Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEE1_LEIMA

TriTrypDb:

LmjF.17.0530 , LMJLV39_170011000 , LMJSD75_170010700

Length:

1064

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	499	503	PF00656	0.680
CLV_MEL_PAP_1	64	70	PF00089	0.631
CLV_NRD_NRD_1	447	449	PF00675	0.870
CLV_NRD_NRD_1	563	565	PF00675	0.861
CLV_NRD_NRD_1	60	62	PF00675	0.686
CLV_NRD_NRD_1	642	644	PF00675	0.608
CLV_NRD_NRD_1	76	78	PF00675	0.681
CLV_NRD_NRD_1	99	101	PF00675	0.716
CLV_NRD_NRD_1	990	992	PF00675	0.835
CLV_PCSK_FUR_1	445	449	PF00082	0.811
CLV_PCSK_FUR_1	721	725	PF00082	0.438
CLV_PCSK_KEX2_1	447	449	PF00082	0.870
CLV_PCSK_KEX2_1	563	565	PF00082	0.861
CLV_PCSK_KEX2_1	60	62	PF00082	0.801
CLV_PCSK_KEX2_1	642	644	PF00082	0.608
CLV_PCSK_KEX2_1	723	725	PF00082	0.670
CLV_PCSK_KEX2_1	76	78	PF00082	0.582
CLV_PCSK_KEX2_1	952	954	PF00082	0.509
CLV_PCSK_KEX2_1	989	991	PF00082	0.827
CLV_PCSK_KEX2_1	99	101	PF00082	0.716
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.670
CLV_PCSK_PC1ET2_1	952	954	PF00082	0.578
CLV_PCSK_PC1ET2_1	989	991	PF00082	0.648
CLV_PCSK_PC7_1	443	449	PF00082	0.831
CLV_PCSK_SKI1_1	156	160	PF00082	0.617
CLV_PCSK_SKI1_1	222	226	PF00082	0.682
CLV_PCSK_SKI1_1	516	520	PF00082	0.843
CLV_PCSK_SKI1_1	538	542	PF00082	0.794
CLV_PCSK_SKI1_1	662	666	PF00082	0.490
CLV_PCSK_SKI1_1	741	745	PF00082	0.678
CLV_PCSK_SKI1_1	842	846	PF00082	0.677
CLV_PCSK_SKI1_1	888	892	PF00082	0.681
CLV_PCSK_SKI1_1	994	998	PF00082	0.730
DEG_APCC_DBOX_1	758	766	PF00400	0.648
DEG_APCC_DBOX_1	802	810	PF00400	0.671
DEG_SCF_FBW7_1	16	23	PF00400	0.785
DEG_SCF_FBW7_1	465	471	PF00400	0.867
DEG_SPOP_SBC_1	11	15	PF00917	0.796
DEG_SPOP_SBC_1	279	283	PF00917	0.660
DEG_SPOP_SBC_1	595	599	PF00917	0.813
DOC_CKS1_1	465	470	PF01111	0.867
DOC_CKS1_1	624	629	PF01111	0.712
DOC_CYCLIN_RxL_1	153	161	PF00134	0.615
DOC_MAPK_gen_1	189	197	PF00069	0.640
DOC_MAPK_gen_1	485	494	PF00069	0.838
DOC_MAPK_gen_1	952	959	PF00069	0.632
DOC_MAPK_MEF2A_6	222	229	PF00069	0.679
DOC_PP2B_LxvP_1	349	352	PF13499	0.628
DOC_USP7_MATH_1	1026	1030	PF00917	0.723
DOC_USP7_MATH_1	1035	1039	PF00917	0.583
DOC_USP7_MATH_1	147	151	PF00917	0.706
DOC_USP7_MATH_1	20	24	PF00917	0.641
DOC_USP7_MATH_1	256	260	PF00917	0.829
DOC_USP7_MATH_1	279	283	PF00917	0.699
DOC_USP7_MATH_1	286	290	PF00917	0.645
DOC_USP7_MATH_1	33	37	PF00917	0.624
DOC_USP7_MATH_1	350	354	PF00917	0.631
DOC_USP7_MATH_1	405	409	PF00917	0.695
DOC_USP7_MATH_1	460	464	PF00917	0.770
DOC_USP7_MATH_1	468	472	PF00917	0.629
DOC_USP7_MATH_1	575	579	PF00917	0.599
DOC_USP7_MATH_1	611	615	PF00917	0.598
