Acyl_transf_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyl CoA binding protein, putative

Species:

Leishmania major

UniProt:

Q4QED3_LEIMA

TriTrypDb:

LmjF.17.0610 , LMJLV39_170012000 , LMJSD75_170011700

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QED3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QED3

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	7
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0008289	lipid binding	2	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0033218	amide binding	2	7
GO:0036094	small molecule binding	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0120227	acyl-CoA binding	3	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:1901567	fatty acid derivative binding	3	7
GO:1901681	sulfur compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.542
CLV_C14_Caspase3-7	41	45	PF00656	0.365
CLV_NRD_NRD_1	100	102	PF00675	0.324
CLV_NRD_NRD_1	123	125	PF00675	0.416
CLV_NRD_NRD_1	325	327	PF00675	0.595
CLV_NRD_NRD_1	337	339	PF00675	0.608
CLV_NRD_NRD_1	381	383	PF00675	0.590
CLV_NRD_NRD_1	47	49	PF00675	0.421
CLV_NRD_NRD_1	8	10	PF00675	0.552
CLV_PCSK_FUR_1	326	330	PF00082	0.609
CLV_PCSK_KEX2_1	226	228	PF00082	0.324
CLV_PCSK_KEX2_1	267	269	PF00082	0.608
CLV_PCSK_KEX2_1	328	330	PF00082	0.524
CLV_PCSK_KEX2_1	336	338	PF00082	0.393
CLV_PCSK_KEX2_1	381	383	PF00082	0.590
CLV_PCSK_KEX2_1	493	495	PF00082	0.609
CLV_PCSK_KEX2_1	8	10	PF00082	0.561
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.324
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.608
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.527
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.393
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.605
CLV_PCSK_SKI1_1	104	108	PF00082	0.421
CLV_PCSK_SKI1_1	173	177	PF00082	0.303
CLV_PCSK_SKI1_1	231	235	PF00082	0.409
CLV_PCSK_SKI1_1	263	267	PF00082	0.576
CLV_PCSK_SKI1_1	474	478	PF00082	0.695
CLV_PCSK_SKI1_1	71	75	PF00082	0.324
DEG_Nend_Nbox_1	1	3	PF02207	0.657
DEG_SPOP_SBC_1	431	435	PF00917	0.639
DOC_CKS1_1	184	189	PF01111	0.421
DOC_PP1_RVXF_1	61	67	PF00149	0.354
DOC_PP4_FxxP_1	29	32	PF00568	0.521
DOC_PP4_FxxP_1	353	356	PF00568	0.544
DOC_USP7_MATH_1	358	362	PF00917	0.571
DOC_USP7_MATH_1	449	453	PF00917	0.753
DOC_USP7_MATH_1	456	460	PF00917	0.678
DOC_USP7_MATH_1	476	480	PF00917	0.579
DOC_USP7_UBL2_3	231	235	PF12436	0.506
DOC_USP7_UBL2_3	263	267	PF12436	0.672
DOC_USP7_UBL2_3	328	332	PF12436	0.593
DOC_USP7_UBL2_3	470	474	PF12436	0.683
DOC_USP7_UBL2_3	483	487	PF12436	0.628
DOC_WW_Pin1_4	183	188	PF00397	0.421
DOC_WW_Pin1_4	432	437	PF00397	0.672
LIG_14-3-3_CanoR_1	124	130	PF00244	0.565
LIG_14-3-3_CanoR_1	302	306	PF00244	0.498
LIG_BIR_III_4	291	295	PF00653	0.548
LIG_BRCT_BRCA1_1	21	25	PF00533	0.569
LIG_deltaCOP1_diTrp_1	137	143	PF00928	0.451
LIG_deltaCOP1_diTrp_1	90	95	PF00928	0.324
LIG_FHA_1	114	120	PF00498	0.253
LIG_FHA_1	50	56	PF00498	0.253
LIG_FHA_2	267	273	PF00498	0.585
LIG_FHA_2	283	289	PF00498	0.429
LIG_FHA_2	307	313	PF00498	0.549
LIG_FHA_2	317	323	PF00498	0.460
LIG_FHA_2	363	369	PF00498	0.721
LIG_FHA_2	386	392	PF00498	0.606
LIG_FHA_2	72	78	PF00498	0.354
LIG_LIR_Apic_2	128	134	PF02991	0.599
LIG_LIR_Apic_2	28	32	PF02991	0.523
LIG_LIR_Gen_1	113	123	PF02991	0.324
LIG_LIR_Gen_1	137	147	PF02991	0.438
