1	183	190	PF00069	0.584
MOD_GSK3_1	200	207	PF00069	0.769
MOD_GSK3_1	209	216	PF00069	0.705
MOD_GSK3_1	224	231	PF00069	0.624
MOD_GSK3_1	259	266	PF00069	0.747
MOD_GSK3_1	327	334	PF00069	0.735
MOD_GSK3_1	344	351	PF00069	0.690
MOD_GSK3_1	374	381	PF00069	0.857
MOD_GSK3_1	38	45	PF00069	0.718
MOD_GSK3_1	387	394	PF00069	0.647
MOD_GSK3_1	429	436	PF00069	0.733
MOD_GSK3_1	469	476	PF00069	0.760
MOD_GSK3_1	481	488	PF00069	0.655
MOD_GSK3_1	490	497	PF00069	0.724
MOD_GSK3_1	513	520	PF00069	0.758
MOD_GSK3_1	523	530	PF00069	0.674
MOD_GSK3_1	540	547	PF00069	0.788
MOD_GSK3_1	561	568	PF00069	0.712
MOD_GSK3_1	57	64	PF00069	0.562
MOD_GSK3_1	570	577	PF00069	0.613
MOD_GSK3_1	612	619	PF00069	0.658
MOD_GSK3_1	634	641	PF00069	0.754
MOD_GSK3_1	673	680	PF00069	0.663
MOD_GSK3_1	702	709	PF00069	0.798
MOD_GSK3_1	737	744	PF00069	0.698
MOD_GSK3_1	755	762	PF00069	0.663
MOD_GSK3_1	765	772	PF00069	0.690
MOD_GSK3_1	789	796	PF00069	0.804
MOD_GSK3_1	88	95	PF00069	0.699
MOD_GSK3_1	9	16	PF00069	0.758
MOD_LATS_1	346	352	PF00433	0.708
MOD_N-GLC_1	150	155	PF02516	0.571
MOD_N-GLC_1	403	408	PF02516	0.754
MOD_N-GLC_1	594	599	PF02516	0.723
MOD_N-GLC_1	666	671	PF02516	0.762
MOD_N-GLC_1	709	714	PF02516	0.762
MOD_N-GLC_1	789	794	PF02516	0.769
MOD_N-GLC_2	478	480	PF02516	0.581
MOD_NEK2_1	171	176	PF00069	0.691
MOD_NEK2_1	183	188	PF00069	0.640
MOD_NEK2_1	249	254	PF00069	0.727
MOD_NEK2_1	290	295	PF00069	0.755
MOD_NEK2_1	47	52	PF00069	0.669
MOD_NEK2_1	512	517	PF00069	0.784
MOD_NEK2_1	519	524	PF00069	0.716
MOD_NEK2_1	570	575	PF00069	0.758
MOD_NEK2_1	656	661	PF00069	0.822
MOD_PIKK_1	175	181	PF00454	0.731
MOD_PIKK_1	224	230	PF00454	0.681
MOD_PIKK_1	331	337	PF00454	0.695
MOD_PIKK_1	42	48	PF00454	0.742
MOD_PIKK_1	492	498	PF00454	0.718
MOD_PIKK_1	769	775	PF00454	0.759
MOD_PIKK_1	793	799	PF00454	0.775
MOD_PKA_1	61	67	PF00069	0.667
MOD_PKA_1	9	15	PF00069	0.719
MOD_PKA_2	167	173	PF00069	0.706
MOD_PKA_2	186	192	PF00069	0.755
MOD_PKA_2	247	253	PF00069	0.731
MOD_PKA_2	298	304	PF00069	0.714
MOD_PKA_2	320	326	PF00069	0.778
MOD_PKA_2	331	337	PF00069	0.664
MOD_PKA_2	497	503	PF00069	0.749
MOD_PKA_2	559	565	PF00069	0.625
MOD_PKA_2	570	576	PF00069	0.666
MOD_PKA_2	60	66	PF00069	0.691
MOD_PKA_2	621	627	PF00069	0.623
MOD_PKA_2	635	641	PF00069	0.688
MOD_PKA_2	656	662	PF00069	0.788
MOD_PKA_2	775	781	PF00069	0.723
MOD_PKA_2	813	819	PF00069	0.677
MOD_PKA_2	820	826	PF00069	0.623
MOD_PKA_2	9	15	PF00069	0.719
MOD_Plk_1	101	107	PF00069	0.708
MOD_Plk_1	403	409	PF00069	0.587
MOD_Plk_1	594	600	PF00069	0.725
MOD_Plk_4	152	158	PF00069	0.820
MOD_Plk_4	167	173	PF00069	0.614
MOD_Plk_4	348	354	PF00069	0.743
MOD_Plk_4	565	571	PF00069	0.775
MOD_Plk_4	581	587	PF00069	0.555
MOD_ProDKin_1	200	206	PF00069	0.822
MOD_ProDKin_1	268	274	PF00069	0.713
MOD_ProDKin_1	293	299	PF00069	0.770
MOD_ProDKin_1	308	314	PF00069	0.589
MOD_ProDKin_1	353	359	PF00069	0.668
MOD_ProDKin_1	369	375	PF00069	0.625
MOD_ProDKin_1	376	382	PF00069	0.781
MOD_ProDKin_1	38	44	PF00069	0.585
MOD_ProDKin_1	388	394	PF00069	0.661
MOD_ProDKin_1	490	496	PF00069	0.769
MOD_ProDKin_1	544	550	PF00069	0.790
MOD_ProDKin_1	617	623	PF00069	0.726
MOD_ProDKin_1	639	645	PF00069	0.808
MOD_ProDKin_1	673	679	PF00069	0.786
MOD_ProDKin_1	738	744	PF00069	0.803
MOD_ProDKin_1	757	763	PF00069	0.714
MOD_ProDKin_1	765	771	PF00069	0.655
MOD_ProDKin_1	832	838	PF00069	0.739
MOD_SUMO_rev_2	209	219	PF00179	0.585
MOD_SUMO_rev_2	271	279	PF00179	0.706
TRG_ENDOCYTIC_2	443	446	PF00928	0.718
TRG_ENDOCYTIC_2	483	486	PF00928	0.593
TRG_ER_diArg_1	455	458	PF00400	0.616
TRG_ER_diArg_1	8	10	PF00400	0.726
TRG_ER_diArg_1	840	843	PF00400	0.703
TRG_NLS_MonoExtN_4	836	843	PF00514	0.700
TRG_Pf-PMV_PEXEL_1	557	561	PF00026	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUD2	Leishmania donovani	87%	100%
A4H8Z5	Leishmania braziliensis	49%	93%
A4HXC6	Leishmania infantum	87%	100%
E9AR21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%