DOC_USP7_MATH_1	757	761	PF00917	0.677
DOC_USP7_MATH_1	770	774	PF00917	0.616
DOC_USP7_MATH_1	9	13	PF00917	0.739
DOC_USP7_MATH_1	970	974	PF00917	0.713
DOC_USP7_UBL2_3	952	956	PF12436	0.579
DOC_WW_Pin1_4	1014	1019	PF00397	0.823
DOC_WW_Pin1_4	1058	1063	PF00397	0.707
DOC_WW_Pin1_4	115	120	PF00397	0.607
DOC_WW_Pin1_4	145	150	PF00397	0.725
DOC_WW_Pin1_4	16	21	PF00397	0.659
DOC_WW_Pin1_4	282	287	PF00397	0.833
DOC_WW_Pin1_4	309	314	PF00397	0.727
DOC_WW_Pin1_4	342	347	PF00397	0.847
DOC_WW_Pin1_4	351	356	PF00397	0.691
DOC_WW_Pin1_4	377	382	PF00397	0.832
DOC_WW_Pin1_4	390	395	PF00397	0.570
DOC_WW_Pin1_4	406	411	PF00397	0.660
DOC_WW_Pin1_4	464	469	PF00397	0.727
DOC_WW_Pin1_4	527	532	PF00397	0.850
DOC_WW_Pin1_4	597	602	PF00397	0.851
DOC_WW_Pin1_4	623	628	PF00397	0.697
DOC_WW_Pin1_4	68	73	PF00397	0.791
DOC_WW_Pin1_4	7	12	PF00397	0.747
DOC_WW_Pin1_4	75	80	PF00397	0.701
DOC_WW_Pin1_4	775	780	PF00397	0.809
LIG_14-3-3_CanoR_1	1058	1062	PF00244	0.763
LIG_14-3-3_CanoR_1	129	138	PF00244	0.726
LIG_14-3-3_CanoR_1	22	28	PF00244	0.801
LIG_14-3-3_CanoR_1	47	54	PF00244	0.789
LIG_14-3-3_CanoR_1	684	692	PF00244	0.625
LIG_14-3-3_CanoR_1	759	763	PF00244	0.639
LIG_14-3-3_CanoR_1	910	918	PF00244	0.593
LIG_14-3-3_CanoR_1	994	1004	PF00244	0.709
LIG_Actin_WH2_1	795	812	PF00022	0.449
LIG_Actin_WH2_2	855	872	PF00022	0.667
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_BRCT_BRCA1_1	126	130	PF00533	0.707
LIG_Clathr_ClatBox_1	733	737	PF01394	0.654
LIG_EVH1_1	292	296	PF00568	0.842
LIG_FHA_1	1047	1053	PF00498	0.617
LIG_FHA_1	115	121	PF00498	0.727
LIG_FHA_1	305	311	PF00498	0.860
LIG_FHA_1	334	340	PF00498	0.749
LIG_FHA_1	598	604	PF00498	0.800
LIG_FHA_1	659	665	PF00498	0.646
LIG_FHA_1	889	895	PF00498	0.530
LIG_FHA_2	105	111	PF00498	0.664
LIG_FHA_2	417	423	PF00498	0.740
LIG_FHA_2	470	476	PF00498	0.795
LIG_FHA_2	502	508	PF00498	0.783
LIG_FHA_2	624	630	PF00498	0.709
LIG_FHA_2	744	750	PF00498	0.678
LIG_FHA_2	830	836	PF00498	0.631
LIG_FHA_2	880	886	PF00498	0.487
LIG_GBD_Chelix_1	798	806	PF00786	0.604
LIG_Integrin_RGD_1	91	93	PF01839	0.640
LIG_LIR_Apic_2	115	119	PF02991	0.608
LIG_LIR_Apic_2	144	149	PF02991	0.731
LIG_LIR_Apic_2	344	350	PF02991	0.653
LIG_LIR_Gen_1	1033	1042	PF02991	0.498
LIG_LIR_Gen_1	157	167	PF02991	0.660
LIG_LIR_Gen_1	656	665	PF02991	0.625
LIG_LIR_Nem_3	1033	1039	PF02991	0.606
LIG_LIR_Nem_3	157	162	PF02991	0.666
LIG_LIR_Nem_3	289	295	PF02991	0.783
LIG_MYND_1	293	297	PF01753	0.844
LIG_PCNA_yPIPBox_3	156	167	PF02747	0.436
LIG_PCNA_yPIPBox_3	707	719	PF02747	0.660
