Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania major

UniProt:

Q4QED9_LEIMA

TriTrypDb:

LmjF.17.0550 , LMJLV39_170011200 , LMJSD75_170010900

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QED9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QED9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.533
CLV_NRD_NRD_1	133	135	PF00675	0.538
CLV_NRD_NRD_1	148	150	PF00675	0.685
CLV_PCSK_FUR_1	93	97	PF00082	0.587
CLV_PCSK_KEX2_1	132	134	PF00082	0.587
CLV_PCSK_KEX2_1	148	150	PF00082	0.567
CLV_PCSK_KEX2_1	42	44	PF00082	0.487
CLV_PCSK_KEX2_1	95	97	PF00082	0.731
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.487
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.723
CLV_PCSK_SKI1_1	43	47	PF00082	0.465
DEG_APCC_DBOX_1	246	254	PF00400	0.471
DEG_APCC_DBOX_1	61	69	PF00400	0.428
DEG_SPOP_SBC_1	88	92	PF00917	0.536
DOC_CYCLIN_yClb3_PxF_3	207	213	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	199	205	PF00134	0.455
DOC_MAPK_gen_1	42	50	PF00069	0.398
DOC_MAPK_MEF2A_6	247	256	PF00069	0.534
DOC_MAPK_MEF2A_6	287	296	PF00069	0.446
DOC_MAPK_MEF2A_6	43	52	PF00069	0.381
DOC_PP2B_LxvP_1	199	202	PF13499	0.537
DOC_PP2B_LxvP_1	203	206	PF13499	0.477
DOC_PP4_FxxP_1	188	191	PF00568	0.636
DOC_PP4_FxxP_1	256	259	PF00568	0.534
DOC_USP7_MATH_1	31	35	PF00917	0.420
DOC_USP7_MATH_1	88	92	PF00917	0.581
DOC_USP7_UBL2_3	38	42	PF12436	0.481
DOC_WW_Pin1_4	78	83	PF00397	0.613
LIG_14-3-3_CanoR_1	12	19	PF00244	0.476
LIG_BIR_III_2	66	70	PF00653	0.464
LIG_EVH1_1	203	207	PF00568	0.439
LIG_FHA_1	283	289	PF00498	0.470
LIG_FHA_1	45	51	PF00498	0.412
LIG_FHA_2	102	108	PF00498	0.493
LIG_FHA_2	20	26	PF00498	0.512
LIG_FHA_2	49	55	PF00498	0.505
LIG_LIR_Gen_1	114	121	PF02991	0.640
LIG_LIR_Gen_1	13	23	PF02991	0.411
LIG_LIR_Gen_1	234	243	PF02991	0.522
LIG_LIR_Gen_1	46	57	PF02991	0.370
LIG_LIR_Nem_3	114	118	PF02991	0.643
LIG_LIR_Nem_3	13	19	PF02991	0.422
LIG_LIR_Nem_3	234	239	PF02991	0.469
LIG_LIR_Nem_3	25	29	PF02991	0.381
LIG_LIR_Nem_3	46	52	PF02991	0.384
LIG_MYND_1	201	205	PF01753	0.670
LIG_MYND_1	208	212	PF01753	0.609
LIG_PTB_Apo_2	219	226	PF02174	0.453
LIG_SH2_STAT3	121	124	PF00017	0.559
LIG_SH2_STAT5	231	234	PF00017	0.511
LIG_SH3_2	204	209	PF14604	0.530
LIG_SH3_3	198	204	PF00018	0.650
LIG_SH3_3	205	211	PF00018	0.478
LIG_SH3_CIN85_PxpxPR_1	204	209	PF14604	0.530
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.534
LIG_SUMO_SIM_par_1	276	283	PF11976	0.515
LIG_TRAF2_1	82	85	PF00917	0.722
LIG_WRC_WIRS_1	32	37	PF05994	0.544
LIG_WRC_WIRS_1	49	54	PF05994	0.500
LIG_WW_2	201	204	PF00397	0.446
LIG_WW_3	206	210	PF00397	0.550
MOD_CK1_1	10	16	PF00069	0.528
MOD_CK1_1	282	288	PF00069	0.410
MOD_CK1_1	91	97	PF00069	0.635
MOD_CK2_1	14	20	PF00069	0.502
MOD_CK2_1	31	37	PF00069	0.548
MOD_GlcNHglycan	16	19	PF01048	0.544
MOD_GlcNHglycan	236	239	PF01048	0.334
MOD_GlcNHglycan	282	285	PF01048	0.386
MOD_GlcNHglycan	78	81	PF01048	0.737
MOD_GSK3_1	103	110	PF00069	0.475
MOD_GSK3_1	44	51	PF00069	0.487
MOD_GSK3_1	6	13	PF00069	0.514
MOD_GSK3_1	87	94	PF00069	0.700
MOD_LATS_1	130	136	PF00433	0.511
MOD_N-GLC_1	161	166	PF02516	0.725
MOD_N-GLC_1	269	274	PF02516	0.291
MOD_NEK2_1	225	230	PF00069	0.534
MOD_NEK2_1	269	274	PF00069	0.491
MOD_NEK2_1	6	11	PF00069	0.507
MOD_NEK2_2	31	36	PF00069	0.426
MOD_PKA_1	132	138	PF00069	0.672
MOD_PKA_2	11	17	PF00069	0.476
MOD_PKA_2	132	138	PF00069	0.749
MOD_Plk_1	19	25	PF00069	0.458
MOD_Plk_1	43	49	PF00069	0.458
MOD_Plk_4	44	50	PF00069	0.410
MOD_ProDKin_1	78	84	PF00069	0.617
MOD_SUMO_rev_2	106	111	PF00179	0.696
TRG_ER_diArg_1	132	134	PF00400	0.574
TRG_ER_diArg_1	148	151	PF00400	0.641
TRG_ER_diArg_1	174	177	PF00400	0.720
TRG_NLS_MonoExtN_4	93	99	PF00514	0.701
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZY5	Leptomonas seymouri	52%	100%
A0A1X0P0T6	Trypanosomatidae	36%	100%
A0A3Q8IAN2	Leishmania donovani	92%	99%
A0A3R7MFN4	Trypanosoma rangeli	35%	100%
A4H8Z8	Leishmania braziliensis	77%	98%
A4HXC9	Leishmania infantum	94%	100%
D0A4S0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AR24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
V5AZY6	Trypanosoma cruzi	37%	100%