LIG_LIR_Gen_1	212	220	PF02991	0.324
LIG_LIR_Nem_3	11	17	PF02991	0.621
LIG_LIR_Nem_3	113	118	PF02991	0.324
LIG_LIR_Nem_3	137	143	PF02991	0.451
LIG_LIR_Nem_3	191	197	PF02991	0.331
LIG_LIR_Nem_3	212	217	PF02991	0.421
LIG_LIR_Nem_3	90	94	PF02991	0.324
LIG_MAD2	453	461	PF02301	0.631
LIG_Pex14_1	140	144	PF04695	0.349
LIG_Pex14_2	25	29	PF04695	0.528
LIG_Pex14_2	66	70	PF04695	0.421
LIG_REV1ctd_RIR_1	3	11	PF16727	0.540
LIG_SH2_CRK	144	148	PF00017	0.336
LIG_SH2_NCK_1	36	40	PF00017	0.421
LIG_SH2_STAP1	115	119	PF00017	0.253
LIG_SH2_STAP1	211	215	PF00017	0.324
LIG_SH2_STAP1	36	40	PF00017	0.421
LIG_SH2_STAT5	115	118	PF00017	0.354
LIG_SH2_STAT5	159	162	PF00017	0.303
LIG_SH2_STAT5	229	232	PF00017	0.324
LIG_SH2_STAT5	242	245	PF00017	0.469
LIG_SH2_STAT5	46	49	PF00017	0.354
LIG_SH3_3	14	20	PF00018	0.550
LIG_SH3_3	240	246	PF00018	0.472
LIG_SH3_3	29	35	PF00018	0.665
LIG_SH3_3	79	85	PF00018	0.328
LIG_TRAF2_1	285	288	PF00917	0.618
LIG_TRAF2_1	319	322	PF00917	0.553
LIG_TRAF2_1	39	42	PF00917	0.365
LIG_UBA3_1	118	125	PF00899	0.409
LIG_UBA3_1	149	155	PF00899	0.421
LIG_WRC_WIRS_1	2	7	PF05994	0.530
LIG_WRC_WIRS_1	305	310	PF05994	0.592
MOD_CK1_1	199	205	PF00069	0.337
MOD_CK1_1	261	267	PF00069	0.670
MOD_CK2_1	282	288	PF00069	0.661
MOD_CK2_1	295	301	PF00069	0.395
MOD_CK2_1	306	312	PF00069	0.506
MOD_CK2_1	316	322	PF00069	0.461
MOD_CK2_1	362	368	PF00069	0.728
MOD_CK2_1	405	411	PF00069	0.752
MOD_CK2_1	454	460	PF00069	0.676
MOD_Cter_Amidation	324	327	PF01082	0.542
MOD_Cter_Amidation	491	494	PF01082	0.557
MOD_Cter_Amidation	6	9	PF01082	0.641
MOD_GlcNHglycan	134	137	PF01048	0.583
MOD_GlcNHglycan	235	238	PF01048	0.453
MOD_GlcNHglycan	260	263	PF01048	0.576
MOD_GlcNHglycan	418	421	PF01048	0.811
MOD_GlcNHglycan	444	447	PF01048	0.655
MOD_GSK3_1	257	264	PF00069	0.666
MOD_GSK3_1	358	365	PF00069	0.676
MOD_GSK3_1	427	434	PF00069	0.681
MOD_N-GLC_1	178	183	PF02516	0.337
MOD_N-GLC_2	397	399	PF02516	0.654
MOD_NEK2_1	1	6	PF00069	0.517
MOD_NEK2_1	398	403	PF00069	0.561
MOD_NEK2_1	442	447	PF00069	0.650
MOD_PKA_1	266	272	PF00069	0.585
MOD_PKA_2	199	205	PF00069	0.356
MOD_PKA_2	301	307	PF00069	0.498
MOD_Plk_1	362	368	PF00069	0.689
MOD_Plk_2-3	405	411	PF00069	0.543
MOD_Plk_4	1	7	PF00069	0.517
MOD_Plk_4	125	131	PF00069	0.608
MOD_Plk_4	19	25	PF00069	0.454
MOD_Plk_4	295	301	PF00069	0.582
MOD_Plk_4	65	71	PF00069	0.354
MOD_Plk_4	83	89	PF00069	0.354
MOD_ProDKin_1	183	189	PF00069	0.421
MOD_ProDKin_1	432	438	PF00069	0.669
MOD_SUMO_for_1	356	359	PF00179	0.647
MOD_SUMO_for_1	463	466	PF00179	0.644
MOD_SUMO_rev_2	11	17	PF00179	0.594
MOD_SUMO_rev_2	75	85	PF00179	0.361
TRG_ENDOCYTIC_2	115	118	PF00928	0.354
TRG_ENDOCYTIC_2	144	147	PF00928	0.331
TRG_ENDOCYTIC_2	194	197	PF00928	0.324
TRG_ENDOCYTIC_2	67	70	PF00928	0.403
TRG_ENDOCYTIC_2	94	97	PF00928	0.421
TRG_ER_diArg_1	197	200	PF00400	0.324
TRG_ER_diArg_1	381	383	PF00400	0.590
TRG_NES_CRM1_1	288	301	PF08389	0.537
TRG_NLS_Bipartite_1	326	340	PF00514	0.531
TRG_NLS_MonoExtN_4	490	497	PF00514	0.578
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	381	386	PF00026	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F7	Leptomonas seymouri	47%	100%
A0A3Q8IDY9	Leishmania donovani	91%	100%
A4H904	Leishmania braziliensis	70%	100%
A4HXD5	Leishmania infantum	91%	100%
E9AR30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%