LIG_PTB_Apo_2	508	515	PF02174	0.709
LIG_PTB_Phospho_1	508	514	PF10480	0.711
LIG_RPA_C_Fungi	259	271	PF08784	0.727
LIG_SH2_CRK	1036	1040	PF00017	0.561
LIG_SH2_CRK	116	120	PF00017	0.608
LIG_SH2_CRK	347	351	PF00017	0.857
LIG_SH2_CRK	621	625	PF00017	0.755
LIG_SH2_NCK_1	347	351	PF00017	0.631
LIG_SH2_SRC	201	204	PF00017	0.666
LIG_SH2_STAP1	925	929	PF00017	0.653
LIG_SH2_STAT3	619	622	PF00017	0.762
LIG_SH2_STAT5	116	119	PF00017	0.733
LIG_SH2_STAT5	166	169	PF00017	0.435
LIG_SH2_STAT5	242	245	PF00017	0.699
LIG_SH2_STAT5	309	312	PF00017	0.858
LIG_SH2_STAT5	347	350	PF00017	0.856
LIG_SH2_STAT5	619	622	PF00017	0.762
LIG_SH3_1	621	627	PF00018	0.740
LIG_SH3_3	290	296	PF00018	0.830
LIG_SH3_3	349	355	PF00018	0.627
LIG_SH3_3	373	379	PF00018	0.710
LIG_SH3_3	481	487	PF00018	0.837
LIG_SH3_3	5	11	PF00018	0.791
LIG_SH3_3	621	627	PF00018	0.740
LIG_SUMO_SIM_par_1	117	125	PF11976	0.593
LIG_SUMO_SIM_par_1	732	737	PF11976	0.660
LIG_TRAF2_1	108	111	PF00917	0.662
LIG_TRAF2_1	180	183	PF00917	0.684
LIG_TRAF2_1	630	633	PF00917	0.695
LIG_TRAF2_1	882	885	PF00917	0.513
LIG_TRAF2_1	896	899	PF00917	0.625
LIG_WW_2	293	296	PF00397	0.842
LIG_WW_3	254	258	PF00397	0.739
MOD_CDK_SPxK_1	16	22	PF00069	0.751
MOD_CDK_SPxK_1	75	81	PF00069	0.796
MOD_CDK_SPxxK_3	406	413	PF00069	0.807
MOD_CK1_1	118	124	PF00069	0.755
MOD_CK1_1	128	134	PF00069	0.604
MOD_CK1_1	23	29	PF00069	0.582
MOD_CK1_1	282	288	PF00069	0.783
MOD_CK1_1	326	332	PF00069	0.769
MOD_CK1_1	345	351	PF00069	0.849
MOD_CK1_1	380	386	PF00069	0.862
MOD_CK1_1	393	399	PF00069	0.637
MOD_CK1_1	464	470	PF00069	0.714
MOD_CK1_1	522	528	PF00069	0.855
MOD_CK1_1	529	535	PF00069	0.723
MOD_CK1_1	602	608	PF00069	0.838
MOD_CK1_1	613	619	PF00069	0.573
MOD_CK1_1	683	689	PF00069	0.561
MOD_CK1_1	7	13	PF00069	0.797
MOD_CK1_1	768	774	PF00069	0.755
MOD_CK1_1	775	781	PF00069	0.626
MOD_CK1_1	85	91	PF00069	0.806
MOD_CK1_1	854	860	PF00069	0.636
MOD_CK1_1	913	919	PF00069	0.657
MOD_CK2_1	104	110	PF00069	0.664
MOD_CK2_1	145	151	PF00069	0.721
MOD_CK2_1	350	356	PF00069	0.795
MOD_CK2_1	501	507	PF00069	0.783
MOD_CK2_1	623	629	PF00069	0.720
MOD_CK2_1	744	750	PF00069	0.659
MOD_CK2_1	758	764	PF00069	0.476
MOD_CK2_1	770	776	PF00069	0.589
MOD_CK2_1	829	835	PF00069	0.635
MOD_CK2_1	837	843	PF00069	0.509
MOD_CK2_1	879	885	PF00069	0.484
MOD_CK2_1	893	899	PF00069	0.623
MOD_CK2_1	920	926	PF00069	0.666
MOD_Cter_Amidation	561	564	PF01082	0.798
MOD_DYRK1A_RPxSP_1	1058	1062	PF00069	0.701
MOD_DYRK1A_RPxSP_1	390	394	PF00069	0.793
MOD_GlcNHglycan	1006	1009	PF01048	0.801
MOD_GlcNHglycan	1018	1021	PF01048	0.546
