Bis(5'-nucleosyl)-tetraphosphatase,symmetrical-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bis(5'-nucleosyl)-tetraphosphatase, symmetrical-like protein

Species:

Leishmania major

UniProt:

Q4QED6_LEIMA

TriTrypDb:

LmjF.17.0580 , LMJLV39_170011500 , LMJSD75_170011200

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QED6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QED6

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006797	polyphosphate metabolic process	4	2
GO:0006798	polyphosphate catabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000298	endopolyphosphatase activity	6	2
GO:0003824	catalytic activity	1	6
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.539
CLV_NRD_NRD_1	247	249	PF00675	0.496
CLV_NRD_NRD_1	266	268	PF00675	0.304
CLV_NRD_NRD_1	308	310	PF00675	0.585
CLV_PCSK_KEX2_1	246	248	PF00082	0.661
CLV_PCSK_KEX2_1	265	267	PF00082	0.284
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.419
DEG_Nend_UBRbox_4	1	3	PF02207	0.387
DOC_MAPK_gen_1	47	57	PF00069	0.310
DOC_MAPK_gen_1	71	78	PF00069	0.328
DOC_USP7_MATH_1	130	134	PF00917	0.409
DOC_USP7_MATH_1	16	20	PF00917	0.559
DOC_USP7_MATH_1	227	231	PF00917	0.602
DOC_USP7_MATH_1	308	312	PF00917	0.548
DOC_USP7_MATH_1	83	87	PF00917	0.351
DOC_USP7_UBL2_3	232	236	PF12436	0.597
DOC_WW_Pin1_4	14	19	PF00397	0.570
DOC_WW_Pin1_4	303	308	PF00397	0.537
LIG_APCC_ABBAyCdc20_2	246	252	PF00400	0.482
LIG_BRCT_BRCA1_1	168	172	PF00533	0.545
LIG_FHA_1	286	292	PF00498	0.486
LIG_FHA_2	77	83	PF00498	0.324
LIG_LIR_Gen_1	169	180	PF02991	0.516
LIG_LIR_Gen_1	252	260	PF02991	0.346
LIG_LIR_Gen_1	96	106	PF02991	0.371
LIG_LIR_Nem_3	169	175	PF02991	0.510
LIG_LIR_Nem_3	252	256	PF02991	0.431
LIG_LIR_Nem_3	41	46	PF02991	0.266
LIG_PDZ_Class_1	308	313	PF00595	0.609
LIG_SH2_CRK	114	118	PF00017	0.480
LIG_SH2_CRK	43	47	PF00017	0.324
LIG_SH2_SRC	273	276	PF00017	0.395
LIG_SH2_STAT3	149	152	PF00017	0.564
LIG_SH2_STAT5	253	256	PF00017	0.402
LIG_SH3_2	305	310	PF14604	0.499
LIG_SH3_3	122	128	PF00018	0.250
LIG_SH3_3	294	300	PF00018	0.457
LIG_SH3_3	3	9	PF00018	0.314
LIG_SH3_3	302	308	PF00018	0.392
LIG_TRAF2_1	200	203	PF00917	0.564
LIG_UBA3_1	65	71	PF00899	0.266
LIG_WW_3	306	310	PF00397	0.509
MOD_CDC14_SPxK_1	306	309	PF00782	0.524
MOD_CDK_SPxK_1	303	309	PF00069	0.504
MOD_CDK_SPxxK_3	303	310	PF00069	0.529
MOD_CK1_1	205	211	PF00069	0.632
MOD_CK1_1	218	224	PF00069	0.702
MOD_CK2_1	76	82	PF00069	0.324
MOD_Cter_Amidation	230	233	PF01082	0.570
MOD_GlcNHglycan	14	17	PF01048	0.635
MOD_GlcNHglycan	168	171	PF01048	0.591
MOD_GlcNHglycan	18	21	PF01048	0.535
MOD_GlcNHglycan	217	220	PF01048	0.769
MOD_GlcNHglycan	228	232	PF01048	0.590
MOD_GlcNHglycan	278	281	PF01048	0.413
MOD_GSK3_1	12	19	PF00069	0.575
MOD_GSK3_1	151	158	PF00069	0.629
MOD_GSK3_1	202	209	PF00069	0.586
MOD_GSK3_1	291	298	PF00069	0.443
MOD_NEK2_1	101	106	PF00069	0.334
MOD_NEK2_1	12	17	PF00069	0.584
MOD_NEK2_1	166	171	PF00069	0.581
MOD_NEK2_1	195	200	PF00069	0.700
MOD_NEK2_2	83	88	PF00069	0.258
MOD_PKA_2	206	212	PF00069	0.555
MOD_PKB_1	211	219	PF00069	0.612
MOD_Plk_1	254	260	PF00069	0.344
MOD_Plk_4	292	298	PF00069	0.441
MOD_Plk_4	83	89	PF00069	0.324
MOD_ProDKin_1	14	20	PF00069	0.572
MOD_ProDKin_1	303	309	PF00069	0.546
TRG_DiLeu_BaEn_1	286	291	PF01217	0.390
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.286
TRG_ENDOCYTIC_2	114	117	PF00928	0.480
TRG_ENDOCYTIC_2	253	256	PF00928	0.440
TRG_ENDOCYTIC_2	43	46	PF00928	0.373
TRG_ER_diArg_1	245	248	PF00400	0.545
TRG_ER_diArg_1	266	268	PF00400	0.435
TRG_NES_CRM1_1	67	82	PF08389	0.286
TRG_NLS_Bipartite_1	247	269	PF00514	0.396
TRG_NLS_MonoCore_2	232	237	PF00514	0.583
TRG_NLS_MonoExtC_3	231	236	PF00514	0.583
TRG_NLS_MonoExtN_4	232	237	PF00514	0.560
TRG_NLS_MonoExtN_4	307	313	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD44	Leptomonas seymouri	56%	72%
A0A3S7WUL2	Leishmania donovani	93%	98%
A0KGT6	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	25%	100%
A0L066	Shewanella sp. (strain ANA-3)	28%	100%
A4H901	Leishmania braziliensis	73%	100%
A4HXD2	Leishmania infantum	93%	98%
B4F2I4	Proteus mirabilis (strain HI4320)	27%	100%
C6DEY8	Pectobacterium carotovorum subsp. carotovorum (strain PC1)	27%	100%
C9ZM70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AR27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q0HS04	Shewanella sp. (strain MR-7)	28%	100%
Q3JBF6	Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)	27%	100%