MOD_GlcNHglycan	1044	1047	PF01048	0.607
MOD_GlcNHglycan	130	133	PF01048	0.692
MOD_GlcNHglycan	258	261	PF01048	0.779
MOD_GlcNHglycan	282	285	PF01048	0.741
MOD_GlcNHglycan	288	291	PF01048	0.655
MOD_GlcNHglycan	328	331	PF01048	0.640
MOD_GlcNHglycan	390	393	PF01048	0.801
MOD_GlcNHglycan	395	398	PF01048	0.728
MOD_GlcNHglycan	468	471	PF01048	0.633
MOD_GlcNHglycan	50	53	PF01048	0.807
MOD_GlcNHglycan	524	527	PF01048	0.858
MOD_GlcNHglycan	553	556	PF01048	0.707
MOD_GlcNHglycan	576	580	PF01048	0.604
MOD_GlcNHglycan	685	688	PF01048	0.534
MOD_GlcNHglycan	772	775	PF01048	0.722
MOD_GlcNHglycan	818	823	PF01048	0.624
MOD_GlcNHglycan	849	852	PF01048	0.560
MOD_GlcNHglycan	853	856	PF01048	0.634
MOD_GlcNHglycan	87	90	PF01048	0.807
MOD_GlcNHglycan	870	873	PF01048	0.346
MOD_GlcNHglycan	912	915	PF01048	0.535
MOD_GlcNHglycan	974	977	PF01048	0.685
MOD_GSK3_1	1004	1011	PF00069	0.762
MOD_GSK3_1	1012	1019	PF00069	0.659
MOD_GSK3_1	1021	1028	PF00069	0.684
MOD_GSK3_1	1042	1049	PF00069	0.695
MOD_GSK3_1	114	121	PF00069	0.741
MOD_GSK3_1	124	131	PF00069	0.592
MOD_GSK3_1	141	148	PF00069	0.562
MOD_GSK3_1	16	23	PF00069	0.665
MOD_GSK3_1	256	263	PF00069	0.754
MOD_GSK3_1	275	282	PF00069	0.561
MOD_GSK3_1	284	291	PF00069	0.665
MOD_GSK3_1	295	302	PF00069	0.708
MOD_GSK3_1	338	345	PF00069	0.832
MOD_GSK3_1	379	386	PF00069	0.820
MOD_GSK3_1	460	467	PF00069	0.745
MOD_GSK3_1	516	523	PF00069	0.845
MOD_GSK3_1	525	532	PF00069	0.705
MOD_GSK3_1	551	558	PF00069	0.790
MOD_GSK3_1	587	594	PF00069	0.842
MOD_GSK3_1	595	602	PF00069	0.618
MOD_GSK3_1	603	610	PF00069	0.697
MOD_GSK3_1	7	14	PF00069	0.797
MOD_GSK3_1	768	775	PF00069	0.640
MOD_GSK3_1	847	854	PF00069	0.630
MOD_GSK3_1	913	920	PF00069	0.668
MOD_N-GLC_1	304	309	PF02516	0.755
MOD_N-GLC_1	461	466	PF02516	0.766
MOD_N-GLC_2	667	669	PF02516	0.599
MOD_NEK2_1	1042	1047	PF00069	0.709
MOD_NEK2_1	1052	1057	PF00069	0.565
MOD_NEK2_1	130	135	PF00069	0.687
MOD_NEK2_1	388	393	PF00069	0.742
MOD_NEK2_1	4	9	PF00069	0.786
MOD_NEK2_1	521	526	PF00069	0.854
MOD_NEK2_1	603	608	PF00069	0.689
MOD_NEK2_1	609	614	PF00069	0.651
MOD_NEK2_1	736	741	PF00069	0.540
MOD_NEK2_1	758	763	PF00069	0.670
MOD_NEK2_1	829	834	PF00069	0.514
MOD_NEK2_1	844	849	PF00069	0.529
MOD_PIKK_1	130	136	PF00454	0.683
MOD_PIKK_1	14	20	PF00454	0.616
MOD_PIKK_1	726	732	PF00454	0.664
MOD_PIKK_1	893	899	PF00454	0.623
MOD_PIKK_1	917	923	PF00454	0.668
MOD_PKA_1	990	996	PF00069	0.773
MOD_PKA_2	104	110	PF00069	0.623
MOD_PKA_2	1042	1048	PF00069	0.708
MOD_PKA_2	1057	1063	PF00069	0.765
MOD_PKA_2	128	134	PF00069	0.697
MOD_PKA_2	21	27	PF00069	0.799
MOD_PKA_2	256	262	PF00069	0.766
MOD_PKA_2	46	52	PF00069	0.805
MOD_PKA_2	683	689	PF00069	0.617
MOD_PKA_2	701	707	PF00069	0.542
MOD_PKA_2	758	764	PF00069	0.645
MOD_PKA_2	990	996	PF00069	0.735
MOD_PKB_1	139	147	PF00069	0.707
MOD_PKB_1	886	894	PF00069	0.687
MOD_Plk_1	182	188	PF00069	0.460
MOD_Plk_1	304	310	PF00069	0.631
MOD_Plk_1	371	377	PF00069	0.635
MOD_Plk_1	461	467	PF00069	0.766
MOD_Plk_1	501	507	PF00069	0.619
MOD_Plk_1	818	824	PF00069	0.634
MOD_Plk_1	902	908	PF00069	0.689
MOD_Plk_4	461	467	PF00069	0.864
MOD_ProDKin_1	1014	1020	PF00069	0.823
MOD_ProDKin_1	1058	1064	PF00069	0.716
MOD_ProDKin_1	115	121	PF00069	0.603
MOD_ProDKin_1	145	151	PF00069	0.721
MOD_ProDKin_1	16	22	PF00069	0.664
MOD_ProDKin_1	282	288	PF00069	0.832
MOD_ProDKin_1	309	315	PF00069	0.726
MOD_ProDKin_1	342	348	PF00069	0.849
MOD_ProDKin_1	351	357	PF00069	0.691
MOD_ProDKin_1	377	383	PF00069	0.833
MOD_ProDKin_1	390	396	PF00069	0.570
MOD_ProDKin_1	406	412	PF00069	0.662
MOD_ProDKin_1	464	470	PF00069	0.727
MOD_ProDKin_1	527	533	PF00069	0.843
MOD_ProDKin_1	597	603	PF00069	0.849
MOD_ProDKin_1	623	629	PF00069	0.693
MOD_ProDKin_1	68	74	PF00069	0.793
MOD_ProDKin_1	7	13	PF00069	0.748
MOD_ProDKin_1	75	81	PF00069	0.703
MOD_ProDKin_1	775	781	PF00069	0.803
MOD_SUMO_for_1	1022	1025	PF00179	0.715
MOD_SUMO_for_1	173	176	PF00179	0.608
MOD_SUMO_for_1	996	999	PF00179	0.728
MOD_SUMO_rev_2	317	324	PF00179	0.784
MOD_SUMO_rev_2	699	709	PF00179	0.665
TRG_DiLeu_BaEn_1	220	225	PF01217	0.644
TRG_DiLeu_BaEn_1	946	951	PF01217	0.506
TRG_DiLeu_BaEn_4	220	226	PF01217	0.684
TRG_DiLeu_BaEn_4	633	639	PF01217	0.690
TRG_DiLeu_BaEn_4	646	652	PF01217	0.457
TRG_DiLeu_BaEn_4	884	890	PF01217	0.505
TRG_ENDOCYTIC_2	1036	1039	PF00928	0.722
TRG_ENDOCYTIC_2	657	660	PF00928	0.627
TRG_ENDOCYTIC_2	954	957	PF00928	0.561
TRG_ER_diArg_1	445	448	PF00400	0.812
TRG_ER_diArg_1	491	494	PF00400	0.786
TRG_ER_diArg_1	59	61	PF00400	0.805
TRG_ER_diArg_1	641	643	PF00400	0.613
TRG_ER_diArg_1	830	833	PF00400	0.673
TRG_ER_diArg_1	886	889	PF00400	0.686
TRG_ER_diArg_1	99	101	PF00400	0.643
TRG_NES_CRM1_1	649	663	PF08389	0.630
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.679
TRG_Pf-PMV_PEXEL_1	642	646	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	695	700	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	910	915	PF00026	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUD7	Leishmania donovani	90%	100%
A4H8Z6	Leishmania braziliensis	69%	100%
A4HXC7	Leishmania infantum	91%	100%
E9AR22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%